List of works - Marie-Therese Schaeffer

A sphingosine 1-phosphate receptor 2 selective allosteric agonist.

scientific article published on 15 June 2013

Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice ⬇️

scientific article published on March 27, 2011

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7) ⬇️

scientific article published on October 2, 2012

Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist

scientific article

Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists

scientific article

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype ⬇️

scientific article published on September 20, 2011

Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions

scientific article

Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4)

Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists

scientific article published on 13 January 2007

Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening

scientific article

Optimization and Characterization of a Second Antagonist for G-protein Coupled Receptor 7 (GPR7)

Optimization and Characterization of an Antagonist for G-Protein Coupled Receptor 7 (GPR7) ⬇️

scientific article published on July 27, 2012

Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3)

article published in 2013

Probe Development Efforts to Identify Novel Agonists of the Sphingosine 1-phosphate Receptor 4 (S1P4) ⬇️

scientific article published on July 27, 2012

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

scientific article published on 9 March 2009

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor ⬇️

scientific article published on July 13, 2011

Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists

scientific article published in February 2005

Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists

scientific article published on 01 March 2005

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists

scientific article published on 02 November 2005

List of works by Marie-Therese Schaeffer

A sphingosine 1-phosphate receptor 2 selective allosteric agonist.

Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice ⬇️

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7) ⬇️

Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist

Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype ⬇️

Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions

Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4)

Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists

Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening

Optimization and Characterization of a Second Antagonist for G-protein Coupled Receptor 7 (GPR7)

Optimization and Characterization of an Antagonist for G-Protein Coupled Receptor 7 (GPR7) ⬇️

Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3)

Probe Development Efforts to Identify Novel Agonists of the Sphingosine 1-phosphate Receptor 4 (S1P4) ⬇️

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor ⬇️

Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists

Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists