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List of works by Eckard Wimmer

A "slide-back" mechanism for the initiation of protein-primed RNA synthesis by the RNA polymerase of poliovirus

scientific article published on 22 August 2003

A C-terminal, cysteine-rich site in poliovirus 2C(ATPase) is required for morphogenesis

scientific article

A Host-Specific, Temperature-Sensitive Translation Defect Determines the Attenuation Phenotype of a Human Rhinovirus/Poliovirus Chimera, PV1(RIPO) ⬇️

scientific article published on May 11, 2011

A Single Amino Acid Substitution in Poliovirus Nonstructural Protein 2CATPase Causes Conditional Defects in Encapsidation and Uncoating

scientific article published on 13 April 2016

Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis

scientific article published on 3 July 2012

An interaction between glutathione and the capsid is required for the morphogenesis of C-cluster enteroviruses

scientific article (publication date: April 2014)

Analysis of the cloverleaf element in a human rhinovirus type 14/poliovirus chimera: correlation of subdomain D structure, ternary protein complex formation and virus replication

scientific article published in August 2003

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

scientific article

Binding of glutathione to enterovirus capsids is essential for virion morphogenesis

scientific article (publication date: April 2014)

Brunenders: a partially attenuated historic poliovirus type I vaccine strain

scientific article

Characterization of the New World monkey homologues of human poliovirus receptor CD155.

scientific article published on 14 May 2008

Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template

scientific article

Cis-acting RNA elements in human and animal plus-strand RNA viruses

scientific article

Cold-Adapted Viral Attenuation (CAVA): Highly Temperature Sensitive Polioviruses as Novel Vaccine Strains for a Next Generation Inactivated Poliovirus Vaccine

scientific article

Complete protein linkage map between the P2 and P3 non-structural proteins of poliovirus

scientific article published in August 2007

Complexes of poliovirus serotypes with their common cellular receptor, CD155

scientific article

Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector ⬇️

scientific article published on August 15, 2011

Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses

scientific article

Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice ⬇️

scientific article published on May 20, 2013

Direct interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesis

scientific article

Don't drop current vaccine until we have new ones

scientific article published in Nature

Eradicating polio: A balancing act.

scientific article published in January 2016

Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets.

scientific article

Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication

scientific article

Evolution of poliovirus defective interfering particles expressing Gaussia luciferase

scientific article

Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog

scientific article

Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes

scientific article published in PLoS ONE

Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes

Functional Dissection of a Poliovirus cis -Acting Replication Element [PV- cre (2C)]: Analysis of Single- and Dual- cre Viral Genomes and Proteins That Bind Specifically to PV- cre RNA ⬇️

scientific article published on May 1, 2003

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure

scientific article published on 03 January 2017

Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses

scientific article published on February 2008

HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage

scientific article

Identification of cellular proteins enhancing activities of internal ribosomal entry sites by competition with oligodeoxynucleotides

scientific article

Identification of two functionally redundant RNA elements in the coding sequence of poliovirus using computer-generated design ⬇️

scientific article published on August 10, 2012

Immunofluorescence analysis of poliovirus receptor expression in Peyer's patches of humans, primates, and CD155 transgenic mice: implications for poliovirus infection

scientific article published on 9 August 2002

Inhibition of hepatitis C virus IRES-mediated translation by oligonucleotides

scientific article published on 29 August 2009

Initiation of protein-primed picornavirus RNA synthesis

scientific article

Interaction of the Poliovirus Receptor CD155 with the Dynein Light Chain Tctex-1 and Its Implication for Poliovirus Pathogenesis ⬇️

scientific article (publication date: 8 March 2002)

Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference

scientific article

Limits of variation, specific infectivity, and genome packaging of massively recoded poliovirus genomes

scientific article published on 25 September 2017

Live attenuated influenza virus vaccines by computer-aided rational design

scientific article

Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration

scientific article published on 11 June 2003

Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication

scientific article published on 07 April 2007

Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence

scientific article

Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo

scientific article published on January 1, 2011

Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model

scientific article published in March 2007

Picornavirus morphogenesis

scientific article

Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation

scientific article

Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event

scientific article

Polypyrimidine Tract Binding Protein-1 (PTB1) Is a Determinant of the Tissue and Host Tropism of a Human Rhinovirus/Poliovirus Chimera PV1(RIPO) ⬇️

scientific article published on April 4, 2013

Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides ⬇️

scientific article published on August 25, 1983

Production of high titer attenuated poliovirus strains on the serum-free PER.C6(®) cell culture platform for the generation of safe and affordable next generation IPV.

scientific article published on 31 October 2015

Profile of Eckard Wimmer. Interview by Sujata Gupta

scientific article

Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro ⬇️

scientific article published on October 16, 1980

Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis

scientific article

Pyrite-induced hydroxyl radical formation and its effect on nucleic acids

scientific article

Recoding of the vesicular stomatitis virus L gene by computer-aided design provides a live, attenuated vaccine candidate

scientific article published on 31 March 2015

Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains

scientific article (publication date: 15 August 2003)

Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity

scientific article

Replication of a novel subgenomic HCV genotype 1a replicon expressing a puromycin resistance gene in Huh-7 cells.

scientific article published on March 2005

Replication of poliovirus requires binding of the poly(rC) binding protein to the cloverleaf as well as to the adjacent C-rich spacer sequence between the cloverleaf and the internal ribosomal entry site

scientific article published on 3 July 2007

Reply to Simmonds et al.: Codon pair and dinucleotide bias have not been functionally distinguished

scientific article published on 12 June 2015

Sequence requirements for viral RNA replication and VPg uridylylation directed by the internal cis-acting replication element (cre) of human rhinovirus type 14.

scientific article

Statement on scientific publication and security.

scientific article

Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro

scientific article

Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro

scientific article

Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis

scientific article published on January 2006

Synchrotron radiation-induced X-ray emission to identify metal ions in preparations of purified protein

scientific article

Synthetic poliovirus and other designer viruses: what have we learned from them? ⬇️

scientific article published on January 1, 2011

Synthetic viruses: a new opportunity to understand and prevent viral disease

scientific article

The C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3A

scientific article (publication date: November 2006)

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.

scientific article published on July 2005

The test-tube synthesis of a chemical called poliovirus. The simple synthesis of a virus has far-reaching societal implications

scientific article (publication date: July 2006)

Tyrosine 3 of poliovirus terminal peptide VPg(3B) has an essential function in RNA replication in the context of its precursor protein, 3AB.

scientific article published on 14 March 2007

Uncensored exchange of scientific results

scholarly article

Vaccination against polio should not be stopped

scientific article

Vaccines should be kept even if polio is wiped out

scientific article published in Nature

Virus attenuation by genome-scale changes in codon pair bias

scientific article

cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome

scientific article

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