List of works - Brian V Geisbrecht

'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

(1)H, (15)N, and (13)C resonance assignments of Staphylococcus aureus extracellular adherence protein domain 4

scientific article published on 2 July 2016

1H, 15N, and 13C resonance assignments of the third domain from the S. aureus innate immune evasion protein Eap.

scientific article

A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins

scientific article

A Structurally Dynamic N-terminal Region Drives Function of the Staphylococcal Peroxidase Inhibitor (SPIN).

scientific article published on 5 January 2018

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family

scientific article

A structural basis for complement inhibition by Staphylococcus aureus

scientific article

Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins

scientific article published on January 2012

Allosteric inhibition of complement function by a staphylococcal immune evasion protein

scientific article

An intra-bacterial activity for a T3SS effector

scientific article published on 23 January 2020

An optimized system for expression and purification of secreted bacterial proteins

scientific article published on 4 October 2005

Anti gC1qR/p32/HABP1 Antibody Therapy Decreases Tumor Growth in an Orthotopic Murine Xenotransplant Model of Triple Negative Breast Cancer

scientific article published on 06 October 2020

Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb

scientific article published on 4 September 2015

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

Backbone and side-chain (1)H, (15)N, and (13)C resonance assignments of a novel Staphylococcal inhibitor of myeloperoxidase

scientific article

Backbone resonance assignments of innate immune evasion protein EapH2 from the S. aureus

scientific article published on 07 February 2019

Binding affects the tertiary and quaternary structures of the Shigella translocator protein IpaB and its chaperone IpgC.

scientific article published on May 2012

Biochemical and Structural Basis for Inhibition of Enterococcus faecalis Hydroxymethylglutaryl-CoA Synthase, mvaS, by Hymeglusin ⬇️

scientific article published on May 25, 2012

Characteristics of an extensive Mycobacterium avium subspecies paratuberculosis recombinant protein set

article

Characterization of Dye-decolorizing Peroxidase (DyP) from Thermomonospora curvata Reveals Unique Catalytic Properties of A-type DyPs

scientific article

Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus

scientific article

Complement evasion by human pathogens

scientific article

Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein.

scientific article

Correlating structure and affinity for PEX5:PTS1 complexes

scientific article

Crystal Structures of Staphylococcus epidermidis Mevalonate Diphosphate Decarboxylase Bound to Inhibitory Analogs Reveal New Insight into Substrate Binding and Catalysis ⬇️

scientific article published on May 11, 2011

Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A

scientific article

Crystallization and X-ray diffraction analysis of the complement component-3 (C3) inhibitory domain of Efb from Staphylococcus aureus.

scientific article

Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN).

scientific article published on 24 April 2009

Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2.

scientific article published on December 2008

Design and optimization of a recombinant system for large-scale production of the MPT64 antigen from Mycobacterium tuberculosis

scientific article published on 16 September 2005

Detecting patterns of protein distribution and gene expression in silico

scholarly article

Dietary flavonoid fisetin binds human SUMO1 and blocks sumoylation of p53

scientific article published on 12 June 2020

Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family

scientific article

Diversity in the C3b contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family

scientific article published in Journal of Biological Chemistry

Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth

scientific article published on 30 March 2020

Electrostatic contributions drive the interaction betweenStaphylococcus aureusprotein Efb-C and its complement target C3d

scientific article

Enantioselective Synthesis of Dilignol Model Compounds and Their Stereodiscrimination Study with a Dye-Decolorizing Peroxidase.

scientific article

Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells

scientific article

Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone

scientific article

Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins

scientific article published on 7 November 2017

Expression, purification, and characterization of a human complement component C3 analog that lacks the C-terminal C345c domain

scientific article published on 15 July 2019

Functional characterization of Delta3, Delta2-enoyl-CoA isomerases from rat liver

scientific journal article

Host Glycan Recognition by a Pore Forming Toxin ⬇️

scientific article published on February 8, 2012

Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini

scientific article published on 7 March 2018

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

scientific article

Identification of Surface-Exposed Protein Radicals and A Substrate Oxidation Site in A-Class Dye-Decolorizing Peroxidase from Thermomonospora curvata

scientific article published on 12 October 2016

Identification of a Staphylococcal Complement Inhibitor with broad host specificity in equid S. aureus strains.

scientific article published on 5 February 2018

Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins

scientific article published on 4 June 2015

Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure.

scientific article

Immune evasion by a staphylococcal inhibitor of myeloperoxidase.

scientific article published on 14 August 2017

Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds

scientific article published on 11 December 2014

Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B

scientific article published on 08 January 2021

Investigation of Human Neutrophil Elastase Inhibition by Staphylococcus aureus EapH1: The Key Role Played by Arginine 89

scientific article published on 30 November 2018

Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases

scientific article published on 17 April 2020

MAP1272c encodes an NlpC/P60 protein, an antigen detected in cattle with Johne's disease

scientific article

Mechanistic Insights into Dye-Decolorizing Peroxidase Revealed by Solvent Isotope and Viscosity Effects

scientific article published on 9 August 2017

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b

scientific article

Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex

scientific article

NMR assignment of protein Rv1980c from Mycobacterium tuberculosis

scientific article published on 01 September 2005

Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin

scientific article (publication date: 29 August 2003)

Neutrophil serine proteases in antibacterial defense

scientific article

NlpC/P60 domain-containing proteins of Mycobacterium avium subspecies paratuberculosis that differentially bind and hydrolyze peptidoglycan

scientific article published on 22 January 2016

Novel Evasion Mechanisms of the Classical Complement Pathway.

scientific article published on September 2016

Quantitative monitoring of two simultaneously binding species using Label-Enhanced surface plasmon resonance.

scientific article published on 7 February 2018

Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB/DnaK bi-chaperone system

scientific article published on 13 November 2020

STRALCP--structure alignment-based clustering of proteins

scientific article

Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry

scientific article

Staphylococcal complement inhibitors: biological functions, recognition of complement components, and potential therapeutic implications.

scientific article published on January 2008

Staphylococcus aureus evasion proteins EapH1 and EapH2: Residue-level investigation of an alternative binding motif for human neutrophil elastase

scientific article published on 14 October 2019

Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors

scientific article (publication date: 9 September 2014)

Structural Basis for Nucleotide Binding and Reaction Catalysis in Mevalonate Diphosphate Decarboxylase

scientific article

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b.

scientific article

Structure of a heparin-dependent complex of Hedgehog and Ihog

scholarly article

Studies of the conformational stability of invasion plasmid antigen B from Shigella

scientific article published on 26 March 2013

Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus

scientific article

Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A

scientific journal article

The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1)1

scientific article published on 01 October 2019

The Extracellular Adherence Protein Eap Is a DNA Binding Protein Capable of Blocking Neutrophil Extracellular Trap Formation

scientific article published on 09 July 2018

The Legionella pneumophila metaeffector Lpg2505 (MesI) regulates SidI-mediated translation inhibition and novel glycosyl hydrolase activity

scientific article published on 02 March 2020

The Staphylococcus aureus extracellular adherence protein (Eap) adopts an elongated but structured conformation in solution.

scientific article

The Structures of Coiled-Coil Domains from Type III Secretion System Translocators Reveal Homology to Pore-Forming Toxins

scientific article

The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens.

scientific article

The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase

scientific article

The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a new family of beta-grasp proteins

scientific article

The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein

scientific article published on 16 May 2017

Using Disruptive Insertional Mutagenesis to Identify the In Situ Structure-Function Landscape of the Shigella Translocator Protein IpaB.

scientific article published on 19 April 2018

List of works by Brian V Geisbrecht

'Stealth' corporate innovation: an emerging threat for therapeutic drug development

(1)H, (15)N, and (13)C resonance assignments of Staphylococcus aureus extracellular adherence protein domain 4

1H, 15N, and 13C resonance assignments of the third domain from the S. aureus innate immune evasion protein Eap.

A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins

A Structurally Dynamic N-terminal Region Drives Function of the Staphylococcal Peroxidase Inhibitor (SPIN).

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family

A structural basis for complement inhibition by Staphylococcus aureus

Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins

Allosteric inhibition of complement function by a staphylococcal immune evasion protein

An intra-bacterial activity for a T3SS effector

An optimized system for expression and purification of secreted bacterial proteins

Anti gC1qR/p32/HABP1 Antibody Therapy Decreases Tumor Growth in an Orthotopic Murine Xenotransplant Model of Triple Negative Breast Cancer

Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development

Backbone and side-chain (1)H, (15)N, and (13)C resonance assignments of a novel Staphylococcal inhibitor of myeloperoxidase

Backbone resonance assignments of innate immune evasion protein EapH2 from the S. aureus

Binding affects the tertiary and quaternary structures of the Shigella translocator protein IpaB and its chaperone IpgC.

Biochemical and Structural Basis for Inhibition of Enterococcus faecalis Hydroxymethylglutaryl-CoA Synthase, mvaS, by Hymeglusin ⬇️

Characteristics of an extensive Mycobacterium avium subspecies paratuberculosis recombinant protein set

Characterization of Dye-decolorizing Peroxidase (DyP) from Thermomonospora curvata Reveals Unique Catalytic Properties of A-type DyPs

Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus

Complement evasion by human pathogens

Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein.

Correlating structure and affinity for PEX5:PTS1 complexes

Crystal Structures of Staphylococcus epidermidis Mevalonate Diphosphate Decarboxylase Bound to Inhibitory Analogs Reveal New Insight into Substrate Binding and Catalysis ⬇️

Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A

Crystallization and X-ray diffraction analysis of the complement component-3 (C3) inhibitory domain of Efb from Staphylococcus aureus.

Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN).

Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2.

Design and optimization of a recombinant system for large-scale production of the MPT64 antigen from Mycobacterium tuberculosis

Detecting patterns of protein distribution and gene expression in silico

Dietary flavonoid fisetin binds human SUMO1 and blocks sumoylation of p53

Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family

Diversity in the C3b contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family

Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth

Electrostatic contributions drive the interaction betweenStaphylococcus aureusprotein Efb-C and its complement target C3d

Enantioselective Synthesis of Dilignol Model Compounds and Their Stereodiscrimination Study with a Dye-Decolorizing Peroxidase.

Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells

Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone

Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins

Expression, purification, and characterization of a human complement component C3 analog that lacks the C-terminal C345c domain

Functional characterization of Delta3, Delta2-enoyl-CoA isomerases from rat liver

Host Glycan Recognition by a Pore Forming Toxin ⬇️

Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

Identification of Surface-Exposed Protein Radicals and A Substrate Oxidation Site in A-Class Dye-Decolorizing Peroxidase from Thermomonospora curvata

Identification of a Staphylococcal Complement Inhibitor with broad host specificity in equid S. aureus strains.

Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins

Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure.

Immune evasion by a staphylococcal inhibitor of myeloperoxidase.

Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds

Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B

Investigation of Human Neutrophil Elastase Inhibition by Staphylococcus aureus EapH1: The Key Role Played by Arginine 89

Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases

MAP1272c encodes an NlpC/P60 protein, an antigen detected in cattle with Johne's disease

Mechanistic Insights into Dye-Decolorizing Peroxidase Revealed by Solvent Isotope and Viscosity Effects

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b

Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex

NMR assignment of protein Rv1980c from Mycobacterium tuberculosis

Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin

Neutrophil serine proteases in antibacterial defense

NlpC/P60 domain-containing proteins of Mycobacterium avium subspecies paratuberculosis that differentially bind and hydrolyze peptidoglycan

Novel Evasion Mechanisms of the Classical Complement Pathway.

Quantitative monitoring of two simultaneously binding species using Label-Enhanced surface plasmon resonance.

Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB/DnaK bi-chaperone system

STRALCP--structure alignment-based clustering of proteins

Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry

Staphylococcal complement inhibitors: biological functions, recognition of complement components, and potential therapeutic implications.

Staphylococcus aureus evasion proteins EapH1 and EapH2: Residue-level investigation of an alternative binding motif for human neutrophil elastase

Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors

Structural Basis for Nucleotide Binding and Reaction Catalysis in Mevalonate Diphosphate Decarboxylase

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b.

Structure of a heparin-dependent complex of Hedgehog and Ihog

Studies of the conformational stability of invasion plasmid antigen B from Shigella

Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus

Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A

The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1)1

The Extracellular Adherence Protein Eap Is a DNA Binding Protein Capable of Blocking Neutrophil Extracellular Trap Formation

The Legionella pneumophila metaeffector Lpg2505 (MesI) regulates SidI-mediated translation inhibition and novel glycosyl hydrolase activity