List of works by David S Perlin

2385. Ceftazidime–Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa

A Novel, Drug Resistance-Independent, Fluorescence-Based Approach To Measure Mutation Rates in Microbial Pathogens

scientific article published in 2019

A Novel, Rapid, and Low-Volume Assay for Therapeutic Drug Monitoring of Posaconazole and Other Long-Chain Azole-Class Antifungal Drugs

scientific article published in 2018

A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA

scientific article published on 19 March 2020

A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus

scientific article published on 27 August 2007

A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance.

scientific article published on 9 January 2018

A multicentre study to optimize echinocandin susceptibility testing of Aspergillus species with the EUCAST methodology and a broth microdilution colorimetric method

scientific article published on 24 April 2020

A naturally inspired antibiotic to target multidrug-resistant pathogens

scientific article published on 5 January 2022

A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility

scientific article published on 28 April 2008

A novel, tomographic imaging probe for rapid diagnosis of fungal keratitis

scientific article published on 8 December 2017

A real-time PCR assay for rapid detection and quantification of Exserohilum rostratum, a causative pathogen of fungal meningitis associated with injection of contaminated methylprednisolone

scientific article published on 9 January 2013

Absence of azole or echinocandin resistance in Candida glabrata isolates in India despite background prevalence of strains with defects in DNA mismatch repair pathway.

scientific article published on 2 April 2018

Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens

scientific article published on 4 September 2007

Adenovirus-mediated delivery of an anti-V antigen monoclonal antibody protects mice against a lethal Yersinia pestis challenge

scientific article published on 05 January 2009

Albumin Enhances Caspofungin Activity against Aspergillus Species by Facilitating Drug Delivery to Germinating Hyphae

scientific article published on 7 December 2015

An Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs

scientific article

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

scientific article published on 25 May 2022

An optimized vaccine vector based on recombinant vesicular stomatitis virus gives high-level, long-term protection against Yersinia pestis challenge

scientific article published on 22 August 2006

Applying host disease status biomarkers to therapeutic response monitoring in invasive aspergillosis patients

scientific article published on 22 January 2018

Are we ready for novel detection methods to treat respiratory pathogens in hospital-acquired pneumonia?

scientific article

Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1

scientific article published on June 2006

Assessment of two new molecular methods for identification of Candida parapsilosis sensu lato species

scientific article published on 27 July 2011

Azole resistance in Aspergillus fumigatus from bronchoalveolar lavage fluid samples of patients with chronic diseases

scientific article published on 05 March 2013

Azole resistance in Aspergillus: a growing public health menace

scientific article

Beyond tissue concentrations: antifungal penetration at the site of infection

scientific article published on 01 April 2019

Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus.

scientific article published on 7 September 2016

Blood Aspergillus RNA is a promising alternative biomarker for invasive aspergillosis

scientific article published on 22 June 2016

Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing.

scientific article published on 22 December 2008

Breakthrough candidemia due to multidrug-resistant Candida glabrata during prophylaxis with a low dose of micafungin.

scientific article published on 27 January 2014

CD101: a novel long-acting echinocandin

scientific article published on 28 June 2016

Candida krusei colonization in patients with gastrointestinal diseases.

scientific article

Carbohydrate-derived fulvic acid is a highly promising topical agent to enhance healing of wounds infected with drug-resistant pathogens

scientific article published on October 2015

Caspofungin uptake is mediated by a high-affinity transporter in Candida albicans

scientific article published on October 2004

Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies

scientific article published on 15 September 2008

Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa

scientific article published on 01 July 2019

Changes in in vitro susceptibility patterns of Aspergillus to triazoles and correlation with aspergillosis outcome in a tertiary care cancer center (1999-2015).

scientific article published on 31 March 2017

Characterization of porin expression in Klebsiella pneumoniae Carbapenemase (KPC)-producing K. pneumoniae identifies isolates most susceptible to the combination of colistin and carbapenems.

scientific article published on 4 March 2013

Clostridium difficile infection in Brazil: a neglected problem?

scientific article published on 20 February 2014

Comparative study for 147 Candida spp. identification and echinocandins susceptibility in isolates obtained from blood cultures in 15 hospitals, Medellin, Colombia.

scientific article

Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

scientific article published on 17 May 2010

Comparison of dimethyl sulfoxide and water as solvents for echinocandin susceptibility testing by the EUCAST methodology

scientific article

Coping with stress and the emergence of multidrug resistance in fungi

scientific article

Correction for Yang et al., "Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling".

scientific article published on 27 March 2018

Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints

scientific article published on 27 October 2008

Cryptococcus flips its lid - membrane phospholipid asymmetry modulates antifungal drug resistance and virulence

scientific article published on August 2016

De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance

scientific article published on 19 June 2017

Delivering on Antimicrobial Resistance Agenda Not Possible without Improving Fungal Diagnostic Capabilities

scientific article published on 15 February 2017

Detection of Aspergillus fumigatus in a rat model of invasive pulmonary aspergillosis by real-time nucleic acid sequence-based amplification ⬇️

scientific article

Detection of Candida auris antifungal drug resistance markers directly from clinical skin swabs

scientific article published on 07 October 2019

Development and multicentre validation of an agar-based screening method for echinocandin susceptibility testing of Aspergillus species

scientific article published on 01 August 2019

Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1

scientific article published on 21 August 2020

Differential in vivo activities of anidulafungin, caspofungin, and micafungin against Candida glabrata isolates with and without FKS resistance mutations

scientific article

Direct Detection of Emergent Fungal Pathogen Candida auris in Clinical Skin Swabs by SYBR Green-Based Quantitative PCR Assay

scientific article published in 2018

Direct Molecular Diagnosis of Aspergillosis and CYP51A Profiling from Respiratory Samples of French Patients

scientific article published on 29 July 2016

Discrepancies among three laboratory methods for Clostridium difficile detection and a proposal for their optimal use.

scientific article published on 11 December 2013

Doripenem, gentamicin, and colistin, alone and in combinations, against gentamicin-susceptible, KPC-producing Klebsiella pneumoniae strains with various ompK36 genotypes

scientific article

Echinocandin failure case due to a previously unreported FKS1 mutation in Candida krusei

scientific article

Echinocandin resistance: an emerging clinical problem?

scientific article (publication date: December 2014)

Echinocandin susceptibility testing of Candida species: comparison of EUCAST EDef 7.1, CLSI M27-A3, Etest, disk diffusion, and agar dilution methods with RPMI and isosensitest media

scientific article published on 2 November 2009

Echinocandin susceptibility testing of Candida spp. Using EUCAST EDef 7.1 and CLSI M27-A3 standard procedures: analysis of the influence of bovine serum albumin supplementation, storage time, and drug lots.

scientific article published on 18 January 2011

Echovirus 30, Jiangsu Province, China

scientific article published in April 2005

Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint

scientific article published on 22 June 2009

Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis

scientific article published on 18 September 2017

Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates

scientific article published on 9 December 2013

Epidemiology and echinocandin susceptibility of Candida parapsilosis sensu lato species isolated from bloodstream infections at a Spanish university hospital. ⬇️

scientific article

Establishing in vitro-in vivo correlations for Aspergillus fumigatus: the challenge of azoles versus echinocandins.

scientific article published on 21 July 2008

Establishing surrogate markers for fluconazole resistance in Candida albicans

scientific article published in January 2005

Evaluation of CLSI M44-A2 disk diffusion and associated breakpoint testing of caspofungin and micafungin using a well-characterized panel of wild-type and fks hot spot mutant Candida isolates

scientific article published on 28 February 2011

Evaluation of caspofungin susceptibility testing by the new Vitek 2 AST-YS06 yeast card using a unique collection of FKS wild-type and hot spot mutant isolates, including the five most common candida species

scientific article published on 22 October 2012

Evaluation of fungal-specific fluorescent labeled echinocandin probes as diagnostic adjuncts

scientific article published on 15 May 2012

Expression turnover profiling to monitor the antifungal activities of amphotericin B, voriconazole, and micafungin against Aspergillus fumigatus

scientific article published on 6 February 2012

Exserohilum infections: review of 48 cases before the 2012 United States outbreak

scientific article published on 28 March 2014

FDJS03 isolates causing an outbreak of aseptic meningitis in China that evolved from a distinct Echovirus 30 lineage imported from countries of the Commonwealth of Independent States

scientific article

FKS2 and FKS3 genes of opportunistic human pathogen Candida albicans influence echinocandin susceptibility.

scientific article published on 22 January 2018

Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance.

scientific article

Fluconazole and Echinocandin Resistance of Candida glabrata Correlates Better with Antifungal Drug Exposure Rather than with MSH2 Mutator Genotype in a French Cohort of Patients Harboring Low Rates of Resistance.

scientific article published on 23 December 2016

Focused multivector ultraviolet (FMUV) technology rapidly eradicates SARS-CoV-2 in-vitro: Implications for hospital disinfection of COVID-19 environments

publication published on 11 February 2022

Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure

scientific article published on July 2009

Fungal DNA detected in blood samples of patients who received contaminated methylprednisolone injections reveals increased complexity of causative agents

scientific article

Fungal Resistance to Echinocandins and the MDR Phenomenon in

scientific article published on 01 September 2018

Genetic Drivers of Multidrug Resistance in Candida glabrata

scientific article published on 15 December 2016

Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus

scientific article

High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease

scientific article

Host biomarkers of invasive pulmonary aspergillosis to monitor therapeutic response

scientific article

Identification of Drug Resistant Candida auris

scientific article published on 20 August 2019

Improved detection of Candida sp. fks hot spot mutants by using the method of the CLSI M27-A3 document with the addition of bovine serum albumin

scientific article published on 7 March 2011

In vitro activities of anidulafungin and other antifungal agents against biofilms formed by clinical isolates of different Candida and Aspergillus species

scientific article published on 21 March 2011

Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations

scientific article published on 13 March 2013

Isavuconazole Prophylaxis in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients

scientific article published on 01 February 2020

Limited Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility

scholarly article by Kelley R Healey et al published October 2018 in Antimicrobial Agents and Chemotherapy

Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans

scientific article

Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans

scientific article

Mechanisms of Antifungal Drug Resistance

scientific article

Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies.

scientific article published on 15 May 2014

Methylprednisolone impairs conidial phagocytosis but does not attenuate hyphal damage by neutrophils against Exserohilum rostratum

scientific article published on 23 July 2014

Molecular Analysis of Resistance and Detection of Non-Wild-Type Strains Using Etest Epidemiological Cutoff Values for Amphotericin B and Echinocandins for Bloodstream Candida Infections from a Tertiary Hospital in Qatar

scientific article published on 27 August 2018

Molecular Diagnostics in the Times of Surveillance for Candida auris

scientific article published on 20 August 2019

Molecular characterization of fluconazole resistance in a case of Candida albicans ocular infection

scientific article published on December 2004

Molecular diagnostic platforms for detecting Aspergillus

scientific article published on 06 June 2008

Molecular evaluation of the plasma membrane proton pump from Aspergillus fumigatus

scientific article published on March 2002

Multi-azole resistance in Aspergillus fumigatus

scientific article published on 10 October 2006

Multicenter, prospective clinical evaluation of respiratory samples from subjects at risk for Pneumocystis jirovecii infection by use of a commercial real-time PCR assay

scientific article

Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells

scientific article published on 10 August 2021

Multilocus Sequence Typing (MLST) Genotypes of Bloodstream Isolates in Korea: Association With Antifungal Resistance, Mutations in Mismatch Repair Gene (Msh2), and Clinical Outcomes

article

Multilocus sequence typing is a reliable alternative method to DNA fingerprinting for discriminating among strains of Candida albicans

scientific article published on June 2004

Multiplex detection of mutations

scientific article published in January 2008

Mutations of the ompK36 porin gene and promoter impact responses of sequence type 258, KPC-2-producing Klebsiella pneumoniae strains to doripenem and doripenem-colistin.

scientific article published on 12 August 2013

Novel FKS mutations associated with echinocandin resistance in Candida species

scientific article

Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

scientific article published on 01 January 2019

Penetration of Ibrexafungerp (Formerly SCY-078) at the Site of Infection in an Intra-abdominal Candidiasis Mouse Model

scientific article published on 21 February 2020

Performance evaluation of culture-independent SYBR Green Candida auris qPCR diagnostics on anterior nares surveillance swabs

scientific article published on 24 June 2020

Pharmacokinetics of posaconazole within epithelial cells and fungi: insights into potential mechanisms of action during treatment and prophylaxis

scientific article published on August 2013

Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata

scientific article

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

scientific article published on 29 March 2016

Progressive esophagitis caused by Candida albicans with reduced susceptibility to caspofungin.

scientific article

Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis

scientific article published on 7 February 2006

Protective immunity against a lethal respiratory Yersinia pestis challenge induced by V antigen or the F1 capsular antigen incorporated into adenovirus capsid

scientific article

Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans

scientific article published on 15 April 2015

Rapid Detection of ERG11-Associated Azole Resistance and FKS-Associated Echinocandin Resistance in Candida auris.

scientific article published on 21 December 2018

Rapid Detection of FKS-Associated Echinocandin Resistance in Candida glabrata

scientific article published on 22 August 2016

Rapid and Accurate Molecular Identification of the Emerging Multidrug-Resistant Pathogen Candida auris

scientific article published on 24 May 2017

Rapid and quantitative detection of SARS-CoV-2 specific IgG for convalescent serum evaluation

scientific article published on 03 September 2020

Rapid antifungal susceptibility testing by matrix-assisted laser desorption ionization-time of flight mass spectrometry analysis

scientific article

Rapid detection of triazole antifungal resistance in Aspergillus fumigatus

scientific article published on 30 January 2008

Rapid real-time nucleic Acid sequence-based amplification-molecular beacon platform to detect fungal and bacterial bloodstream infections

scientific article published on 29 April 2009

Rapid, high-throughput, multiplex, real-time PCR for identification of mutations in the cyp51A gene of Aspergillus fumigatus that confer resistance to itraconazole

scientific article

Recent Increase in the Prevalence of Fluconazole-Non-susceptible Candida tropicalis Blood Isolates in Turkey: Clinical Implication of Azole-Non-susceptible and Fluconazole Tolerant Phenotypes and Genotyping

scientific article published on 06 October 2020

Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment

scientific article published on 31 March 2008

Reply to "detection of multiple fungal species in blood samples by real-time PCR: an interpretative challenge".

scientific article

Reply to "not over yet: fungal infections following methyl prednisolone injections smoulder on"

scientific article

Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs

scientific article

Review of the Novel Echinocandin Antifungal Rezafungin: Animal Studies and Clinical Data

scientific article published on 28 September 2020

Serum differentially alters the antifungal properties of echinocandin drugs

scientific article published on 9 April 2007

Set of classical PCRs for detection of mutations in Candida glabrata FKS genes linked with echinocandin resistance

scientific article published on 14 May 2014

Significantly Improved Pharmacokinetics Enhances Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis

scholarly article by Yanan Zhao et al published October 2018 in Antimicrobial Agents and Chemotherapy

Single-dose, virus-vectored vaccine protection against Yersinia pestis challenge: CD4+ cells are required at the time of challenge for optimal protection

scientific article published on October 2008

Spontaneous mutational frequency and mutation rates vary by echinocandin agent against

scientific article published on 21 December 2018

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.

scientific article published on 4 June 2019

Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

scholarly article by Clare F Vickers et al published 27 September 2018 in Journal of Medicinal Chemistry

The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Candida glabrata Colonization Mouse Model

scientific article published on 4 October 2017

The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination.

scientific article

Tissue Distribution and Penetration of Isavuconazole at the Site of Infection in Experimental Invasive Aspergillosis in Mice with Underlying Chronic Granulomatous Disease

scientific article published on 24 May 2019

Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling

scientific article published on 21 February 2017

Understanding echinocandin resistance in the emerging pathogen Candida auris.

scientific article published on 9 April 2018

Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-Abdominal Abscess Model.

scientific article published on 24 July 2017

Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-Abdominal Abscess Model.

scientific article published on 4 October 2017

Update on Antifungal Drug Resistance

scientific article published on June 2015

Use of matrix-assisted laser desorption ionization-time of flight mass spectrometry for caspofungin susceptibility testing of Candida and Aspergillus species

scientific article

VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.

scientific article

What can we learn and what do we need to know amidst the iatrogenic outbreak of Exserohilum rostratum meningitis?

scientific article published on 06 May 2013

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