List of works - Rashid Deane

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

scientific article

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

scientific article

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

scientific article

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

scientific article published on 19 October 2009

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

scientific article

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system

scientific article

Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain.

scientific article published on February 2004

Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain

scientific article

Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging

scientific article published on 30 November 2020

Clearance of amyloid-beta by circulating lipoprotein receptors

scientific article

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

scientific article published on 23 April 2015

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

scientific article

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

scientific article published on 12 January 2017

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

scientific article

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

scientific article published on 08 December 2016

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease ⬇️

scientific article published on January 1, 2011

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice

scientific article

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

scientific article

Impairment of paravascular clearance pathways in the aging brain

scientific article

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

scientific article published on August 2004

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

scientific article

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.

scientific article

Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities ⬇️

scientific article published on July 20, 2012

Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain ⬇️

scientific article published on October 5, 2010

Methamphetamine causes sustained depression in cerebral blood flow

scientific article

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

scientific article published on March 2009

Neurovascular pathways and Alzheimer amyloid beta-peptide

scientific article

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

scientific article published on 20 October 2005

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

scientific article

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging ⬇️

scientific article published on November 4, 2010

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

scientific article

Role of the Blood-Brain Barrier in the Pathogenesis of Alzheimers Disease

scientific article

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

scientific journal article

SARS-CoV-2: is there neuroinvasion?

scientific article published in 2021

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

scientific article

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

scientific article

Sleep drives metabolite clearance from the adult brain

scientific article

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

scientific article published on 24 May 2016

The Effect of Body Posture on Brain Glymphatic Transport

scientific article

The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy

scientific article

The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy

scientific article

Transport of L-[125I]thyroxine by in situ perfused ovine choroid plexus: inhibition by lead exposure.

scientific article published on March 2003

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

scientific article published in November 2006

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease

scientific article published on February 2007

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

scientific article published on 13 November 2008

List of works by Rashid Deane

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system

Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain.

Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain

Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging

Clearance of amyloid-beta by circulating lipoprotein receptors

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease ⬇️

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

Impairment of paravascular clearance pathways in the aging brain

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.

Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities ⬇️

Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain ⬇️

Methamphetamine causes sustained depression in cerebral blood flow

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

Neurovascular pathways and Alzheimer amyloid beta-peptide

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging ⬇️

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

Role of the Blood-Brain Barrier in the Pathogenesis of Alzheimers Disease

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

SARS-CoV-2: is there neuroinvasion?

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

Sleep drives metabolite clearance from the adult brain

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

The Effect of Body Posture on Brain Glymphatic Transport

The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy

The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy

Transport of L-[125I]thyroxine by in situ perfused ovine choroid plexus: inhibition by lead exposure.

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain