List of works - Todd Vanderah

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

scientific article published on 09 March 2016

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss

scientific article

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

scientific article published on July 2015

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain.

scientific article

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

scientific article

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain

scientific article

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord

scientific article published on 24 October 2011

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

scientific article published on 13 April 2020

Antinociceptive and nociceptive actions of opioids

scientific article published in October 2004

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines

scientific article

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

scientific article

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

scientific article

CB2 cannabinoid receptor mediation of antinociception.

scientific article published on 23 March 2006

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

scientific journal article

Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists

scientific article

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

scientific article

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

scientific article published on 02 May 2019

Development of potent μ and δ opioid agonists with high lipophilicity

scientific article

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

scientific article

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies

scientific article

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord

scientific article

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

scientific article

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

scientific article published on 31 July 2017

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

scientific article

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

scientific article published on 13 July 2011

Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain

scientific article

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306

scientific article published on 01 December 2019

Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake

scientific article published on 29 May 2020

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists

scientific article

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

scientific article

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors ⬇️

scientific article published on October 1, 2003

Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.

scientific article published on 20 October 2011

Inhibition of pain responses by activation of CB(2) cannabinoid receptors

scientific article

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

scientific article

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

scientific article published in February 2017

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.

scientific article published on 16 July 2018

Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis

scientific article

Melanocortin receptors, melanotropic peptides and penile erection

scientific article

Multiple actions of systemic artemin in experimental neuropathy ⬇️

scientific article (publication date: November 2003)

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

scientific article

New paradigms and tools in drug design for pain and addiction

scientific article published on 14 July 2006

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

scientific article

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

scientific article published on 20 April 2011

Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling

scientific article

Pathophysiology of pain

scientific article 2007

Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain

scientific article published on 01 September 2018

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

scientific article

Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists

scientific article

Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids

scientific article published on 01 April 2011

Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist

scientific article published on 30 January 2012

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

scientific article

Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats

scientific article published on 08 November 2021

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

scientific article published on 08 May 2019

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

scientific article

Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner ⬇️

scientific article published on September 15, 2010

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

scientific article published on September 2016

Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists

scientific article

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

scientific article

TRPV1 receptor in expression of opioid-induced hyperalgesia

scientific article

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

scientific article published on 31 May 2017

The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area

scientific article published on 16 April 2021

The pharmacology of neurokinin receptors in addiction: prospects for therapy

scientific article

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

scientific article

Unmasking the tonic-aversive state in neuropathic pain

scientific article

Use of Animal Models in Understanding Cancer-induced Bone Pain

scientific article

List of works by Todd Vanderah

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain.

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

Antinociceptive and nociceptive actions of opioids

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

CB2 cannabinoid receptor mediation of antinociception.

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

Development of potent μ and δ opioid agonists with high lipophilicity

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306

Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors ⬇️

Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.

Inhibition of pain responses by activation of CB(2) cannabinoid receptors

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.

Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis

Melanocortin receptors, melanotropic peptides and penile erection

Multiple actions of systemic artemin in experimental neuropathy ⬇️

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

New paradigms and tools in drug design for pain and addiction

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling

Pathophysiology of pain

Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists

Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids

Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner ⬇️

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

TRPV1 receptor in expression of opioid-induced hyperalgesia

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area

The pharmacology of neurokinin receptors in addiction: prospects for therapy

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

Unmasking the tonic-aversive state in neuropathic pain

Use of Animal Models in Understanding Cancer-induced Bone Pain