List of works - Winfried Denk

3D segmentation of SBFSEM images of neuropil by a graphical model over supervoxel boundaries

scientific article published on 19 December 2011

3D structural imaging of the brain with photons and electrons

scientific article published on December 2008

A dendrite-autonomous mechanism for direction selectivity in retinal starburst amacrine cells

scientific article

Action potentials reliably invade axonal arbors of rat neocortical neurons.

scientific article published on August 2000

Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing

scientific article

Alpha-herpesvirus infection induces the formation of nuclear actin filaments

scientific article

Anatomical and functional imaging of neurons using 2-photon laser scanning microscopy

scientific article

Axon tracking in serial block-face scanning electron microscopy

scientific article published on 5 June 2008

Axons and synaptic boutons are highly dynamic in adult visual cortex

scientific article

Boundary Learning by Optimization with Topological Constraints

article

Coherence-gated wave-front sensing in strongly scattering samples

scientific article

Connectomic reconstruction of the inner plexiform layer in the mouse retina

scientific article published in August 2013

Contour-propagation algorithms for semi-automated reconstruction of neural processes

scientific article

Convolutional networks can learn to generate affinity graphs for image segmentation.

scientific article

Corrigendum to "Progress and remaining challenges in high-throughput volume electron microscopy" [Curr Opin Neurobiol 50 (June 2018) 261-267]

scientific article published on 01 April 2019

Dendritic processing

scientific article

Direct measurement of coupling between dendritic spines and shafts.

scientific article published in May 1996

Directionally selective calcium signals in dendrites of starburst amacrine cells

scientific article published on 4 August 2002

EM connectomics reveals axonal target variation in a sequence-generating network

scientific article

Enhanced two-photon excitation through optical fiber by single-mode propagation in a large core

scientific article published on 01 May 2002

Eyecup scope--optical recordings of light stimulus-evoked fluorescence signals in the retina.

scientific article

Full reconstruction of large lobula plate tangential cells in Drosophila from a 3D EM dataset

scientific article published in PLoS ONE

Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control

scientific article

Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging

scholarly article

High sensitivity of Stark-shift voltage-sensing dyes by one- or two-photon excitation near the red spectral edge.

scientific article published on July 2004

High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe

scientific article

High-accuracy neurite reconstruction for high-throughput neuroanatomy.

scientific article published on 10 July 2011

High-precision automated reconstruction of neurons with flood-filling networks

article published in 2018

High-resolution whole-brain staining for electron microscopic circuit reconstruction

scientific article (publication date: 13 April 2015)

Imaging calcium dynamics in dendritic spines

scientific article published on June 1996

Imaging in vivo: watching the brain in action

scientific article

In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons

scientific article published in November 1999

In vivo dendritic calcium dynamics in neocortical pyramidal neurons

scientific article published on January 1997

Large-scale automated histology in the pursuit of connectomes

scientific article

Learning to Agglomerate Superpixel Hierarchies ⬇️

scientific article published in January 2011

Learning to segment neurons with non-local quality measures

scientific article published on 01 January 2013

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo

scientific article

Light-efficient, quantum-limited interferometric wavefront estimation by virtual mode sensing

scientific article published on 01 May 2006

Long Duration Three-Dimensional Imaging of Calcium Waves in Zebrafish Using Multiphoton Fluorescence Microscopy ⬇️

scientific article published on 01 October 2003

Low-dosage Maximum-A-Posteriori Focusing and Stigmation

scientific article

Maximin affinity learning of image segmentation ⬇️

scientific article published in January 2009

Mechanisms of calcium influx into hippocampal spines: heterogeneity among spines, coincidence detection by NMDA receptors, and optical quantal analysis.

scientific article published in March 1999

Miniaturization of two-photon microscopy for imaging in freely moving animals

scientific article

Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis

scientific article

Neurotechnology: Summa technologiae

scientific article published on 03 February 2012

New developments in multiphoton microscopy

scientific article

On the fundamental imaging-depth limit in two-photon microscopy

scientific article published in December 2006

Oscillations and gaseous oxides in invertebrate olfaction

scientific article

Photon upmanship: why multiphoton imaging is more than a gimmick

scientific article

Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development

scientific article published on 20 August 2006

Principles of multiphoton-excitation fluorescence microscopy

scientific article published on 01 October 2007

Progress and remaining challenges in high-throughput volume electron microscopy

scientific article published on 12 May 2018

Properties of coherence-gated wavefront sensing

scientific article published in November 2007

Rapid axonal sprouting and pruning accompany functional reorganization in primary visual cortex

scientific article published on December 2009

Second-harmonic generation imaging of membrane potential with retinal analogues.

scientific article published in January 2011

Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure

scientific article

Single-protein detection in crowded molecular environments in cryo-EM images

scientific article published on 3 May 2017

Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor

scientific article published in September 2008

Space-time wiring specificity supports direction selectivity in the retina

scientific article

Spatiotemporally graded NMDA spike/plateau potentials in basal dendrites of neocortical pyramidal neurons

scientific article

Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo

scientific article published in January 1999

Staining and embedding the whole mouse brain for electron microscopy

scientific article

Structural neurobiology: missing link to a mechanistic understanding of neural computation

scientific article published on 22 February 2012

Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo

scientific article published on 23 December 2007

Targeted whole-cell recordings in the mammalian brain in vivo

scientific article published in September 2003

The Kavli Prize winners. Interview by Darran Yates

scientific article

The Mind of a Mouse

scientific article published on 01 September 2020

The big and the small: challenges of imaging the brain's circuits

scientific article

The three-dimensional micro- and nanostructure of the aortic medial lamellar unit measured using 3D confocal and electron microscopy imaging

scientific article published on 13 November 2007

Towards neural circuit reconstruction with volume electron microscopy techniques

scientific article published on 8 September 2006

Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo

scientific article

Two-photon imaging to a depth of 1000 microm in living brains by use of a Ti:Al2O3 regenerative amplifier

scientific article published in June 2003

Two-photon targeted patching (TPTP) in vivo

scientific article

Visually evoked activity in cortical cells imaged in freely moving animals

scientific article

Volume EM Reconstruction of Spinal Cord Reveals Wiring Specificity in Speed-Related Motor Circuits

scientific article published on 01 June 2018

Wiring specificity in the direction-selectivity circuit of the retina

scientific article

You can't teach a middle-aged ganglion new tricks

scientific article published on 01 September 2003

List of works by Winfried Denk

3D segmentation of SBFSEM images of neuropil by a graphical model over supervoxel boundaries

3D structural imaging of the brain with photons and electrons

A dendrite-autonomous mechanism for direction selectivity in retinal starburst amacrine cells

Action potentials reliably invade axonal arbors of rat neocortical neurons.

Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing

Alpha-herpesvirus infection induces the formation of nuclear actin filaments

Anatomical and functional imaging of neurons using 2-photon laser scanning microscopy

Axon tracking in serial block-face scanning electron microscopy

Axons and synaptic boutons are highly dynamic in adult visual cortex

Boundary Learning by Optimization with Topological Constraints

Coherence-gated wave-front sensing in strongly scattering samples

Connectomic reconstruction of the inner plexiform layer in the mouse retina

Contour-propagation algorithms for semi-automated reconstruction of neural processes

Convolutional networks can learn to generate affinity graphs for image segmentation.

Corrigendum to "Progress and remaining challenges in high-throughput volume electron microscopy" [Curr Opin Neurobiol 50 (June 2018) 261-267]

Dendritic processing

Direct measurement of coupling between dendritic spines and shafts.

Directionally selective calcium signals in dendrites of starburst amacrine cells

EM connectomics reveals axonal target variation in a sequence-generating network

Enhanced two-photon excitation through optical fiber by single-mode propagation in a large core

Eyecup scope--optical recordings of light stimulus-evoked fluorescence signals in the retina.

Full reconstruction of large lobula plate tangential cells in Drosophila from a 3D EM dataset

Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control

Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging

High sensitivity of Stark-shift voltage-sensing dyes by one- or two-photon excitation near the red spectral edge.

High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe

High-accuracy neurite reconstruction for high-throughput neuroanatomy.

High-precision automated reconstruction of neurons with flood-filling networks

High-resolution whole-brain staining for electron microscopic circuit reconstruction

Imaging calcium dynamics in dendritic spines

Imaging in vivo: watching the brain in action

In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons

In vivo dendritic calcium dynamics in neocortical pyramidal neurons

Large-scale automated histology in the pursuit of connectomes

Learning to Agglomerate Superpixel Hierarchies ⬇️

Learning to segment neurons with non-local quality measures

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo

Light-efficient, quantum-limited interferometric wavefront estimation by virtual mode sensing

Long Duration Three-Dimensional Imaging of Calcium Waves in Zebrafish Using Multiphoton Fluorescence Microscopy ⬇️

Low-dosage Maximum-A-Posteriori Focusing and Stigmation

Maximin affinity learning of image segmentation ⬇️

Mechanisms of calcium influx into hippocampal spines: heterogeneity among spines, coincidence detection by NMDA receptors, and optical quantal analysis.

Miniaturization of two-photon microscopy for imaging in freely moving animals

Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis

Neurotechnology: Summa technologiae

New developments in multiphoton microscopy

On the fundamental imaging-depth limit in two-photon microscopy

Oscillations and gaseous oxides in invertebrate olfaction

Photon upmanship: why multiphoton imaging is more than a gimmick

Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development

Principles of multiphoton-excitation fluorescence microscopy

Progress and remaining challenges in high-throughput volume electron microscopy

Properties of coherence-gated wavefront sensing

Rapid axonal sprouting and pruning accompany functional reorganization in primary visual cortex

Second-harmonic generation imaging of membrane potential with retinal analogues.

Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure

Single-protein detection in crowded molecular environments in cryo-EM images

Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor

Space-time wiring specificity supports direction selectivity in the retina

Spatiotemporally graded NMDA spike/plateau potentials in basal dendrites of neocortical pyramidal neurons

Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo

Staining and embedding the whole mouse brain for electron microscopy

Structural neurobiology: missing link to a mechanistic understanding of neural computation

Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo

Targeted whole-cell recordings in the mammalian brain in vivo

The Kavli Prize winners. Interview by Darran Yates

The Mind of a Mouse

The big and the small: challenges of imaging the brain's circuits

The three-dimensional micro- and nanostructure of the aortic medial lamellar unit measured using 3D confocal and electron microscopy imaging

Towards neural circuit reconstruction with volume electron microscopy techniques

Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo

Two-photon imaging to a depth of 1000 microm in living brains by use of a Ti:Al2O3 regenerative amplifier

Two-photon targeted patching (TPTP) in vivo

Visually evoked activity in cortical cells imaged in freely moving animals

Volume EM Reconstruction of Spinal Cord Reveals Wiring Specificity in Speed-Related Motor Circuits

Wiring specificity in the direction-selectivity circuit of the retina

You can't teach a middle-aged ganglion new tricks