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Authors whose works are in public domain in at least one jurisdiction

List of works by Bruce Beutler

A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

scientific article published on November 17, 2003

A catechol-O-methyltransferase that is essential for auditory function in mice and humans

scientific article

A conversation with Bruce Beutler. Interview by Ushma S. Neill

scientific article published on 3 September 2013

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

scientific article

A model for familial exudative vitreoretinopathy caused by LPR5 mutations

scientific article

A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha

scientific article

A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding

scientific article published on 7 March 2011

A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria

scientific journal article

A viable hypomorphic mutation causes hyperphagic obesity, diabetes and hepatic steatosis

scientific article published on 18 December 2018

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections

scientific article

ATP-sensitive potassium channels mediate survival during infection in mammals and insects

scientific article

Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium

scientific article published on 01 May 1997

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling

scientific article

Akirins versus infection

scientific article published in January 2008

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

scientific article

An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue

scientific article published on 15 September 2017

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

scientific article

Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor

scientific article

Analysis of the MCMV resistome by ENU mutagenesis

scientific article published in May 2006

Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation

scholarly article by Zuping Zhou et al published June 2005 in European Journal of Immunology

Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency

scientific article

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility

scientific article

Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response

scientific article

Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria

scientific article published on 2 July 2008

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.

scientific article

Bruce Beutler wins the 2013 ASCI/Stanley J. Korsmeyer Award. Interview by Kathryn Claiborn

scientific article published in April 2013

Bruce Beutler: the persistent prospector. Interview by Ruth Williams

scientific article published in March 2013

Bulk segregation mapping of mutations in closely related strains of mice

scientific article

CD14 is required for MyD88-independent LPS signaling.

scientific article published on 15 May 2005

CD36 is a sensor of diacylglycerides

scientific journal article

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

scientific article published on 5 January 2017

Characterization of mouse mutants with abnormal RPE cells

scientific article published on January 2006

Chimeric tumor necrosis factor receptors with constitutive signaling activity

scientific article

Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors

scientific article

Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery

scientific article

Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance

scientific article published on 17 February 2014

Creating diseases to understand what prevents them: genetic analysis of inflammation in the gastrointestinal tract

scientific article published on November 1, 2012

Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency

scientific article

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing

scientific article

Cutting edge: Priming of NK cells by IL-18.

scientific article published on August 2008

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

scientific article

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

scientific article

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

scientific article

Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice

scientific article

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease

scientific article

Dominant atopy risk mutations identified by mouse forward genetic analysis

scientific article published on 18 August 2020

ENU mutagenesis in mice

scientific article published in January 2008

ENU-induced phenovariance in mice: inferences from 587 mutations

scientific article

Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway

scientific article (publication date: June 2006)

Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

scientific article published on 02 July 2009

Endotoxin antagonism: conceptual basis and therapeutic potential

scientific article

Endotoxin-mimetic effect of antibodies against Toll-like receptor 4.

scientific article

Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling

scientific article published in July 2005

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

scholarly article

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

scientific article published on 16 May 2019

Ernest Beutler: his life and contribution to medical science

scientific article published on 17 January 2011

Erratum: Corrigendum: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections

scientific article published in Nature

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

scientific article published on 4 February 2013

Essential requirement for nicastrin in marginal zone and B-1 B cell development

scientific article published on 18 February 2020

Evolution of the TIR, tolls and TLRs: functional inferences from computational biology

scientific article (publication date: 2002)

Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans

scientific article

Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function

scientific article published on 15 November 2018

Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections

scientific article published in March 2005

Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules

scientific article published in September 2004

Expression of an adenovirally encoded lymphotoxin-beta inhibitor prevents clearance of Listeria monocytogenes in mice

scientific article published on 01 January 1995

Fighting malaria: mosquitoes know how.

scientific article published in October 2006

Finding New Components of the Mammalian Immune System

scientific article published on 28 July 2016

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells

scientific journal article

Forward genetic analysis of TLR-signaling pathways: an evaluation

scientific article published on 15 February 2008

Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice

scientific article published on 26 May 2020

Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses

scientific article published in June 2004

From phenomenon to phenotype and from phenotype to gene: forward genetics and the problem of sepsis

scientific article

Genetic Analysis of Host Responses in Sepsis

scientific article published in October 2001

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

scientific article

Genetic analysis of host responses in sepsis

scientific article published in October 2007

Genetic analysis of innate immunity

scientific article published on January 2006

Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses

scientific article

Genetic analysis of innate immunity: identification and function of the TIR adapter proteins

scientific article

Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).

scientific article

Genetic analysis of resistance to viral infection

scientific article published on October 2007

Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

scientific article

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function

scientific article published on 27 March 2020

Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model

scientific article

Going forward with genetics: recent technological advances and forward genetics in mice.

scientific article published on May 2013

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.

scientific article published on 2 October 2017

Helsinki alert of biodiversity and health

scientific article published on 23 April 2015

Herpes simplex virus encephalitis in human UNC-93B deficiency

scientific article

Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens

scientific article published on March 2016

Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation

scientific article published on 4 April 2013

How the mighty have fallen: fatal infectious diseases of divine composers.

scientific article

How we detect microbes and respond to them: the Toll-like receptors and their transducers

scientific article

Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype

scientific article published on 15 November 2011

Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression

scientific journal article

Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner

scientific article

Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice

scientific article published in April 2012

I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development

scientific article

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

scientific journal article

Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies

scientific article

Identification of a TLR4- and TRIF-dependent activation program of dendritic cells

scientific article published in February 2004

Immunology: Toll-like receptors and antibody responses

scientific article published on May 2006

Impact of β2 integrin deficiency on mouse natural killer cell development and function

scientific article published on 14 January 2011

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation

scientific article published on 23 November 2011

Inferences, questions and possibilities in Toll-like receptor signalling

scientific article published in July 2004

Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism

scientific article published on July 2009

Innate immune responses to microbial poisons: discovery and function of the Toll-like receptors

scientific article

Innate immune sensing and its roots: the story of endotoxin

scientific article

Innate immunity and the new forward genetics

scientific article published on 21 October 2016

Innate immunity: an overview

scientific article published on February 2004

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice

scientific article published on 05 October 2016

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity

scientific article published on 19 February 2018

Intracellular nucleic acid sensors and autoimmunity

scientific article

Intracellular toll-like receptors

scientific article published on March 2010

JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis

scientific article

Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

scientific journal article

Jinx, an MCMV susceptibility phenotype caused by disruption ofUnc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

scientific article

LGP2: positive about viral sensing

scientific article

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

scientific article published on 01 May 2019

LPS in microbial pathogenesis: promise and fulfilment

scientific article

LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins

scientific article published on January 2004

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

scientific article published on 21 November 2011

Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity

scientific article published on 27 December 2007

Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice

scientific article

Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses

scientific article published on January 2003

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening

scientific article published in January 2003

Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection

scientific article

Metabolic characterization of a mouse deficient in all known leptin receptor isoforms

scientific article

Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function

scientific article

Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases

scientific article

Murine cerebral malaria development is independent of toll-like receptor signaling

scientific article

Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells

scientific article published on April 2007

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling

scientific article

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection

scientific journal article

Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice

scientific article

Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation

scientific article published on 01 January 2020

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands

scientific article

N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

scientific article published on 02 March 2021

NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses

scientific article published on 30 April 2009

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

scientific article published on 7 December 2015

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria

scientific article published on 20 August 2006

Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease

scientific article published on December 2007

New frontiers in immunology. Workshop on the road ahead: future directions in fundamental and clinical immunology

scientific article published in July 2005

Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways

scientific article

Not "molecular patterns" but molecules

scientific article published in August 2003

Obituary: Ernest Beutler (1928-2008)

scientific article

PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene

scientific article (publication date: 31 March 2000)

PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development

scientific article published in June 2006

Pathogens, Commensals, and Immunity: From the Perspective of the Urinary Bladder.

scientific article

Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4)

scientific article

Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation

scientific article

Plant and animal sensors of conserved microbial signatures

scientific article

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR

scientific article published on 26 September 2019

Precis on forward genetics in mice

scientific article published on July 2007

Prion-like behavior of MAVS in RIG-I signaling

scientific article published on 20 September 2011

Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer

scientific article

Q&A: Chance encounters

scientific article published in October 2015

QnAs with Bruce Beutler. Interview by Nicholette Zeliadt

scientific article published on 16 July 2012

R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells

scientific article published in March 2006

RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

retracted scientific article

RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events

scientific article

Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes

scientific article published on March 2007

Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis

scientific article

Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.

scientific article published on 30 March 2007

Reconstruction of the Mouse Inflammasome System in HEK293T Cells

scientific article

Resisting viral infection: the gene by gene approach

scientific article

Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice".

scientific article published in November 2013

Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells

scientific article published on 15 April 2013

Science review: key inflammatory and stress pathways in critical illness - the central role of the Toll-like receptors

scientific article

Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha

scientific article

Sensors of the innate immune system: their link to rheumatic diseases

scientific article published on 9 February 2010

Sensors of the innate immune system: their mode of action

scientific article published on 14 July 2009

Severe retinal degeneration caused by a novel rhodopsin mutation.

scientific article

Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.

scientific article published on 12 June 2017

Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation

scientific article

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

scientific article

Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.

scientific article

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids

scientific article published on 03 March 2014

Sox17 regulates liver lipid metabolism and adaptation to fasting

scientific article

Special delivery: granulin brings CpG DNA to Toll-like receptor 9.

scientific article published on April 2011

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis

scientific article published on 19 January 2017

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

scientific journal article

Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

scientific article published on 19 August 2019

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses

scientific article

TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy

scientific article published on January 2006

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

scientific article published on May 2007

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.

scientific article published on February 2016

TLR7: A new sensor of viral infection

scientific article

TNF, Apoptosis and Autoimmunity: A Common Thread?

scientific article published on June 1, 1998

TRAF3: a new component of the TLR-signaling apparatus

The BTB-ZF transcription factors

scientific article published on 16 August 2012

The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung

scientific article published in November 2005

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

scientific article

The Toll-like receptors: analysis by forward genetic methods

scientific article

The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease

scientific article published in December 2009

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

scientific article

The central answer. Interview by Kristie Nybo

scientific article published on May 1, 2013

The class I myosin MYO1D binds to lipid and protects against colitis

scientific article published on 27 September 2018

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis

scientific article

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

scientific journal article

The interface between innate and adaptive immunity

scientific article published in October 2004

The role of Vldlr in intraretinal angiogenesis in mice

scientific article

The serine protease TMPRSS6 is required to sense iron deficiency

scientific article

The sole gateway to endotoxin response: how LPS was identified as Tlr4, and its role in innate immunity

scientific article published in April 2001

The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes

scientific article published on 29 March 2022

Three novel mammalian toll-like receptors: gene structure, expression, and evolution

scientific article (publication date: September 2000)

Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome

scientific article published on 07 May 2020

Toll-like receptor 4 polymorphisms and atherogenesis

scientific article published in December 2002

Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease

scientific article

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

scientific article

Toll-like receptors and their place in immunology. Where does the immune response to infection begin?

scientific article published in July 2004

Toll-like receptors: how they work and what they do

scientific article published on January 1, 2002

Tumor necrosis factor in the pathogenesis of infectious diseases

scientific article published on October 1993

Tumour predisposition and cancer syndromes as models to study gene-environment interactions

scientific article published on 29 May 2020

Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses

scientific article

Type I interferons (alpha/beta) in immunity and autoimmunity

scientific article

UNC93B1 mediates host resistance to infection with Toxoplasma gondii

scientific article

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

scientific article

Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations

scientific article

Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis

scientific article

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

scientific article published on 16 November 2003

Use of transcriptome data to unravel the fine structure of genes involved in sepsis

scientific article

Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice

scientific article

Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway

scientific article published on 12 February 2007

Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis

scientific article published on 22 October 2009

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C

scientific article

YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity

scientific article published on 09 July 2019

Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice

scientific article

ZBTB1 is a determinant of lymphoid development

scientific journal article

iRhom2 is required for the secretion of mouse TNFα

scientific article