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List of works by Ian Chopra

2-Aminotetralones: novel inhibitors of MurA and MurZ.

scientific article published on 30 January 2008

6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase

scientific article published in 2012

A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli

scientific article published in October 2005

A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates.

scientific article

Accumulation of tetracyclines by Escherichia coli K-12 ⬇️

scientific article published on August 22, 1977

Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase

scientific article published on 14 February 2011

Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques

scientific article published on November 2004

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques

scientific article published on 21 April 2009

Analysis of tetracycline resistance encoded by transposon Tn10: deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes ⬇️

scientific article published on February 1, 1983

Anti-infectives: the way forward.

scientific article published in August 2002

Anti-staphylococcal activity and mode of action of clofazimine.

scientific article published on 4 February 2004

Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections

scientific article published on 8 July 2004

Antibiotic resistance in Staphylococcus aureus: concerns, causes and cures

scientific article published in June 2003

Antimicrobial properties and mode of action of the pyrrothine holomycin

scientific article

Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175).

scientific article

Assessment of a microplate method for determining the post-antibiotic effect in Staphylococcus aureus and Escherichia coli

scientific article published on 18 May 2004

Bacterial RNA polymerase: a promising target for the discovery of new antimicrobial agents

scientific article published on August 2007

Bacterial resistance to the tetracyclines ⬇️

scientific article published on December 1, 1978

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

scientific article

Biochemical and genetic basis of tetracycline resistance in Staphylococcus aureus

scientific article published on October 1974

Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem

scientific article published on 10 January 2012

Biological properties of novel antistaphylococcal quinoline-indole agents

scientific article

Characterization of global patterns and the genetics of fusidic acid resistance

scientific article published on June 2011

Comparison of assays for detection of agents causing membrane damage in Staphylococcus aureus

scientific article published on 5 November 2004

Comparison of the polypeptide composition of Escherichia coli outer membranes prepared by two methods

scientific article published on October 1980

Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus

scientific article published on 31 July 2008

Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents

scientific article

Deletion of the multiple-drug efflux pump AcrAB in Escherichia coli prolongs the postantibiotic effect

scientific article published on March 2005

Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl).

scientific article published on 17 January 2007

Diffusion of tetracycline across the outer membrane of Escherichia coli K-12: Involvement of protein Ia ⬇️

scientific article published on July 28, 1978

Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening

scientific article published in December 2008

Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening

scientific article published on 29 January 2009

Dissecting structural and functional diversity of the lantibiotic mersacidin

scientific article

Effect of short-chain organic acids on macromolecular synthesis inEscherichia coli ⬇️

scientific article published on January 1, 1990

Effects of tetracyclines on the production of extracellular proteins by members of the propionibacteriaceae.

scientific article

Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase.

scientific article

Emergence and maintenance of resistance to fluoroquinolones and coumarins in Staphylococcus aureus: predictions from in vitro studies.

scientific article published on 7 June 2007

Energetics of tetracycline transport into Escherichia coli ⬇️

scientific article published on April 1, 1984

Escherichia coli mutators present an enhanced risk for emergence of antibiotic resistance during urinary tract infections

scientific article published on January 2004

Evidence for more than one mechanism of plasmid-determined tetracycline resistance in Escherichia coli

scientific article published on 01 November 1980

Evidence that tetracycline analogs whose primary target is not the bacterial ribosome cause lysis of Escherichia coli ⬇️

scientific article published on May 1, 1992

Evolution of extended-spectrum beta-lactamases in a MutS-deficient Pseudomonas aeruginosa hypermutator

scientific article published on 10 August 2006

Exploiting current understanding of antibiotic action for discovery of new drugs.

scientific article published in January 2002

Functional and biochemical analysis of Chlamydia trachomatis MurC, an enzyme displaying UDP-N-acetylmuramate:amino acid ligase activity

scientific article

Functional and biochemical analysis of the Chlamydia trachomatis ligase MurE.

scientific article published on 09 October 2009

Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase

scientific article published on 26 July 2010

Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies

scientific article published on 31 January 2011

Genetic and biochemical basis of tetracycline resistance

scientific article

Glycylcyclines: third-generation tetracycline antibiotics

scientific article

In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.

scientific article published on 7 November 2005

Increased mutability of Staphylococci in biofilms as a consequence of oxidative stress

scientific article

Induction of Tetracycline Resistance in Staphylococcus aureus in the Absence of Lipid Synthesis ⬇️

scientific article published on 01 December 1975

Induction of the Citrobacter freundii group I beta-lactamase in Escherichia coli is not dependent on entry of beta-lactam into the cytoplasm

scientific article

Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low.

scientific article published in August 2002

Intrinsic novobiocin resistance in Staphylococcus saprophyticus

scientific article published on 17 September 2007

Lack of evidence for a saturable tetracycline transport system in Staphylococcus aureus ⬇️

scientific article published on December 1, 1991

Lack of evidence for involvement of hypermutability in emergence of vancomycin-intermediate Staphylococcus aureus

scientific article published on April 2003

Limitations of a fluorescence assay for studies on tetracycline transport into Escherichia coli ⬇️

scientific article published on January 1, 1983

Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center

scientific article published on 7 January 2008

Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

scientific article published in May 2003

Mechanisms of the post-antibiotic effects induced by rifampicin and gentamicin in Escherichia coli

scientific article published on 30 May 2006

Mecillinam has potent in vitro activity against Chlamydophila pneumoniae ATCC VR1310.

scientific article published on 29 April 2004

Molecular basis of beta-lactamase induction in bacteria

scientific article

Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus.

scientific article published in January 2006

Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome ⬇️

scientific article published on November 1, 1991

New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors

scientific article

Organic acids: chemistry, antibacterial activity and practical applications

scientific article published on January 1991

Origin of tetracycline efflux proteins: conclusions from nucleotide sequence analysis

scientific article

Penicillin-binding protein 2 is required for induction of the Citrobacter freundii class I chromosomal beta-lactamase in Escherichia coli

scientific article

Plasmid-Determined Tetracycline Resistance in Escherichia coli K12: Lack of Evidence that Resistance is Related to Changes in Lipid Metabolism ⬇️

scientific article published on January 1, 1978

Population diversification in Staphylococcus aureus biofilms may promote dissemination and persistence ⬇️

scientific article

Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques

scientific article published in August 2004

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents

scientific article

Reduced Expression of Tn10-mediated Tetracycline Resistance in Escherichia coli Containing More Than One Copy of the Transposon

scientific article published on September 1, 1981

Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes.

scientific article published in June 2002

SB 205952, a novel semisynthetic monic acid analog with at least two modes of action

scientific article published on September 1995

Sensitive biological detection method for tetracyclines using a tetA-lacZ fusion system

scientific article

Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor

scientific article

Staphylococcus aureus Biofilms Promote Horizontal Transfer of Antibiotic Resistance ⬇️

scientific article published on January 28, 2013

Structure-based discovery of antibacterial drugs

scientific article

Structure-based ligand design of novel bacterial RNA polymerase inhibitors

scientific article published on 29 July 2011

Susceptibility of protein synthesis in Escherichia coli to tetracycline and minocycline

scientific article published on 01 May 1981

Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases.

scientific article

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

scientific article

Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes ⬇️

scientific article published on April 1, 1992

Tetracycline Resistance in Escherichia coli K12 is not Associated with a Decrease in Cyclopropane Fatty Acid Content

scientific article published on December 1, 1977

Tetracycline analogs whose primary target is not the bacterial ribosome

scientific article published on April 1994

Tetracycline resistance determinants from groups A to D vary in their ability to confer decreased accumulation of tetracycline derivatives by Escherichia coli.

scientific article

Tetracycline resistance genes from Bacillus plasmid pAB124 confer decreased accumulation of the antibiotic in Bacillus subtilis but not in Escherichia coli

scientific article

Tetracyclines, molecular and clinical aspects

scientific article

The 2012 Garrod lecture: discovery of antibacterial drugs in the 21st century

scientific article

The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?

scientific article

The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.

scientific article

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors

scientific article published on 3 March 2009

The role of mutators in the emergence of antibiotic-resistant bacteria

scientific article

The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies

scientific article published on 25 September 2012

The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens

scientific article published on 31 October 2012

The tetracyclines: prospects at the beginning of the 1980s

scientific article published on July 1981

Translational medicine for antibacterial drug development - A Marcus Evans conference: overcoming the challenge of proof of concept.

scientific article published in April 2008

Transport of tetracyclines into Escherichia coli requires a carboxamide group at the C2 position of the molecule.

scientific article

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

scientific article published on February 2008

Uptake of tetracycline by Escherichia coli is not mediated by the sodium dependent glutamate transport system.

scientific article

XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms

scientific article published in January 2010

XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity

scientific article published on 18 August 2009

Zeocin resistance suppresses mutation in hypermutable Escherichia coli.

scientific article

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