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List of works by Tomasz I Michalak

Aberrant lymphocyte activation precedes delayed virus-specific T-cell response after both primary infection and secondary exposure to hepadnavirus in the woodchuck model of hepatitis B virus infection.

scientific article

Anti-HCV core antibody: a potential new marker of occult and otherwise serologically silent HCV infection

scientific article published on 03 December 2008

Asymptomatic Hepadnaviral Persistence and Its Consequences in the Woodchuck Model of Occult Hepatitis B Virus Infection

scientific article

Authentic Patient-Derived Hepatitis C Virus Infects and Productively Replicates in Primary CD4+ and CD8+ T Lymphocytes In Vitro

scientific article published on 22 November 2017

Bicistronic woodchuck hepatitis virus core and gamma interferon DNA vaccine can protect from hepatitis but does not elicit sterilizing antiviral immunity

scientific article published on November 2006

Characterization of bioactive recombinant woodchuck interleukin-2 amplified by RLM-RACE and produced in eukaryotic expression system

scientific article published on 24 April 2006

Chronic hepatitis and occult HCV infection

scientific article published in January 2010

De novo infection and propagation of wild-type Hepatitis C virus in human T lymphocytes in vitro

scientific article published in December 2006

Differential Expression of Woodchuck Toll-Like Receptors 1-10 in Distinct Forms of Infection and Stages of Hepatitis in Experimental Hepatitis B Virus Infection

scientific article published in 2018

Differential expression of candidate virus receptors in human T lymphocytes prone or resistant to infection with patient-derived hepatitis C virus

scientific article

Differential expression of interferon alpha inducible genes in peripheral blood mononuclear cells from patients chronically infected with hepatitis C virus and healthy donors.

scientific article published on 10 March 2015

Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions

scientific article published on 20 March 2009

Epidemiologic and clinical features of chronic hepatitis B virus infection in 8 Canadian provinces: a descriptive study by the Canadian HBV Network

scientific article published on 22 October 2019

Flow cytometric quantification of T cell proliferation and division kinetics in woodchuck model of hepatitis B.

scientific article published in January 2005

Hepadnaviral infection augments hepatocyte cytotoxicity mediated by both CD95 ligand and perforin pathways

scientific article

Hepatitis B virus quasispecies in hepatic and extrahepatic viral reservoirs in liver transplant recipients on prophylactic therapy

scientific article

Hepatitis C virus in peripheral blood mononuclear cells of individuals with isolated anti-hepatitis C virus antibody reactivity

scientific article published on July 2008

Hepatitis C virus infection of human T lymphocytes is mediated by CD5.

scientific article published on 25 January 2012

Hepatitis C virus load and expression of a unique subset of cellular genes in circulating lymphoid cells differentiate non-responders from responders to pegylated interferon alpha-ribavirin treatment

scientific article

Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C.

scientific article

Hepatitis C virus persisting after clinically apparent sustained virological response to antiviral therapy retains infectivity in vitro.

scientific article published on May 2009

Hepatitis C virus replicates in the same immune cell subsets in chronic hepatitis C and occult infection.

scientific article published on 14 December 2007

Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor

scientific article published on 21 July 2011

Hepatocytes as cytotoxic effector cells can induce cell death by CD95 ligand-mediated pathway.

scientific article

Hepatocytes can induce death of contacted cells via perforin-dependent mechanism

scientific article

Immune cell reservoirs of persisting hepatitis C virus

scientific article published in July 2010

Immune cell subsets and their gene expression profiles from human PBMC isolated by Vacutainer Cell Preparation Tube (CPT™) and standard density gradient

scientific article published on 26 August 2015

Inhibition by woodchuck hepatitis virus of class I major histocompatibility complex presentation on hepatocytes is mediated by virus envelope pre-S2 protein and can be reversed by treatment with gamma interferon

scientific article published in September 2006

Intrahepatic expression of genes affiliated with innate and adaptive immune responses immediately after invasion and during acute infection with woodchuck hepadnavirus

scientific article published on 2 July 2008

Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver

scientific article published on February 2004

Mitogen-induced upregulation of hepatitis C virus expression in human lymphoid cells

scientific article published on March 2005

Modulation of the outcome and severity of hepadnaviral hepatitis in woodchucks by antibodies to hepatic asialoglycoprotein receptor

scientific article published in September 2003

Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model

scientific article published on 07 April 2020

Occult hepatitis C virus infection and its relevance in clinical practice

scientific article

Occult hepatitis C virus infection: what does it mean?

scientific article

Occult hepatits C virus persistence: identification and characteristics.

scientific article published in February 2006

Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes

scientific article

Patient-derived hepatitis C virus inhibits CD4⁺ but not CD8⁺ T lymphocyte proliferation in primary T cells

scientific article published on 19 June 2015

Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C

scientific article published on 16 October 2015

Persistence of hepatitis C virus during and after otherwise clinically successful treatment of chronic hepatitis C with standard pegylated interferon α-2b and ribavirin therapy

scientific article

Persistence of isolated antibodies to woodchuck hepatitis virus core antigen is indicative of occult infection

scientific article

Persistent occult hepatitis B virus infection: experimental findings and clinical implications

scientific article published on November 2007

Pre-acute hepadnaviral infection is associated with activation-induced apoptotic death of lymphocytes in the woodchuck (Marmota monax) model of hepatitis B

scientific article published on 14 May 2010

Primary occult hepadnavirus infection induces virus-specific T-cell and aberrant cytokine responses in the absence of antiviral antibody reactivity in the Woodchuck model of hepatitis B virus infection

scientific article published on 04 February 2009

Primary seronegative but molecularly evident hepadnaviral infection engages liver and induces hepatocarcinoma in the woodchuck model of hepatitis B

scientific article (publication date: August 2014)

Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B

scientific article published on 29 June 2009

Profound suppression of chronic hepatitis C following superinfection with hepatitis B virus

scientific article published in June 2007

Quantitative detection of hepadnavirus-infected lymphoid cells by in situ PCR combined with flow cytometry: implications for the study of occult virus persistence

scientific article

Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management.

scientific article published in March 2018

Repeated exposure to trace amounts of woodchuck hepadnavirus induces molecularly evident infection and virus-specific T cell response in the absence of serological infection markers and hepatitis

scientific article published on 7 November 2012

Repeated passage of wild-type woodchuck hepatitis virus in lymphoid cells does not generate cell type-specific variants or alter virus infectivity

scientific article

Retrotransposon elements among initial sites of hepatitis B virus integration into human genome in the HepG2-NTCP cell infection model

scientific article published on 24 April 2019

Virological characteristics of occult hepatitis B virus in a North American cohort of human immunodeficiency virus type 1-positive patients on dual active anti-HBV/HIV therapy

scientific article published on 4 May 2014

Woodchuck hepatitis virus hepatocyte culture models

scientific article published in January 2004

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