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List of works by Peter K Quashie

A high-throughput assay for HIV-1 integrase 3'-processing activity using time-resolved fluorescence.

scientific article

A resveratrol analog termed 3,3',4,4',5,5'-hexahydroxy-trans-stilbene is a potent HIV-1 inhibitor

scientific article published on 18 May 2015

Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.

scientific article

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity.

scientific article published on 17 July 2013

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase.

scientific article published in January 2014

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase.

scientific article published in June 2014

Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase

scientific article published on 30 September 2013

Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.

scientific article

Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir

scientific article

Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations

scientific article

Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors.

scientific article

Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase

scientific article

Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout

scientific article

Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors

scientific article

Evolution of HIV integrase resistance mutations.

scientific article published on February 2013

Evolution of a novel pathway leading to dolutegravir resistance in a patient harbouring N155H and multiclass drug resistance

scientific article published on 3 October 2014

Genomic analysis of SARS-CoV-2 reveals local viral evolution in Ghana

scientific article published on 16 December 2020

HIV Drug Resistance and the Advent of Integrase Inhibitors.

scientific article published on February 2013

HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug.

scientific article published on 21 May 2012

HIV-1 Group O Resistance Against Integrase Inhibitors

scientific article published on 21 May 2015

HIV-1 group O integrase displays lower enzymatic efficiency and higher susceptibility to raltegravir than HIV-1 group M subtype B integrase

scientific article

HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M.

scientific article published on 2 November 2014

Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase

scientific article published on 16 November 2015

In vitro and structural evaluation of PL-100 as a potential second-generation HIV-1 protease inhibitor

scientific article

Integrase strand transfer inhibitors in the management of HIV-positive individuals

scientific article published on 03 March 2014

Low COVID-19 impact in Africa: The multifactorial Nexus

scientific article published in 2021

Molecular mechanism of antagonism between the Y181C and E138K mutations in HIV-1 reverse transcriptase

scientific article

Novel therapeutic strategies targeting HIV integrase

scientific article

Progressive emergence of an S153F plus R263K combination of integrase mutations in the proviral DNA of one individual successfully treated with dolutegravir

scientific article published on 13 November 2020

Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors

scientific article published on March 2014

Resistance to HIV integrase inhibitors.

scientific article published on September 2012

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor

scientific article

Subtype-specific analysis of the K65R substitution in HIV-1 that confers hypersusceptibility to a novel nucleotide-competing reverse transcriptase inhibitor

scientific article published on 16 March 2015

Subunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase

scientific article

The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness

scientific article published on 17 January 2014

The R263K mutation in HIV integrase that is selected by dolutegravir may actually prevent clinically relevant resistance to this compound

scientific article

The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B.

scientific article published on July 2015

The development of novel HIV integrase inhibitors and the problem of drug resistance.

scientific article published on 16 September 2012

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

scientific article published on 22 February 2013

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