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List of works by Melvin H Freedman

A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes

scientific article published on 01 April 2005

A high-performance liquid chromatographic method for the measurement of deferoxamine in body fluids

scientific article published on 01 January 1989

A new frameshift β°-thalassemia mutation (codons 27–28 +C) found in a Chinese family ⬇️

scientific article published on 01 May 1991

A practical, comprehensive classification for pediatric myelodysplastic syndromes: the CCC system

scientific article published in October 2002

A practical, comprehensive classification for pediatric myelodysplastic syndromes: the CCC system

scientific article published on 01 June 2002

A variant form of Bernard-Soulier syndrome: mild haemostatic defect associated with partial platelet GPIb deficiency

scientific article published on 01 January 1988

Abnormal telomere shortening in leucocytes of children with Shwachman-Diamond syndrome

scientific article published on 01 April 2002

Acquired aplastic anemia: Antibody-mediated hematopoietic failure ⬇️

scientific article published on January 1, 1979

Acute changes in renal function associated with deferoxamine therapy

scientific article published on 01 September 1989

Adenovirus-mediated p53 gene therapy in pediatric soft-tissue sarcoma cell lines: sensitization to cisplatin and doxorubicin.

scientific article published on April 2005

Administration of recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation in children with acute myelogenous leukemia: a note of caution.

scientific article published on July 1996

Allogeneic bone marrow transplantation in children with chronic myelogenous leukemia

scientific article published on 01 March 2002

Allogeneic bone marrow transplantation vs chemotherapy for children with Philadelphia chromosome-positive acute lymphoblastic leukemia

scientific article published on 01 January 2004

Allogeneic hematopoietic stem cell transplantation of patients with FA and high risk features using fludarabine without radiation

scientific article published in May 2009

Alternative donor bone marrow transplantation for children with juvenile myelomonocytic leukemia

scientific article published on 01 November 1999

An improved limited sampling method for individualised busulphan dosing in bone marrow transplantation in children ⬇️

scientific article published on 01 September 1997

Anemia of chronic renal failure: inhibition of erythropoiesis by uremic serum

scientific article published on 01 January 1983

Autoerythrocyte sensitization

scientific article published on 01 July 1983

Bone marrow from children in relapse with pre-B acute lymphoblastic leukemia proliferates and disseminates rapidly in scid mice ⬇️

scientific article published on December 1, 1991

Central role of tumour necrosis factor, GM‐CSF, and interleukin 1 in the pathogenesis of juvenile chronic myelogenous leukaemia ⬇️

scientific article published on January 1, 1992

Characterization of bone marrow stromal abnormalities in a patient with constitutional trisomy 8 mosaicism and myelodysplastic syndrome

scientific article published on April 2004

Characterization of malignant peripheral blood cells of juvenile chronic myelogenous leukemia

scientific article published on 01 December 1986

Childhood erythroleukemia. Studies on pathogenesis using colony assays

scientific article published on 01 January 1986

Clinical studies on iron chelation in patients with thalassemia major

scientific article published on September 1990

Clinical utility of marrow cell tissue cultures in acute leukemia of childhood

scientific article published on 01 September 1986

Clonal evolution in marrows of patients with Shwachman-Diamond syndrome: a prospective 5-year follow-up study

scientific article published in July 2002

Clostridium septicum myonecrosis in congenital neutropenia.

scientific article published in December 2004

Combined corticosteroid/granulocyte colony-stimulating factor (G-CSF) therapy in the treatment of severe congenital neutropenia unresponsive to G-CSF: Activated glucocorticoid receptors synergize with G-CSF signals

scientific article

Comparison of DR5 and Fas expression levels relative to the chemosensitivity of acute lymphoblastic leukemia cell lines

scientific article published in May 2002

Comparison of deferoxamine pharmacokinetics between asymptomatic thalassemic children and those exhibiting severe neurotoxicity

scientific article (publication date: April 1990)

Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients

scientific article published on November 1990

Computed tomography scanning of the liver to determine efficacy of iron chelation therapy in thalassemia major

scientific article published on 01 March 1989

Congenital Amegakaryocytic Thrombocytopenia

Congenital amegakaryocytic thrombocytopenia: an intrinsic hematopoietic stem cell defect.

scientific article

Constitutional aplastic anaemia: defective haematopoietic stem cell growth in vitro

scientific article published on 01 October 1978

Deferoxamine: a reversible S-phase inhibitor of human lymphocyte proliferation

scientific article published on 01 September 1984

Detection of residual acute lymphoblastic leukemia cells in cultures of bone marrow obtained during remission

scientific article published on 01 August 1986

Diamond-Blackfan anemia: promotion of marrow erythropoiesis in vitro by recombinant interleukin-3

scientific article published on 01 April 1989

Diamond-Blackfan syndrome. I. Erythropoiesis in prednisone responsive and resistant disease

scientific article published on 01 June 1982

Diamond-Blackfan syndrome. II. In vitro corticosteroid effect on erythropoiesis.

scientific article published in June 1982

Diamond-Blackfan syndrome: evidence against cell-mediated erythropoietic suppression ⬇️

scientific article published on June 1, 1978

Differences in cell cycle kinetics of candidate engrafting cells in human bone marrow and mobilized peripheral blood

scientific article published in April 2001

Disease progression in recently diagnosed patients with inherited marrow failure syndromes: a Canadian Inherited Marrow Failure Registry (CIMFR) report

scientific article published in December 2006

Duplication of distal thumb phalanx in Shwachman-Diamond syndrome ⬇️

scientific article published on June 16, 1998

Early hematopoietic reconstitution after clinical stem cell transplantation: evidence for stochastic stem cell behavior and limited acceleration in telomere loss

scientific article published in April 2002

Effect of age at the start of iron chelation therapy on gonadal function in beta-thalassemia major

scientific article published in September 1990

Effect of deferoxamine on DNA synthesis, DNA repair, cell proliferation, and differentiation of HL-60 cells

scientific article published on 01 May 1987

Erythropoietic inhibitors in uremic serum

scientific article published on 01 January 1982

Evaluation of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients.

scientific article published on January 1990

Factors affecting erythroid colony growth (CFU-E) from human marrow

scientific article published on January 1, 1977

Failure of recombinant human interleukin-3 therapy to induce erythropoiesis in patients with refractory Diamond-Blackfan anemia

scientific article published on 01 May 1994

Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia

scientific article published in August 2008

Granulopoiesis in severe congenital neutropenia ⬇️

scientific article published on 01 April 1976

Growth Failure and Bony Changes Induced by Deferoxamine

article

Growth inhibitory effect of gene-cloned interferons on human myeloblast colonies

scientific article published on 01 October 1985

Growth requirements for human acute lymphoblastic leukemia cells: refinement of a clonogenic assay

scientific article published on 01 October 1988

Hematopoiesis in the human spleen

scientific article

Hodgkin's disease in children: treatment results with MOPP and low-dose, extended-field irradiation

scientific article published on 01 April 1982

Hodgkin's disease in children: treatment with MOPP and low-dose, extended field irradiation without laparotomy. Late results and toxicity

scientific article published in January 1990

Identification of human juvenile chronic myelogenous leukemia stem cells capable of initiating the disease in primary and secondary SCID mice

scientific article published on 01 October 1996

Immune function in patients with Shwachman-Diamond syndrome

scientific article published in September 2001

Improved survival in severe acquired aplastic anemia of childhood

scientific article published in December 2000

In vitro and in vivo effects of deferoxamine in neonatal acute leukemia

scientific article published on 01 March 1987

Induction of differentiation in HL-60 promyelocytic cells: a comparative study in two sublines.

scientific article

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

scientific article

Juvenile Chronic Myelogenous Leukemia Multilineage CD34+Cells: Aberrant Growth and Differentiation Properties

Juvenile chronic myelogenous leukemia

scientific article published on January 1988

Juvenile chronic myelogenous leukemia: characterization of the disease using cell cultures

scientific article published on 01 May 1986

Juvenile chronic myelogenous leukemia: differentiation from infantile cytomegalovirus infection

scientific article published on 01 January 1990

Lessons learned from a privacy breach at an academic health science centre

scientific article published on 01 January 2009

Letter: Primary thrombocythemia in a child

scientific article published on 01 July 1973

Malignant hematological disorders in children with Wolf–Hirschhorn syndrome ⬇️

scientific article published on June 1, 2003

Malignant myeloid transformation in congenital forms of neutropenia.

scientific article published in November 2002

Malignant myeloid transformation with isochromosome 7q in Shwachman-Diamond syndrome

scientific article published on 01 October 1998

Mastocytosis cells bearing a c-kit activating point mutation are characterized by hypersensitivity to stem cell factor and increased apoptosis

scientific article published on 01 March 2000

Matched unrelated bone marrow transplantation for combined immunodeficiency

scientific article published on March 2000

Modulation of human hematopoiesis by prostaglandins and lithium

scientific article published on 01 January 1980

Mutant p53 in bone marrow stromal cells increases VEGF expression and supports leukemia cell growth

scientific article published on 01 August 2003

Mutation analysis of SBDS in pediatric acute myeloblastic leukemia.

scientific article published in December 2005

Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia.

scientific article published on January 1997

Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment.

scientific article

Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major.

scientific article

Pulmonary syndrome in patients with thalassemia major receiving intravenous deferoxamine infusions

scientific article published in May 1990

Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology

scientific article

Rarity of systemic lupus erythematosus after oral iron chelator L1 ⬇️

scientific article published on April 13, 1991

Recombinant human granulocyte colony-stimulating factor therapy for patients with neutropenia and/or neutrophil dysfunction secondary to glycogen storage disease type 1b.

scientific article published in January 2001

Recombinant human interferon alpha-2 and juvenile chronic myelogenous leukemia: cell receptor binding, enzymatic induction, and growth suppression in vitro

scientific article published on 01 February 1987

Reply to Hasle et al ⬇️

scientific article published on 01 December 2003

Residual juvenile chronic myelogenous leukemia cells detected in peripheral blood during clinical remission

scientific article published on 01 November 1987

Ribonuclease inhibition of erythropoiesis in anemia of uremia

scientific article published on 01 March 1983

Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias

scientific article

Separation of lymphoid and myeloid blasts in the mixed blast crisis of chronic myelogenous leukemia: no evidence for Ig gene rearrangement in CALLA-positive blasts

scientific article published in December 1985

Serial studies of auditory neurotoxicity in patients receiving deferoxamine therapy

scientific article published on December 1987

Severe acquired aplastic anemia in children: 11-year experience with bone marrow transplantation and immunosuppressive therapy

scientific article published on 01 January 1989

Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry

scientific article

Shwachman syndrome: phenotypic manifestations of sibling sets and isolated cases in a large patient cohort are similar

scientific article

Shwachman-Diamond syndrome marrow cells show abnormally increased apoptosis mediated through the Fas pathway

scientific article published on 01 May 2001

Shwachman-Diamond syndrome: An inherited preleukemic bone marrow failure disorder with aberrant hematopoietic progenitors and faulty marrow microenvironment

scientific article published on 01 November 1999

Shwachman-Diamond syndrome: an inherited model of aplastic anaemia with accelerated angiogenesis

scientific article published on June 2006

Shwachman-diamond syndrome.

scientific article

Single-centre experience with allogeneic bone marrow transplantation for acute lymphoblastic leukaemia in childhood: similar survival after matched-related and matched-unrelated donor transplants

scientific article published on 01 February 2002

Studies of the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one in thalassemia patients

scientific article published on 01 April 1990

Sustained cyclosporine-induced erythropoietic response in identical male twins with diamond-blackfan anemia

scientific article published on 01 November 2003

Synergistic antiproliferative effects on HL-60 cells: deferoxamine enhances cytosine arabinoside, methotrexate, and daunorubicin cytotoxicity

scientific article published on 01 January 1988

Telomere shortening in leucocyte subsets of long-term survivors of allogeneic bone marrow transplantation

scientific article published on 01 June 1999

Telomeres, X-inactivation ratios, and hematopoietic stem cell transplantation in humans: a review

scientific article

The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report

scientific article published on 01 July 2006

The evolution of juvenile myelomonocytic leukemia in a female patient with paternally inherited neurofibromatosis type 1

scientific article published on 01 February 2003

The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy

scientific article published on 23 February 2006

The regulatory role of interleukin 2-responsive T lymphocytes on early and mature erythroid progenitor proliferation

scientific article published on 01 June 1986

The regulatory role of interleukin 2-responsive T lymphocytes on human marrow granulopoiesis

scientific article published on 01 April 1987

The utility of plasma polymerase chain reaction for human herpes virus-6 among pediatric bone marrow transplant recipients: results of a pilot study

scientific article

Thrombocytopenia with absent radii: frequency of marrow megakaryocyte progenitors, proliferative characteristics, and megakaryocyte growth and development factor responsiveness

scientific article

Transient myelodysplastic syndrome associated with isochromosome 7q abnormality

scientific article published on 01 October 2003

Trial of recombinant human erythropoietin: three patients with thalassemia intermedia ⬇️

scientific article published on December 15, 1992

Unexpected complications after bone marrow transplantation in transfusion-dependent children

scientific article

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