List of works - Alice Kaganovich

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

scientific article

A soluble α-synuclein construct forms a dynamic tetramer

scientific article published on 17 October 2011

Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.

scientific article published on 27 January 2012

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

scientific article

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

scientific article published on 05 October 2018

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

scientific article published on 22 October 2020

Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes

scientific article published on 12 October 2020

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria ⬇️

scientific article published on August 19, 2013

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

scientific article published on 01 October 2020

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

scientific article published on 27 October 2018

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies

scientific article published on 23 March 2018

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

scientific article

Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue

scientific article

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

scientific article

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

scientific article published on 20 March 2017

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

scientific article

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

scientific article

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

scientific article published on 01 May 2020

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

scientific article

Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

scientific article published on 15 May 2019

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

scientific article

List of works by Alice Kaganovich

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

A soluble α-synuclein construct forms a dynamic tetramer

Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria ⬇️

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease