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List of works by Wijnand Helfrich

(99m)technetium-HYNIC(tricine/TPPTS)-Aca-bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model

scientific article published on 30 June 2011

A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity.

scientific article published on 26 October 2013

A CSPG4-specific immunotoxin kills rhabdomyosarcoma cells and binds to primary tumor tissues

scientific article

A better TRAIL variant for tumor cell-specific targeting? - letter

scientific article published on 05 October 2010

A discordance between the human muscle NCAM sequence and those seen in other NCAM cDNA clones

scientific article published on February 28, 1992

A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein.

scientific article published on April 2016

A novel bispecific antibody for EGFR-directed blockade of the PD-1/PD-L1 immune checkpoint

scientific article published on 31 May 2018

A single chain (scFv425):sTRAIL fusion protein with specificity for the EGF receptor is effective in vitro but not in an in vivo brain tumor animal model

scientific article

A versatile pretargeting approach for tumour-selective delivery and activation of TNF superfamily members

scientific article published on 16 October 2017

Adenovirus-mediated interleukin-13 gene therapy attenuates acute kidney allograft injury

scientific article published in December 2007

An update of radiolabeled bombesin analogs for gastrin-releasing peptide receptor targeting

scientific article published on January 2013

Analysis of in vitro lymphocyte adhesion and transendothelial migration by fluorescent-beads-based flow cytometric cell counting

scientific article published on 01 May 1998

Antibody-based fusion proteins to target death receptors in cancer.

scientific article published on 06 January 2011

Antigen-specific active immunotherapy for ovarian cancer

scientific article (publication date: 17 September 2014)

Antigen-specific active immunotherapy for ovarian cancer

scientific article

Antigen-specific active immunotherapy for ovarian cancer

scientific article (publication date: 16 July 2008)

Antigen-specific active immunotherapy for ovarian cancer

Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients: a first-in-man study

scientific article published on 26 July 2013

Bifunctional antibody fragment-based fusion proteins for the targeted elimination of pathogenic T-cell subsets

scientific article published in January 2014

Bispecific Antibody Approach for Improved Melanoma-Selective PD-L1 Immune Checkpoint Blockade

scientific article published on 23 May 2019

Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα "don't eat me" immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation

scientific article published on 29 September 2020

C-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity

scientific article

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy.

scientific article published on 16 September 2016

CD20(+) T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer

scientific article

CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination

scientific article published on 12 June 2014

CD20-selective inhibition of CD47-SIRPα “don't eat me” signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab

scientific article published on 31 October 2017

CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia

scientific article

CSPG4: A Target for Selective Delivery of Human Cytolytic Fusion Proteins and TRAIL.

scientific article published on 28 June 2017

Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats

scientific article published on 5 May 2010

Cell surface delivery of TRAIL strongly augments the tumoricidal activity of T cells

scientific article published on 13 July 2011

Construction and characterization of a bispecific diabody for retargeting T cells to human carcinomas

scientific article published on 01 April 1998

Development of Bispecific Antibody Derivatives for Cancer Immunotherapy

scientific article published on 01 January 2019

Dual-Modality Image-Guided Surgery of Prostate Cancer with a Radiolabeled Fluorescent Anti-PSMA Monoclonal Antibody

scientific article published on 3 April 2014

EpCAM-selective elimination of carcinoma cells by a novel MAP-based cytolytic fusion protein

scientific article

EpCAM-targeted induction of apoptosis.

scientific article published on May 2008

Evaluation of a technetium-99m labeled bombesin homodimer for GRPR imaging in prostate cancer

scientific article

Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells

scientific article

Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer

scientific article published in July 2009

Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to fas-induced apoptosis

scientific article published on February 2007

Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects

scientific article published on 15 December 2011

Galectin-9 activates and expands human T-helper 1 cells.

scientific article

Granzyme B-based cytolytic fusion protein targeting EpCAM specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model

scientific article published on 21 January 2016

Human scFv SIgA expressed onLactococcus lactisas a vector for the treatment of mucosal disease

scientific article published on 01 August 2008

In vitro and in vivo characterization of temoporfin-loaded PEGylated PLGA nanoparticles for use in photodynamic therapy

In vivo responses of human A375M melanoma to a σ ligand: 18F-FDG PET imaging

scientific article published on 12 August 2013

Melanoma-Directed Activation of Apoptosis Using a Bispecific Antibody Directed at MCSP and TRAIL Receptor-2/Death Receptor-5.

scientific article published on 2 December 2015

Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo

scientific article published on 23 November 2010

Modular medical imaging agents based on azide-alkyne Huisgen cycloadditions: Synthesis and pre-clinical evaluation of 18F-labeled PSMA-tracers for prostate cancer imaging

scientific article published on 21 April 2020

Near-infrared fluorescence (NIRF) imaging in breast-conserving surgery: Assessing intraoperative techniques in tissue-simulating breast phantoms ⬇️

scientific article published on November 24, 2010

Photochemical internalization (PCI)-mediated enhancement of bleomycin cytotoxicity by liposomal mTHPC formulations in human head and neck cancer cells

scientific article

Potent systemic anticancer activity of adenovirally expressed EGFR-selective TRAIL fusion protein

scientific article published on 23 September 2008

Pretargeted dual-modality immuno-SPECT and near-infrared fluorescence imaging for image-guided surgery of prostate cancer

scientific article published on 24 September 2014

Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction

scientific article published on 6 July 2016

Prospects in radionuclide imaging of prostate cancer

scientific article

Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition

scientific article published on 10 October 2018

SNAP-tag based agents for preclinical in vitro imaging in malignant diseases.

scientific article published in January 2013

Selective elimination of pathogenic synovial fluid T-cells from rheumatoid arthritis and juvenile idiopathic arthritis by targeted activation of Fas-apoptotic signaling

scientific article published on 15 April 2011

Selective induction of apoptosis in leukemic B-lymphoid cells by a CD19-specific TRAIL fusion protein

scientific article published on 31 July 2007

Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with speci

scientific article

Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists

scientific article

Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.

scientific article published in March 2004

Target cell-restricted apoptosis induction of acute leukemic T cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7.

scientific article

Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death

scientific article published on 17 April 2014

Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells

scientific article

Targeted elimination of activated hepatic stellate cells by an anti-epidermal growth factor-receptor single chain fragment variable antibody-tumor necrosis factor-related apoptosis-inducing ligand (scFv425-sTRAIL).

scientific article

Targeted induction of apoptosis for cancer therapy: current progress and prospects.

scientific article published on 23 June 2006

Targeting human prostate cancer with 111In-labeled D2B IgG, F(ab')2 and Fab fragments in nude mice with PSMA-expressing xenografts

scientific article published on 25 April 2014

Targeting the messengers of death: the advent of selective activation of apoptosis for cancer therapy

scientific article published on 01 June 2006

The efficacy of alginate encapsulated CHO-K1 single chain-TRAIL producer cells in the treatment of brain tumors

scientific article published on 6 April 2006

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

scientific article

The ever-expanding immunomodulatory role of calreticulin in cancer immunity

scientific article

The glycan-binding protein galectin-9 has direct apoptotic activity toward melanoma cells.

scientific article published on 10 May 2012

Therapeutic potential of Galectin-9 in human disease

scientific article published on 26 July 2011

Tumor-targeted immune complex formation: effects on myeloid cell activation and tumor-directed immune cell migration

scientific article published on April 2002

Use of the EGP-2/Ep-CAM promoter for targeted expression of heterologous genes in carcinoma derived cell lines

scientific article published in September 2004

Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein

scholarly article

Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway

scientific journal article

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