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List of works by John Challis

15-Hydroxyprostaglandin dehydrogenase protein expression in human fetal membranes with and without subclinical inflammation

scientific article

15-hydroxyprostaglandin dehydrogenase and cyclooxygenase 2 messenger ribonucleic acid expression and immunohistochemical localization in human cervical tissue during term and preterm labor.

scientific article published in June 2004

A cohort study found that white blood cell count and endocrine markers predicted preterm birth in symptomatic women

scientific article published on 01 March 2005

A periconceptional nutritional origin for noninfectious preterm birth

scientific article published in April 2003

Adult offspring of undernourished sheep exhibit epigenetic alterations in HPA axis glucocorticoid receptor

Antenatal dexamethasone treatment in midgestation reduces system A-mediated transport in the late-gestation murine placenta

scientific article published on 5 July 2011

Brief undernutrition in late-gestation sheep programs the hypothalamic-pituitary-adrenal axis in adult offspring

scientific article

Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis.

scientific article

Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.

scientific article published on 12 May 2011

Corticotropin releasing hormone and Urocortin 2 activate inflammatory pathways in cultured trophoblast cell lines

scientific article published on 10 November 2015

Corticotropin-releasing hormone and urocortin induce secretion of matrix metalloproteinase-9 (MMP-9) without change in tissue inhibitors of MMP-1 by cultured cells from human placenta and fetal membranes

scientific article published on 20 September 2005

Cortisol/progesterone antagonism in regulation of 15-hydroxysteroid dehydrogenase activity and mRNA levels in human chorion and placental trophoblast cells at term

scientific article published on February 2002

Development of the Fetal Hypothalamic-Pituitary-Adrenal-Placental Axis: Implications for Postnatal Health

Differential Expression and Regulation of Microsomal Prostaglandin E2Synthase in Human Fetal Membranes and Placenta with Infection and in Cultured Trophoblast Cells

scientific article published on 01 December 2003

Do alterations in placental 11beta-hydroxysteroid dehydrogenase (11betaHSD) activities explain differences in fetal hypothalamic-pituitary-adrenal (HPA) function following periconceptional undernutrition or twinning in sheep?

scientific article published on 18 September 2009

Dose-dependent effects of meloxicam administration on cyclooxygenase-1 and cyclooxygenase-2 protein expression in intrauterine tissues and fetal tissues of a sheep model of preterm labor

scientific article published in December 2007

Early dexamethasone treatment induces placental apoptosis in sheep

scientific article published on 25 July 2014

Early life origins of obesity

scientific article

Early-life glucocorticoid exposure: the hypothalamic-pituitary-adrenal axis, placental function, and long-term disease risk

scientific article published on 22 August 2013

Effect of Lactobacillus rhamnosus GR-1 Supernatant on Cytokine and Chemokine Output From Human Amnion Cells Treated With Lipoteichoic Acid and Lipopolysaccharide

scientific article published on January 2017

Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of pr

scientific article published on 14 March 2009

Effect of Oral Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the Vaginal Microbiota, Cytokines and Chemokines in Pregnant Women

scientific article published on 30 January 2020

Effect of calcium ionophore A23187 on prostaglandin synthase type 2 and 15-hydroxy-prostaglandin dehydrogenase expression in human chorion trophoblast cells

scientific article published on 17 July 2008

Effect of labor on glucocorticoid receptor (GRTotal, GRα, and GRβ) proteins in ovine intrauterine tissues

scientific article published on April 1, 2003

Effect of maternal age and growth on placental nutrient transport: potential mechanisms for teenagers' predisposition to small-for-gestational-age birth?

scientific article published on 25 October 2011

Effect of periconceptional undernutrition in sheep on late gestation expression of mRNA and protein from genes involved in fetal adrenal steroidogenesis and placental prostaglandin production

scientific article published on 16 March 2009

Effect of pro-inflammatory cytokines on expression and activity of 11beta-hydroxysteroid dehydrogenase type 2 in cultured human term placental trophoblast and human choriocarcinoma JEG-3 cells

scientific article published in July 2005

Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts

scientific article published on 21 November 2007

Effects of dexamethasone and sulfasalazine on prostaglandin E2 output by human placental cells in vitro.

scientific article published on January 2004

Effects of maternal dexamethasone treatment in early pregnancy on pituitary-adrenal axis in fetal sheep

scientific article published on 21 October 2009

Effects of periconceptional undernutrition on the initiation of parturition in sheep

scientific article

Effects of tail docking and castration on stress responses in lambs and the influence of prenatal glucocorticoid treatment

scientific article published in January 2013

Electromyographic and kinetic analysis of two abdominal muscle performance tests

scientific article published on 14 October 2015

Endocrine and paracrine regulation of birth at term and preterm

scientific article

Endocrinology of human parturition

scientific article published on 4 May 2016

Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning

scientific article published on 5 January 2012

Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition.

scientific article published on 23 June 2010

Expression and Function of Myometrial PSF Suggest a Role in Progesterone Withdrawal and the Initiation of Labor ⬇️

scientific article published on June 5, 2012

Expression and regulation of prostaglandin receptors in the human placenta and fetal membranes at term and preterm

scientific article published in January 2010

Expression of Membrane Prostaglandin E Synthase in Human Placenta and Fetal Membranes and Effect of Labor ⬇️

scientific article published on April 1, 2003

Expression of extracellular matrix metalloproteinase inducer in human placenta and fetal membranes at term labor

scientific article published in June 2004

Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11beta-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure

scientific article published in May 2008

Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in human placenta and fetal membranes in relation to preterm and term labor

scientific article published on 01 March 2002

Fetal HPA activation, preterm birth and postnatal programming

Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration

scientific article

Fetal gender effects on induction of labor in postdate pregnancies

scientific article published on 26 November 2012

Fetal signals and parturition

scientific article

Glucocorticoids, 11beta-hydroxysteroid dehydrogenase: mother, fetus, or both?

scientific article published in March 2009

Hepatic glucose regulation and metabolism in adult sheep: effects of prenatal betamethasone

scientific article published on 31 May 2005

How to build a healthy heart from scratch

scientific article published on January 2014

Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3.

scientific article published on 8 July 2010

Identification and characterization of the protein-associated splicing factor as a negative co-regulator of the progesterone receptor

scientific article published on March 2016

Identification and characterization of the protein-associated splicing factor as a negative co-regulator of the progesterone receptor.

scientific article published on 24 January 2005

Inflammation and pregnancy.

scientific article published on February 2009

Is there a role for probiotics in the prevention of preterm birth?

scientific article

L4. Placental inflammatory factors and preeclampsia

scientific article published on 01 July 2011

Lactobacillus rhamnosus GR-1 stimulates colony-stimulating factor 3 (granulocyte) (CSF3) output in placental trophoblast cells in a fetal sex-dependent manner

scientific article published on September 2010

Lactobacillus rhamnosus GR-1-induced IL-10 production in human placental trophoblast cells involves activation of JAK/STAT and MAPK pathways

scientific article published on 21 September 2010

Late gestation increase in 11beta-hydroxysteroid dehydrogenase 1 expression in human fetal membranes: a novel intrauterine source of cortisol

scientific article published in October 2003

Lipopolysaccharide-Induced Profiles of Cytokine, Chemokine, and Growth Factors Produced by Human Decidual Cells Are Altered by Lactobacillus rhamnosus GR-1 Supernatant

scientific article

Maternal betamethasone administration reduces binucleate cell number and placental lactogen in sheep

scientific article published on 01 August 2007

Maternal undernutrition programs tissue-specific epigenetic changes in the glucocorticoid receptor in adult offspring

scientific article published on 24 September 2013

Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term

scientific article (publication date: June 2003)

Mechanism of parturition and preterm labor

scientific article

Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD).

scientific article published in May 2007

Meloxicam effectively inhibits preterm labor uterine contractions in a chronically catheterized pregnant sheep model: impact on fetal blood flow and fetal-maternal physiologic parameters

scientific article published on 19 April 2006

Neuroendocrine mechanisms in pregnancy and parturition.

scientific article published on 14 July 2010

Nutrition and the early origins of adult disease

scientific article

Opposite effect of phorbol ester PMA on PTGS2 and PGDH mRNA expression in human chorion trophoblast cells

scientific article

Periconceptional origins of adult obesity

Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic-pituitary-adrenal axis in late gestation

scientific article

Prediction of preterm birth in symptomatic women using decision tree modeling for biomarkers

scientific article published in April 2008

Prenatal betamethasone exposure results in pituitary-adrenal hyporesponsiveness in adult sheep

scientific article published in August 2006

Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice

scientific article

Proliferative action of the androgen receptor in human uterine myometrial cells--a key regulator for myometrium phenotype programming

scientific article published on 23 October 2012

Prostaglandins and mechanisms of preterm birth

scientific article

Quality of systematic reviews on specific spinal stabilization exercise for chronic low back pain

scientific article published on 14 January 2013

Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny

scientific article published on 20 May 2008

Report on the 2nd World Congress on Fetal Origins of Adult Disease, Brighton, U.K., June 7-10, 2003.

scientific article published on 5 February 2004

Solid advice: Handbook of Research Laboratory Management

scientific article published in September 1988

Synthetic glucocorticoid reduces human placental system a transport in women treated with antenatal therapy

scientific article published on 8 August 2014

The Role of the Placenta in Fetal Programming

The dilution effect and the importance of selecting the right internal control genes for RT-qPCR: a paradigmatic approach in fetal sheep

scientific article published on 27 February 2015

The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta

scientific article published in May 2005

The effects of dexamethasone treatment in early gestation on hypothalamic-pituitary-adrenal responses and gene expression at 7 months of postnatal age in sheep

scientific article published on 18 November 2011

The fetal hypothalamic–pituitary–adrenal axis: relevance to developmental origins of health and disease

article

The role of prostaglandins in the mechanism of lipopolysaccharide-induced proMMP9 secretion from human placenta and fetal membrane cells

scientific article published on 13 December 2006

Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb.

scientific article

Transcriptional regulation of human myometrium and the onset of labor

scientific article published on 01 February 2005

Tumor necrosis factor stimulates matrix metalloproteinase 9 secretion from cultured human chorionic trophoblast cells through TNF receptor 1 signaling to IKBKB-NFKB and MAPK1/3 pathway

scientific article published on 12 May 2010

Uising WinBUGS to fit nonlinear mixed models with an application to pharmacokinetic modelling of insulin response to glucose challenge in sheep exposed antenatally to glucocorticoids

scientific article published in February 2003

Urocortin 2 stimulates estradiol secretion from cultured human placental cells: an effect mediated by the type 2 corticotrophin-releasing hormone (CRH) receptor.

scientific article published on 5 May 2009

Urocortin: a mechanism for the sustained activation of the HPA axis in the late-gestation ovine fetus?

scientific article

p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene, connexin 43 (Gja1).

scientific article

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