List of works - Paul Vezina

A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior

scientific article published on 01 August 1988

A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.

scientific article

Absence of functional alternative complement pathway alleviates lupus cerebritis

scientific article

Activation of group II mGlu receptors blocks the enhanced drug taking induced by previous exposure to amphetamine.

scientific article published in January 2005

Activation of metabotropic glutamate receptors in the rat nucleus accumbens increases locomotor activity in a dopamine-dependent manner ⬇️

scientific article published on November 1, 1997

Alpha-1 Adrenergic Receptors are Localized on Presynaptic Elements in the Nucleus Accumbens and Regulate Mesolimbic Dopamine Transmission ⬇️

scientific article published on May 16, 2012

Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects

scientific article published in May 1990

Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine

scientific article published on 01 August 1994

Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat.

scientific article

Amphetamine-induced changes in dendritic morphology in rat forebrain correspond to associative drug conditioning rather than nonassociative drug sensitization

scientific article published on 05 February 2009

An overview of commonalities in the mechanisms underlying gambling and substance use disorders

scientific article published on 11 April 2020

Appetitive sensitization by amphetamine does not reduce its ability to produce conditioned taste aversion to saccharin

scientific article published on 4 October 2006

Behavioral sensitization to quinpirole is not associated with increased nucleus accumbens dopamine overflow

scientific article published on January 2003

Blockade of D-1 dopamine receptors in the medial prefrontal cortex produces delayed effects on pre- and postsynaptic indices of dopamine function in the nucleus accumbens

scientific article

Blockade of D2 dopamine receptors in the VTA induces a long-lasting enhancement of the locomotor activating effects of amphetamine

scientific article published in September 2004

Blockade of glutamate reuptake in the rat nucleus accumbens increases locomotor activity

scientific article

Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine.

scientific article

Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment

scientific article

Blockade of prefronto-cortical alpha 1-adrenergic receptors prevents locomotor hyperactivity induced by subcortical D-amphetamine injection

scientific article published on March 1994

Casein kinase 1 enables nucleus accumbens amphetamine‐induced locomotion by regulating AMPA receptor phosphorylation ⬇️

scientific article published on June 6, 2011

Cerebrospinal fluid glutamate concentration correlates with impulsive aggression in human subjects ⬇️

scientific article published on June 18, 2013

Cocaine inhibits leptin-induced increase of the cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens in rats.

scientific article published on 13 June 2017

Conditioned cues and the expression of stimulant sensitization in animals and humans

scientific article published on 09 July 2008

Conditioned locomotion and place preference elicited by tactile cues paired exclusively with morphine in an open field

scientific article published in January 1987

Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTA.

scientific article published in June 1984

Cortico-subcortical interactions in behavioral sensitization: differential effects of daily nicotine and morphine

scientific article

D 1 dopamine receptor blockade prevents the facilitation of amphetamine self-administration induced by prior exposure to the drug ⬇️

scientific article published on 01 July 1998

D1 dopamine receptor activation is necessary for the induction of sensitization by amphetamine in the ventral tegmental area.

scientific article published in April 1996

Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation

scientific article published in November 1998

Deprenyl in Parkinson's disease: mechanisms, neuroprotective effect, indications and adverse effects.

scientific article

Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model

scientific article

Dorsal as well as ventral striatal lesions affect levels of intravenous cocaine and morphine self-administration in rats ⬇️

scientific article published on February 12, 2011

Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons

scientific article published on 16 March 2016

Effects of naltrexone on amphetamine-induced locomotion and rearing: acute and repeated injections

scientific article published on 01 June 1997

Enhanced dorsolateral striatal activity in drug use: The role of outcome in stimulus–response associations ⬇️

scientific article published on August 3, 2012

Enhanced nicotinic receptor function and drug abuse vulnerability

scientific article published in August 2007

Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamine

scientific article published on 01 February 1989

Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure

scientific article published on 25 August 2018

Excitatory synaptic function and plasticity is persistently altered in ventral tegmental area dopamine neurons after prenatal ethanol exposure

scientific article

Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests

scientific article published on 14 June 2007

Exposure to conditions of uncertainty promotes the pursuit of amphetamine

scientific article published on 22 May 2018

Exposure to nicotine and sensitization of nicotine-induced behaviors

scientific article

Exposure to nicotine enhances its subsequent self-administration: contribution of nicotine-associated contextual stimuli

scientific article published on December 2013

Extinction procedures abolish conditioned stimulus control but spare sensitized responding to amphetamine

scientific article published on 01 February 1991

Group II, but not group I, metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion

scientific article published on 01 July 2000

Hyperthermia induced by morphine administration to the VTA of the rat brain: an effect dissociable from morphine-induced reward and hyperactivity

scientific article published on March 1985

In vivo microdialysis in the rat: low cost and low labor construction of a small diameter, removable, concentric-style microdialysis probe system

scientific article published on October 1996

Induction of locomotor sensitization by amphetamine requires the activation of NMDA receptors in the rat ventral tegmental area

scientific article published on 01 August 2000

Inhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioning

scientific article

Inhibition of CaMKII in the nucleus accumbens shell decreases enhanced amphetamine intake in sensitized rats.

scientific article published on 07 August 2008

Injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat.

scientific article

Intermittent nicotine exposure upregulates nAChRs in VTA dopamine neurons and sensitises locomotor responding to the drug ⬇️

scientific article published on January 21, 2013

Involvement of dopamine neurons in the regulation of beta-adrenergic receptor sensitivity in rat prefrontal cortex

scientific article published in June 1990

Leptin in the nucleus accumbens core disrupts acute cocaine effects: Implications for GSK3β connections.

scientific article published on 27 September 2017

Locomotor activity and cocaine-seeking behavior during acquisition and reinstatement of operant self-administration behavior in rats

scientific article published on 12 January 2005

Locomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens

scientific article

Locomotor response to novelty predicts a rat's propensity to self-administer nicotine ⬇️

scientific article published on November 1, 2001

Maladaptive consequences of repeated intermittent exposure to uncertainty

scientific article published on 15 January 2020

Mesoaccumbens dopamine and the self-administration of amphetamine

scientific article

Metabotropic glutamate receptors and the generation of locomotor activity: interactions with midbrain dopamine

scientific article

Metabotropic glutamate receptors are necessary for sensitization by amphetamine ⬇️

scientific article published on February 16, 1998

Metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion ⬇️

scientific article published on January 1, 1998

Microinjection of CART peptide 55-102 into the nucleus accumbens blocks amphetamine-induced locomotion.

scientific article published in December 2003

Microinjections of Sch-23390 into the ventral tegmental area and substantia nigra pars reticulata attenuate the development of sensitization to the locomotor activating effects of systemic amphetamine

scientific article published on 01 August 1989

Morphine conditioned place preference and locomotion: the effect of confinement during training

scientific article published in January 1987

Neuronal and psychological underpinnings of pathological gambling

scientific article

Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections ⬇️

scientific article published on May 1, 1992

Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction

scientific article published on 18 June 2009

Nicotinic excitation of serotonergic projections from dorsal raphe to the nucleus accumbens ⬇️

scientific article published on May 18, 2011

On Cue: Striatal Ups and Downs in Addictions ⬇️

scientific article published on July 11, 2012

Operant responding for optogenetic excitation of LDTg inputs to the VTA requires D1 and D2 dopamine receptor activation in the NAcc

scientific article published on 27 June 2017

Opposed Behavioural Outputs of Increased Dopamine Transmission in Prefrontocortical and Subcortical Areas: A Role for the Cortical D-1 Dopamine Receptor

scientific article published on 01 January 1991

PKC phosphorylates residues in the N-terminal of the DA transporter to regulate amphetamine-induced DA efflux

scientific article

Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition

scientific article published on January 2013

Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug

scientific article

Prenatal ethanol exposure increases risk of psychostimulant addiction

scientific article published on 01 August 2018

Previous Exposure to Nicotine Enhances the Incentive Motivational Effects of Amphetamine via Nicotine-Associated Contextual Stimuli ⬇️

scientific article published on May 23, 2012

Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner.

scientific article published in December 2002

Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in an NMDA, AMPA/kainate, and metabotropic glutamate receptor-dependent manner.

scientific article published on 5 March 2003

Previous exposure to amphetamine enhances the subsequent locomotor response to a D1 dopamine receptor agonist when glutamate reuptake is inhibited.

scientific article

Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule

scientific article published in January 2000

Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine

scientific article

Previous exposure to psychostimulants enhances the reinstatement of cocaine seeking by nucleus accumbens AMPA.

scientific article

Repeated ventral tegmental area amphetamine administration alters dopamine D1 receptor signaling in the nucleus accumbens

scientific article

Sensitization occurs to the locomotor effects of morphine and the specific mu opioid receptor agonist, DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbens

scientific article published in August 1987

Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs

scientific article published on January 2004

Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine.

scientific article published in June 2002

Sensitization, drug addiction and psychopathology in animals and humans

scientific article

Sensitizing exposure to amphetamine increases AMPA receptor phosphorylation without increasing cell surface expression in the rat nucleus accumbens

scientific article published on 18 February 2017

Stimuli associated with the presence or absence of amphetamine regulate cytoskeletal signaling and behavior

scientific journal article

Striatal ups and downs: Their roles in vulnerability to addictions in humans ⬇️

scientific article published on January 16, 2013

The PKC inhibitor Ro31-8220 blocks acute amphetamine-induced dopamine overflow in the nucleus accumbens

scientific article published on 11 March 2009

The effect of dopamine receptor blockade on the development of sensitization to the locomotor activating effects of amphetamine and morphine

scientific article

The effect of previous exposure to amphetamine on drug-induced locomotion and self-administration of a low dose of the drug

scientific article published on 01 November 1999

The mGlu2/3 receptor agonist LY379268 blocks the expression of locomotor sensitization by amphetamine.

scientific article

The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats ⬇️

scientific article published on January 1, 1998

Transient overexpression of alpha-Ca2+/calmodulin-dependent protein kinase II in the nucleus accumbens shell enhances behavioral responding to amphetamine

scientific article

Transient viral-mediated overexpression of alpha-calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell leads to long-lasting functional upregulation of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors: dopamin

scientific article published on 19 March 2010

Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine.

scientific article published on 8 September 2011

List of works by Paul Vezina

A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior

A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.

Absence of functional alternative complement pathway alleviates lupus cerebritis

Activation of group II mGlu receptors blocks the enhanced drug taking induced by previous exposure to amphetamine.

Activation of metabotropic glutamate receptors in the rat nucleus accumbens increases locomotor activity in a dopamine-dependent manner ⬇️

Alpha-1 Adrenergic Receptors are Localized on Presynaptic Elements in the Nucleus Accumbens and Regulate Mesolimbic Dopamine Transmission ⬇️

Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects

Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine

Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat.

Amphetamine-induced changes in dendritic morphology in rat forebrain correspond to associative drug conditioning rather than nonassociative drug sensitization

An overview of commonalities in the mechanisms underlying gambling and substance use disorders

Appetitive sensitization by amphetamine does not reduce its ability to produce conditioned taste aversion to saccharin

Behavioral sensitization to quinpirole is not associated with increased nucleus accumbens dopamine overflow

Blockade of D-1 dopamine receptors in the medial prefrontal cortex produces delayed effects on pre- and postsynaptic indices of dopamine function in the nucleus accumbens

Blockade of D2 dopamine receptors in the VTA induces a long-lasting enhancement of the locomotor activating effects of amphetamine

Blockade of glutamate reuptake in the rat nucleus accumbens increases locomotor activity

Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine.

Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment

Blockade of prefronto-cortical alpha 1-adrenergic receptors prevents locomotor hyperactivity induced by subcortical D-amphetamine injection

Casein kinase 1 enables nucleus accumbens amphetamine‐induced locomotion by regulating AMPA receptor phosphorylation ⬇️

Cerebrospinal fluid glutamate concentration correlates with impulsive aggression in human subjects ⬇️

Cocaine inhibits leptin-induced increase of the cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens in rats.

Conditioned cues and the expression of stimulant sensitization in animals and humans

Conditioned locomotion and place preference elicited by tactile cues paired exclusively with morphine in an open field

Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTA.

Cortico-subcortical interactions in behavioral sensitization: differential effects of daily nicotine and morphine

D 1 dopamine receptor blockade prevents the facilitation of amphetamine self-administration induced by prior exposure to the drug ⬇️

D1 dopamine receptor activation is necessary for the induction of sensitization by amphetamine in the ventral tegmental area.

Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation

Deprenyl in Parkinson's disease: mechanisms, neuroprotective effect, indications and adverse effects.

Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model

Dorsal as well as ventral striatal lesions affect levels of intravenous cocaine and morphine self-administration in rats ⬇️

Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons

Effects of naltrexone on amphetamine-induced locomotion and rearing: acute and repeated injections

Enhanced dorsolateral striatal activity in drug use: The role of outcome in stimulus–response associations ⬇️

Enhanced nicotinic receptor function and drug abuse vulnerability

Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamine

Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure

Excitatory synaptic function and plasticity is persistently altered in ventral tegmental area dopamine neurons after prenatal ethanol exposure

Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests

Exposure to conditions of uncertainty promotes the pursuit of amphetamine

Exposure to nicotine and sensitization of nicotine-induced behaviors

Exposure to nicotine enhances its subsequent self-administration: contribution of nicotine-associated contextual stimuli

Extinction procedures abolish conditioned stimulus control but spare sensitized responding to amphetamine

Group II, but not group I, metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion

Hyperthermia induced by morphine administration to the VTA of the rat brain: an effect dissociable from morphine-induced reward and hyperactivity

In vivo microdialysis in the rat: low cost and low labor construction of a small diameter, removable, concentric-style microdialysis probe system

Induction of locomotor sensitization by amphetamine requires the activation of NMDA receptors in the rat ventral tegmental area

Inhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioning

Inhibition of CaMKII in the nucleus accumbens shell decreases enhanced amphetamine intake in sensitized rats.

Injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat.

Intermittent nicotine exposure upregulates nAChRs in VTA dopamine neurons and sensitises locomotor responding to the drug ⬇️

Involvement of dopamine neurons in the regulation of beta-adrenergic receptor sensitivity in rat prefrontal cortex

Leptin in the nucleus accumbens core disrupts acute cocaine effects: Implications for GSK3β connections.

Locomotor activity and cocaine-seeking behavior during acquisition and reinstatement of operant self-administration behavior in rats

Locomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens

Locomotor response to novelty predicts a rat's propensity to self-administer nicotine ⬇️

Maladaptive consequences of repeated intermittent exposure to uncertainty

Mesoaccumbens dopamine and the self-administration of amphetamine

Metabotropic glutamate receptors and the generation of locomotor activity: interactions with midbrain dopamine

Metabotropic glutamate receptors are necessary for sensitization by amphetamine ⬇️

Metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion ⬇️

Microinjection of CART peptide 55-102 into the nucleus accumbens blocks amphetamine-induced locomotion.

Microinjections of Sch-23390 into the ventral tegmental area and substantia nigra pars reticulata attenuate the development of sensitization to the locomotor activating effects of systemic amphetamine

Morphine conditioned place preference and locomotion: the effect of confinement during training

Neuronal and psychological underpinnings of pathological gambling

Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections ⬇️

Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction

Nicotinic excitation of serotonergic projections from dorsal raphe to the nucleus accumbens ⬇️

On Cue: Striatal Ups and Downs in Addictions ⬇️

Operant responding for optogenetic excitation of LDTg inputs to the VTA requires D1 and D2 dopamine receptor activation in the NAcc

Opposed Behavioural Outputs of Increased Dopamine Transmission in Prefrontocortical and Subcortical Areas: A Role for the Cortical D-1 Dopamine Receptor

PKC phosphorylates residues in the N-terminal of the DA transporter to regulate amphetamine-induced DA efflux

Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition

Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug

Prenatal ethanol exposure increases risk of psychostimulant addiction

Previous Exposure to Nicotine Enhances the Incentive Motivational Effects of Amphetamine via Nicotine-Associated Contextual Stimuli ⬇️

Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner.

Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in an NMDA, AMPA/kainate, and metabotropic glutamate receptor-dependent manner.