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List of works by Alexander D Crawford

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

scientific article

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling

scientific article (publication date: 2013)

Anti-Inflammatory Activity and Cheminformatics Analysis of New Poten t 2-Substituted 1-Methyl-5-Nitroindazolinones

scientific article published on 19 January 2018

Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models.

scientific article published on 5 April 2012

Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles ⬇️

scientific article published on 20 May 2020

Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

scientific article published on 6 February 2015

Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.

scientific article published in October 2011

CHD2 variants are a risk factor for photosensitivity in epilepsy

scientific article published on 17 March 2015

CaSiAn: a Calcium Signaling Analyzer tool

scientific article published on 01 September 2018

Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio).

scientific article published in October 2009

Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.

scientific article

De novo loss-of-function mutations in CHD2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with Dravet syndrome

scientific article

Deep learning image recognition enables efficient genome editing in zebrafish by automated injections

scientific article published in PLoS ONE

Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: the nitroindazolinone chemotype

scientific article

Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae

scientific article

Fishing Anti-Inflammatories from Known Drugs: In Silico Repurposing, Design, Synthesis and Biological Evaluation of Bisacodyl Analogues

scientific article published on 17 August 2017

Fishing for a deeper understanding of nicotine effects using zebrafish behavioural models

scientific article published on 26 November 2019

Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery

scientific article published on May 2008

High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae)

scientific article published in February 2019

Identification of GSK-3 as a potential therapeutic entry point for epilepsy

article

Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products

scientific article

Marine Biodiscovery Goes Deeper: Using In Vivo Bioassays Based on Model Organisms to Identify Biomedically Relevant Marine Metabolites

scientific article published on 18 May 2016

Metabolite profiling of Javanese ginger Zingiber purpureum and identification of antiseizure metabolites via a low-cost open-source zebrafish bioassay-guided isolation

scientific article published on 06 July 2020

Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes

scientific article published on 2 November 2014

Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolites

scientific article (publication date: 2013)

Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine

scientific article

Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency

scientific article published on 27 September 2019

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target

scientific article published on 19 June 2013

Potential of zebrafish as a model for exploring the role of the amygdala in emotional memory and motivational behavior

scientific article published on 2 February 2016

Seizing the moment: Zebrafish epilepsy models

scientific article published on 13 June 2020

Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.

scientific article

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination

scientific article

Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish

scientific article published on 18 September 2008

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.

scientific article

Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products

scientific article published on 01 January 2012

Zebrafish bioassay-guided isolation of antiseizure compounds from the Cameroonian medicinal plant Cyperus articulatus L

scientific article published on 23 January 2020

Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum

scientific article published on 8 September 2014

Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants

scientific article

Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B ⬇️

scientific article published on 25 October 2019

Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi.

scientific article

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