List of works - Mitsuo Ikebe

A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX

scientific article

A unique mechanism for the processive movement of single-headed myosin-IX

scientific article

Activated full-length myosin-X moves processively on filopodia with large steps toward diverse two-dimensional directions

scientific article

Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse

scientific article

BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity

scientific article

Cargo binding activates myosin VIIA motor function in cells ⬇️

scientific article published on April 11, 2011

Characterization of the motor activity of mammalian myosin VIIA

scientific journal article

Crosstalk between adenosine A1 and β1‐adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytes ⬇️

scientific article published on September 1, 2012

Cryo-EM structure of the inhibited (10S) form of myosin II

scientific article published on 02 December 2020

DOC-2/DAB2 is the binding partner of myosin VI.

scientific article

Determination of human myosin III as a motor protein having a protein kinase activity

scientific article

Exosomes in Human Breast Milk Promote EMT.

scientific article

F-actin and myosin II binding domains in supervillin

scientific article

Force-dependent detachment of kinesin-2 biases track switching at cytoskeletal filament intersections.

scientific article

Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity

scientific article

Human myosin III is a motor having an extremely high affinity for actin

scientific article

Human myosin VIIa is a very slow processive motor protein on various cellular actin structures

scientific article published on 15 May 2017

Human myosin Vc is a low duty ratio nonprocessive motor

scientific article

Impacts of Usher syndrome type IB mutations on human myosin VIIa motor function

scientific article

Inhibition of Glycogen Synthase Kinase 3β Blocks Mesomesenchymal Transition and Attenuates Streptococcus pneumonia-Mediated Pleural Injury in Mice

scientific article

KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis

scientific article published on 4 July 2017

Mechanical characterization of one-headed myosin-V using optical tweezers

scientific article

Mesomesenchymal transition of pleural mesothelial cells is PI3K and NF-κB dependent

scientific article published on 17 April 2015

Myocardin Is Involved in Mesothelial-Mesenchymal Transition of Human Pleural Mesothelial Cells

scientific article published on 01 July 2019

Myosin IXb is a single-headed minus-end-directed processive motor

scientific article

Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity

scientific article

Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation

scientific article

Myosin X transports Mena/VASP to the tip of filopodia.

scientific article

Myosin-Va regulates exocytosis through the submicromolar Ca2+-dependent binding of syntaxin-1A.

scientific article

Myosin-X induces filopodia by multiple elongation mechanism

scientific article

NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection

scientific article

Novel ZIP kinase isoform lacks leucine zipper

scientific article

Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency

scientific article published on 13 May 2016

Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase

scientific journal article

Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungs

scientific article

Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene

scientific article published on 18 October 2019

Reverse conformational changes of the light chain-binding domain of myosin V and VI processive motor heads during and after hydrolysis of ATP by small-angle X-ray solution scattering

scientific article

Single-molecule stepping and structural dynamics of myosin X.

scientific article

Smooth muscle myosin phosphorylated at single head shows sustained mechanical activity

scientific article

Structure and Regulation of the Movement of Human Myosin VIIA.

scientific article published on 22 May 2015

Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery

scientific article

The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella

scientific article

The cellular and molecular basis of bitter tastant-induced bronchodilation

scientific article (publication date: 2013)

The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss.

scientific article

The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.

scientific article

The phosphorylation of myosin II at the Ser1 and Ser2 is critical for normal platelet-derived growth factor induced reorganization of myosin filaments

scientific article

Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella

scientific article

Unconstrained steps of myosin VI appear longest among known molecular motors

scientific article

ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts

scientific journal article

ZIPK is critical for the motility and contractility of VSMCs through the regulation of nonmuscle myosin II isoforms

scientific article

p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA

scientific article

p53- and PAI-1-mediated induction of C-X-C chemokines and CXCR2: importance in pulmonary inflammation due to cigarette smoke exposure

scientific article

List of works by Mitsuo Ikebe

A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX

A unique mechanism for the processive movement of single-headed myosin-IX

Activated full-length myosin-X moves processively on filopodia with large steps toward diverse two-dimensional directions

Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse

BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity

Cargo binding activates myosin VIIA motor function in cells ⬇️

Characterization of the motor activity of mammalian myosin VIIA

Crosstalk between adenosine A1 and β1‐adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytes ⬇️

Cryo-EM structure of the inhibited (10S) form of myosin II

DOC-2/DAB2 is the binding partner of myosin VI.

Determination of human myosin III as a motor protein having a protein kinase activity

Exosomes in Human Breast Milk Promote EMT.

F-actin and myosin II binding domains in supervillin

Force-dependent detachment of kinesin-2 biases track switching at cytoskeletal filament intersections.

Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity

Human myosin III is a motor having an extremely high affinity for actin

Human myosin VIIa is a very slow processive motor protein on various cellular actin structures

Human myosin Vc is a low duty ratio nonprocessive motor

Impacts of Usher syndrome type IB mutations on human myosin VIIa motor function

Inhibition of Glycogen Synthase Kinase 3β Blocks Mesomesenchymal Transition and Attenuates Streptococcus pneumonia-Mediated Pleural Injury in Mice

KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis

Mechanical characterization of one-headed myosin-V using optical tweezers

Mesomesenchymal transition of pleural mesothelial cells is PI3K and NF-κB dependent

Myocardin Is Involved in Mesothelial-Mesenchymal Transition of Human Pleural Mesothelial Cells

Myosin IXb is a single-headed minus-end-directed processive motor

Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity

Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation

Myosin X transports Mena/VASP to the tip of filopodia.

Myosin-Va regulates exocytosis through the submicromolar Ca2+-dependent binding of syntaxin-1A.

Myosin-X induces filopodia by multiple elongation mechanism

NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection

Novel ZIP kinase isoform lacks leucine zipper

Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency

Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase

Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungs

Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene

Reverse conformational changes of the light chain-binding domain of myosin V and VI processive motor heads during and after hydrolysis of ATP by small-angle X-ray solution scattering

Single-molecule stepping and structural dynamics of myosin X.

Smooth muscle myosin phosphorylated at single head shows sustained mechanical activity

Structure and Regulation of the Movement of Human Myosin VIIA.

Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery

The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella

The cellular and molecular basis of bitter tastant-induced bronchodilation

The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss.

The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.

The phosphorylation of myosin II at the Ser1 and Ser2 is critical for normal platelet-derived growth factor induced reorganization of myosin filaments

Total internal reflection fluorescence (TIRF) microscopy of Chlamydomonas flagella

Unconstrained steps of myosin VI appear longest among known molecular motors

ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts

ZIPK is critical for the motility and contractility of VSMCs through the regulation of nonmuscle myosin II isoforms

p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA

p53- and PAI-1-mediated induction of C-X-C chemokines and CXCR2: importance in pulmonary inflammation due to cigarette smoke exposure