List of works - Edwin R Speck

A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP).

scientific article

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy

scientific article

A novel immunosuppressive pathway involving peroxynitrite-mediated [corrected] nitration of platelet antigens within antigen-presenting cells

scientific article published on 28 June 2008

Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia

scientific article

Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia

scientific article published on 01 July 2018

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia

scientific article

DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.

scientific article published on 13 October 2016

Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets

scientific article

Evaluation of platelet gel characteristics using thrombin produced by the thrombin processing device: a comparative study

scientific article

Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity

scientific article published on 01 January 1999

Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury

article

IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-gamma response that is regulated by CD8+ T cells

scientific article

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype

scientific article published on 01 November 2004

Indirect allorecognition of platelets by T helper cells during platelet transfusions correlates with anti-major histocompatibility complex antibody and cytotoxic T lymphocyte formation ⬇️

scientific article published on July 15, 1995

Major histocompatibility complex class II molecules function as a template for the processing of a partially processed insulin peptide into a T-cell epitope

scientific article published on 01 December 1996

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets

scientific article published on 08 September 2017

Naturally processed heterodimeric disulfide-linked insulin peptides bind to major histocompatibility class II molecules on thymic epithelial cells

scientific article

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo

scientific article

Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells

scientific article published in November 2007

Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets

scientific article

Processing and presentation of insulin. III. Insulin degrading enzyme: a neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells ⬇️

scientific article (publication date: October 1992)

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

scientific article published on 08 July 2010

Recipient humoral immunity against leukoreduced allogeneic platelets is suppressed by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase

scientific article published on 01 October 1996

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10.

scientific article published on 15 February 2017

Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)

scientific article published on 30 May 2019

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

scientific article

Transfusion-related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cells

scientific article published on 02 June 2008

Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens

scientific article published on March 2000

List of works by Edwin R Speck

A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP).

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy

A novel immunosuppressive pathway involving peroxynitrite-mediated [corrected] nitration of platelet antigens within antigen-presenting cells

Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia

Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia

DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.

Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets

Evaluation of platelet gel characteristics using thrombin produced by the thrombin processing device: a comparative study

Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity

Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury

IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-gamma response that is regulated by CD8+ T cells

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype

Indirect allorecognition of platelets by T helper cells during platelet transfusions correlates with anti-major histocompatibility complex antibody and cytotoxic T lymphocyte formation ⬇️

Major histocompatibility complex class II molecules function as a template for the processing of a partially processed insulin peptide into a T-cell epitope

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets

Naturally processed heterodimeric disulfide-linked insulin peptides bind to major histocompatibility class II molecules on thymic epithelial cells

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo

Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells

Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets

Processing and presentation of insulin. III. Insulin degrading enzyme: a neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells ⬇️

Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury

Recipient humoral immunity against leukoreduced allogeneic platelets is suppressed by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10.

Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Transfusion-related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cells

Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens