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List of works by Tooru Shimosegawa

4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells

scientific article

A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells

scientific article published on 31 March 2004

A new manometry device for evaluating the sphincter of Oddi using a fiber-optic pressure sensor

scientific article published on 12 December 2017

Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells

scientific journal article

Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice

scientific article published on February 2007

Acute Pancreatitis-Progress and Challenges: A Report on an International Symposium

scientific article

Acute pancreatitis due to pancreatic arteriovenous malformation: 2 case reports and review of the literature.

scientific article

Alcohol Consumption and the Risk for Developing Pancreatitis

scientific article published on 01 January 2015

Alteration of pancreatic cancer cell functions by tumor-stromal cell interaction

scientific article

Alteration of the microRNA expression profile during the activation of pancreatic stellate cells.

scientific article

Analysis of cell damage in Helicobacter pylori-associated gastritis

scientific article

Autoimmune pancreatitis with hepatic inflammatory pseudotumor

scientific article published in November 2005

Bismuth classification is associated with the requirement for multiple biliary drainage in preoperative patients with malignant perihilar biliary stricture

scientific article published on 3 October 2014

Bone marrow contributes to the population of pancreatic stellate cells in mice

scientific article published in October 2009

Bone morphogenetic protein 4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line

scientific article published on December 2007

CUB-domain containing protein 1 represses the epithelial phenotype of pancreatic cancer cells

scientific article published on 30 December 2013

Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoma.

scientific article

Clinical Impact of Elevated Serum Triglycerides in Acute Pancreatitis: Validation from the Nationwide Epidemiological Survey in Japan

scientific article published on 01 April 2016

Clinical Profile of Autoimmune Pancreatitis and Its Histological Subtypes

scientific article published on 01 August 2011

Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease

scientific article published on 08 May 2018

Clinicopathological Characteristics of Young Patients With Pancreatic Cancer: An Analysis of Data From Pancreatic Cancer Registry of Japan Pancreas Society

scientific article

Clinicopathological Features of Type 2 Autoimmune Pancreatitis in Japan: Results of a Multicenter Survey.

scientific article published on 2 September 2015

Common variants atPRSS1–PRSS2andCLDN2–MORC4loci associate with chronic pancreatitis in Japan

scientific article published on 22 May 2015

Comprehensive Analysis of Serum microRNAs in Autoimmune Pancreatitis

scientific article published on 11 April 2015

Connexins regulate cell functions in pancreatic stellate cells.

scientific article published in March 2013

Curcumin blocks activation of pancreatic stellate cells

scientific article

Detection of Acetaldehyde in the Esophageal Tissue among Healthy Male Subjects after Ethanol Drinking and Subsequent L-Cysteine Intake

scientific article published in January 2018

Diagnosis of autoimmune pancreatitis by EUS-FNA by using a 22-gauge needle based on the International Consensus Diagnostic Criteria

scientific article

Diagnosis of autoimmune pancreatitis by EUS-guided FNA using a 22-gauge needle: a prospective multicenter study

scientific article published on 8 April 2016

Differences in Gut Microbiota Profiles between Autoimmune Pancreatitis and Chronic Pancreatitis

scientific article published in January 2018

Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells

scientific article published in February 2003

Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis.

scientific article published in January 2007

Disseminated Intravascular Coagulation on Admission Predicts Complications and Poor Prognosis of Acute Pancreatitis

scientific article published on 01 February 2017

Distinct Clinical Features of Two Patients That Progressed from the Early Phase of Chronic Pancreatitis to the Advanced Phase

scientific article published on 01 November 2012

Do genetic variants in the SPINK1 gene affect the level of serum PSTI?

scientific article published on 20 April 2012

Early detection of low enhanced pancreatic parenchyma by contrast-enhanced computed tomography predicts poor prognosis of patients with acute pancreatitis

scientific article

Ectopic Opening of the Common Bile Duct Accompanied by Choledochocele and Pancreas Divisum

scientific article published in May 2016

Effects of Oral Ingestion of the Elemental Diet in Patients With Painful Chronic Pancreatitis in the Real-Life Setting in Japan

scientific article published on 01 April 2014

Effects of ethanol and its metabolites on human pancreatic stellate cells

scientific article published on 23 January 2009

Ellagic acid blocks activation of pancreatic stellate cells

scientific article published in September 2005

Ellagic acid inhibits pancreatic fibrosis in male Wistar Bonn/Kobori rats

scientific article published on 25 July 2008

Endoscopic approaches for the diagnosis of autoimmune pancreatitis

scientific article published on 16 October 2014

Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells

scientific article published on October 2005

Establishment and characterization of a rat pancreatic stellate cell line by spontaneous immortalization

scientific article

Estrogen Receptors (α and β) and 17β-Hydroxysteroid Dehydrogenase Type 1 and 2 in Thyroid Disorders: Possible In Situ Estrogen Synthesis and Actions ⬇️

scientific article published on May 1, 2003

Estrogen-Dependent Nrf2 Expression Protects Against Reflux-Induced Esophagitis

scientific article published on 27 December 2017

Evaluation of MSX2 mRNA in brush cytology specimens distinguished pancreatic carcinoma from chronic pancreatitis.

scientific article published on 21 October 2010

Exosomes Derived From Pancreatic Stellate Cells: MicroRNA Signature and Effects on Pancreatic Cancer Cells

scientific article published on 10 November 2016

Exosomes derived from pancreatic cancer cells induce activation and profibrogenic activities in pancreatic stellate cells

scientific article published on 27 October 2017

Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas

scientific article

Expression of the calcium-binding protein S100P is regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines

scientific article

Galectin-1 induces chemokine production and proliferation in pancreatic stellate cells

scientific article published on 22 December 2005

Genetic background is different between sentinel and recurrent acute pancreatitis

scientific article published on 01 June 2011

Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells

scientific article

Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S.

scientific article published in April 2004

Human leukocyte antigen-DR expression on peripheral monocytes as a predictive marker of sepsis during acute pancreatitis

scientific article published in October 2002

Hydrogen peroxide activates activator protein-1 and mitogen-activated protein kinases in pancreatic stellate cells

scientific article published on 22 April 2006

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer

scientific article published on 31 July 2008

IL-6/STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells

scientific article published on 6 January 2016

Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis

scientific article published on 7 November 2012

IgG4-unrelated type 1 autoimmune pancreatitis

scientific article published on September 2015

Impaired glucose tolerance in acute pancreatitis

scientific article published on June 2015

In situ androgen production in human gastric carcinoma--androgen synthesizing and metabolizing enzymes

scientific article published on 01 May 2006

Inflammation and pancreatic cancer: disease promoter and new therapeutic target

scientific article

Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells

scientific article

Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury

scientific article published in January 2004

International consensus for the treatment of autoimmune pancreatitis

scientific article published on 12 December 2016

International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, America

scientific article published on 21 May 2018

Kindlin-2 in pancreatic stellate cells promotes the progression of pancreatic cancer

scientific article published on 13 January 2017

Leptin Aggravates Reflux Esophagitis by Increasing Tissue Levels of Macrophage Migration Inhibitory Factor in Rats

scientific article published on 01 May 2018

Long-Period Pancreatic Stenting for Painful Chronic Calcified Pancreatitis Required Higher Medical Costs and Frequent Hospitalizations Compared With Surgery

article

MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells

scientific article published in November 2005

Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis

scientific article

Management of acute pancreatitis in Japan: Analysis of nationwide epidemiological survey

scientific article published on July 2016

MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9.

scientific article

MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX.

scientific article published on 9 November 2013

Microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene is associated with susceptibility to acute pancreatitis in Japan

scientific article published in March 2009

Multicenter study of early pancreatic cancer in Japan

scientific article published on 20 November 2017

Multiple Gastrointestinal Stromal Tumors Associated with Neurofibromatosis Type I Preoperatively Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration: Report of a Case and Review of Literature

scientific article published on 01 December 2012

Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis

scientific article published on 23 June 2005

N34S Mutation in the SPINK1 Gene Is Not Associated With Alternative Splicing

article

NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells

scientific article published on 25 October 2007

NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study

scientific article published on 19 June 2018

Nationwide epidemiological survey of acute pancreatitis in Japan

scientific article published in November 2014

Nationwide epidemiological survey of acute pancreatitis in Japan

scientific article published in May 2011

Nationwide epidemiological survey of autoimmune pancreatitis in Japan

scientific article published in August 2012

Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2011.

scientific article published on May 2015

Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016

scientific article published on 23 December 2019

Nationwide epidemiological survey of chronic pancreatitis in Japan: introduction and validation of the new Japanese diagnostic criteria 2019

scientific article published on 16 July 2020

Nationwide epidemiological survey of early chronic pancreatitis in Japan

scientific article published on 27 January 2017

Nationwide survey of hereditary pancreatitis in Japan

scientific article published on 31 August 2017

No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations

scientific article published on 02 March 2016

Novel therapeutic strategies targeting tumor-stromal interactions in pancreatic cancer

scientific article

Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis

scientific article

Nuclear Factor Kappa B Expression in Peripheral Blood Mononuclear Cells of Patients with Acute Pancreatitis

scientific article published on 01 May 2003

Nuclear expression of interleukin-33 in pancreatic stellate cells.

scientific article

PRSS1 c.623G>C (p.G208A) variant is associated with pancreatitis in Japan

scientific article published on 17 May 2013

Pancreatic duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy

scientific article published on August 2013

Pancreatic intraepithelial neoplasia-3 with localized acute pancreatitis in the main pancreatic duct.

scientific article

Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells

scientific article

Pancreatic stellate cells express Toll-like receptors.

scientific article published in July 2008

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

scientific article published on 20 November 2010

Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells

scientific article

Pancreatic stellate cells--multi-functional cells in the pancreas

scientific article published on March 2013

Pancreatic stellate cells: A dynamic player of the intercellular communication in pancreatic cancer

scientific article published on 16 July 2015

Perfusion computed tomography findings of autoimmune pancreatitis

scientific article published in November 2011

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

scientific article

Phenotypic variability of the homozygous IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene in patients with chronic pancreatitis

scientific article published in July 2010

Plasma Kallikrein-Dependent Transforming Growth Factor-β Activation in Patients With Chronic Pancreatitis and Pancreatic Cancer.

scientific article published in March 2017

Prediction of invasive carcinoma in branch type intraductal papillary mucinous neoplasms of the pancreas.

scientific article published on 10 April 2010

Prevalence of IgG4-Related Disease in Japan Based on Nationwide Survey in 2009.

scientific article

Prospective study of early chronic pancreatitis diagnosed based on the Japanese diagnostic criteria

scientific article published on 03 July 2019

Protease-Activated Receptor-2-Mediated Proliferation and Collagen Production of Rat Pancreatic Stellate Cells

article

Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells

scientific article

Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells

scientific article published on 4 April 2018

Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis.

scientific article published on 19 August 2016

Recent advances in autoimmune pancreatitis

Regulators of epithelial mesenchymal transition in pancreatic cancer

scientific article published on 10 July 2012

Repeated pancreatectomy for metachronous duodenal and pancreatic metastases of renal cell carcinoma

scientific article published on 09 October 2013

Rho kinase inhibitors block activation of pancreatic stellate cells

scientific article

Risk factors for recurrent biliary obstruction following placement of self-expandable metallic stents in patients with malignant perihilar biliary stricture

scientific article

Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis

scientific article

SPINK1 gene mutations and pancreatitis in Japan.

scientific article

SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan

scientific article published in March 2008

Serous cystic neoplasms of the whole pancreas in a patient with von Hippel-Lindau disease.

scientific article published on 15 June 2011

Severity assessment of acute pancreatitis using four prognostic factors - a nationwide multicenter study of 3682 cases in Japan

scientific article published on 3 August 2017

Sex and age differences in alcoholic pancreatitis in Japan: a multicenter nationwide survey

scientific article published in May 2013

Signal transduction in pancreatic stellate cells

scientific article published on 07 March 2009

Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma

scientific article published on 28 September 2017

Successful Endoscopic Treatment of Severe Pancreaticojejunostomy Strictures by Puncturing the Anastomotic Site with an EUS-guided Guidewire

scientific article published on 20 November 2017

Successful treatment of benign biliary stricture by a covered self-expandable metallic stent in a patient with chronic pancreatitis

scientific article published in May 2012

Sudden disappearance of the blood flow in a case of pancreatic acinar cell carcinoma

scientific article

Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues

scientific article

Targeted next-generation sequencing effectively analyzed the cystic fibrosis transmembrane conductance regulator gene in pancreatitis

scientific article published on 10 December 2014

The Expression of MUC4 and MUC5AC Is Related to the Biologic Malignancy of Intraductal Papillary Mucinous Neoplasms of the Pancreas

scientific article published on 01 November 2006

The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice

scientific article published on 11 March 2013

The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2.

scientific article published on February 2012

The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients

scientific article published on 3 September 2014

The sixth nationwide epidemiological survey of chronic pancreatitis in Japan

scientific article

The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification

article

The zinc transporter LIV-1 is a novel regulator of stemness in pancreatic cancer cells

scientific article published on 2 December 2013

Transition of early-phase treatment for acute pancreatitis: An analysis of nationwide epidemiological survey

scientific article published on April 2017

Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells

scientific article published on 18 March 2008

Variants in CPA1 are strongly associated with early onset chronic pancreatitis

scientific article published on 18 August 2013

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis

scientific article

Variants in the UBR1 gene are not associated with chronic pancreatitis in Japan

scientific article published on 2 July 2016

Variants in the interferon regulatory factor-2 gene are not associated with pancreatitis in Japan.

scientific article

Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy

scientific article

[Recent findings on chronic pancreatitis]

scientific article published on 01 October 2006

miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin

scientific article

miR-210 regulates the interaction between pancreatic cancer cells and stellate cells

scientific article published on 4 July 2013

−651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan

article

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