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List of works by Emma Saavedra

Air-adapted Methanosarcina acetivorans shows high methane production and develops resistance against oxygen stress

scientific article

Albendazole induces oxidative stress and DNA damage in the parasitic protozoan Giardia duodenalis

scientific article published on 6 August 2015

Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism.

scientific article

Biochemistry and Physiology of Heavy Metal Resistance and Accumulation in Euglena.

scientific article published on January 2017

Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi

scientific article published on 11 November 2017

Cadmium removal by Euglena gracilis is enhanced under anaerobic growth conditions.

scientific article published on 11 February 2015

Complement is a rat natural resistance factor to amoebic liver infection

scholarly article by Alfonso Olivos-García published in October 2018

Computational Drug Repositioning for Chagas Disease Using Protein-Ligand Interaction Profiling

scientific article published on 16 June 2020

Conserved cysteine 126 in triosephosphate isomerase is required not for enzymatic activity but for proper folding and stability.

scientific article published in March 2004

Control and regulation of the pyrophosphate-dependent glucose metabolism in Entamoeba histolytica

scientific article published on 14 February 2019

Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria

scientific article published on 24 July 2018

Control of the NADPH supply for oxidative stress handling in cancer cells

scientific article

Dehydroepiandrosterone decreases while cortisol increases in vitro growth and viability of Entamoeba histolytica

scientific article

Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling

scientific article published on 01 January 2019

Drug target validation of the trypanothione pathway enzymes through metabolic modelling

scientific article published on 4 April 2012

Dual regulation of energy metabolism by p53 in human cervix and breast cancer cells

scientific article published in October 2015

Endoplasmic reticulum stress-sensing mechanism is activated in Entamoeba histolytica upon treatment with nitric oxide

scientific article (publication date: 2012)

Energy metabolism in tumor cells

scientific article

Entamoeba histolytica: apoptosis induced in vitro by nitric oxide species

scientific article

Entamoeba histolytica: kinetic and molecular evidence of a previously unidentified pyruvate kinase.

scientific article published in January 2004

Entamoeba histolytica: oxygen resistance and virulence

scientific article

Experimental validation of metabolic pathway modeling

scientific article published on 28 May 2008

Functional characterization and subcellular distribution of two recombinant cytosolic HSP70 isoforms from Entamoeba histolytica under normal and stress conditions

scientific article published on 13 February 2020

Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity

scientific article published on 28 May 2019

Gene cloning and biochemical characterization of an alcohol dehydrogenase from Euglena gracilis

scientific article published in November 2008

Glycolysis in Entamoeba histolytica. Biochemical characterization of recombinant glycolytic enzymes and flux control analysis.

scientific article published in April 2005

Glycolysis in Ustilago maydis.

scientific article

Heart myxoma develops oncogenic and metastatic phenotype

scientific article published on 21 March 2019

Identification of flux checkpoints in a metabolic pathway through white-box, grey-box and black-box modeling approaches

scientific article published on 10 August 2020

In vivo identification of the steps that control energy metabolism and survival of Entamoeba histolytica

scientific article published on 21 November 2014

Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps

scientific article published on 23 September 2016

Kinetic modeling can describe in vivo glycolysis in Entamoeba histolytica

scientific article published on 01 September 2007

Kinetic modeling of glucose central metabolism in hepatocytes and hepatoma cells

scientific article published on 23 July 2020

Maintenance of intracellular hypoxia and adequate heat shock response are essential requirements for pathogenicity and virulence of Entamoeba histolytica

scientific article published on 18 February 2015

Mechanisms of natural resistance of Balb/c mice to experimental liver amoebiasis.

scientific article published on 3 May 2019

Metabolic Control Analysis for Drug Target Prioritization in Trypanosomatids

scientific article published on 01 January 2020

Metabolic Control Theory

scientific article published in 2013

Metabolic control analysis indicates a change of strategy in the treatment of cancer

scientific article published on 25 June 2010

Metabolic control analysis of the Trypanosoma cruzi peroxide detoxification pathway identifies tryparedoxin as a suitable drug target

scientific article published on 30 October 2014

Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.

scientific article published on January 2008

Modeling cancer glycolysis

scientific article published on 24 November 2010

Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms.

scientific article published in July 2014

Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase.

scientific article published in April 2009

Mutant p53 downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells

scientific article published on 10 September 2018

Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma

scientific article published on 21 July 2010

Phosphofructokinase type 1 kinetics, isoform expression, and gene polymorphisms in cancer cells

scientific article

Physiological Role of Glutamate Dehydrogenase in Cancer Cells

scientific article published on 09 April 2020

Plant-like traits associated with metabolism of Trypanosoma parasites

scientific article

Pyruvate:ferredoxin oxidoreductase (PFO) is a surface-associated cell-binding protein in Trichomonas vaginalis and is involved in trichomonal adherence to host cells

scientific article

Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde-alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica.

scientific article published on 12 July 2010

Rabeprazole inhibits several functions of Entamoeba histolytica related with its virulence

scientific article published on 04 September 2020

Roles of acetyl-CoA synthetase (ADP-forming) and acetate kinase (PPi-forming) in ATP and PPi supply in Entamoeba histolytica

scientific article

Sulfate uptake in photosynthetic Euglena gracilis. Mechanisms of regulation and contribution to cysteine homeostasis.

scientific article published on 18 May 2012

Synthesis and biological evaluation of 2-methyl-1H-benzimidazole-5-carbohydrazides derivatives as modifiers of redox homeostasis of Trypanosoma cruzi.

scientific article

Targeting Trypanothione Metabolism in Trypanosomatid Human Parasites ⬇️

scientific article published on December 1, 2010

The 2-oxoglutarate supply exerts significant control on the lysine synthesis flux in Saccharomyces cerevisiae.

scientific article published on 13 September 2013

The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae

scientific article published on 29 September 2011

The bifunctional aldehyde-alcohol dehydrogenase controls ethanol and acetate production in Entamoeba histolytica under aerobic conditions

scientific article published on 28 November 2012

The bioenergetics of cancer: is glycolysis the main ATP supplier in all tumor cells?

scientific article published on March 2009

The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy

scientific article published on 02 March 2010

The contribution of two isozymes to the pyruvate kinase activity of Vibrio cholerae: One K+-dependent constitutively active and another K+-independent with essential allosteric activation

scientific article published on 7 July 2017

The nutritional status of Methanosarcina acetivorans regulates glycogen metabolism and gluconeogenesis and glycolysis fluxes.

scientific article

The oxygen reduction pathway and heat shock stress response are both required for Entamoeba histolytica pathogenicity

scientific article

Transcriptional Regulation of Energy Metabolism in Cancer Cells

scientific article published on 09 October 2019

Understanding the cancer cell phenotype beyond the limitations of current omics analyses

scientific article published on 29 September 2015

Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

scientific article published on 07 February 2014

Zn-bis-glutathionate is the best co-substrate of the monomeric phytochelatin synthase from the photosynthetic heavy metal-hyperaccumulator Euglena gracilis

scientific article published on 24 January 2014

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