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List of works by Jack Szostak

1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element

scientific article published on May 1994

2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities

scientific article published on 24 February 2007

29 Hybridization with synthetic oligonucleotides

scientific article published on January 1, 1979

A DNA aptamer that binds adenosine and ATP.

scientific article

A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying

A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying

scientific article published on 06 July 2018

A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension.

scientific article

A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5'-phosphoro-2-aminoimidazolide.

scientific article published on 12 October 2017

A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension.

scientific article published on 7 November 2017

A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides

scientific article published on 22 January 2020

A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene

scientific article

A kinetic study of the growth of fatty acid vesicles

scientific article

A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality

scientific article

A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae

scientific article published on January 1991

A small aptamer with strong and specific recognition of the triphosphate of ATP

scientific article published on July 2004

A strategy for the generation of conditional mutations by protein destabilization ⬇️

scientific article published on February 15, 1992

Activated Ribonucleotides Undergo a Sugar Pucker Switch upon Binding to a Single-Stranded RNA Template ⬇️

scientific article published on February 3, 2012

An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides

scientific article

An in vitro selection system for TNA

scientific article (publication date: 9 March 2005)

An optimal degree of physical and chemical heterogeneity for the origin of life? ⬇️

scientific article published on October 27, 2011

Aptamers Selected for Higher-Affinity Binding Are Not More Specific for the Target Ligand

scientific article (publication date: June 2006)

Artificial lantipeptides from in vitro translations ⬇️

scientific article published on April 28, 2011

Attempts to Define Life Do Not Help to Understand the Origin of Life ⬇️

scientific article published on January 1, 2012

Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms

scientific article published on 23 October 2015

Catalysis of Template-Directed Nonenzymatic RNA Copying by Iron(II)

scholarly article by Lin Jin et al published 7 November 2018 in Journal of the American Chemical Society

Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions

scientific article

Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water.

scientific article published on 28 February 2011

Chemoselective multicomponent one-pot assembly of purine precursors in water

scientific article published on 2 November 2010

Chromosome segregation in mitosis and meiosis

scientific article

Cloning yeast telomeres on linear plasmid vectors

scientific article

Collaboration between primitive cell membranes and soluble catalysts

scientific article published on 21 March 2016

Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation.

scientific article published on 22 June 2017

Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.

scientific article published on 25 September 2017

Competition between model protocells driven by an encapsulated catalyst ⬇️

scientific article published on May 19, 2013

Concentration-Driven Growth of Model Protocell Membranes ⬇️

scientific article published on December 14, 2012

Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy

scientific article published on September 2009

Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations

scientific article published on 28 May 2015

Controlled growth of filamentous fatty acid vesicles under flow

scientific article

Copying of Mixed-Sequence RNA Templates inside Model Protocells

article

Coupled Growth and Division of Model Protocell Membranes

scientific article published on April 2009

Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairs

scientific article

Crystallographic observation of nonenzymatic RNA primer extension

DNA Ends: Just the Beginning (Nobel Lecture) ⬇️

scientific article published on October 4, 2010

DNA polymerase activity on synthetic N3'→P5' phosphoramidate DNA templates

scientific article published on 01 September 2019

DNA polymerase-mediated DNA synthesis on a TNA template

scientific article published in January 2003

DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA ⬇️

scientific article published on July 1, 1981

DNA sequences of telomeres maintained in yeast

scientific article

Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast

scientific article published on December 1990

Deep sequencing of non-enzymatic RNA primer extension

scientific article published on 19 May 2020

Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display

scientific article published in February 2006

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

scientific article published on 19 May 2017

Double-strand breaks at an initiation site for meiotic gene conversion

scientific article published in Nature

Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes

scientific article

Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication

scientific article

Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension

scientific article published in September 2016

Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers

scientific article

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides

scientific article

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides.

scientific article published on 24 January 2017

Enzymatic activity of the conserved core of a group I self-splicing intron

scientific article published in July 1986

Enzymatic aminoacylation of tRNA with unnatural amino acids

scientific article published on 13 March 2006

Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates

scientific article

Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template

scientific article

Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer ⬇️

scientific article published on December 1, 2003

Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity

scientific article

Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability

scientific article

Expanding roles for diverse physical phenomena during the origin of life

scientific article

Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis

scientific article

Experimental models of primitive cellular compartments: encapsulation, growth, and division

scientific article (publication date: 24 October 2003)

Exploding vesicles

Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer

scientific article published on 07 October 2013

Formation of protocell-like vesicles in a thermal diffusion column

scientific article

Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying

scientific article published on 21 April 2022

Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity

scientific article

Functional information and the emergence of biocomplexity

scholarly article

Functional information: Molecular messages

scientific article

Fungal recombination

scientific article published on March 1985

Gene conversion adjacent to regions of double-strand break repair

scientific article published on December 1988

Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension

scientific article published on 31 December 2014

Genetic and physical analyses of sister chromatid exchange in yeast meiosis

scientific article published on December 1991

Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities

scientific article published on 01 November 2006

HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA.

scientific article

High fidelity TNA synthesis by Therminator polymerase

scientific article

How Did Life Begin?

journal article; published in Nature on 2018-05-09

Identification of epitope-like consensus motifs using mRNA display

scientific article published in May 2002

Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe

scientific article published on December 1987

In Vitro Selection of Functional Lantipeptides ⬇️

scientific article published on May 3, 2012

In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors ⬇️

scientific article published on March 29, 2012

In vitro evolution suggests multiple origins for the hammerhead ribozyme

scientific article

In vitro genetics

scientific article

In vitro selection of RNA aptamers against a composite small molecule-protein surface

scientific article

In vitro selection of RNA aptamers specific for cyanocobalamin

scientific article published on February 1994

In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole-activated substrates

scientific article published on 02 March 2020

Informational complexity and functional activity of RNA structures

scientific article

Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA

article published in the Proceedings of the National Academy of Sciences of the United States of America

Insertion of a genetic marker into the ribosomal DNA of yeast ⬇️

scientific article published on October 1, 1979

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex

scientific article published on 3 July 2017

Interpreting turbidity measurements for vesicle studies

Introduction: Combinatorial Chemistry

scientific article published on 01 April 1997

Isolation and characterization of fluorophore-binding RNA aptamers

scientific article

Isolation of a fluorophore-specific DNA aptamer with weak redox activity

scientific article published in November 1998

Isolation of a ribozyme with 5′-5′ ligase activity ⬇️

scientific article published on May 1, 1995

Isolation of high-affinity GTP aptamers from partially structured RNA libraries

scientific article

Kinetic analysis of an efficient DNA-dependent TNA polymerase

scientific article published on May 2005

Kinetic and Thermodynamic Characterization of the Reaction Catalyzed by a Polynucleotide Kinase Ribozyme ⬇️

scientific article published on November 21, 1995

Large Phenotypic Enhancement of Structured Random RNA Pools

scientific article published on 14 January 2020

Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles

scientific article

Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization

scientific article published in February 2008

Mineral Surface Directed Membrane Assembly

scientific article published on 15 August 2006

Miniribozymes, small derivatives of the sunY intron, are catalytically active

scientific article published on December 1989

Molecular biology: RNA gets a grip on translation

scientific article published in October 2002

Molecular diversity comes of age !

scientific article published in 1995

Multicomponent assembly of proposed DNA precursors in water

scientific article published on 9 August 2012

Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding ⬇️

scientific article published on October 24, 1997

Mutations in a semiconserved region of the Tetrahymena intron

scientific article published on March 1991

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes

scientific article

N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system

scientific article

Natural soda lakes provide compatible conditions for RNA and membrane function that could have enabled the origin of life

scientific article published in March 2024

Non-enzymatic primer extension with strand displacement

scientific article published on 08 November 2019

Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3'-NP-DNA up to 25 Nucleotides Long Inside Model Protocells

scientific article published on 20 June 2019

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides

scientific article

Nonenzymatic template-directed RNA synthesis inside model protocells

scientific article

Not just Salk

scientific article published in September 2017

Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication

retracted scientific article published on 27 June 2016

On the origin of life

scientific article published in January 2016

Optimal Codon Choice Can Improve the Efficiency and Fidelity of N‐Methyl Amino Acid Incorporation into Peptides by In‐Vitro Translation ⬇️

scientific article published on March 4, 2011

Origin of life on earth.

scientific article

Origins of life: Systems chemistry on early Earth

scientific article

Pedigree analysis of plasmid segregation in yeast ⬇️

scientific article published on October 1, 1983

Photochemically driven redox chemistry induces protocell membrane pearling and division ⬇️

scientific article published on June 4, 2012

Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns

scientific article published in October 1990

Physical effects underlying the transition from primitive to modern cell membranes ⬇️

scientific article published on March 14, 2011

Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides

scientific article

Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.

scientific article published in September 1990

Prebiotically Plausible "Patching" of RNA Backbone Cleavage through a 3'-5' Pyrophosphate Linkage

scientific article published on 01 November 2019

Preparation of fatty acid micelles

scientific article published on January 2013

Preparation of fatty acid or phospholipid vesicles by thin-film rehydration

scientific article published in January 2013

Preparation of large monodisperse vesicles

scientific article

Preparation, Purification, and Use of Fatty Acid-containing Liposomes.

scientific article published on 9 February 2018

Progress toward synthetic cells

scientific article published on 03 March 2014

RETRACTED: Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display

retracted scientific article

RNA catalysis in model protocell vesicles

scientific article (publication date: 28 September 2005)

RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron

scientific article

Rapid RNA exchange in aqueous two-phase system and coacervate droplets

scientific article published on 28 February 2014

Ray Wu, as remembered by a former student

scientific article published in February 2009

Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension

scientific article published on 16 February 2015

Replicating vesicles as models of primitive cell growth and division

scientific article

Replication and Resolution of Telomeres in Yeast ⬇️

scientific article published on January 1, 1983

Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display".

scholarly article

Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication

scientific article published in November 2017

Ribosomal synthesis of N-methyl peptides

scientific article

Ribosomal synthesis of dehydroalanine-containing peptides

scientific article published on June 2006

Ribosomal synthesis of unnatural peptides

scientific article published in August 2005

Ribozyme-catalyzed primer extension by trinucleotides: A model for the RNA-catalyzed replication of RNA ⬇️

scientific article published on March 2, 1993

Ribozyme-catalyzed tRNA aminoacylation

scientific article

Ribozymes: aiming at RNA replication and protein synthesis

scientific article published on September 1996

Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae

scientific article published on October 1987

Scanning the human proteome for calmodulin-binding proteins

scientific article

Selection and evolution of enzymes from a partially randomized non-catalytic scaffold

scientific article

Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures

scientific article published on February 27, 1992

Selection of a ribozyme that functions as a superior template in a self-copying reaction

scientific article published on December 18, 1992

Selective labeling and detection of specific RNAs in an RNA mixture

scientific article published in April 2003

Shrink-wrap vesicles

scientific article published on December 2005

Single-molecule binding experiments on long time scales

scientific article

Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics

scientific article

Solid-Phase Synthesis of Sequence-Defined Informational Oligomers

scientific article published on 16 October 2020

Solution structure of an informationally complex high-affinity RNA aptamer to GTP

scientific article

Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth

scientific article published on 15 January 2018

Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA ⬇️

scientific article published on January 6, 1977

Stereochemical course of catalysis by the Tetrahymena ribozyme

scientific article

Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold Optimization

scientific article

Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.

scientific article published on 7 February 2018

Structural and kinetic characterization of an acyl transferase ribozyme

scientific article published on February 1998

Structural insights into the effects of 2'-5' linkages on the RNA duplex

scientific article

Structure and evolutionary analysis of a non-biological ATP-binding protein

scientific article

Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization

scientific article published on December 1994

Synthesis and nonenzymatic template-directed polymerization of 2'-amino-2'-deoxythreose nucleotides

scientific article

Synthesis of N3′-P5′-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension ⬇️

scientific article published on January 7, 2013

Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5′ splice site of theTetrahymenagroup I intron ⬇️

scientific article published on August 11, 1991

Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension.

scientific article

Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs).

scientific article published on April 2005

Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase

scientific article published on 18 March 2020

TNA synthesis by DNA polymerases

scientific article published in August 2003

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

scientific article

Telomeric repeat from T. thermophila cross hybridizes with human telomeres

scientific article

Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension

scientific article published on 31 December 2018

Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine

scientific article published on 23 July 2019

Template-directed synthesis of a genetic polymer in a model protocell

scientific article

The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways

article

The Mechanism of Nonenzymatic Template Copying with Imidazole-Activated Nucleotides

scientific article published on 04 July 2019

The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life

scientific article published on 17 May 2017

The Virtual Circular Genome Model for Primordial RNA Replication

scientific article published on 07 October 2020

The eightfold path to non-enzymatic RNA replication

The emergence of competition between model protocells

scientific article

The free energy landscape of pseudorotation in 3'-5' and 2'-5' linked nucleic acids

scientific article

The guanosine binding site of the Tetrahymena ribozyme

scientific article

The origins of cellular life

scientific article

Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization

scientific article

Thermostability of model protocell membranes

scholarly article

Transfer of Sequence Information and Replication of Diimine Duplexes

scientific article published on 15 March 2019

Transfer of yeast telomeres to linear plasmids by recombination ⬇️

scientific article published on November 1, 1984

Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity

scientific article published on 26 October 2023

UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth

scientific article published on 01 August 2019

Uncovering the thermodynamics of monomer binding for RNA replication

scientific article

Unusual Base-Pairing Interactions in Monomer-Template Complexes

scientific article

Unusual Metal Ion Catalysis in an Acyl-Transferase Ribozyme ⬇️

scientific article published on July 14, 1998

Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods

scientific article published on 30 January 2019

Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder

scientific article published on January 2013

[14] Genetic applications of yeast transformation with linear and gapped plasmids

article published in 1983

mRNA display: from basic principles to macrocycle drug discovery

scientific article

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