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List of works by Keiichi Hiramatsu

"Slow VISA," a novel phenotype of vancomycin resistance, found in vitro in heterogeneous vancomycin-intermediate Staphylococcus aureus strain Mu3.

scientific article published on 19 May 2014

1843. Prescribers’ Characteristics and Unnecessary/Inappropriate Antimicrobial Prescription in the Emergency Department: An Observational Study at a Tertiary Care Center

A Pediatric Case of Septic Arthritis due to methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin and toxic shock syndrome toxin-1

scientific article published on 30 April 2020

A latex agglutination assay for specific detection of Panton-Valentine leukocidin

scientific article published on 22 July 2008

A mutation of RNA polymerase β' subunit (RpoC) converts heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA) into "slow VISA"

scientific article published on 4 May 2015

A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus

scientific article (publication date: 2008)

A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds

scientific article published on 3 October 2002

A novel type-III staphylococcal cassette chromosome mec (SCCmec) variant among Indian isolates of methicillin-resistant Staphylococcus aureus

scientific article published on 29 January 2009

A soluble fiber diet increases Bacteroides fragilis group and IgA production in the gut

scientific article published on 24 April 2020

Activated ADI pathway: the initiator of intermediate vancomycin resistance in Staphylococcus aureus.

scientific article published on 19 October 2016

Activity of tick antimicrobial peptide from Ixodes persulcatus (persulcatusin) against cell membranes of drug-resistant Staphylococcus aureus

scientific article

An RpoB Mutation Confers Dual Heteroresistance to Daptomycin and Vancomycin in Staphylococcus aureus ⬇️

scientific article published on September 13, 2010

An effective active surveillance method for controlling nosocomial MRSA transmission in a Japanese hospital

scientific article published on 5 April 2013

Analysis of Staphylococcal Cassette Chromosome mec in BD GeneOhm MRSA Assay-Negative Strains ⬇️

scientific article published on April 9, 2013

Antibacterial activity of 2,4-diacetylphloroglucinol produced by Pseudomonas sp. AMSN isolated from a marine alga, against vancomycin-resistant Staphylococcus aureus.

scientific article published in November 2003

Antimicrobial cathelicidin polypeptide CAP11 suppresses the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice

scientific article

Apigenin as an anti-quinolone-resistance antibiotic

scientific article published on 22 October 2015

Beta-hemolysin promotes skin colonization by Staphylococcus aureus

scientific article

Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus

scientific article

Changes in Intestinal Microbiota Following Combination Therapy with Fecal Microbial Transplantation and Antibiotics for Ulcerative Colitis

scientific article published on 01 January 2017

Characterization of Staphylococci with Reduced Susceptibilities to Vancomycin and Other Glycopeptides

scientific article published in 1998

Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions

scientific article published on 16 October 2006

Community-acquired methicillin-resistant Staphylococcus aureus, Uruguay

scientific article

Community-associated MRSA: current status and molecular epidemiological perspective

scientific article published in September 2010

Community-associated methicillin-resistant Staphylococcus aureus: current status and molecular epidemiological perspective

scientific article

Comparative analysis of MRSA.

scientific article published in January 2007

Comparison of USA300 with non-USA300 methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit

scientific article published on 29 November 2018

Complete Genome Sequence of Macrococcus caseolyticus Strain JCSC5402, Reflecting the Ancestral Genome of the Human-Pathogenic Staphylococci

scientific article published in May 2009

Complete Genome Sequence of Methicillin-Resistant Staphylococcus schleiferi Strain TSCC54 of Canine Origin

scientific article published on 29 October 2015

Complete Genome Sequence of Vancomycin-Intermediate Staphylococcus aureus Strain MI (HIP5827).

scientific article published on 17 March 2016

Complete Genome Sequence of the Drug-Naive Classical Staphylococcus aureus Strain FDA209P

scientific article published on 12 November 2015

Complete Reconstitution of the Vancomycin-Intermediate Staphylococcus aureus Phenotype of Strain Mu50 in Vancomycin-Susceptible S. aureus

scientific article published on 11 April 2016

Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, [corrected] reflecting the ancestral genome of the human-pathogenic staphylococci

scientific article published on 12 December 2008

Complete genome sequence of a methicillin-resistant Staphylococcus lugdunensis strain and characteristics of its staphylococcal cassette chromosome mec

scientific article published on 26 May 2020

Comprehensive identification of mutations responsible for heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA)-to-VISA conversion in laboratory-generated VISA strains derived from hVISA clinical strain Mu3

scientific article published on 09 September 2013

Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.

scientific article published on 5 January 2009

Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria ⬇️

scientific article published on May 29, 2012

Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.

scientific article published on March 2006

Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature ⬇️

scientific article published on April 23, 2012

DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.

scientific article published in August 2005

Detection of IMP Metallo-β-Lactamase in Carbapenem-Nonsusceptible Enterobacteriaceae and Non-Glucose-Fermenting Gram-Negative Rods by Immunochromatography Assay ⬇️

scientific article published on March 27, 2013

Development and validation of microarray-based assay for epidemiological study of MRSA

scientific article published on 05 June 2007

Development of new application for comprehensive viability analysis based on microbiome analysis by next-generation sequencing: insights into staphylococcal carriage in human nasal cavities

scientific article published on 6 April 2018

Differences between "classical" risk factors for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and risk factors for nosocomial bloodstream infections caused by multiple clones of the staphylococcal cassette chromosome mec t

scientific article published in February 2009

Dissemination of methicillin-resistant staphylococci among healthy Japanese children

scientific article

Dissemination of multiple MRSA clones among community-associated methicillin-resistant Staphylococcus aureus infections from Japanese children with impetigo

scientific article published on 17 February 2011

Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community

scientific article

Effect of PMX-DHP for sepsis due to ESBL-producing E. coli in an extremely low-birthweight infant

scientific article published on 29 December 2015

Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage phi MR11.

scientific article published on 11 September 2007

Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin.

scientific article published on December 2004

Emergence of quinolone-resistant Bordetella pertussis in Japan

scientific article published on 04 May 2009

Emergence of vancomycin resistance during therapy against methicillin-resistant Staphylococcus aureus in a burn patient—importance of low-level resistance to vancomycin ⬇️

scientific article published on December 1, 2002

Epidemiology of Methicillin Resistant Staphylococcus aureus in a Japanese NICU

scientific article published on 25 March 2020

Epidural abscess caused by community-associated methicillin-resistant Staphylococcus aureus strain USA300 in Japan

scientific article published on 3 April 2010

Evaluation of a simple protein extraction method for species identification of clinically relevant staphylococci by matrix-assisted laser desorption ionization-time of flight mass spectrometry

scientific article

Expression and Functional Characterization of Retinoic Acid-Inducible Gene-I-Like Receptors of Mast Cells in Response to Viral Infection ⬇️

scientific article published on November 21, 2012

Extreme genetic diversity of methicillin-resistant Staphylococcus epidermidis strains disseminated among healthy Japanese children

scientific article

First report of sasX-positive methicillin-resistant Staphylococcus aureus in Japan

scientific article

First report on USA300 outbreak in a neonatal intensive care unit detected by polymerase chain reaction-based open reading frame typing in Japan

scientific article published on 28 December 2018

Genetic and Transcriptomic Analyses of Ciprofloxacin-Tolerant Staphylococcus aureus Isolated by the Replica Plating Tolerance Isolation System (REPTIS)

scientific article published on 29 January 2019

Genetic characterization of methicillin-resistant Staphylococcus aureus.

scientific article published in December 2004

Genetic differentiation of methicillin-resistant Staphylococcus aureus strains from Korea and Japan

scientific article published in January 2005

Genetic diversity of methicillin-resistant Staphylococcus aureus carrying type IV SCCmec in Orebro County and the western region of Sweden

scientific article published on 11 November 2008

Genetic diversity of staphylocoagulase genes (coa): insight into the evolution of variable chromosomal virulence factors in Staphylococcus aureus

scientific article

Genome and virulence determinants of high virulence community-acquired MRSA

scientific article (publication date: 25 May 2002)

Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands

scientific journal article

Genome sequencing and annotation: an overview

scientific article published in January 2004

Genomic Basis for Methicillin Resistance in Staphylococcus aureus

scientific article published on 26 June 2013

Guidelines for reporting novel mecA gene homologues

scientific article

Has vancomycin-resistant Staphylococcus aureus started going it alone?

scientific article

Heterogeneous vancomycin-resistant Staphylococcus aureus (hetero-VISA) in Singapore

scientific article published in February 2005

Heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA) emerged before the clinical introduction of vancomycin in Japan: a retrospective study ⬇️

scientific article published on October 29, 2011

Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells ⬇️

scientific article published on March 1, 2011

Identification in Methicillin-Susceptible Staphylococcus hominis of an Active Primordial Mobile Genetic Element for the Staphylococcal Cassette Chromosome mec of Methicillin-Resistant Staphylococcus aureus ⬇️

scientific article published on May 1, 2003

Identification of a Novel Gene Associated with High-Level β-Lactam Resistance in Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Strain Mu3 and Methicillin-Resistant S. aureus Strain N315

scientific article published on 29 January 2019

Identification of a novel variant of staphylococcal cassette chromosome mec, type II.5, and Its truncated form by insertion of putative conjugative transposon Tn6012.

scientific article published on 13 April 2009

Identification of the third type of PVL phage in ST59 methicillin-resistant Staphylococcus aureus (MRSA) strains ⬇️

scientific article published on August 9, 2011

Impact of reduced vancomycin susceptibility on the therapeutic outcome of MRSA bloodstream infections.

scientific article

Impact of rpoB Mutations on Reduced Vancomycin Susceptibility in Staphylococcus aureus ⬇️

scientific article published on April 27, 2011

Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus

scientific article published on 18 August 2008

Improved selective isolation of Bordetella pertussis by use of modified cyclodextrin solid medium

scientific article published on 21 October 2009

In Vitro Tolerance of Drug-Naive Staphylococcus aureus Strain FDA209P to Vancomycin

scientific article published on 14 November 2016

Infective endocarditis with Lactococcus garvieae in Japan: a case report ⬇️

scientific article published on August 9, 2011

Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence

scientific article published on 14 November 2012

Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC.

scientific article

Intestinal carriage of methicillin-resistant Staphylococcus aureus in nasal MRSA carriers hospitalized in the neonatal intensive care unit

scientific article

Is Histoplasma capsulatum a native inhabitant of Japan?

scientific article published in September 2008

LacR mutations are frequently observed in Streptococcus intermedius and are responsible for increased intermedilysin production and virulence

scientific article published on 24 June 2013

MRSA (methicillin-resistant Staphylococcus aureus)

scientific article published on March 1, 2003

Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.

scientific article published on 11 October 2017

Methicillin-resistant Staphylococcus pseudintermedius in a veterinary teaching hospital

scientific article published on 31 January 2007

Misuse of Discharge Antimicrobial Prescription in the Emergency Department: An Observational Study at a Tertiary Care Center

scientific article published on 10 January 2019

Mobile Genetic Element SCCmec-encoded psm-mec RNA Suppresses Translation of agrA and Attenuates MRSA Virulence ⬇️

scientific article published on April 4, 2013

Molecular Epidemiology of Community-Associated and Hospital-associated Methicillin-resistant Staphylococcus aureus in a Japanese University Hospital

scientific article published on 4 October 2017

Molecular characterization of methicillin-resistant Panton-valentine leukocidin positive staphylococcus aureus clones disseminating in Tunisian hospitals and in the community ⬇️

scientific article published on January 7, 2013

Molecular epidemiologic study of community-associated methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin gene among family members in Japan

scientific article published on 30 May 2015

Molecular genetics of methicillin-resistant Staphylococcus aureus

scientific article

Multiplex PCRs for assignment of Staphylocoagulase types and subtypes of type VI Staphylocoagulase.

scientific article published on 13 July 2008

Multiplex-PCR method for species identification of coagulase-positive staphylococci

scientific article published on 6 January 2010

Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.

scientific article published on 22 October 2007

Mutation of RNA Polymerase β Subunit ( rpoB ) Promotes hVISA-to-VISA Phenotypic Conversion of Strain Mu3 ⬇️

scientific article published on July 11, 2011

Mutation of RNA Polymerase β-Subunit Gene Promotes Heterogeneous-to-Homogeneous Conversion of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus ⬇️

scientific article published on July 22, 2013

New trends in Staphylococcus aureus infections: glycopeptide resistance in hospital and methicillin resistance in the community

scientific article

Nosocomial spread of a Staphylococcus capitis strain with heteroresistance to vancomycin in a neonatal intensive care unit

scientific article

Novel Types of Staphylococcal Cassette Chromosome mec Elements Identified in Clonal Complex 398 Methicillin-Resistant Staphylococcus aureus Strains ⬇️

scientific article published on March 21, 2011

Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus.

scientific article published on February 2006

Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC.

scientific article

Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains

scientific article published on April 2002

Novel type of staphylococcal cassette chromosome mec in a methicillin-resistant Staphylococcus aureus strain isolated in Sweden

scientific article published on August 2008

Nucleic acid-based testing for methicillin-resistant Staphylococcus aureus infection

scientific article published in December 2005

Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315.

scientific article

Origin and Molecular Evolution of the Determinant of Methicillin Resistance in Staphylococci.

scientific article published in February 2011

Origin and molecular evolution of the determinant of methicillin resistance in staphylococci

scientific article

Oxidative stress resistance and fitness-compensatory response in vancomycin-intermediate Staphylococcus aureus (VISA)

scientific article published on 07 May 2019

Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible and resistant Staphylococcus aureus in Taiwan: identification of oxacillin-susceptible mecA-positive methicillin-resistant S. aureus

scientific article published on 19 September 2009

Phenol-soluble modulin alpha 3 enhances the human neutrophil lysis mediated by Panton-Valentine leukocidin

scientific article published on 01 September 2009

Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.

scientific article

Physiological and molecular analysis of a mecA-negative Staphylococcus aureus clinical strain that expresses heterogeneous methicillin resistance

scientific article

Population Genetic Structures of Staphylococcus aureus Isolates from Cats and Dogs in Japan ⬇️

scientific article published on March 21, 2012

Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphyl

scientific article published on 19 May 2008

Potential Impact of Rapid Blood Culture Testing for Gram-Positive Bacteremia in Japan with the Verigene Gram-Positive Blood Culture Test.

scientific article

Precise excision and self-integration of a composite transposon as a model for spontaneous large-scale chromosome inversion/deletion of the Staphylococcus haemolyticus clinical strain JCSC1435.

scientific article published on 19 January 2007

Predominance of clones carrying Panton-Valentine leukocidin genes among methicillin-resistant Staphylococcus aureus strains isolated in Japanese hospitals from 1979 to 1985.

scientific article

Preliminary report of SCCmec-types and antimicrobial susceptibilities of methicillin-resistant Staphylococcus aureus isolates from a university hospital in Thailand

scientific article published on July 1, 2010

Prophages of Staphylococcus aureus Newman and their contribution to virulence

scientific article published in November 2006

Protective activity of anti-lipoteichoic acid monoclonal antibody in single or combination therapies in methicillin-resistant Staphylococcus aureus-induced murine sepsis models

scientific article published on 27 January 2020

Pseudomonas atagosis sp. nov., and Pseudomonas akappagea sp. nov., New Soil Bacteria Isolated from Samples on the Volcanic Island Izu Oshima, Tokyo

scientific article published on 18 March 2020

Pseudomonas izuensis sp. nov., a novel species isolated from Izu Oshima, Japan

scientific article published on 18 June 2020

RNA sequencing identifies a common physiology in vancomycin- and ciprofloxacin-tolerant Staphylococcus aureus induced by ileS mutations

scientific article published on 20 July 2020

Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination

scientific article

Rapid and Accurate Identification of Human-Associated Staphylococci by Use of Multiplex PCR ⬇️

scientific article published on August 10, 2011

Rapid detection of Staphylococcus aureus strains having reduced susceptibility to vancomycin using a chemiluminescence-based drug-susceptibility test

scientific article published on 14 June 2007

Reclassification of phenotypically identified staphylococcus intermedius strains

scientific article

Recurrence of heterogeneous methicillin-resistant Staphylococcus aureus (MRSA) among the MRSA clinical isolates in a Japanese university hospital

scientific article

Regional outbreak of community-associated methicillin-resistant Staphylococcus aureus ST834 in Japanese children

scientific article published on 09 January 2019

Risk factors of fecal colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae in special nursing homes in Japan.

scientific article published on 23 March 2018

Role of catabolite control protein A in the regulation of intermedilysin production by Streptococcus intermedius

scientific article

ST9 MRSA strains carrying a variant of type IX SCCmec identified in the Thai community ⬇️

scientific article published on May 11, 2013

Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem

scientific article published on 18 May 2009

Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.

scientific article

Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia

scientific article published on 21 July 2008

Standard nomenclature for the superantigens expressed by Staphylococcus

scientific article published on 26 May 2004

Staphylococcal Cassette Chromosome mec (SCCmec) analysis of MRSA

scientific article published on 01 January 2014

Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus strains isolated in 11 Asian countries: a proposal for a new nomenclature for SCCmec elements

scientific article published in March 2006

Staphylococcal cassette chromosome mec(SCC mec) analysis of MRSA.

scientific article published in January 2007

Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus

scientific article

Staphylococcal infections

scientific article published in February 2003

Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway

scientific article published on 01 November 2010

Structural and biological characterization of a capsular polysaccharide produced by Staphylococcus haemolyticus.

scientific article

Subinhibitory concentrations of beta-lactam induce haemolytic activity in Staphylococcus aureus through the SaeRS two-component system

scientific article published on March 2007

Successful selection of an infection-protective anti-Staphylococcus aureus monoclonal antibody and its protective activity in murine infection models

scientific article published on April 2015

Susceptibilities of healthcare- and community-associated methicillin-resistant staphylococci to the novel des-F(6)-quinolone DX-619.

scientific article published on 21 September 2007

Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 1999.

scientific article

TSLP expression induced via Toll-like receptor pathways in human keratinocytes

scientific article published on 01 January 2014

The Microbial Composition of Bacteroidetes Species in Ulcerative Colitis Is Effectively Improved by Combination Therapy With Fecal Microbiota Transplantation and Antibiotics

scientific article published on 01 November 2018

The first vancomycin-intermediate Staphylococcus aureus strains isolated from patients in Thailand

scientific article published on 29 April 2009

The grIA Mutation in Norfloxacin-Resistant First-Step Mutants and Clinical Isolates of Staphylococcus aureus

scientific article published in January 1996

Time-suppression test using a colorimetric probe (alamarBlue) that measures bacterial metabolic activity

scientific article published in June 2008

Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence

scientific article published in 2011

Trial to control an outbreak of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus at a boarding school in Japan.

scientific article published on 12 June 2011

Two different Panton-Valentine leukocidin phage lineages predominate in Japan

scientific article published on 6 August 2008

Two heterogeneously vancomycin-intermediate clinical isolates of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in a Turkish university hospital: brief report of a surveillance study

scientific article published on 26 October 2005

Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus

scientific article

Type IV SCCmec found in decade old Brazilian MRSA isolates

scientific article published in June 2008

Use of a sensitive chemiluminescence-based assay to evaluate the metabolic suppression activity of linezolid on methicillin-resistant Staphylococcus aureus showing reduced susceptibility to vancomycin

scientific article published in July 2009

Vancomycin heteroresistance in methicillin-resistant Staphylococcus aureus, Taiwan.

scientific article published on September 2004

Vancomycin-intermediate resistance in Staphylococcus aureus

scientific article published on 7 June 2014

Whole-Genome Sequencing of Staphylococcus haemolyticus Uncovers the Extreme Plasticity of Its Genome and the Evolution of Human-Colonizing Staphylococcal Species

scientific article

[Evolution and spread of SCCmec among staphylococci]

scientific article published on 01 February 2007

[MRSA clones identified in outpatient dermatology clinics]

scientific article published on 01 November 2014

[Staphylococcus]

scientific article published on 01 March 2003

walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.

scientific article published on 31 May 2011

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