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List of works by Lake-Ee Quek

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

scientific article published on November 2016

A depth-first search algorithm to compute elementary flux modes by linear programming

scientific article

A multi-omics analysis of recombinant protein production in Hek293 cells

scientific article

A multi-tissue genome-scale metabolic modeling framework for the analysis of whole plant systems

scientific article published on 22 January 2015

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake

scientific article

AlgaGEM--a genome-scale metabolic reconstruction of algae based on the Chlamydomonas reinhardtii genome

scientific article

AraGEM, a genome-scale reconstruction of the primary metabolic network in Arabidopsis

scientific article

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways.

scientific article

C4GEM, a genome-scale metabolic model to study C4 plant metabolism

scientific article published on 25 October 2010

Customization of ¹³C-MFA strategy according to cell culture system.

scientific article

Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

scientific article published on 21 January 2020

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism

scientific article published in December 2017

Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolism

article

Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma

scientific article published on 17 October 2016

Erratum: Dynamic <sup>13</sup>C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

scientific article published on 23 November 2020

Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation

article

Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment ⬇️

scientific article published on 04 July 2016

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

scientific article

From reconstruction to C 4 metabolic engineering: A case study for overproduction of polyhydroxybutyrate in bioenergy grasses

article

Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle

scientific article published on 5 March 2018

Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

scientific article published on 28 April 2018

Insulin signalling requires glucose to promote lipid anabolism in adipocytes

scientific article published on 28 July 2020

Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes

scientific article published on 20 August 2020

Lactate production is a prioritized feature of adipocyte metabolism

scientific article published on 05 November 2019

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

scientific article published on 4 April 2016

Metabolic flux analysis in mammalian cell culture

scientific article published on 13 October 2009

Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations

scientific article

Metabolite profiling of CHO cells with different growth characteristics.

scientific article published on 30 March 2012

Metabolites downstream of predicted loss-of-function variants inform relationship to disease

scientific article published on 17 October 2019

Myocardial substrate changes in advanced ischaemic and advanced dilated human heart failure

scientific article published on 11 June 2019

Network thermodynamic curation of human and yeast genome-scale metabolic models.

scientific article published on July 2014

On the reconstruction of the Mus musculus genome-scale metabolic network model.

scientific article published in January 2008

OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis

scientific article published on May 2009

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

scientific article published on 05 November 2019

Plant Genome-Scale Modeling and Implementation

article

Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice

article

Recon 2.2: from reconstruction to model of human metabolism ⬇️

scientific article

Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production

scientific article published on 31 July 2012

Reducing Recon 2 for steady-state flux analysis of HEK cell culture

article

Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells

scientific article published on 08 June 2019

Steady-state ¹³C fluxomics using OpenFLUX.

scientific article published in January 2014

Using the Human Genome-Scale Metabolic Model Recon 2 for Steady-State Flux Analysis of Cancer Cell Metabolism

scientific article published on 01 January 2019

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