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List of works by William F. Dall'Acqua

A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format

scientific article published on 15 October 2015

A glycoengineered anti‐CD19 antibody with potent antibody‐dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo ⬇️

scientific article published on September 9, 2011

A high-throughput platform for population reformatting and mammalian expression of phage display libraries to enable functional screening as full-length IgG.

scientific article

A novel antibody discovery platform identifies anti-influenza A broadly neutralizing antibodies from human memory B cells.

scientific article

Amber suppression coupled with inducible surface display identifies cells with high recombinant protein productivity

scientific article published on 18 January 2019

An "Fc-Silenced" IgG1 Format With Extended Half-Life Designed for Improved Stability

scientific article published on 2 January 2017

Analysis of human and primate CD2 molecules by protein sequence and epitope mapping with anti-human CD2 antibodies

scientific article published in August 2004

Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA.

scientific article

Antibody Fragment F(ab')2 Targeting Caveolae-Associated Protein PV1 for Selective Kidney Targeting and Retention

scientific article published on 30 December 2019

Antibody humanization by framework shuffling.

scientific article published in May 2005

Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors

scientific article published on June 2009

B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody

scientific article published on 6 July 2010

Bi-epitope SPR surfaces: a solution to develop robust immunoassays

scientific article

Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-alpha toxin antibody fragment and alpha toxin

scientific article published on 23 February 2013

Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon alpha-2A.

scientific article published on 25 December 2008

Crystallization and preliminary X-ray diffraction analysis of the complex of a human anti-ephrin type-A receptor 2 antibody fragment and its cognate antigen

scientific article

Design and efficacy of a monovalent bispecific PD-1/CTLA-4 antibody that enhances CTLA-4 blockade on PD-1+ activated T cells

scientific article published on 08 January 2021

Development of a high yielding expression platform for the introduction of non-natural amino acids in protein sequences

scientific article published on 01 January 2020

Development of a parallel reaction monitoring (PRM) mass spec-trometry-assay for the detection of SARS-CoV-2 spike glycoprotein and nucleoprotein

scientific article published on 23 September 2020

Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy

scientific article published in PLoS ONE

Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells

scientific article published on 01 January 2020

Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs

scientific article published on 13 March 2020

Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression

scientific article published on 14 February 2013

Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence

scientific article published on 9 January 2017

Enhancement of Immune Effector Functions by Modulating IgG's Intrinsic Affinity for Target Antigen

scientific article

Enhancement of antibody functions through Fc multiplications

scientific article published on 19 January 2017

Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding

scientific article

Enhancing IgG distribution to lung mucosal tissue improves protective effect of anti-Pseudomonas aeruginosa antibodies

scientific article published on 21 June 2018

Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties

scientific article published on 22 January 2007

Functional mimetic of the G-protein coupled receptor CXCR4 on a soluble antibody scaffold

scientific article published on 16 April 2019

Generation and Characterization of an IgG4 Monomeric Fc Platform.

scientific article

Humanized antibodies and their applications

scientific article published on 01 May 2005

Immunotherapies against antibiotics-resistant Klebsiella pneumoniae

scientific article published on 18 July 2016

Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension

scientific article published on 03 April 2019

Improving target cell specificity using a novel monovalent bispecific IgG design

scientific article

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

scientific article published in November 2002

Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

scientific article published on 08 February 2016

Insights into the molecular basis of a bispecific antibody's target selectivity

scientific article published on January 2015

Long-acting antibody ligand mimetics for HER4-selective agonism

scientific article published on 14 October 2020

Mechanisms of neutralization of a human anti-α-toxin antibody

scientific article published on 10 September 2014

Modulation of the effector functions of a human IgG1 through engineering of its hinge region

scientific article published on July 2006

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody

scientific article published on January 2015

Molecular basis for the antagonistic activity of an anti-CXCR4 antibody

scientific article published on 29 October 2015

Molecular basis for the mechanism of action of an anti-TACE antibody

scientific article published on 9 September 2016

PET-guided evaluation and optimization of internalized antibody-drug conjugates targeting erythropoietin producing hepatoma A2 receptor.

scientific article

Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region

scientific article published on 01 January 2020

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

scientific article published on 21 June 2006

Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen

scientific article published on 01 January 2020

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

scientific article

Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab

scientific article published on 29 April 2015

Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody

scientific article

Structural characterization of a human Fc fragment engineered for lack of effector functions

scientific article

Structural characterization of a mutated, ADCC-enhanced human Fc fragment

scientific article

Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding

scientific article

Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody

scientific article published on 18 April 2018

Tag-on-Demand: exploiting amber codon suppression technology for the enrichment of high-expressing membrane protein cell lines

scientific article published on 01 October 2018

Target-Agnostic Identification of Functional Monoclonal Antibodies Against Klebsiella pneumoniae Multimeric MrkA Fimbrial Subunit

scientific article published on 14 January 2016

Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis

The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA

scientific article (publication date: 2012)

The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan.

scientific article published on 11 November 2016

Tumor uptake of pegylated diabodies: Balancing systemic clearance and vascular transport.

scientific article published on 10 April 2018

Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models

scientific article published on 04 June 2020

pH-dependent binding engineering reveals an FcRn affinity threshold that governs IgG recycling

scientific article

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