List of works - Patricia J Giardina

A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD).

scientific article published on 03 April 2013

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia

scientific article

A preclinical approach for gene therapy of beta-thalassemia.

scientific article published on August 2010

Bone disease in thalassemia: a frequent and still unresolved problem

scientific article

Bone loss caused by iron overload in a murine model: importance of oxidative stress

scientific article

Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea

scientific article

Changes in bone microarchitecture and biomechanical properties in the th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual.

scientific article

Chelation use and iron burden in North American and British thalassemia patients: a report from the Thalassemia Longitudinal Cohort ⬇️

scientific article published on January 25, 2012

Combined iron chelation therapy

scientific article published on August 2010

Contextually appropriate emotional word use predicts adaptive health behavior: Emotion context sensitivity and treatment adherence

scientific article published on 6 May 2014

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

scientific article published on 14 May 2008

Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America

scientific article

Education and employment status of children and adults with thalassemia in North America

scientific article

Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial ⬇️

scientific article published on May 10, 2003

Epidemiologic and clinical characteristics of nontransfusion-dependent thalassemia in the United States.

scientific article published on 10 April 2018

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

scientific article published on January 2005

Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial

scientific article published on October 2010

Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia

scientific article published on 15 March 2008

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

scientific article

Hemoglobin H-constant spring in North America: an alpha thalassemia with frequent complications

scientific article

Hepcidin and Hfe in iron overload in beta-thalassemia

scientific article published on August 2010

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

scientific article

How I treat thalassemia ⬇️

scientific article published on 02 August 2011

Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients

scientific article published on 12 March 2013

Human T-cell lymphotropic virus type 1 infection among U.S. Thalassemia patients.

scientific article published on 7 January 2014

Increased leucocyte apoptosis in transfused β‐thalassaemia patients ⬇️

scientific article published on December 6, 2012

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

scientific article published on 13 February 2007

Inflammation and oxidant-stress in beta-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial

scientific article published on 10 May 2008

Iron chelation adherence to deferoxamine and deferasirox in thalassemia

scientific article

Late complications of mixed chimerism following allogeneic bone marrow transplantation for thalassemia major

scientific article published on 21 March 2015

Longitudinal monitoring of cardiac siderosis using cardiovascular magnetic resonance T2* in patients with thalassemia major on various chelation regimens: A 6‐year study ⬇️

scientific article published on June 28, 2013

Low bone mass in prepubertal children with thalassemia major: insights into the pathogenesis of low bone mass in thalassemia

scientific article published on 01 October 2004

Low bone mineral density in adolescents with beta-thalassemia

scientific article published on January 2005

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

scientific article published on 17 March 2013

Managing incidentally diagnosed isolated factor VII deficiency perioperatively: a brief expert consensus report

scientific article

Negative affect differentiation and adherence during treatment for thalassemia

scientific article published in February 2014

Pain as an emergent issue in thalassemia

scientific article published in May 2010

Parental and other factors associated with hydroxyurea use for pediatric sickle cell disease

scientific article published on 5 November 2012

Phase Ib clinical trial of starch-conjugated deferoxamine (40SD02): a novel long-acting iron chelator

scientific article published on 01 August 2007

Pregnancy outcomes in women with thalassemia in North America and the United Kingdom

scientific article

Red blood cell transfusions for thalassemia: results of a survey assessing current practice and proposal of evidence-based guidelines

scientific article published on 24 February 2014

Red cell alloimmunization in a diverse population of transfused patients with thalassaemia ⬇️

scientific article published on February 17, 2011

Relationship between chronic transfusion therapy and body composition in subjects with thalassemia

scientific article

Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial

scientific article published on 10 March 2011

Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study

scientific article

Renal dysfunction in patients with thalassaemia ⬇️

scientific article published on February 21, 2011

Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report ⬇️

scientific article published on July 19, 2011

Safe mobilization of CD34+ cells in adults with β-thalassemia and validation of effective globin gene transfer for clinical investigation.

scientific article published on 15 January 2014

Safety and efficacy of pegylated interferon alpha-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia

scientific article published on 12 June 2008

Safety and pharmacokinetics of the oral iron chelator SP-420 in β-thalassemia.

scientific article published on 22 September 2017

Strategy for a multicenter phase I clinical trial to evaluate globin gene transfer in beta-thalassemia

scientific article published on 01 August 2010

Symptoms of depression and anxiety in patients with thalassemia: prevalence and correlates in the thalassemia longitudinal cohort.

scientific article

The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores

scientific article published on 26 April 2010

The palatability and tolerability of deferasirox taken with different beverages or foods ⬇️

scientific article published on April 23, 2013

Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients

scientific article (publication date: 2012)

Therapeutic options for patients with severe beta-thalassemia: the need for globin gene therapy

scientific article published on January 2007

Toward optimizing the use of deferasirox: potential benefits of combined use with deferoxamine ⬇️

scientific article published on August 8, 2012

Transfusion complications in thalassemia patients: a report from the Centers for Disease Control and Prevention (CME).

scientific article published on 25 July 2013

Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone

scientific article published on 20 May 2013

Unreliable oral glucose tolerance test and haemoglobin A1C in beta thalassaemia major – a case for continuous glucose monitoring? ⬇️

scientific article published on April 18, 2013

List of works by Patricia J Giardina

A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD).

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia

A preclinical approach for gene therapy of beta-thalassemia.

Bone disease in thalassemia: a frequent and still unresolved problem

Bone loss caused by iron overload in a murine model: importance of oxidative stress

Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea

Changes in bone microarchitecture and biomechanical properties in the th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual.

Chelation use and iron burden in North American and British thalassemia patients: a report from the Thalassemia Longitudinal Cohort ⬇️

Combined iron chelation therapy

Contextually appropriate emotional word use predicts adaptive health behavior: Emotion context sensitivity and treatment adherence

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America

Education and employment status of children and adults with thalassemia in North America

Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial ⬇️

Epidemiologic and clinical characteristics of nontransfusion-dependent thalassemia in the United States.

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial

Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

Hemoglobin H-constant spring in North America: an alpha thalassemia with frequent complications

Hepcidin and Hfe in iron overload in beta-thalassemia

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

How I treat thalassemia ⬇️

Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients

Human T-cell lymphotropic virus type 1 infection among U.S. Thalassemia patients.

Increased leucocyte apoptosis in transfused β‐thalassaemia patients ⬇️

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Inflammation and oxidant-stress in beta-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial

Iron chelation adherence to deferoxamine and deferasirox in thalassemia

Late complications of mixed chimerism following allogeneic bone marrow transplantation for thalassemia major

Longitudinal monitoring of cardiac siderosis using cardiovascular magnetic resonance T2* in patients with thalassemia major on various chelation regimens: A 6‐year study ⬇️

Low bone mass in prepubertal children with thalassemia major: insights into the pathogenesis of low bone mass in thalassemia

Low bone mineral density in adolescents with beta-thalassemia

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

Managing incidentally diagnosed isolated factor VII deficiency perioperatively: a brief expert consensus report

Negative affect differentiation and adherence during treatment for thalassemia

Pain as an emergent issue in thalassemia

Parental and other factors associated with hydroxyurea use for pediatric sickle cell disease

Phase Ib clinical trial of starch-conjugated deferoxamine (40SD02): a novel long-acting iron chelator

Pregnancy outcomes in women with thalassemia in North America and the United Kingdom

Red blood cell transfusions for thalassemia: results of a survey assessing current practice and proposal of evidence-based guidelines

Red cell alloimmunization in a diverse population of transfused patients with thalassaemia ⬇️

Relationship between chronic transfusion therapy and body composition in subjects with thalassemia

Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial

Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study

Renal dysfunction in patients with thalassaemia ⬇️

Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report ⬇️

Safe mobilization of CD34+ cells in adults with β-thalassemia and validation of effective globin gene transfer for clinical investigation.

Safety and efficacy of pegylated interferon alpha-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia

Safety and pharmacokinetics of the oral iron chelator SP-420 in β-thalassemia.

Strategy for a multicenter phase I clinical trial to evaluate globin gene transfer in beta-thalassemia

Symptoms of depression and anxiety in patients with thalassemia: prevalence and correlates in the thalassemia longitudinal cohort.

The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores

The palatability and tolerability of deferasirox taken with different beverages or foods ⬇️

Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients

Therapeutic options for patients with severe beta-thalassemia: the need for globin gene therapy

Toward optimizing the use of deferasirox: potential benefits of combined use with deferoxamine ⬇️

Transfusion complications in thalassemia patients: a report from the Centers for Disease Control and Prevention (CME).

Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone

Unreliable oral glucose tolerance test and haemoglobin A1C in beta thalassaemia major – a case for continuous glucose monitoring? ⬇️