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List of works by Ines Batinic-Haberle

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations

scientific article

A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.

scientific article published on May 2011

A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics

scientific article published on 27 May 2015

A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.

scientific article published on October 2005

A mechanism-based antioxidant approach for the reduction of skin carcinogenesis

scientific article published in February 2005

A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone

scientific article published on February 2002

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity ⬇️

scientific article published on February 13, 2012

A no-laminectomy spinal cord compression injury model in mice

scientific article

A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

scientific article

ACTR-28. PHASE 1 DOSE ESCALATION TRIAL OF THE SAFETY OF BMX-001 CONCURRENT WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED PATIENTS WITH HIGH-GRADE GLIOMAS

Amelioration of Renal Ischemia-Reperfusion Injury With a Novel Protective Cocktail

scientific article published on 21 October 2011

Amphiphilic cationic Zn-porphyrins with high photodynamic antimicrobial activity.

scientific article published on January 2015

An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation.

scientific article published on July 2008

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways

scientific article

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor

scientific article published on 08 July 2009

Antibacterial Activity of Synthetic Cationic Iron Porphyrins

scientific article published on 10 October 2020

Anticancer therapeutic potential of Mn porphyrin/ascorbate system

scientific article

Antioxidative, Antinitrative, and Vasculoprotective Effects of a Peroxisome Proliferator–Activated Receptor-γ Agonist in Hypercholesterolemia ⬇️

scientific article published on November 10, 2003

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site

scientific article

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.

scientific article

Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency

scientific article published on 18 October 2017

Cellular Redox Modulator, ortho Mn(III) meso-tetrakis(N-n-Hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP5+ in the Treatment of Brain Tumors ⬇️

scientific article published on February 1, 2011

Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues

scientific article published on 5 January 2017

Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection

scientific article published on 21 November 2007

Complex chemistry and biology of redox-active compounds, commonly known as SOD mimics, affect their therapeutic effects

scientific article published on May 2014

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

scientific article published on 15 January 2013

Corrigendum to ‘An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H2O2-driven pathways’ [Redox Biology 5C (2015) 43–65].

scientific article published on 10 September 2015

Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth

scientific article

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

scientific article

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

scientific article

Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.

scientific article published on 16 October 2012

Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System

scientific article published on 27 January 2017

Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.

scientific article published on 06 May 2013

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae

scientific article

Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion

scientific article published on 11 January 2019

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics

scientific article

Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage

scientific article published on 20 January 2010

Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death

scientific article

Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins.

scientific article published on 8 November 2013

Effect of potent redox-modulating manganese porphyrin, MnTM-2-PyP, on the Na(+)/H(+) exchangers NHE-1 and NHE-3 in the diabetic rat.

scientific article published in January 2009

Effects of Manganese Porphyrins on Cellular Sulfur Metabolism

scientific article published on 22 February 2020

Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+.

scientific article published on 9 December 2002

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells

scientific article published on 11 May 2011

Erratum to "Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite" [Free Radic. Biol. Med. 126 (2018) 379-392]

scientific article published on 11 October 2018

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP4+, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H2O)MnTnHex-2-PyP5

scientific article published on 01 June 2020

Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity

scientific article

Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung.

scientific article published on July 2016

IDH1 and IDH2 mutations in gliomas

scientific article

INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.

scientific article published on 26 April 2018

Important cellular targets for antimicrobial photodynamic therapy.

scientific article published on 24 May 2016

Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin.

scientific article published on 23 June 2007

Induction of oxidative cell damage by photo-treatment with zinc meta N-methylpyridylporphyrin

scientific article published in January 2007

Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.

scientific article published in February 2007

Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin

scientific article published on 18 May 2017

Intracellular targeting and pharmacological activity of the superoxide dismutase mimics MnTE-2-PyP5+ and MnTnHex-2-PyP5+ regulated by their porphyrin ring substituents

scientific article published on 3 April 2013

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications

scientific article published on 20 September 2013

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury

scientific article published on February 2007

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.

scientific article

Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation

scientific article published in November 2007

Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells

scientific article published on 26 February 2015

Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models

scientific article published on 02 December 2020

Manganese Porphyrin, MnTE-2-PyP5+, Acts as a Pro-Oxidant to Potentiate Glucocorticoid-Induced Apoptosis in Lymphoma Cells ⬇️

scientific article published on February 11, 2012

Manganese Porphyrin-Based SOD Mimetics Produce Polysulfides from Hydrogen Sulfide

scientific article published on 12 December 2019

Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite

scientific article published on 23 August 2018

Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion.

scientific article published on 28 February 2007

Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats ⬇️

scientific article published on June 12, 2011

Manganese superoxide dismutase, MnSOD and its mimics

scientific article published on 09 December 2011

Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin

scientific article published on May 2014

Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia

scientific article published on 20 July 2013

Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.

scientific article published on 30 March 2017

Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells

scientific article published on November 2013

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.

scientific article published on 8 March 2011

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

scientific article published on 20 March 2018

Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury

scientific article published on 28 August 2018

Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death

scientific article

Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells

scientific article published on 05 July 2013

Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo

scientific article published on 01 June 2020

Mn porphyrins as novel molecular magnetic resonance imaging contrast agents

scientific article

Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression ⬇️

scientific article published on April 14, 2011

Mn-porphyrins as novel molecular magnetic resonance imaging contrast agents

scientific article

MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management

scientific article published on 23 October 2018

Motor Deficits Are Triggered by Reperfusion-Reoxygenation Injury as Diagnosed by MRI and by a Mechanism Involving Oxidants ⬇️

scientific article published on April 18, 2012

Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy

scientific article

NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability ⬇️

scientific article published on March 17, 2011

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

scientific article

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier

scientific article published on 25 May 2016

Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage

scientific article

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

scientific article

Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.

scientific article published on 9 December 2015

Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints.

scientific article published on 25 November 2015

Opinion on Schmidt et al

scientific article published on 01 March 2016

Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy.

scientific article

Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: Detection, oxidative damage and catalytic removal by Mn–porphyrins ⬇️

scientific article published on November 8, 2012

Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells.

scientific article published on May 2006

Porphyrin-Based SOD Mimic MnTnBu OE -2-PyP Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis

scientific article published on 01 October 2018

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.

scientific article published on 7 March 2018

Post-illumination cellular effects of photodynamic treatment

scientific article published on 4 December 2017

Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide

scientific article

Protein damage by photo-activated Zn(II) N-alkylpyridylporphyrins.

scientific article published on 18 June 2010

Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+).

scientific article

Radiation induces aerobic glycolysis through reactive oxygen species.

scientific article published on 28 March 2013

Radiation-mediated tumor growth inhibition is significantly enhanced with redox-active compounds that cycle with ascorbate

scientific article published in February 2018

Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.

scientific article

Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.

scientific article published on 21 April 2009

Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents

scientific article

Reactions of Manganese Porphyrins with Peroxynitrite and Carbonate Radical Anion ⬇️

scientific article published on April 16, 2003

Redox-Active Drug, MnTE-2-PyP5+, Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function

scientific article published on 21 March 2020

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.

scientific article published on 10 October 2015

Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite

scientific article published on 11 May 2006

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).

scientific article published on 09 January 2014

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways ⬇️

scientific article published on May 20, 2014

Second-Sphere Coordination of Ferrioxamine B and Association of Deferriferrioxamine B, CH3(CH2)4NH3+, NH4+, K+, and Mg2+ with Synthetic Crown Ethers and the Natural Ionophores Valinomycin and Nonactin in Chloroform ⬇️

scientific article published on April 10, 1996

Sublethal Photodynamic Treatment Does Not Lead to Development of Resistance

scientific article published on 31 July 2018

Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages

scientific article published on 01 January 2007

Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum

scientific article published on 25 October 2013

Targeting mitochondria by Zn(II)N-alkylpyridylporphyrins: the impact of compound sub-mitochondrial partition on cell respiration and overall photodynamic efficacy

scientific article

The Administration of Renoprotective Agents Extends Warm Ischemia in a Rat Model ⬇️

scientific article published on February 25, 2013

The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells

scientific article published on 17 October 2019

The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies

scientific article

The manganese(III) porphyrin MnTnHex-2-PyP modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells

The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: impact in doxorubicin-treated cells

article published in 2018

The potential of Zn(II) N-alkylpyridylporphyrins for anticancer therapy.

scientific article published on February 2011

Thiol regulation by Mn porphyrins, commonly known as SOD mimics

scientific article published on 13 February 2019

UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation

scientific article published on 11 March 2019

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

scientific article published on 15 March 2017

Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues

scientific article published on 01 January 2019

Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells.

scientific article published on 19 January 2018

XIAP Inhibition and Generation of Reactive Oxygen Species Enhances TRAIL Sensitivity in Inflammatory Breast Cancer Cells ⬇️

scientific article published on April 16, 2012

p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase

scientific article

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