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List of works by Kazunari Akiyoshi

A hybrid hydrogel biomaterial by nanogel engineering: bottom-up design with nanogel and liposome building blocks to develop a multidrug delivery system

scientific article published on 29 August 2012

A light sensitive self-assembled nanogel as a tecton for protein patterning materials

scientific article published on 26 November 2015

A polyion complex nanogel

scientific article published on 19 September 2012

A soft and flexible biosensor using a phospholipid polymer for continuous glucose monitoring

scientific article

ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events

scientific article published on 20 February 2009

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells.

scientific article published on 30 January 2018

Affinity-mediated capture and release of amphiphilic copolymers for controlling antimicrobial activity

scientific article published on 01 August 2015

Amphiphilic Polysaccharide Nanoballs: A New Building Block for Nanogel Biomedical Engineering and Artificial Chaperones ⬇️

scientific article published on 07 December 2010

Amphiphilic block copolymer with a molecular recognition site: induction of a novel binding characteristic of amylose by self-assembly of poly(ethylene oxide)-block-amylose in chloroform

scientific article published in March 2002

Amphiphilic polysaccharide nanogels as artificial chaperones in cell-free protein synthesis.

scientific article published on 7 March 2011

Amylose engineering: phosphorylase-catalyzed polymerization of functional saccharide primers for glycobiomaterials

scientific article

Amylose-Based Cationic Star Polymers for siRNA Delivery

scientific article published on 11 October 2015

Antigen Delivery to Antigen-Presenting Cells for Adaptive Immune Response by Self-Assembled Anionic Polysaccharide Nanogel Vaccines

scientific article published on 12 December 2019

Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

scientific article published on 11 February 2019

Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells

scientific article

Artificial Chaperone Polysaccharide Nanogels for Protein Delivery: A Thermodynamic Study of Protein-Nanogel Interactions Using Fluorescence Correlation Spectroscopy ⬇️

scientific article published on 01 December 2011

Artificial Molecular Chaperone Systems for Proteins, Nucleic Acids, and Synthetic Molecules

scientific article published on 26 April 2020

Biomedical soft contact-lens sensor for in situ ocular biomonitoring of tear contents

scientific article published on 01 August 2011

Biotransporting Biocatalytic Reactors toward Therapeutic Nanofactories

scientific article from 2018

Biotransporting Self-Assembled Nanofactories Using Polymer Vesicles with Molecular Permeability for Enzyme Prodrug Cancer Therapy

scientific article published on 17 July 2017

Botryoidal Assembly of Cholesteryl−Pullulan/Poly(N-isopropylacrylamide) Nanogels†

Cadherin-integrated liposomes with potential application in a drug delivery system.

scientific article published on 22 September 2011

Calcium-deficient Hydroxyapatite as a Potential Sorbent for Strontium.

scientific article

Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation

scientific article published on 15 May 2013

Cell Specific Peptide‐Conjugated Polysaccharide Nanogels for Protein Delivery ⬇️

scientific article published on April 13, 2011

Cell separation in microcanal coated with electrically charged phospholipid polymers

scientific article published on 26 January 2005

Cell-sized asymmetric lipid vesicles facilitate the investigation of asymmetric membranes.

scientific article

Cell-specific delivery of polymeric nanoparticles to carbohydrate-tagging cells

scientific article published on 21 September 2007

Changes in the morphology of cell-size liposomes in the presence of cholesterol: formation of neuron-like tubes and liposome networks.

scientific article published on 24 February 2005

Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering

scientific article published on 15 July 2012

Comparison of refolding activities between nanogel artificial chaperone and GroEL systems

scientific article published on 23 November 2007

Comprehensive study of liposome-assisted synthesis of membrane proteins using a reconstituted cell-free translation system.

scientific article

Control of nanobiointerfaces generated from well-defined biomimetic polymer brushes for protein and cell manipulations.

scientific article

Controlled Association of Amphiphilic Polymers in Water: Thermosensitive Nanoparticles Formed by Self-Assembly of Hydrophobically Modified Pullulans and Poly(N-isopropylacrylamides)

Covalent immobilization of antibody fragments on well-defined polymer brushes via site-directed method

scientific article published on 4 November 2007

Crosslinked nanogel-based porous hydrogel as a functional scaffold for tongue muscle regeneration

scientific article published on 25 March 2020

Current advances in self-assembled nanogel delivery systems for immunotherapy.

scientific article

Cycloamylose-nanogel drug delivery system-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment

scientific article

DNA separation by cholesterol-bearing pullulan nanogels ⬇️

scientific article published on September 30, 2010

Design of hybrid hydrogels with self-assembled nanogels as cross-linkers: interaction with proteins and chaperone-like activity

scientific article published on 01 July 2005

Development of a Novel Tetravalent Synthetic Peptide That Binds to Phosphatidic Acid

scientific article published on 6 July 2015

Development of an artificial chaperone system based on cyclodextrin

scientific article published on April 2010

Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes.

scientific article

Direct integration of cell-free-synthesized connexin-43 into liposomes and hemichannel formation

scientific article published on 01 July 2010

Direct preparation of giant proteo-liposomes by in vitro membrane protein synthesis

scientific article published on 17 August 2007

Dual Stimuli-Responsive Nanogels by Self-Assembly of Polysaccharides Lightly Grafted with Thiol-Terminated Poly(N-isopropylacrylamide) Chains

article published in 2008

Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery

scientific article published on 19 September 2011

Effects of a polysaccharide nanogel-crosslinked membrane on wound healing

scientific article

Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin E1 on wound healing

scientific article published in October 2009

Engineering hybrid exosomes by membrane fusion with liposomes

scientific article

Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer

scientific article published on 03 June 2020

Enzyme-degradable phosphorylcholine porous hydrogels cross-linked with polyphosphoesters for cell matrices

scientific article published on 14 November 2006

Enzyme-responsive artificial chaperone system with amphiphilic amylose primer.

scientific article published on 4 February 2009

Enzyme-responsive molecular assembly system with amylose-primer surfactants

scientific article published on 01 January 2007

Evaluation of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated dressing on surgical wounds.

scientific article published in June 2005

Exosome surface glycans reflect osteogenic differentiation of mesenchymal stem cells: Profiling by an evanescent field fluorescence-assisted lectin array system

scientific article published on 08 August 2019

Exosome-mediated regulation of tumor immunology

scientific article published on 01 August 2018

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA.

scientific article

Exploitation of a novel polysaccharide nanogel cross-linking membrane for guided bone regeneration (GBR) ⬇️

scientific article published on November 17, 2011

Fluorogenically active leucine zipper peptides as tag-probe pairs for protein imaging in living cells

scientific article published in January 2009

Functional cycloamylose as a polysaccharide-based biomaterial: application in a gene delivery system

scientific article published in February 2010

Gene expression within cell-sized lipid vesicles

scientific article published on 01 November 2003

Glucose sensor using a phospholipid polymer-based enzyme immobilization method.

scientific article

Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells

scientific article published on 24 July 2017

Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types

scientific article

HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan

scientific article published on 01 December 2006

Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans

scientific article

Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel

scientific article published on 15 December 2007

Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function

scientific article published on 29 November 2009

Hybrid nanogels with physical and chemical cross-linking structures as nanocarriers

scientific article published in August 2005

Identification of a dominant CD8+ CTL epitope in the SARS-associated coronavirus 2 spike protein

scientific article published on 19 October 2020

Improving a self-curing dental resin by eliminating oxygen, hydroquinone and water from its curing process.

scientific article published in December 2002

In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging

scientific article published on 25 September 2020

Induction of neuron-like tubes and liposome networks by cooperative effect of gangliosides and phospholipids

scientific article published on 01 January 2003

Inhibition of the formation of amyloid β-protein fibrils using biocompatible nanogels as artificial chaperones

scholarly article by Keisuke Ikeda published in November 2006

Injectable Hydrogel for Sustained Protein Release by Salt‐Induced Association of Hyaluronic Acid Nanogel ⬇️

scientific article published on 01 April 2012

Innovative gas injection technique for closed-hollow obturator.

scientific article published in May 2004

Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone

Intracellular delivery and passive tumor targeting of a self-assembled nanogel containing carborane clusters for boron neutron capture therapy

scientific article published on 27 December 2016

Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells

scientific article

Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents

scientific article published on 21 August 2017

Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent

scientific article

Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

scientific article published on 11 January 2019

Magnetically Guided Protein Transduction by Hybrid Nanogel Chaperones with Iron Oxide Nanoparticles.

scientific article published on 13 June 2016

Magnetically Navigated Intracellular Delivery of Extracellular Vesicles Using Amphiphilic Nanogels

scientific article published on 02 August 2019

Membrane Protein Sorting: Proteoliposome Engineering with Cell-Free Membrane Protein Synthesis: Control of Membrane Protein Sorting into Liposomes by Chaperoning Systems (Adv. Sci. 10/2018)

Molecular logistics using cytocleavable polyrotaxanes for the reactivation of enzymes delivered in living cells

scientific article published on January 2013

Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor.

scientific article published on 11 December 2015

Nano-encapsulation of lipase by self-assembled nanogels: induction of high enzyme activity and thermal stabilization

scientific article published in April 2010

Nano-scale surface modification of a segmented polyurethane with a phospholipid polymer

scientific article

Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems.

scientific article published on 21 July 2015

Nanogel DDS enables sustained release of IL-12 for tumor immunotherapy

scientific article published on 26 December 2007

Nanogel Engineering by Associating Polymers for Biomedical Applications

Nanogel Tectonics for Tissue Engineering: Protein Delivery Systems with Nanogel Chaperones

scientific article published on 16 September 2018

Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines.

scientific article published on 20 June 2010

Nanogel engineering for new nanobiomaterials: from chaperoning engineering to biomedical applications ⬇️

scientific article published on September 10, 2010

Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering

scientific article published on 01 January 2020

Nanogel tectonic porous 3D scaffold for direct reprogramming fibroblasts into osteoblasts and bone regeneration

scientific article published in Scientific Reports

Nanogel tectonic porous gel loading biologics, nanocarriers, and cells for advanced scaffold

scientific article published on 30 October 2014

Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae

scientific article published on 4 March 2013

Nanogel-based antigen-delivery system for nasal vaccines.

scientific article published on January 2013

Nanogel-based delivery system enhances PGE2 effects on bone formation

scientific article published on 01 August 2007

Nanogel-based immunologically stealth vaccine targets macrophages in the medulla of lymph node and induces potent antitumor immunity

scientific article published on 2 September 2014

Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model.

scientific article

Nanogel-quantum dot hybrid nanoparticles for live cell imaging.

scientific article

Nanogelation and Thermal Stabilization of Enzyme by Vitamin B<sub>6</sub>-Bearing Polysaccharide as Biocrosslinker

scientific article published on 22 April 2019

Nanogel‐based scaffold delivery of prostaglandin E2 receptor–specific agonist in combination with a low dose of growth factor heals critical‐size bone defects in mice ⬇️

scientific article published on April 1, 2011

Nanoscopic Structural Investigation of Physically Cross-Linked Nanogels Formed from Self-Associating Polymers.

scientific article published on 10 November 2016

Novel Thermoresponsive Polymers Having Biodegradable Phosphoester Backbones

scholarly article by Yasuhiko Iwasaki et al published November 2007 in Macromolecules

Novel biodegradable polyphosphate cross-linker for making biocompatible hydrogel.

scientific article published on May 2004

Osteoblastic bone formation is induced by using nanogel-crosslinking hydrogel as novel scaffold for bone growth factor

scientific article published in July 2009

Osteogenic response of mesenchymal progenitor cells to natural polysaccharide nanogel and atelocollagen scaffolds: A spectroscopic study

scientific article published on 21 February 2019

Photoresponsive nanogels formed by the self-assembly of spiropyrane-bearing pullulan that act as artificial molecular chaperones

scientific article published in September 2004

Platelet separation from whole blood in an aqueous two-phase system with water-soluble polymers

scientific article published on 01 May 2006

Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays

scientific article published on 20 December 2020

Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss

scientific article

Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A2.

scientific article published on 24 December 2010

Polysaccharide-hair cationic polypeptide nanogels: self-assembly and enzymatic polymerization of amylose primer-modified cholesteryl poly(L-lysine).

scientific article published on 14 May 2013

Possible molecular evolution of biomembranes: from single-chain to double-chain lipids

scientific article published on 01 May 2007

Preparation of connexin43-integrated giant Liposomes by a baculovirus expression-liposome fusion method.

scientific article

Preparation of engineered extracellular vesicles with full-length functional PD-1 membrane proteins by baculovirus expression system

scientific article published on 14 April 2020

Presentation of a major histocompatibility complex class 1-binding peptide by monocyte-derived dendritic cells incorporating hydrophobized polysaccharide-truncated HER2 protein complex: implications for a polyvalent immuno-cell therapy

scientific article published on 01 May 2002

Protein refolding assisted by self-assembled nanogels as novel artificial molecular chaperone

scientific article published in October 2003

Protein synthesis in giant liposomes using the in vitro translation system of Thermococcus kodakaraensis.

scientific article

Protein-conjugated quantum dots effectively delivered into living cells by a cationic nanogel.

scientific article

Proteoliposome Engineering with Cell-Free Membrane Protein Synthesis: Control of Membrane Protein Sorting into Liposomes by Chaperoning Systems

article published in 2018

Raspberry-like assembly of cross-linked nanogels for protein delivery.

scientific article published on 29 June 2009

Saccharide Recognition Based on Self-assembly of Amphiphilic Phenylboronic Acid Azoprobes.

scientific article published on 22 September 2016

Salt effect on the heat-induced association behavior of gold nanoparticles coated with poly(N-isopropylacrylamide) prepared via reversible addition-fragmentation chain transfer (RAFT) radical polymerization

scientific article published on 10 November 2007

Selective biorecognition and preservation of cell function on carbohydrate-immobilized phosphorylcholine polymers

scientific article

Selective cell attachment to a biomimetic polymer surface through the recognition of cell-surface tags.

scientific article

Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials.

scientific article published on 23 September 2016

Self-Assembled Polypeptide Nanogels with Enzymatically Transformable Surface as a Small Interfering RNA Delivery Platform

scientific article published on 23 October 2017

Self-Assembled pH-Sensitive Cholesteryl Pullulan Nanogel As a Protein Delivery Vehicle ⬇️

scientific article published on December 21, 2012

Self-assembled cationic nanogels for intracellular protein delivery

scientific article published on 13 March 2008

Self-assembled nanogel of cholesterol-bearing xyloglucan as a drug delivery nanocarrier

scientific article published on 20 April 2017

Self-assembled nanogel of hydrophobized dendritic dextrin for protein delivery

scientific article published in July 2009

Self-assembled nanogels of cholesteryl-modified polysaccharides: effect of the polysaccharide structure on their association characteristics in the dilute and semidilute regimes

scientific article

Sequential Coating of Insulin Secreting Beta Cells within Multilayers of Polysaccharide Nanogels

scientific article published on 25 March 2018

Soft contact lens biosensor for in situ monitoring of tear glucose as non-invasive blood sugar assessment

scientific article published on 04 November 2010

Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2.

scientific article published on 30 January 2013

Staphylococcus aureus-specific IgA antibody in milk suppresses the multiplication of S. aureus in infected bovine udder

scientific article published on 09 August 2019

Structural effects and lymphocyte activation properties of self-assembled polysaccharide nanogels for effective antigen delivery

scientific article published in Scientific Reports

Substrate-Sorting Nanoreactors Based on Permeable Peptide Polymer Vesicles and Hybrid Liposomes with Synthetic Macromolecular Channels

scientific article published on 10 December 2019

Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice

scientific article published on 01 September 2010

Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

scientific article published on 01 October 2019

Surface modification with well-defined biocompatible triblock copolymers Improvement of biointerfacial phenomena on a poly(dimethylsiloxane) surface

scientific article

Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N-Methylpyrrole–N-Methylimidazole Polyamide Conjugates ⬇️

scientific article published on February 17, 2012

Synthesis and Characterization of Shell-Cross-Linked Glycopolymer Bilayer Vesicles

scientific article published on 30 July 2018

Synthesis and characterization of amphiphilic polyphosphates with hydrophilic graft chains and cholesteryl groups as nanocarriers

scientific article published on 01 May 2006

Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

scientific article published on 01 March 2019

Synthesis and in situ insertion of a site-specific fluorescently labeled membrane protein into cell-sized liposomes

scientific article published on 26 June 2011

The binding of pullulan modified cholesteryl nanogels to Abeta oligomers and their suppression of cytotoxicity.

scientific article published on 4 July 2009

The effect of hydrophilic ionic liquids 1-ethyl-3-methylimidazolium lactate and choline lactate on lipid vesicle fusion

scientific article

The improvement of calvarial bone healing by durable nanogel-crosslinked materials

scientific article published on 03 October 2018

The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae

scientific article published in June 2011

The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate ⬇️

scientific article published on May 24, 2011

Therapeutic Nanofactories: Biotransporting Biocatalytic Reactors toward Therapeutic Nanofactories (Adv. Sci. 11/2018)

Therapeutic effect of nanogel-based delivery of soluble FGFR2 with S252W mutation on craniosynostosis

scientific article

Thermo-Responsive Hydrogels with Nanodomains: Rapid Shrinking of a Nanogel-Crosslinking Hydrogel of Poly(N-isopropyl acrylamide)

Thermo-responsive Polysaccharide Graft Polymer Vesicles with Tunable Size and Structural Memory

scientific article published on 07 June 2020

Thermoresponsive controlled association of protein with a dynamic nanogel of hydrophobized polysaccharide and cyclodextrin: heat shock protein-like activity of artificial molecular chaperone

scientific article published in January 2005

[Nanogel engineering and chaperone engineering]

scientific article published on 01 February 2006

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