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List of works by Brian H Annex

A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits

scientific article

A mouse model of hypercholesterolemia-induced erectile dysfunction

scientific article

A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse

scientific article

A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia

scientific article

A sex-specific relationship between capillary density and anaerobic threshold

scientific article

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.

scientific article published on 16 October 2009

A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans

scientific article published on 01 July 2002

Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia.

scientific article published on 29 November 2004

Aging, progenitor cell exhaustion, and atherosclerosis

scientific article

Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training

scientific article

Alterations in endothelial cell proliferation and apoptosis contribute to vascular remodeling following hind-limb ischemia in rabbits

scientific article published in May 2002

An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia

scientific article published on 6 June 2006

Angiogenesis in skeletal muscle precede improvements in peak oxygen uptake in peripheral artery disease patients

scientific article

Angiopoietin-Tie Signaling Pathway in Endothelial Cells: A Computational Model

scientific article published on 03 October 2019

Antiangiogenic VEGF165b Regulates Macrophage Polarization via S100A8/S100A9 in Peripheral Artery Disease

scientific article published on 01 January 2019

Can Endothelial Injury Provide the Passage to Explain the Vascular Effects of Proton Pump Inhibitors?

scientific article published on June 2016

Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues.

scientific article published in September 2005

Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics

scientific article

Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport

scientific article

Deconditioning fails to explain peripheral skeletal muscle alterations in men with chronic heart failure

scientific article published on 01 April 2002

Decreases in corporeal vascular endothelial growth factor expression precede vasoreactivity changes in cholesterol fed rabbits

scientific article

Design of the Del-1 for therapeutic angiogenesis trial (DELTA-1), a phase II multicenter, double-blind, placebo-controlled trial of VLTS-589 in subjects with intermittent claudication secondary to peripheral arterial disease

scientific article published in June 2004

Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice

scientific article

Diabetes status differentiates endothelial function and plasma nitrite response to exercise stress in peripheral arterial disease following supervised training

scientific article published on 17 December 2013

Differential effects of exercise training in men and women with chronic heart failure

scientific article published on 01 May 2003

Does Multicolor Lineage Tracing of Endothelial Cells Provide a Black and White Answer on Clonal Expansion in Post-Natal Angiogenesis?

scientific article published in March 2018

Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication.

scientific article published on 26 September 2011

Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia.

scientific article

Endothelial interleukin-21 receptor up-regulation in peripheral artery disease

scientific article

Endothelial progenitor cells (EPCs) mobilized and activated by neurotrophic factors may contribute to pathologic neovascularization in diabetic retinopathy

scientific article

Engineered transcription factors for therapeutic angiogenesis

scientific article published on April 2007

Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia

scientific article published on 11 October 2004

Epidemiology of peripheral arterial disease and critical limb ischemia in an insured national population.

scientific article

Exposure of Endothelium to Biomimetic Flow Waveforms Yields Identification of miR-199a-5p as a Potent Regulator of Arteriogenesis

scientific article published on 8 August 2018

Gene therapy from the perspective of systems biology ⬇️

scientific article published on October 1, 2010

Growth factors for therapeutic angiogenesis in hypercholesterolemic erectile dysfunction

scientific article published on January 2008

High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue.

scientific article published in May 2008

Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults

scientific article published on July 2008

Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1

scientific article published on 06 September 2007

In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia

scientific article published in March 2007

Increased levels of apoptosis in gastrocnemius skeletal muscle in patients with peripheral arterial disease

article

Intracavernosal basic fibroblast growth factor improves vasoreactivity in the hypercholesterolemic rabbit

scientific article published in March 2006

LMO2 (LIM Domain Only 2) and Endothelial Cell Migration in Developmental and Postnatal Angiogenesis

scientific article published in October 2017

Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia

scientific article

MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis

scientific article published on 22 January 2018

Mouse model of erectile dysfunction due to diet-induced diabetes mellitus

scientific article

Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice

scientific article published on 2 October 2017

Myocyte specific overexpression of myoglobin impairs angiogenesis after hind-limb ischemia

scientific article

Myoglobin overexpression inhibits reperfusion in the ischemic mouse hindlimb through impaired angiogenesis but not arteriogenesis

scientific article

Neovascularization in intimal hyperplasia is associated with vein graft failure after coronary artery bypass surgery

scientific article published on 01 January 2003

Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.

scientific article published on February 2007

PADPIN: protein-protein interaction networks of angiogenesis, arteriogenesis, and inflammation in peripheral arterial disease

scientific article

Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial

scientific article published on February 2002

Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease

scientific article published on July 2008

Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise training

scientific article

Plasma nitrite response and arterial reactivity differentiate vascular health and performance

scientific article

Preclinical models of human peripheral arterial occlusive disease: implications for investigation of therapeutic agents

scientific article published on 23 April 2004

Regional Angiogenesis with Vascular Endothelial Growth Factor (VEGF) in peripheral arterial disease: Design of the RAVE trial

scientific article published on 01 June 2003

Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermitt

scientific article

Relationship between leg muscle capillary density and peak hyperemic blood flow with endurance capacity in peripheral artery disease

scientific article

Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women

scientific article published on August 2008

Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: Results of the HGF-0205 trial ⬇️

scientific article published on December 1, 2010

Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease

scientific article published on 25 August 2020

Sodium nitrite in patients with peripheral artery disease and diabetes mellitus: safety, walking distance and endothelial function

scientific article published on 20 December 2013

Systemic basic fibroblast growth factor induces favorable histological changes in the corpus cavernosum of hypercholesterolemic rabbits

scientific article

Systems Pharmacology of VEGF165b in Peripheral Artery Disease

scientific article published on 28 November 2017

Systems biology of pro-angiogenic therapies targeting the VEGF system

scientific article

Testing clinical therapeutic angiogenesis using basic fibroblast growth factor (FGF-2)

scientific article

The Microbiome and Endothelial Function

scientific article published on 01 October 2018

The VEGF 165 b “ICE-o-form” Puts a Chill on the VEGF Story ⬇️

scientific article published on July 22, 2011

The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis

scientific article published on 01 March 2003

Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial

scientific article published on June 2002

VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model

scientific article

VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease

scientific article

Vascular rarefaction in peripheral skeletal muscle after experimental heart failure

scientific article published on 01 October 2003

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