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List of works by Theodore J. Torphy

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Phosphodiesterase isozymes: molecular targets for novel antiasthma agents

scientific article published on February 1998
Cysteinyl leukotrienes in asthma: old mediators up to new tricks

scientific article published on September 1995
Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase

scientific article
Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.

scientific article published on December 1999
Beta-adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogma

scientific article published on October 1994
1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

scientific article published on March 12, 1998
Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody

scientific article published in October 1996
Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

scientific article published on 01 April 1996
Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists

scientific article
Characterization and selective inhibition of cyclic nucleotide phosphodiesterase isozymes in canine tracheal smooth muscle

scientific article published in February 1990
Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response

scientific article published on June 1, 1993
A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA

scientific article
SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions

scientific article published on January 1, 1998
Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast

scientific article published on January 25, 1992
Lower esophageal sphincter relaxation is associated with increased cyclic nucleotide content

scientific article published in December 1986
Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle

scientific article published on 01 June 1993
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs

scientific article published on 01 July 1994
A Candida albicans cyclic nucleotide phosphodiesterase: cloning and expression in Saccharomyces cerevisiae and biochemical characterization of the recombinant enzyme

scientific article published in July 1994
Pharmacologic profile of SK&F 104353: a novel, potent and selective peptidoleukotriene receptor antagonist in guinea pig and human airways

scientific article published on November 1987
Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.

scientific article published in July 1993
Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site

scientific article published on 01 June 1995
Inhibitors of CoA-independent transacylase block the movement of arachidonate into 1-ether-linked phospholipids of human neutrophils

scientific article published on April 1995
Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.

scientific article published in October 1996
Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B

scientific article published on 01 February 1996
Cyclic GMP-dependent protein kinase activation in canine tracheal smooth muscle by methacholine and sodium nitroprusside

scientific article published on December 11, 1984
Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil

scientific article published on 01 July 1993
Phosphodiesterases: the journey towards therapeutics

scientific article published on 01 May 2000
Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma

scientific article published on December 1994
Inhibitory effect of methacholine on drug-induced relaxation, cyclic AMP accumulation, and cyclic AMP-dependent protein kinase activation in canine tracheal smooth muscle

scientific article published on 01 May 1985
Preliminary identification and role of phosphodiesterase isozymes in human basophils

scientific article published on April 15, 1992
Cyclic GMP: a potential mediator of neurally- and drug-induced relaxation of opossum lower esophageal sphincter

scientific article published in May 1989
Functional antagonism in canine tracheal smooth muscle: inhibition by methacholine of the mechanical and biochemical responses to isoproterenol

scientific article published on 01 December 1983
Role of cyclic nucleotide phosphodiesterase isozymes in intact canine trachealis

scientific article published on March 1, 1991
Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig.

scientific article
Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity.

scientific article published on December 1992
Cyclic nucleotide-dependent protein kinases in airway smooth muscle

scientific article published on October 10, 1982
Studies on β-adrenoceptors mediating changes in mechanical events and adenosine 3′,5′-monophosphate levels. Rat atria

scientific article published on February 1, 1978
Is the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine- and antigen-induced contractions

scientific article published on November 1987
Association between leukotriene B4-induced phospholipase D activation and degranulation of human neutrophils

scientific article published on 01 July 1993
Expression of human recombinant cAMP phosphodiesterase isozyme IV reverses growth arrest phenotypes in phosphodiesterase-deficient yeast

scientific article published on 01 February 1991
Critical Role of Conserved Histidine Pairs HNXXH and HDXXH in Recombinant Human Phosphodiesterase 4A

scientific article published on 01 July 1998
SK&F 104353, a selective leukotriene receptor antagonist, inhibits leukotriene D4- and antigen-induced bronchoconstriction in cynomolgus monkeys

scientific article published on September 1, 1992
Differential relaxant effects of isoproterenol on methacholine- versus leukotriene D4-induced contraction in the guinea-pig trachea

scientific article
Role of conserved histidines in catalytic activity and inhibitor binding of human recombinant phosphodiesterase 4A

scientific article published on 01 June 1997
Identification, characterization, and functional role of phosphodiesterase type IV in cerebral vessels: effects of selective phosphodiesterase inhibitors

scientific article published on 01 February 1997
Dissociation between myosin phosphorylation and shortening velocity in canine trachea

scientific article published on 01 March 1990
Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell

scientific article published on April 25, 1990
Action of mediators on airway smooth muscle: functional antagonism as a mechanism for bronchodilator drugs

scientific article published on January 1988
Characterization of two human cAMP‐specific phosphodiesterase subtypes expressed in baculovirus‐infected insect cells

scientific article published on June 1, 1995
Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma

scientific article published on January 1, 1992

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