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List of works by Daniel S Lorrain

5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor

scientific article

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical ad

scientific article published on 8 June 2010

8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats ⬇️

scientific article published on April 20, 1998

A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo

scientific article

A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye

scientific article

A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

scientific article

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

scientific article published on 27 September 2016

Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment

scientific article published in July 2002

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma ⬇️

scientific article published on May 1, 2011

Castration decreases extracellular, but increases intracellular, dopamine in medial preoptic area of male rats ⬇️

scientific article published on January 26, 1998

Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels

scientific article published in June 2005

Copulation increases dopamine activity in the medial preoptic area of male rats

scientific article published in January 1993

DP2 (CRTh2) Antagonism Reduces Ocular Inflammation Induced by Allergen Challenge and Respiratory Syncytial Virus ⬇️

scientific article published on October 28, 2011

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis ⬇️

scientific article published on January 11, 2011

Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies

scientific article published on 21 December 2018

Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition

scientific article published on 03 January 2008

Dopamine release in the medial preoptic area of female rats in response to hormonal manipulation and sexual activity

scientific article published on 01 August 2000

Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

scientific article published in January 2003

Effects of morphiceptin in the medial preoptic area on male sexual behavior

scientific article

Estrogen receptor (ER) subtype agonists alter monoamine levels in the female rat brain

scientific article published on 26 August 2010

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats ⬇️

scientific article published on December 1, 1997

Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation.

scientific article

Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge

scientific article

Hormone-neurotransmitter interactions in the control of sexual behavior

scientific article

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.

scientific article

Identification of the first potent, selective and bioavailable PPARα antagonist

scientific article published on 04 April 2014

In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist

scientific article published on 5 May 2017

In vivo pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies

scientific article published in October 2003

Lateral hypothalamic serotonin inhibits nucleus accumbens dopamine: implications for sexual satiety

scientific article published in September 1999

Mesoaccumbens dopamine and the self-administration of amphetamine

scientific article

Nitric oxide increases dopamine and serotonin release in the medial preoptic area

scientific article published on 01 October 1993

Nitric oxide promotes medial preoptic dopamine release during male rat copulation.

scientific article published in December 1996

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

scientific article published on 25 June 2009

Partial antagonism of 8-OH-DPAT'S effects on male rat sexual behavior with a D2, but not a 5-HT1A, antagonist

scientific article published in February 1999

Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP).

scientific article published on 24 February 2010

Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist ⬇️

scientific article published on December 15, 2010

Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung

scientific article

Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces

scientific article published on 11 September 2009

Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation

scientific article published on 12 April 2011

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation

scientific journal article

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor

scientific article

Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule

scientific article published in January 2000

Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine

scientific article

Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors

scientific article published on 29 January 2019

Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine.

scientific article published in June 2002

Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist

scientific article published on 09 December 2010

Testosterone, Preoptic Dopamine, and Copulation in Male Rats ⬇️

scientific article published on January 1, 1997

The Antinociceptive Effect of the Asthma Drug Ibudilast in Rat Models of Peripheral and Central Neuropathic Pain ⬇️

scientific article published on October 19, 2011

The effect of previous exposure to amphetamine on drug-induced locomotion and self-administration of a low dose of the drug

scientific article published on 01 November 1999

The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion

scientific article published on 01 October 1995

The roles of nitric oxide in sexual function of male rats

scientific article published in November 1994

Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation

scientific article published on 4 May 2010

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