List of works - Claus H. Nielsen

<i>PADI4</i> Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With <i>HLA-DRB1*04</i> and Smoking

scientific article published on 18 October 2021

A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?

A role for autoantibodies in enhancement of pro-inflammatory cytokine responses to a self-antigen, thyroid peroxidase

scientific article published on 01 September 2009

Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay

scientific article published on 22 December 2015

Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

scientific article published on 18 September 2013

Application of new therapies in Graves' disease and thyroid-associated ophthalmopathy: animal models and translation to human clinical trials

scientific article published on September 2008

Associations between gastrointestinal toxicity, micro RNA and cytokine production in patients undergoing myeloablative allogeneic stem cell transplantation

scientific article published on 20 January 2015

Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy

scientific article published on 04 July 2019

Autoantibodies in autoimmune thyroid disease promote immune complex formation with self antigens and increase B cell and CD4+ T cell proliferation in response to self antigens

scientific article published in January 2004

B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study

scientific article published on 06 February 2007

B-cell depletion with rituximab in the treatment of autoimmune diseases. Graves' ophthalmopathy the latest addition to an expanding family

scientific article published on July 2007

B-cell exposure to self-antigen induces IL-10 producing B cells as well as IL-6- and TNF-α-producing B-cell subsets in healthy humans

scientific article published on 17 July 2012

B-cell frequencies and immunoregulatory phenotypes in myeloproliferative neoplasms: Influence of ruxolitinib, interferon-α2, or combination treatment

scientific article published on 18 August 2019

Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis

scientific article published on 26 April 2017

Characterization of Regulatory B Cells in Graves' Disease and Hashimoto's Thyroiditis

scientific article published on 27 May 2015

Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis

scientific article

Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure

scientific article published on 12 November 2019

Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

scientific article

Complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) cooperate in the binding of hydrolyzed complement factor 3 (C3i) to human B lymphocytes

scientific article published on 01 December 2003

Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment

scientific article published on 18 July 2020

Complement's participation in acquired immunity.

scientific article

Decreased interleukin-2 responses to Fusobacterium nucleatum and Porphyromonas gingivalis in generalized aggressive periodontitis

scientific article published in May 2009

Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen

scientific article

Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab.

scientific article published in February 2018

Dietary exposure to benzoxazinoids enhances bacteria-induced monokine responses by peripheral blood mononuclear cells.

scientific article

Diminished ability of erythrocytes from patients with systemic lupus erythematosus to limit opsonized immune complex deposition on leukocytes and activation of granulocytes ⬇️

scientific article published on 01 April 1998

Does a causal relation between cardiovascular disease and periodontitis exist?

scientific article published on 13 December 2011

Effect of Polarization on Airway Epithelial Conditioning of Monocyte-Derived Dendritic Cells

scientific article

Effect of thrombopoietin-receptor agonists on circulating cytokine and chemokine levels in patients with primary immune thrombocytopenia (ITP).

scientific article

Effects of rituximab and dexamethasone on regulatory and proinflammatory B-cell subsets in patients with primary immune thrombocytopenia

scientific article published on 27 September 2017

Effects of the Commercial Flame Retardant Mixture DE-71 on Cytokine Production by Human Immune Cells

scientific article

Enhancement of human adaptive immune responses by administration of a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis

scientific article published in June 2008

Enhancement of natural killer cell activity in healthy subjects by Immulina®, a Spirulina extract enriched for Braun-type lipoproteins

scientific article published on 17 June 2010

Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*

scientific article published on 19 March 2008

Erythrocytes restrict microvesicle-induced production of reactive oxygen species by polymorphonuclear leukocytes

scientific article published on 24 May 2019

Evidence of intrathyroidal B-lymphocyte depletion after rituximab therapy in a patient with Graves' disease

scientific article published on 01 October 2007

Evidence of orbital B and T cell depletion after rituximab therapy in Graves' ophthalmopathy

scientific article published on 01 November 2009

Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients

scientific article published on 10 August 2019

Gene expression profiling in autoimmune diseases: chronic inflammation or disease specific patterns?

scientific article published on 01 May 2007

Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay

scientific article published on 31 December 2013

Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis.

scientific article published on 10 September 2017

Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses

scientific article published on January 2012

Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers.

scientific article

Increased plasma levels of IL-6 in bacteremic periodontis patients after scaling

scientific article published on 10 August 2006

Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group

scientific article published on 01 January 2019

Inflammatory markers and clustered cardiovascular disease risk factors in Danish adolescents

scientific article published on 7 December 2012

Influence of phthalates on cytokine production in monocytes and macrophages: a systematic review of experimental trials

scientific article

Influence of phthalates on in vitro innate and adaptive immune responses

scientific article published on 25 June 2015

Insulin‐like growth factor‐1 and insulin‐like growth factor binding protein‐3: impact on early haematopoietic reconstitution following allogeneic haematopoietic stem cell transplantation

scientific article published in 2021

Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis

scientific article published on August 2014

Lactobacillus reuteri supplements do not affect salivary IgA or cytokine levels in healthy subjects: A randomized, double-blind, placebo-controlled, cross-over trial

scientific article published on 22 April 2016

Lipoprotein cholesterol fractions are related to markers of inflammation in children and adolescents with juvenile idiopathic arthritis: a cross sectional study.

scientific article published on 11 November 2016

Low pretreatment levels of myeloid-related protein-8/14 and C-reactive protein predict poor adherence to treatment with tumor necrosis factor inhibitors in juvenile idiopathic arthritis.

scientific article published on 25 August 2016

Microparticles from patients with systemic lupus erythematosus induce production of reactive oxygen species and degranulation of polymorphonuclear leukocytes

scientific article published on 17 October 2017

Microvesicles in active lupus nephritis show TLR9-dependent co-expression of galectin-3 binding protein and double-stranded DNA

scientific article published on 23 December 2020

Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints".

scientific article published in October 2010

New treatment options for primary immune thrombocytopenia

scientific article

Novel treatment of Graves' disease using the B-lymphocyte depleting agent rituximab

scientific article published in June 2008

Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation

scientific article published on 7 February 2017

Phthalates Are Metabolised by Primary Thyroid Cell Cultures but Have Limited Influence on Selected Thyroid Cell Functions In Vitro

scientific article

Porphyromonas gingivalis in saliva associates with chronic and aggressive periodontitis

scientific article published on 09 August 2019

Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure

scientific article published on 17 January 2019

Protein array-based companion diagnostics in precision medicine

scientific article published on 14 December 2020

Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction

scientific article

Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis-an observational study.

scientific article

Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase

scientific article published in December 2017

Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity.

scientific article published on 28 September 2017

Reconstitution of Th17, Tc17 and Treg cells after paediatric haematopoietic stem cell transplantation: Impact of interleukin-7.

scientific article published on 9 October 2017

Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase

scientific article published on 5 May 2016

Release of active peptidylarginine deiminase into the circulation during acute inflammation induced by coronary artery bypass surgery.

scientific article

Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia

scientific article

Role of a Novel Human Leukocyte Antigen-DQA101:02;DRB115:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.

scientific article published on 24 April 2015

Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis: a phase II study

scientific article published on 26 December 2019

Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis

scientific article published on 20 February 2019

Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis

scientific article published on 22 June 2018

Self-reactive CD4+ T cells and B cells in the blood in health and autoimmune disease: increased frequency of thyroglobulin-reactive cells in Graves' disease

scientific article published on 01 March 2006

Sex differences in the association between level of childhood interleukin-6 and insulin resistance in adolescence

scientific article published on 5 January 2012

Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner

scientific article published on 11 October 2019

Surface complement C3 fragments and cellular binding of microparticles in patients with SLE

scientific article

Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis

scientific article published on 18 December 2018

Targeted biological therapies for Graves' disease and thyroid-associated ophthalmopathy. Focus on B-cell depletion with Rituximab

scientific article

The atherogenic bacterium Porphyromonas gingivalis evades circulating phagocytes by adhering to erythrocytes

scientific article

The classical and alternative pathways of complement activation play distinct roles in spontaneous C3 fragment deposition and membrane attack complex (MAC) formation on human B lymphocytes

scientific article published in January 2004

The extracellular polysaccharide matrix of Pseudomonas aeruginosa biofilms is a determinant of polymorphonuclear leukocyte responses

scientific article published on 19 October 2020

The flame retardant DE-71 (a mixture of polybrominated diphenyl ethers) inhibits human differentiated thyroid cell function in vitro

scientific article

The pathogenesis of primary immune thrombocytopenia

scientific article published on January 24, 2011

The rationale for B lymphocyte depletion in Graves' disease. Monoclonal anti-CD20 antibody therapy as a novel treatment option.

scientific article

The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells

scientific article

The roles of complement receptors type 1 (CR1, CD35) and type 3 (CR3, CD11b/CD18) in the regulation of the immune complex‐elicited respiratory burst of polymorphonuclear leukocytes in whole blood ⬇️

scientific article published on 01 November 1997

Thyroid Peroxidase Antibodies and Prospective Live Birth Rate: A Cohort Study of Women with Recurrent Pregnancy Loss

scientific article published on 24 September 2019

Transcriptomic Fingerprint of Bacterial Infection in Lower Extremity Ulcers

preprint

Transcriptomic fingerprint of bacterial infection in lower extremity ulcers

scientific article published in August 2022

Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies.

scientific article published on 28 October 2008

Treatment-resistant severe, active Graves' ophthalmopathy successfully treated with B lymphocyte depletion

scientific article published on 01 July 2006

Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⁺ T-cell proliferation in human mononuclear cell cultures

scientific article published on 14 December 2011

Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease

scientific article published on 01 May 2008

Uptake and presentation of myelin basic protein by normal human B cells

scientific article

Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis

scientific article

Viable bacteria associated with red blood cells and plasma in freshly drawn blood donations

scientific article

[A possible correlation between periodontitis and ischaemic heart disease] ⬇️

scientific article published on 01 April 2014

[Biological treatment options for Graves' ophthalmopathy]

scientific article published on 01 June 2008

[Rationales for using JAK 1/2 inhibitors in severely afflicted patients with COVID-19 pneumonia] ⬇️

scientific article published on 01 June 2020

[Rituximab (MabThera) as treatment of active rheumatoid arthritis]

scientific article published on 01 November 2006

List of works by Claus H. Nielsen

<i>PADI4</i> Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With <i>HLA-DRB1*04</i> and Smoking

A matrix of cholesterol crystals, but not cholesterol alone, primes human monocytes/macrophages for excessive endotoxin-induced production of tumor necrosis factor-alpha. Role in atherosclerotic inflammation?

A role for autoantibodies in enhancement of pro-inflammatory cytokine responses to a self-antigen, thyroid peroxidase

Absence of Bacteria on Coronary Angioplasty Balloons from Unselected Patients: Results with Use of a High Sensitivity Polymerase Chain Reaction Assay

Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

Application of new therapies in Graves' disease and thyroid-associated ophthalmopathy: animal models and translation to human clinical trials

Associations between gastrointestinal toxicity, micro RNA and cytokine production in patients undergoing myeloablative allogeneic stem cell transplantation

Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy

Autoantibodies in autoimmune thyroid disease promote immune complex formation with self antigens and increase B cell and CD4+ T cell proliferation in response to self antigens

B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study

B-cell depletion with rituximab in the treatment of autoimmune diseases. Graves' ophthalmopathy the latest addition to an expanding family

B-cell exposure to self-antigen induces IL-10 producing B cells as well as IL-6- and TNF-α-producing B-cell subsets in healthy humans

B-cell frequencies and immunoregulatory phenotypes in myeloproliferative neoplasms: Influence of ruxolitinib, interferon-α2, or combination treatment

Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis

Characterization of Regulatory B Cells in Graves' Disease and Hashimoto's Thyroiditis

Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis

Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure

Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

Complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) cooperate in the binding of hydrolyzed complement factor 3 (C3i) to human B lymphocytes

Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment

Complement's participation in acquired immunity.

Decreased interleukin-2 responses to Fusobacterium nucleatum and Porphyromonas gingivalis in generalized aggressive periodontitis

Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen

Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab.

Dietary exposure to benzoxazinoids enhances bacteria-induced monokine responses by peripheral blood mononuclear cells.

Diminished ability of erythrocytes from patients with systemic lupus erythematosus to limit opsonized immune complex deposition on leukocytes and activation of granulocytes ⬇️

Does a causal relation between cardiovascular disease and periodontitis exist?

Effect of Polarization on Airway Epithelial Conditioning of Monocyte-Derived Dendritic Cells

Effect of thrombopoietin-receptor agonists on circulating cytokine and chemokine levels in patients with primary immune thrombocytopenia (ITP).

Effects of rituximab and dexamethasone on regulatory and proinflammatory B-cell subsets in patients with primary immune thrombocytopenia

Effects of the Commercial Flame Retardant Mixture DE-71 on Cytokine Production by Human Immune Cells

Enhancement of human adaptive immune responses by administration of a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis

Enhancement of natural killer cell activity in healthy subjects by Immulina®, a Spirulina extract enriched for Braun-type lipoproteins

Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*

Erythrocytes restrict microvesicle-induced production of reactive oxygen species by polymorphonuclear leukocytes

Evidence of intrathyroidal B-lymphocyte depletion after rituximab therapy in a patient with Graves' disease

Evidence of orbital B and T cell depletion after rituximab therapy in Graves' ophthalmopathy

Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients

Gene expression profiling in autoimmune diseases: chronic inflammation or disease specific patterns?

Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay

Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis.

Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses

Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers.

Increased plasma levels of IL-6 in bacteremic periodontis patients after scaling

Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group

Inflammatory markers and clustered cardiovascular disease risk factors in Danish adolescents

Influence of phthalates on cytokine production in monocytes and macrophages: a systematic review of experimental trials

Influence of phthalates on in vitro innate and adaptive immune responses

Insulin‐like growth factor‐1 and insulin‐like growth factor binding protein‐3: impact on early haematopoietic reconstitution following allogeneic haematopoietic stem cell transplantation

Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis

Lactobacillus reuteri supplements do not affect salivary IgA or cytokine levels in healthy subjects: A randomized, double-blind, placebo-controlled, cross-over trial

Lipoprotein cholesterol fractions are related to markers of inflammation in children and adolescents with juvenile idiopathic arthritis: a cross sectional study.

Low pretreatment levels of myeloid-related protein-8/14 and C-reactive protein predict poor adherence to treatment with tumor necrosis factor inhibitors in juvenile idiopathic arthritis.

Microparticles from patients with systemic lupus erythematosus induce production of reactive oxygen species and degranulation of polymorphonuclear leukocytes

Microvesicles in active lupus nephritis show TLR9-dependent co-expression of galectin-3 binding protein and double-stranded DNA

Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints".

New treatment options for primary immune thrombocytopenia

Novel treatment of Graves' disease using the B-lymphocyte depleting agent rituximab

Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation

Phthalates Are Metabolised by Primary Thyroid Cell Cultures but Have Limited Influence on Selected Thyroid Cell Functions In Vitro

Porphyromonas gingivalis in saliva associates with chronic and aggressive periodontitis

Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure

Protein array-based companion diagnostics in precision medicine

Pseudomonas aeruginosa Microcolonies in Coronary Thrombi from Patients with ST-Segment Elevation Myocardial Infarction

Rapid eye movement-sleep is reduced in patients with acute uncomplicated diverticulitis-an observational study.

Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase

Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity.

Reconstitution of Th17, Tc17 and Treg cells after paediatric haematopoietic stem cell transplantation: Impact of interleukin-7.

Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase

Release of active peptidylarginine deiminase into the circulation during acute inflammation induced by coronary artery bypass surgery.

Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia

Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.

Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis: a phase II study

Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis

Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis

Self-reactive CD4+ T cells and B cells in the blood in health and autoimmune disease: increased frequency of thyroglobulin-reactive cells in Graves' disease

Sex differences in the association between level of childhood interleukin-6 and insulin resistance in adolescence

Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner

Surface complement C3 fragments and cellular binding of microparticles in patients with SLE

Role of a Novel Human Leukocyte Antigen-DQA101:02;DRB115:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.