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Authors whose works are in public domain in at least one jurisdiction

List of works by Joann B. Sweasy

3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

scientific article

A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant

scientific article

A DNA polymerase beta mutant from colon cancer cells induces mutations

scholarly article

A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation ⬇️

scientific article published on November 8, 2012

A Triad Interaction in the Fingers Subdomain of DNA Polymerase Beta Controls Polymerase Activity ⬇️

scientific article published on March 31, 2011

A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation

scientific article (publication date: November 2014)

A new perspective on oxidation of DNA repair proteins and cancer

scientific article published on 18 February 2019

A pre-catalytic non-covalent step governs DNA polymerase β fidelity

scientific article published on 01 December 2019

Abstract 4319: Lupus antibody-based cancer therapy

Base Excision Repair Variants in Cancer

scientific article published on 5 May 2017

Base excision repair and cancer

scientific article

Catalytic Effects of Mutations of Distant Protein Residues in Human DNA Polymerase β: Theory and Experiment ⬇️

scientific article published on October 29, 2012

Cellular roles of DNA polymerase beta

scientific article published on 13 December 2013

Colon Cancer-associated DNA Polymerase β Variant Induces Genomic Instability and Cellular Transformation ⬇️

scientific article published on May 9, 2012

Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

scientific article

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy

scientific article published on 10 January 2017

DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.

scientific article published in September 2017

DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage

scientific article

DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line

scientific article published on June 2004

DNA polymerase beta is critical for genomic stability of sperm cells ⬇️

scientific article published on February 18, 2011

DNA polymerase beta is critical for mouse meiotic synapsis

scientific article

DNA polymerase beta participates in DNA End-joining.

scientific article published on 17 November 2017

DNA polymerase family X: function, structure, and cellular roles

scientific article

DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation

scientific article published on 21 August 2012

DNA polymerase κ: Friend or foe?

scientific article published on 28 April 2020

DNA polymerases and human diseases

scientific article published on November 2006

DNA repair and personalized breast cancer therapy ⬇️

scientific article published on October 1, 2010

DNA repair and systemic lupus erythematosus

scientific article

Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity

scientific article

Differential immunomodulatory Effect of PARP Inhibition in BRCA1 deficient and competent tumor cells

scientific article published on 04 December 2020

Dna polymerases and their role in genomic stability ⬇️

scientific article published on October 11, 2012

Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.

scientific article published on 12 September 2016

Estrogen withdrawal, increased breast cancer risk and the KRAS-variant.

scientific article

Eukaryotic gene invasion by a bacterial mobile insertion sequence element IS2 during cloning into a plasmid vector

scientific article

Evelyn M. Witkin awarded the National Medal of Science

scientific article

Evelyn Witkin and the coordinated response to DNA damage

scientific article published on 21 October 2015

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation

scientific article

Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity

scientific article published on 16 June 2020

Fidelity mechanisms of DNA polymerase beta

scientific article

Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.

scientific article

Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

scientific article

Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing

scientific article

Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation

scientific article published on 12 August 2013

Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta

scientific article published on March 2010

Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity

scientific article

Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors ⬇️

scientific article published on May 10, 2012

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity

Interplay between DNA repair and inflammation, and the link to cancer

scientific article

Introduction

Is base excision repair a tumor suppressor mechanism?

scientific article

Is there a link between DNA polymerase beta and cancer?

scientific article

Kinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells ⬇️

scientific article published on January 1, 2013

Loop II of DNA polymerase beta is important for discrimination during substrate binding

scientific article published on 5 December 2008

Loop II of DNA polymerase beta is important for polymerization activity and fidelity

scientific article published on 16 April 2007

MBD4 and TDG: Multifaceted DNA glycosylases with ever expanding biological roles ⬇️

scientific article published on November 26, 2012

Mechanistic understanding of cellular responses to genomic stress

scientific article published on 26 December 2019

MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease

scientific article published on 08 December 2020

Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β

scientific article published on 31 December 2019

Mouse models of DNA polymerases.

scientific article published on 22 September 2012

Mutation of POLB causes lupus in mice ⬇️

scientific journal article

NTHL1 in genomic integrity, aging and cancer

scientific article published on 01 September 2020

Novel SOS phenotypes caused by second-site mutations in the recA430 gene of Escherichia coli

scientific article published on 01 April 1991

Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair

scientific article

Pools and Pols: Mechanism of a mutator phenotype

scientific article published on 30 April 2015

Population-specific variation in haplotype composition and heterozygosity at the POLB locus

scientific article published on 23 January 2009

Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation

scientific article

Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.

scientific article published on 19 June 2018

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator

scientific article published on 01 December 2005

RecA kicks Pol V into gear

scientific article

RecA protein of Escherichia coli has a third essential role in SOS mutator activity

scientific article

Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA+ strains of Escherichia coli

scientific article

Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.

scientific article

Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography

scientific article published on 12 February 2020

Sequence context-specific mutagenesis and base excision repair

scientific article published on April 2009

Shortening of NIH RO1 grant applications: your response is important

scientific article published on 06 December 2006

Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase β ⬇️

scientific article published on June 12, 2013

Substrate-dependent millisecond domain motions in DNA polymerase β.

scientific article

Synthesis of ortho-Formylphenylphosphonic Acids as Covalent Probes of Active Site Lysines

scientific article published on 13 February 2019

Targeting cancer with a lupus autoantibody

scientific article published on October 2012

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding

scientific article

The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site

scientific article published on 16 October 2003

The E249K mutator mutant of DNA polymerase beta extends mispaired termini

scientific article

The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator

scientific article published on 19 June 2012

The E295K Cancer Variant of Human Polymerase   Favors the Mismatch Conformational Pathway during Nucleotide Selection

scientific article

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

scientific article published on 25 May 2007

The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates

scientific article published on 21 October 2008

The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient

scientific article

The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation.

scientific article published on 8 September 2017

The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformation

scientific article published on 14 May 2015

The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency

scientific article

The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype

scientific article

The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery

scientific article

The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation ⬇️

scientific article published on February 15, 2012

The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry

scientific article published on 17 May 2005

The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase β

scientific article published on 01 August 2018

The role of cysteines in the structure and function of OGG1

scientific article published on 17 November 2020

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site

scientific article

Timing Is Everything: Misincorporation of 8oxodG during Mitosis Is Lethal

scientific article published on 01 September 2020

Tipping the Balance in the Powerhouse of the Cell to “Protect” Colorectal Cancer ⬇️

scientific article published on June 7, 2012

Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality

scientific article published on 12 October 2012

Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase

scientific article

Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s Pathway

scientific article

Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of Pol β-DNA complexes

scientific article published on 08 May 2020

Variant base excision repair proteins: contributors to genomic instability

scientific article

Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate

scientific article

Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates ⬇️

scientific article published on April 9, 2012

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