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List of works by Kristen Jan Nikula

A microassay for measuring cytosine DNA methyltransferase activity during tumor progression

scientific article published on 01 December 1995

A mouse model of cigarette smoke-induced emphysema

scientific article published on 01 May 2000

Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens

scientific article published on February 2002

Aberrant methylation of p16 INK4a is an early event in lung cancer and a potential biomarker for early diagnosis ⬇️

scientific article published on September 29, 1998

Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.

scientific article published on 6 May 2010

Alterations in the K-ras and p53 genes in rat lung tumors ⬇️

scientific article published on June 1, 1997

Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.

scientific article

Animal models of beryllium-induced lung disease

scientific article

Animal models of chronic bronchitis and their relevance to studies of particle-induced disease

scientific article

Animal models of emphysema and their relevance to studies of particle-induced disease

scientific article

Animal models of pulmonary infection in the compromised host: potential usefulness for studying health effects of inhaled particles

scientific article

Biochemical and morphologic response of nasal epithelia to hyperoxia

scientific article published on 01 January 1991

Biochemical and morphologic responses of rat nasal epithelia to hyperoxia*1 ⬇️

scientific article published on 01 November 1991

Biological effects of 137CsCl injected in beagle dogs

scientific article published on 01 June 1995

C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats

scientific article

Carcinogenic Responses of Transgenic Heterozygous p53 Knockout Mice to Inhaled 239PuO2 or Metallic Beryllium ⬇️

scientific article published on July 1, 1998

Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.

scientific article published on 13 February 2014

Chronic cigarette smoke exposure increases the pulmonary retention and radiation dose of 239Pu inhaled as 239PuO2 by F344 rats.

scientific article published in December 1998

Chronic granulomatous pneumonia and lymphocytic responses induced by inhaled beryllium metal in A/J and C3H/HeJ mice

scientific article published on January 1997

Cigarette smoke exposure produces more evidence of emphysema in B6C3F1 mice than in F344 rats

scientific article published on 01 October 1999

Comparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate hexahydrate chronic exposures in the lung ⬇️

scientific article published on November 15, 1995

Comparative localization of carboxylesterase in F344 rat, beagle dog, and human nasal tissue

scientific article published on 01 May 1994

Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rats

scientific article published in April 1995

Distribution of retained particulate material in rat and human lungs ⬇️

abstract published in 1999

Dose-response relationships between inhaled beryllium metal and lung toxicity in C3H mice

scientific article published on 01 March 1998

Effect of chronic cigarette smoke exposure on lung clearance of tracer particles inhaled by rats

scientific article published on 01 January 1995

Effect of cigarette smoke on CYP1A1, CYP1A2 and CYP2B1/2 of nasal mucosae in F344 rats ⬇️

scientific article published on April 1, 1998

Effects of cigarette smoke exposure and cessation on inflammatory cells and matrix metalloproteinase activity in mice

scientific article published in January 2004

Effects of concurrent ozone exposure on the pathogenesis of cigarette smoke-induced emphysema in B6C3F1 mice

scientific article published in December 2002

Effects of strain and treatment with inhaled aII-trans-retinoic acid on cigarette smoke-induced pulmonary emphysema in mice

scientific article published in September 2005

Effects of subchronic inhalation exposure of rats to emissions from a diesel engine burning soybean oil-derived biodiesel fuel

scientific article published in October 2002

Enhanced pulmonary epithelial replication and axial airway mucosubstance changes in F344 rats exposed short-term to mainstream cigarette smoke

scientific article published in December 1999

Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse.

scientific article

Frequent aberrant methylation of p16INK4a in primary rat lung tumors

scientific article published on March 1997

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer

scientific article published on April 1996

Induction of nasal carboxylesterase in F344 rats following inhalation exposure to pyridine ⬇️

scientific article published on 01 May 1995

Influence of exposure concentration or dose on the distribution of particulate material in rat and human lungs ⬇️

journal article published in 2001

Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicity.

scientific article published on 22 May 2018

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

scientific article published on 01 January 2021

Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder

scientific article published on 12 October 2020

Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black.

scientific article

Lung tissue responses and sites of particle retention differ between rats and cynomolgus monkeys exposed chronically to diesel exhaust and coal dust

scientific article published on 01 May 1997

Multiple modes of responses to air pollution particulate materials in A549 alveolar type II cells

scientific article published in January 2000

Mutagenicity and in vivo toxicity of combined particulate and semivolatile organic fractions of gasoline and diesel engine emissions

scientific article published on December 2002

Olfactory mucosal lesions in F344 rats following inhalation exposure to pyridine at threshold limit value concentrations

scientific article published in November 1994

Particle clearance and histopathology in lungs of C3H/HeJ mice administered beryllium/copper alloy by intratracheal instillation

scientific article published on 01 August 2000

Pulmonary carcinogenicity of relatively low doses of beta-particle radiation from inhaled 144CeO2 in rats ⬇️

journal article published in 1996

Rat lung tumors induced by exposure to selected poorly soluble nonfibrous particles

scientific article

Regulatory Forum Opinion Piece*: An Experienced Pathologist Need Not Always Be Present at Necropsy for Small Molecule or Biotherapeutic Safety Studies

scientific article published on 10 December 2015

Regulatory Forum Opinion Piece*: An Experienced Pathologist Should Be Present at Necropsy for Novel Medical Device Studies

scientific article published on 10 December 2015

Regulatory Forum Opinion Piece: Blind Reading of Histopathology Slides in General Toxicology Studies* ⬇️

scientific article published on March 9, 2012

STP position paper: interpreting the significance of increased alveolar macrophages in rodents following inhalation of pharmaceutical materials

scientific article published on 31 October 2013

Sites of particle retention and lung tissue responses to chronically inhaled diesel exhaust and coal dust in rats and cynomolgus monkeys ⬇️

scientific article published on September 1, 1997

Structural, functional, and molecular characterization of the SHHF model of heart failure

scientific article published on 01 November 2002

Symposium Summary: "Breathe In, Breathe Out, Its Easy: What You Need to Know About Developing Inhaled Drugs".

scientific article published on 7 February 2016

Thirteen-week, repeated inhalation exposure of F344/N rats and B6C3F1 mice to ferrocene.

scientific article published in August 1993

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