List of works - Holly Ingraham

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

scientific article published on 11 December 2015

A lipid for fat disorders

scientific article published on 22 June 2011

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

scientific article published in November 1988

An affective disorder in zebrafish with mutation of the glucocorticoid receptor

scientific article

An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.

scientific article

Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary

scientific article

Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease

scientific article

Characterization of two atypical promoters and alternate mRNA processing in the mouse Thy-1.2 glycoprotein gene

scientific article published on August 1986

Contact Lens-related Deep Stromal intracorneal Hemorrhage ⬇️

scientific article published on 01 December 1991

DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate

scientific article published on 01 June 1986

Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1).

scientific article published on 06 October 2008

Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes

scientific article

Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function

scientific journal article

Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.

scientific article published in October 2006

Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.

scientific article published on 19 June 2012

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

scientific article

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development

scientific journal article

Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.

scientific article published on 21 June 2017

Erratum: Expression of a large family of POU-domain regulatory genes in mammalian brain development

scientific article published in Nature

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

scientific article published in Nature Communications

Expression of a large family of POU-domain regulatory genes in mammalian brain development

scientific article

Expression of the Thy-1 glycoprotein gene by DNA-mediated gene transfer ⬇️

scientific article published on September 1, 1984

Gene dosage effects of steroidogenic factor 1 (SF-1) in adrenal development and the stress.

scientific article published in November 2000

Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH.

scientific article

International Union of Pharmacology. LXVI. Orphan nuclear receptors

scientific article

Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development

scientific article

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

scientific article published in Nature Communications

LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.

scientific article

Mechanism of thymineless death

scientific article published on 01 January 1986

Molecular Cloning of the Acetylcholine Receptor ⬇️

scientific article published on 01 January 1983

Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation

scientific article

Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia

scientific article

Müllerian inhibitory substance induces growth of rat preantral ovarian follicles

scientific journal article

Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish.

scientific article published on 23 June 2009

Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes.

scientific article published on August 1998

New solutions to an ancient riddle: defining the differences between Adam and Eve.

scientific article

Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade

scientific article

Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior.

scientific article published in January 2017

Orphan nuclear receptors adopted by crystallography

scientific article

Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.

scientific article

Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.

scientific article

Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins

scientific journal article

Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons.

scientific article published on April 2003

SF-1 and DAX-1

Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.

scientific article

Should We Make More Bone or Not, As Told by Kisspeptin Neurons in the Arcuate Nucleus

scientific article published on 01 May 2019

Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

scientific article

Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes.

scientific article published on 14 August 2003

Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.

scientific article published on 23 June 2009

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

scientific article published on February 2005

Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1

scientific article

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket

scientific article

Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory Ligands

scientific article

Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α.

scientific article published on 21 November 2016

The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification

scientific article

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products

scientific article

The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells

scientific article

The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.

scientific article published on December 2007

The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling

scientific journal article

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.

scientific article

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

scientific article

Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain

scientific article

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

scientific article

Tissue growth and remodeling of the embryonic and adult adrenal gland

scientific article

Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression

scientific article

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

scientific article

List of works by Holly Ingraham

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

A lipid for fat disorders

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

An affective disorder in zebrafish with mutation of the glucocorticoid receptor

An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.

Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary

Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease

Characterization of two atypical promoters and alternate mRNA processing in the mouse Thy-1.2 glycoprotein gene

Contact Lens-related Deep Stromal intracorneal Hemorrhage ⬇️

DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate

Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1).

Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes

Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function

Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.

Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development

Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.

Erratum: Expression of a large family of POU-domain regulatory genes in mammalian brain development

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

Expression of a large family of POU-domain regulatory genes in mammalian brain development

Expression of the Thy-1 glycoprotein gene by DNA-mediated gene transfer ⬇️

Gene dosage effects of steroidogenic factor 1 (SF-1) in adrenal development and the stress.

Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH.

International Union of Pharmacology. LXVI. Orphan nuclear receptors

Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.

Mechanism of thymineless death

Molecular Cloning of the Acetylcholine Receptor ⬇️

Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation

Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia

Müllerian inhibitory substance induces growth of rat preantral ovarian follicles

Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish.

Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes.

New solutions to an ancient riddle: defining the differences between Adam and Eve.

Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade

Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior.

Orphan nuclear receptors adopted by crystallography

Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.

Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.

Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins

Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons.

SF-1 and DAX-1

Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.

Should We Make More Bone or Not, As Told by Kisspeptin Neurons in the Arcuate Nucleus

Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes.

Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket

Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory Ligands

Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α.

The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products

The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells

The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.

The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

Tissue growth and remodeling of the embryonic and adult adrenal gland

Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy