List of works - Christiane Guguen-Guillouzo

A new subfamily of structurally related human F-box proteins

scientific article (publication date: 21 August 2002)

A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes

scientific journal article

Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors

scientific article published on 27 June 2015

Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays.

scientific article published on 30 July 2010

C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

scientific article

CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload ⬇️

scientific article published on July 21, 2011

Cationic lipids derived from glycine betaine promote efficient and non-toxic gene transfection in cultured hepatocytes

scientific article

Co-cultures of enterocytes and hepatocytes for retinoid transport and metabolism.

scientific article published on 20 April 2012

Combined Stimulation with the Tumor Necrosis Factorαand the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices ⬇️

scientific article published on October 16, 2012

Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes

scientific article published on 17 February 2015

Cyclin-dependent kinase 1 plays a critical role in DNA replication control during rat liver regeneration

scientific journal article

Cytotoxic evaluation of sarcodifurines A and B, two novel dihydrofuroquinolines from Sarcomelicope follicularis (Rutaceae)

scientific article published on 01 October 2008

Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors

scientific article published on 21 January 2014

Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells

scientific article

Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α.

scientific article published on 13 June 2016

Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells

scientific article published on 20 March 2010

Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression

scientific article

Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis

scientific article published on 18 August 2016

Electrochemical synthesis and characterisation of alternating tripyridyl-dipyrrole molecular strands with multiple nitrogen-based donor-acceptor binding sites

scientific article published on October 2010

Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

scientific article published on 27 November 2017

Evolving concepts in liver tissue modeling and implications for in vitro toxicology

scientific article published on 01 October 2008

Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system.

scientific article

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

scientific article published on 4 October 2005

From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells

scientific article published on 24 March 2017

Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

scientific article published on 20 February 2006

Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes.

scientific article published on 2 January 2016

General review on in vitro hepatocyte models and their applications

scientific article published on January 2010

Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix.

scientific article published on 5 February 2016

Hepatic environment elicits monocyte differentiation into a dendritic cell subset directing Th2 response

scientific article published on 15 September 2005

Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line.

scientific article published on December 2005

Immunostimulatory properties of dendritic cells after Leishmania donovani infection using an in vitro model of liver microenvironment

scientific article published on 8 June 2010

Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells

scientific article

Improvement of HepG2/C3a cell functions in a microfluidic biochip ⬇️

scientific article published on March 11, 2011

In vitro and ex vivo permissivity of hepatocytes for Leishmania donovani

scientific article published on November 2005

In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

scientific article published on 21 February 2019

Infection of a human hepatoma cell line by hepatitis B virus

scientific article

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

scientific article published on 28 August 2012

Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α.

scientific article

Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.

scientific article published on 4 October 2002

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

scientific article

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors

scientific article

Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts

scientific article

Optimization of the HepaRG cell model for drug metabolism and toxicity studies ⬇️

scientific article published on May 27, 2012

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

scientific article published on 4 March 2013

PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

scientific journal article

Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

scientific article

Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential

scientific article published on 01 April 2019

Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes

scientific article (publication date: 17 May 2002)

Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation

scientific article published on 19 September 2017

Proliferation of epidermal growth factor-stimulated hepatocytes in a hormonally defined serum-free medium.

scientific article published in June 2004

Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth

scientific article published on 19 March 2003

Reperfusion stress induced during intermittent selective clamping accelerates rat liver regeneration through JNK pathway

scientific article published on 13 February 2010

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

scientific article

Setup and Use of HepaRG Cells in Cholestasis Research

scientific article published on 01 January 2019

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

scientific article

Stem cell-derived hepatocytes and their use in toxicology

scientific article published on 06 October 2009

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents

scientific article published on 8 September 2011

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors ⬇️

scientific article published on September 10, 2012

Synthesis and biological evaluation of novel oxophenylarcyriaflavins as potential anticancer agents

scientific article

Synthesis and kinase inhibitory activity of novel substituted indigoids.

scientific article

TNFalpha-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes

scientific article published on 01 March 2005

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor

scientific article published on 5 February 2014

The application of 3D micropatterning of agarose substrate for cell culture and in situ comet assays

scientific article

The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis

scientific article

The hepatocyte is a direct target for transforming-growth factor beta activation via the insulin-like growth factor II/mannose 6-phosphate receptor

scientific journal article

The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.

scientific article published on 25 September 2013

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

scientific article published on 16 December 2006

The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation

scientific article published on 27 March 2011

Three-dimensional HepaRG model as an attractive tool for toxicity testing

scientific article

Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.

scientific article published on April 2007

Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes

scientific article published in September 2003

Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism.

scientific article published on 6 July 2015

List of works by Christiane Guguen-Guillouzo

A new subfamily of structurally related human F-box proteins

A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes

Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors

Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays.

C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload ⬇️

Cationic lipids derived from glycine betaine promote efficient and non-toxic gene transfection in cultured hepatocytes

Co-cultures of enterocytes and hepatocytes for retinoid transport and metabolism.

Combined Stimulation with the Tumor Necrosis Factorαand the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices ⬇️

Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes

Cyclin-dependent kinase 1 plays a critical role in DNA replication control during rat liver regeneration

Cytotoxic evaluation of sarcodifurines A and B, two novel dihydrofuroquinolines from Sarcomelicope follicularis (Rutaceae)

Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors

Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells

Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α.

Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells

Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression

Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis

Electrochemical synthesis and characterisation of alternating tripyridyl-dipyrrole molecular strands with multiple nitrogen-based donor-acceptor binding sites

Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

Evolving concepts in liver tissue modeling and implications for in vitro toxicology

Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system.

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells

Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes.

General review on in vitro hepatocyte models and their applications

Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix.

Hepatic environment elicits monocyte differentiation into a dendritic cell subset directing Th2 response

Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line.

Immunostimulatory properties of dendritic cells after Leishmania donovani infection using an in vitro model of liver microenvironment

Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells

Improvement of HepG2/C3a cell functions in a microfluidic biochip ⬇️

In vitro and ex vivo permissivity of hepatocytes for Leishmania donovani

In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Infection of a human hepatoma cell line by hepatitis B virus

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip.

Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α.

Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors

Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts

Optimization of the HepaRG cell model for drug metabolism and toxicity studies ⬇️

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential

Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes

Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation

Proliferation of epidermal growth factor-stimulated hepatocytes in a hormonally defined serum-free medium.

Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth

Reperfusion stress induced during intermittent selective clamping accelerates rat liver regeneration through JNK pathway

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

Setup and Use of HepaRG Cells in Cholestasis Research

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

Stem cell-derived hepatocytes and their use in toxicology

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors ⬇️

Synthesis and biological evaluation of novel oxophenylarcyriaflavins as potential anticancer agents

Synthesis and kinase inhibitory activity of novel substituted indigoids.

TNFalpha-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor

The application of 3D micropatterning of agarose substrate for cell culture and in situ comet assays

The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis

The hepatocyte is a direct target for transforming-growth factor beta activation via the insulin-like growth factor II/mannose 6-phosphate receptor

The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation

Three-dimensional HepaRG model as an attractive tool for toxicity testing

Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.

Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes

Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism.