List of works - György Panyi

A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5

scientific article published in 2021

A disulfide-stabilised helical hairpin fold in acrorhagin I: an emerging structural motif in peptide toxins

scientific article published on 30 December 2020

A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore

scientific article published on 30 March 2017

A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus.

scientific article published on 22 August 2008

Active and passive behaviour in the regulation of stiffness of the lateral wall in outer hair cells of the guinea-pig ⬇️

scientific article published on October 29, 2003

An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility.

scientific article published on 22 December 2015

C-type inactivation of a voltage-gated K+ channel occurs by a cooperative mechanism

scientific article

Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions

scientific article published on 9 August 2016

Cross talk between activation and slow inactivation gates of Shaker potassium channels

scientific article

Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the K<sub>V</sub>1.3 Ion Channel Independent of Membrane Cholesterol Extraction

publication published on 04 November 2021

Determining the target of membrane sterols on voltage-gated potassium channels

scientific article published on 13 December 2018

Developmental switch of the expression of ion channels in human dendritic cells.

scientific article published on 11 September 2009

Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes

scientific article published on 10 May 2016

Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels

scientific article published on 01 April 2020

Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes

scientific article published on June 2016

Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family

Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells

scientific article published on 01 December 2021

Ion channels and anti-cancer immunity.

scientific article published on 03 February 2014

Ion channels in T lymphocytes: an update on facts, mechanisms and therapeutic targeting in autoimmune diseases

scientific article published on 21 December 2009

Isolation, chemical and functional characterization of several new K(+)-channel blocking peptides from the venom of the scorpion Centruroides tecomanus

scientific article published on 24 February 2016

KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology

scientific article published on 16 July 2021

Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels

scientific article

Multiple binding sites for melatonin on Kv1.3

scientific article

N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis

scientific article published on 16 December 2019

Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockade Kv1.3 over IKCa1 K+ channels of T cells

scientific article published on September 2005

OcyKTx2, a new K⁺-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum

scientific article published on 15 May 2013

Of Seven New K+ Channel Inhibitor Peptides of Centruroides bonito, α-KTx 2.24 Has a Picomolar Affinity for Kv1.2

scientific article published in 2023

Peptide Inhibitors of Kv1.5: An Option for the Treatment of Atrial Fibrillation

scientific article

Periodic Membrane Potential and Ca2+ Oscillations in T Cells Forming an Immune Synapse

scientific article published on 25 February 2020

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.

scientific article

Pore-modulating toxins exploit inherent slow inactivation to block K+ channels

scientific article published on 23 August 2019

Potassium channel expression in human CD4+ regulatory and naïve T cells from healthy subjects and multiple sclerosis patients

scientific article published on 3 May 2009

Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds

scientific article published on 21 December 2015

Probing the cavity of the slow inactivated conformation of shaker potassium channels

scientific article

Selective Na1.1 activation rescues Dravet syndrome mice from seizures and premature death

article published in the Proceedings of the National Academy of Sciences of the United States of America

Sterol Regulation of Voltage-Gated K+ Channels

scientific article published on 24 July 2017

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

scientific article published on 25 December 2019

Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes

scientific article

Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi.

scientific article published on 10 April 2014

Switch of voltage-gated K+ channel expression in the plasma membrane of chondrogenic cells affects cytosolic Ca2+-oscillations and cartilage formation

scientific article (publication date: 2011)

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

scientific article published on 19 May 2018

The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane.

scientific article

The activation gate controls steady-state inactivation and recovery from inactivation in Shaker

scientific article published on 01 August 2020

The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation.

scientific article published on 6 February 2016

The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides

scientific article published on 09 July 2020

The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells

scientific article published on 28 April 2020

Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus

scientific article

Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells

scientific article

Voltage-gated sodium channel Nav1.7 maintains the membrane potential and regulates the activation and chemokine-induced migration of a monocyte-derived dendritic cell subset

scientific article published on 29 June 2011

Weaponisation 'on the fly': Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies

scientific article published on 21 December 2019

List of works by György Panyi

A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5

A disulfide-stabilised helical hairpin fold in acrorhagin I: an emerging structural motif in peptide toxins

A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore

A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus.

Active and passive behaviour in the regulation of stiffness of the lateral wall in outer hair cells of the guinea-pig ⬇️

An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility.

C-type inactivation of a voltage-gated K+ channel occurs by a cooperative mechanism

Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions

Cross talk between activation and slow inactivation gates of Shaker potassium channels

Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the K<sub>V</sub>1.3 Ion Channel Independent of Membrane Cholesterol Extraction

Determining the target of membrane sterols on voltage-gated potassium channels

Developmental switch of the expression of ion channels in human dendritic cells.

Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes

Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels

Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes

Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family

Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells

Ion channels and anti-cancer immunity.

Ion channels in T lymphocytes: an update on facts, mechanisms and therapeutic targeting in autoimmune diseases

Isolation, chemical and functional characterization of several new K(+)-channel blocking peptides from the venom of the scorpion Centruroides tecomanus

KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology

Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels

Multiple binding sites for melatonin on Kv1.3

N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis

Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockade Kv1.3 over IKCa1 K+ channels of T cells

OcyKTx2, a new K⁺-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum

Of Seven New K+ Channel Inhibitor Peptides of Centruroides bonito, α-KTx 2.24 Has a Picomolar Affinity for Kv1.2

Peptide Inhibitors of Kv1.5: An Option for the Treatment of Atrial Fibrillation

Periodic Membrane Potential and Ca2+ Oscillations in T Cells Forming an Immune Synapse

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.

Pore-modulating toxins exploit inherent slow inactivation to block K+ channels

Potassium channel expression in human CD4+ regulatory and naïve T cells from healthy subjects and multiple sclerosis patients

Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds

Probing the cavity of the slow inactivated conformation of shaker potassium channels

Selective Na1.1 activation rescues Dravet syndrome mice from seizures and premature death

Sterol Regulation of Voltage-Gated K+ Channels

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes

Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi.

Switch of voltage-gated K+ channel expression in the plasma membrane of chondrogenic cells affects cytosolic Ca2+-oscillations and cartilage formation

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane.

The activation gate controls steady-state inactivation and recovery from inactivation in Shaker

The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation.

The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides

The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells

Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus

Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells

Voltage-gated sodium channel Nav1.7 maintains the membrane potential and regulates the activation and chemokine-induced migration of a monocyte-derived dendritic cell subset

Weaponisation 'on the fly': Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies