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List of works by Bruce M Ewenstein

A cost minimization model for the treatment of minor bleeding episodes in patients with haemophilia A and high-titre inhibitors

scientific article

A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy

scientific article published on 01 December 1996

A systematic approach to controlling problem bleeds in patients with severe congenital haemophilia A and high-titre inhibitors.

scientific article published in May 2007

AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs. Hemophilia Malignancy Study Group

scientific article

Advancing personalized care in hemophilia A: ten years' experience with an advanced category antihemophilic factor prepared using a plasma/albumin-free method

scientific article published on 05 April 2014

Anionic polysaccharides inhibit adhesion of sickle erythrocytes to the vascular endothelium and result in improved hemodynamic behavior

scientific article published on 01 February 1999

Anticoagulation and hemostasis in cardiac surgical patients

scientific article published on 01 July 1994

Antithrombotic Agents and Thromboembolic Disease ⬇️

scientific article published on 01 November 1997

Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis

scientific article

Autosomal recessive transmission of hemophilia A due to a von Willebrand factor mutation

scientific article

BAX 335 hemophilia B gene therapy clinical trial results - potential impact of CpG sequences on gene expression

scientific article published on 16 October 2020

Biochemical studies on the H-2K antigens of the MHC mutant bml.

scientific article published on January 1981

Biochemical studies on the H-2K antigens of the MHC mutants bm3 and bm11.

scientific article published on January 1980

Biochemical studies on the H-2K mutant B6.C-H-2bm10

scientific article published on 01 January 1983

Bleeding reduction during secondary prophylaxis with bypassing agents in inhibitor patients ⬇️

scientific article published on September 1, 2010

Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A.

scientific article

Bypassing agent prophylaxis for preventing arthropathy in patients with inhibitors

scientific article

Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells ⬇️

scientific article published on September 1, 1992

Cancer and venous thromboembolism

scientific article published on 01 October 1996

Central venous access devices in haemophilia

scientific article published on March 2004

Clinical evaluation of an advanced category antihaemophilic factor prepared using a plasma/albumin-free method: pharmacokinetics, efficacy, and safety in previously treated patients with haemophilia A.

scientific article

Comparative pharmacokinetics of plasma- and albumin-free recombinant factor VIII in children and adults: the influence of blood sampling schedule on observed age-related differences and implications for dose tailoring

scientific article

Composition of the von Willebrand factor storage organelle (Weibel-Palade body) isolated from cultured human umbilical vein endothelial cells

scientific article

Consensus perspectives on surgery in haemophilia patients with inhibitors: summary statement.

scientific article

Consensus recommendations for use of central venous access devices in haemophilia

scientific article published in September 2004

Continuous infusion of recombinant factor VIIa: continue or not?

scientific article published on 01 October 2001

Cost minimization analysis to compare activated prothrombin complex concentrate (APCC) and recombinant factor VIIa for haemophilia patients with inhibitors undergoing major orthopaedic surgeries

scientific article published on 27 April 2009

Development of a plasma- and albumin-free recombinant von Willebrand factor.

scientific article published in October 2009

Development of novel treatment options for patients with haemophilia.

scientific article published on January 2013

Economic burden of major bleeding events in commercially insured patients with von Willebrand disease based on claims data from the United States

scientific article published on 14 December 2020

Efficacy and safety of OBI-1, an antihaemophilic factor VIII (recombinant), porcine sequence, in subjects with acquired haemophilia A.

scientific article

Emerging clinical concerns in the ageing haemophilia patient

scientific article published on 21 July 2009

Experience of Advate rAHF-PFM in previously untreated patients and minimally treated patients with haemophilia A

scientific article published on 04 April 2012

Expression and activation of protein kinase C isoforms in a human megakaryocytic cell line.

scientific article published on November 1996

FEIBA safety profile in multiple modes of clinical and home-therapy application

scientific article published in September 2004

FVIII administration in surgery ⬇️

scientific article published on June 20, 2011

Factor IX inhibitors and anaphylaxis in haemophilia B.

scientific article

Factor IX inhibitors and anaphylaxis in hemophilia B

scientific article published on 01 July 1997

Factor IX inhibitors and anaphylaxis in hemophilia B.

scientific article

Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: influences of variance in pharmacokinetics and treatment regimens

scientific article published on 23 November 2009

Further structural analysis of the murine H-Kkb glycoprotein using radiochemical methodology ⬇️

scientific article published on January 1, 1979

Haemophilia Inhibitor Genetics Study - evaluation of a model for studies of complex diseases using linkage and association methods

scientific article

Health care utilization of patients diagnosed with idiopathic thrombotic thrombocytopenic purpura in a commercially insured population in the United States

scientific article

Hemophilia therapy innovation: development of an advanced category recombinant factor VIII by a plasma/albumin-free method. Proceedings of a Special Symposium at the XIXth Congress of the International Society on Thrombosis and Haemostasis, July 12-

scientific article

Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease

scientific article

Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors.

scientific article

IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis

scientific article published on 01 June 1989

IgE-mediated allergy and desensitization to factor IX in hemophilia B ⬇️

scientific article published on July 1, 1998

Immortalization of human endothelial cells by murine sarcoma viruses, without morphologic transformation

scientific article

Immune tolerance induction in hemophilia patients with inhibitors: costly can be cheaper.

scientific article

Individualizing prophylaxis in hemophilia: a review

scientific article

Inhibition of CD40 ligand (CD154) in the treatment of factor VIII inhibitors.

scientific article published in October 2000

Inhibition of sickle erythrocyte adhesion to immobilized thrombospondin by von Willebrand factor under dynamic flow conditions

scientific article published on 01 April 1997

Inhibitor development in patients receiving recombinant factor VIII (Recombinate rAHF/Bioclate): a prospective pharmacovigilance study

scientific article

Integrated analysis of safety and efficacy of a plasma- and albumin-free recombinant factor VIII (rAHF-PFM) from six clinical studies in patients with hemophilia A

article

Intramyocardial, Autologous CD34+ Cell Therapy for Refractory Angina ⬇️

scientific article published on July 7, 2011

Localization of the papain cleavage site of H-2 glycoproteins ⬇️

scientific article published on March 1, 1976

Management of von Willebrand disease: a survey on current clinical practice from the haemophilia centres of North America

scientific article

Membranous glomerulonephritis and nephrosis post factor IX infusions in hemophilia B.

scientific article published in October 1998

Modeling costs and outcomes associated with a treatment algorithm for problem bleeding episodes in patients with severe hemophilia a and high-titer inhibitors

scientific article published on July 2011

Molecular studies of von Willebrand disease: reduced von Willebrand factor biosynthesis, storage, and release in endothelial cells derived from patients with type I von Willebrand disease

scientific article published on 01 April 1990

Nephrotic syndrome as a complication of immune tolerance in hemophilia B.

scientific article

Patient Experience with Congenital (Hereditary) Thrombotic Thrombocytopenic Purpura: A Conceptual Framework of Symptoms and Impacts

scientific article published on 01 October 2019

Pegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A

scientific article

Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells

scientific article published on 01 December 1995

Pharmacokinetic analysis of plasma-derived and recombinant F IX concentrates in previously treated patients with moderate or severe hemophilia B.

scientific article

Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial ⬇️

scientific article published on June 18, 2013

Plasma and albumin-free recombinant factor VIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients

scientific article

Population pharmacokinetics of recombinant factor VIII: the relationships of pharmacokinetics to age and body weight ⬇️

scientific article published on October 31, 2011

Porcine factor VIII: pharmacoeconomics of inhibitor therapy

scientific article

Postauthorization safety surveillance of ADVATE [antihaemophilic factor (recombinant), plasma/albumin-free method] demonstrates efficacy, safety and low-risk for immunogenicity in routine clinical practice

scientific article published in November 2010

Primary structural: analysis of the transplantation antigens of the murine H-2 major histocompatibility complex

scientific article published on January 1981

Primary structure of murine H-2Kb and beta 2-microglobulin

scientific article published on 01 December 1981

Primary structure of murine major histocompatibility alloantigens: amino acid sequence of the cyanogen bromide fragment Ia (positions 139-228) from the H-2Kb molecule

scientific article published on 01 December 1980

Primary structure of murine major histocompatibility complex alloantigens: Amino acid sequence studies of the cyanogen bromide fragments of the H-2K b glycoprotein ⬇️

scientific article published on July 1, 1978

Primary structure of murine major histocompatibility complex alloantigens: amino acid sequence of the amino-terminal one hundred and seventy-three residues of the H-2Kb glycoprotein

scientific article published on 01 January 1980

Primary structure of murine major histocompatibility complex alloantigens: completion of the sequence of the amino-terminal 284 residues of H-2Kb

scientific article published on 01 December 1980

Primary structure of murine major histocompatibility complex alloantigens: isolation, biochemical characterization, and preliminary alignment of CNBr fragments from the H-2Ib glycoprotein ⬇️

scientific article published on June 1, 1978

Pro- and anticoagulant factors facilitate thrombin generation and balance the haemostatic response to FEIBA(®) in prophylactic therapy

scientific article

Prolonged peak elevations in cytoplasmic free calcium ions, derived from intracellular stores, correlate with the extent of thrombin-stimulated exocytosis in single human umbilical vein endothelial cells

scientific article published on September 1994

Pulmonary embolism and deep venous thrombosis during pregnancy or oral contraceptive use: prevalence of factor V Leiden

scientific article published on 01 June 1996

Randomized comparison of prophylaxis and on-demand regimens with FEIBA NF in the treatment of haemophilia A and B with inhibitors.

scientific article

Re: low incidence of factor VIII inhibitors in PUPs during prophylaxis, on‐demand treatment and surgical procedures, with Octanate®: interim report from an ongoing prospective clinical study ⬇️

scientific article published on July 13, 2011

Recombinant ADAMTS 13 in thrombotic thrombocytopenic purpura

scientific article published on 28 November 2017

Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura

scientific article published on 14 September 2017

Recombinant factor VIII: are we really getting more for less?

scientific article

Regulated Secretion in Vascular Endothelium ⬇️

scientific article published on January 1, 1991

Regulated secretion in endothelial cells: biology and clinical implications

scientific article published on 01 November 2001

Risk factors for infection with HBV and HCV in a largecohort of hemophiliac males

scientific article published in March 2001

Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature

scientific article published on February 2008

Rurioctocog alfa pegol PK-guided prophylaxis in hemophilia A: Results from the phase 3 PROPEL study

scientific article published on 04 November 2020

Severe haemophilia A in a female resulting from two de novo factor VIII mutations.

scientific article published in August 1995

Structural Differences between Parent and Variant H-2K Glycoproteins from Mouse Strains Carrying H-2 Gene Mutations ⬇️

scientific article published on January 1, 1977

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

scientific article published in Nature

Successful treatment for patients with von Willebrand disease undergoing urgent surgery using factor VIII/VWF concentrate (Humate-P).

scientific article published in January 2004

Successful treatment of urgent bleeding in von Willebrand disease with factor VIII/VWF concentrate (Humate-P): use of the ristocetin cofactor assay (VWF:RCo) to measure potency and to guide therapy

scientific article published in November 2003

Surgical evaluation of a recombinant factor VIII prepared using a plasma/albumin-free method: efficacy and safety of Advate in previously treated patients

scientific article published on 01 August 2008

Targeting of a heterologous protein to a regulated secretion pathway in cultured endothelial cells

scientific article published on 01 October 1999

The 1st International Standard for von Willebrand Factor concentrate: more to come?

scientific article published on 01 September 2002

The application of bypassing-agent prophylaxis in haemophilia A patients with inhibitors: a meeting report.

scientific article

The burden of bleeding in haemophilia: is one bleed too many?

scientific article published on 29 January 2014

The economic impact of factor VIII inhibitors in patients with haemophilia

scientific article published in January 2004

The pathophysiology of bleeding disorders presenting as abnormal uterine bleeding

scientific article

The relative burden of haemophilia A and the impact of target joint development on health-related quality of life: results from the ADVATE Post-Authorization Safety Surveillance (PASS) study

scientific article published on 21 February 2011

The role of previously untreated patient studies in understanding the development of FVIII inhibitors

scientific article published on 27 August 2015

The role of ultralarge multimers in recombinant human von Willebrand factor - a review of physico-and biochemical studies and findings in in vivo models and in humans with von Willebrand disease

scientific article published on 28 December 2017

The structural-genetic relationships of the H-2K and H-2D products of the mouse major histocompatibility complex

scientific article

Thrombin activates nuclear factor-kappaB and potentiates endothelial cell activation by TNF ⬇️

scientific article published on 01 December 1997

Thrombin and histamine rapidly stimulate the phosphorylation of the myristoylated alanine-rich C-kinase substrate in human umbilical vein endothelial cells: evidence for distinct patterns of protein kinase activation

scientific article published on 01 July 1992

Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study ⬇️

scientific article published on January 15, 2002

Trends in bleeding patterns during prophylaxis for severe haemophilia: observations from a series of prospective clinical trials

scientific article published on 7 February 2011

Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. Studies with phorbol myristate acetate and staurosporine ⬇️

scientific article published on 01 May 1991

Use of Bypassing Agents and Risk of Thromboembolic Events in Patients with Haemophilia and Inhibitors.

scientific article published on 6 December 2017

Use of ristocetin cofactor activity in the management of von Willebrand disease

scientific article

Variation in incidence of indinavir-associated nephrolithiasis among HIV-positive patients

scientific article published on December 1998

Von Willebrand's disease

scientific article published in January 1997

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