List of works - Katsuya Tsuchihara

A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing.

scientific article published on 7 June 2018

A nationwide genomic screening project for small cell lung cancer in Japan (LC-SCRUM-Japan)

A secondary RET mutation in the activation loop conferring resistance to vandetanib.

scientific article published on 12 February 2018

Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines

scientific article

Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015

scientific article

Amplification of EGFR Wild-Type Alleles in Non-Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors

scientific article published on 15 February 2017

Apparent absence of a proton beam dose rate effect and possible differences in RBE between Bragg peak and plateau ⬇️

scientific article published on October 1, 2010

Association between the mutational smoking signature and the immune microenvironment in lung adenocarcinoma

scientific article published on 01 July 2020

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

scientific article published on 09 August 2016

Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues

scientific article

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation

scientific article

Biased discordance of KRAS mutation detection in archived colorectal cancer specimens between the ARMS-Scorpion method and direct sequencing

scientific article

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

scientific article

Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer.

scientific article published in June 2018

Characterization of cancer omics and drug perturbations in panels of lung cancer cells

scientific article published on 20 December 2019

Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia

scientific article published on 06 November 2018

Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner

scientific article

Clinical application of next-generation sequencing technologies to achieve cancer precision medicine

scientific article published on January 2014

Clinical outcome of Japanese metastatic colorectal cancer patients harbouring the KRAS p.G13D mutation treated with cetuximab + irinotecan

scientific article published on 15 October 2012

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (Edition 1.0)

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)

scientific article published on 29 November 2020

Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehen

scientific article published on 3 October 2017

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

scientific article published on 05 October 2020

Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung

scientific article

Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells via mTOR activation through Akt-independent pathway.

scientific article published on 27 April 2018

Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response.

scientific article published on 22 February 2018

Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy

Comprehensive screening for drugs that modify radiation-induced immune responses

scientific article published on 19 February 2022

Contribution of nationwide genome screening in Japan (LC-SCRUM-Japan) to the development of precision medicine for non-small cell lung cancer

Contribution to the development of precision medicine and clinical utility of nationwide lung cancer genomic screening in Japan (LC-SCRUM-Japan)

Correction: Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients.

scientific article published on 4 May 2018

Critical role of H2O2 generated by NOX4 during cellular response under glucose deprivation

scientific article

DBTSS as an integrative platform for transcriptome, epigenome and genome sequence variation data

scientific article

DBTSS/DBKERO for integrated analysis of transcriptional regulation

scientific article published on 8 November 2017

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

scientific article published on 15 December 2016

Development of a nationwide genomic screening network for squamous cell lung cancer in Japan (LC-SCRUM-Japan)

Development of nationwide genomic screening project (LC-SCRUM-Japan) contributing to the establishment of precision medicine in Japan

Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak

scientific article

Distinct clinicopathologic characteristics of lung mucinous adenocarcinoma with KRAS mutation

scientific article

Effect of 5-fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of spread-out Bragg peak

scientific article published on 11 January 2019

Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines

scientific article

Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma

scientific article

Evaluation and application of RNA-Seq by MinION

scientific article published on 01 February 2019

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing

scientific article published on 11 April 2015

Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma

scientific article

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

scientific article published on 09 June 2019

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

scientific article

Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers

scientific article published on 09 August 2010

Fecal microbiota in patients with a stoma decreases anaerobic bacteria and alters taxonomic and functional diversities

scientific article published in 2022

Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis

scientific article published on 12 November 2018

Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing

scientific article

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung

scientific article published on 9 August 2016

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors

scientific article published on 20 December 2016

Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast

scientific article published on 01 April 2021

Histopathological factors affecting the extraction of high quality genomic DNA from tissue sections for next-generation sequencing

scientific article published on 21 August 2019

Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

scientific article

Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs

scientific article published on 7 March 2011

Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts

scientific article

Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo

scientific article published on 12 May 2013

Identification of potential regulatory mutations using multi-omics analysis and haplotyping of lung adenocarcinoma cell lines

scientific article published on 21 March 2018

Identification of the mutation signature of the cancer genome caused by irradiation

scientific article published on 16 October 2020

Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia

scientific article published on 5 October 2017

Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation

scientific article published on 20 February 2022

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

scientific article published in March 2010

Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition

scientific article published on 08 July 2019

Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion

scientific article published on 24 January 2020

Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, Third Edition.

scientific article published in June 2018

Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients

scientific article

Long-read sequencing for non-small-cell lung cancer genomes

scientific article published on 04 September 2020

Massive transcriptional start site analysis of human genes in hypoxia cells

scientific article

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.

scientific article published on 28 February 2018

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare mutations

scientific article published on 01 May 2019

Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles

scientific article published on 20 June 2019

Nation-wide genome screening data-base

scientific article published on 01 October 2017

Nationwide genomic screening network for the development of novel targeted therapies in advanced non-small cell lung cancer (LC-SCRUM-Japan)

Nationwide genomic screening network for the development of targeted therapies in NSCLC (LC-SCRUM-Japan)

scientific article

Nuclear localization of SNARK; its impact on gene expression

scientific article

PARP inhibitor olaparib sensitizes esophageal carcinoma cells to fractionated proton irradiation

scientific article published on 01 March 2020

Phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine

scientific article published on 29 September 2016

Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma

scientific article published on 6 March 2018

Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens

scientific article published on 11 January 2021

Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice

scientific article published on 10 March 2009

RET fusion gene: translation to personalized lung cancer therapy

scientific article

RET-targeting molecular stratified non-small-cell lung cancers

scientific article

ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress

scientific article

Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients

scientific article published on 10 April 2018

Rationale for and Design of the PARADIGM Study: Randomized Phase III Study of mFOLFOX6 Plus Bevacizumab or Panitumumab in Chemotherapy-naïve Patients With RAS (KRAS/NRAS) Wild-type, Metastatic Colorectal Cancer

scientific article published on 24 January 2017

Reply to `Comment on `Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal A

scientific article published on 22 March 2018

SCRUM-Japan GI-SCREEN and MONSTAR-SCREEN: Path to the realization of biomarker-guided precision oncology in advanced solid tumors

Sequencing and phasing cancer mutations in lung cancers using a long-read portable sequencer

scientific article published on 27 June 2017

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

scientific article published on 28 May 2015

Simultaneous identification of 36 mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA in a single reaction by multiplex assay kit.

scientific article

Simultaneous quantification of arctigenin and its glucuronide conjugate in mouse plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry

scientific article published on 02 January 2021

Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer

scientific article published on 09 July 2021

Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment

scientific article published on 3 April 2015

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.

scientific article

Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci

scientific article published on 27 February 2007

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

scientific article published on 19 September 2008

TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity

scientific article

The Lung Cancer Genomic Screening Project for Individualized Medicine in Japan (LC-SCRUM-Japan): Screening for RET and ROS1 fusions in advanced EGFR mutation-negative nonsquamous lung cancer and development of molecular targeted therapy

Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis

scientific article

Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial

scientific article published on 4 November 2016

[Current Status and Future Perspectives of SCRUM-Japan].

scientific article published in August 2017

[Transcriptome analyses using massively paralleled sequencers].

scientific article

List of works by Katsuya Tsuchihara

A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing.

A nationwide genomic screening project for small cell lung cancer in Japan (LC-SCRUM-Japan)

A secondary RET mutation in the activation loop conferring resistance to vandetanib.

Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines

Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015

Amplification of EGFR Wild-Type Alleles in Non-Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors

Apparent absence of a proton beam dose rate effect and possible differences in RBE between Bragg peak and plateau ⬇️

Association between the mutational smoking signature and the immune microenvironment in lung adenocarcinoma

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation

Biased discordance of KRAS mutation detection in archived colorectal cancer specimens between the ARMS-Scorpion method and direct sequencing

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer.

Characterization of cancer omics and drug perturbations in panels of lung cancer cells

Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia

Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner

Clinical application of next-generation sequencing technologies to achieve cancer precision medicine

Clinical outcome of Japanese metastatic colorectal cancer patients harbouring the KRAS p.G13D mutation treated with cetuximab + irinotecan

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (Edition 1.0)

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)

Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehen

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung

Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells via mTOR activation through Akt-independent pathway.

Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response.

Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy

Comprehensive screening for drugs that modify radiation-induced immune responses

Contribution of nationwide genome screening in Japan (LC-SCRUM-Japan) to the development of precision medicine for non-small cell lung cancer

Contribution to the development of precision medicine and clinical utility of nationwide lung cancer genomic screening in Japan (LC-SCRUM-Japan)

Correction: Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients.

Critical role of H2O2 generated by NOX4 during cellular response under glucose deprivation

DBTSS as an integrative platform for transcriptome, epigenome and genome sequence variation data

DBTSS/DBKERO for integrated analysis of transcriptional regulation

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

Development of a nationwide genomic screening network for squamous cell lung cancer in Japan (LC-SCRUM-Japan)

Development of nationwide genomic screening project (LC-SCRUM-Japan) contributing to the establishment of precision medicine in Japan

Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak

Distinct clinicopathologic characteristics of lung mucinous adenocarcinoma with KRAS mutation

Effect of 5-fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of spread-out Bragg peak

Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines

Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma

Evaluation and application of RNA-Seq by MinION

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing

Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers

Fecal microbiota in patients with a stoma decreases anaerobic bacteria and alters taxonomic and functional diversities

Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis

Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors

Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast

Histopathological factors affecting the extraction of high quality genomic DNA from tissue sections for next-generation sequencing

Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs

Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts

Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo

Identification of potential regulatory mutations using multi-omics analysis and haplotyping of lung adenocarcinoma cell lines

Identification of the mutation signature of the cancer genome caused by irradiation

Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia

Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition

Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion

Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, Third Edition.

Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients

Long-read sequencing for non-small-cell lung cancer genomes

Massive transcriptional start site analysis of human genes in hypoxia cells

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare mutations

Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles

Nation-wide genome screening data-base

Nationwide genomic screening network for the development of novel targeted therapies in advanced non-small cell lung cancer (LC-SCRUM-Japan)

Nationwide genomic screening network for the development of targeted therapies in NSCLC (LC-SCRUM-Japan)

Nuclear localization of SNARK; its impact on gene expression

PARP inhibitor olaparib sensitizes esophageal carcinoma cells to fractionated proton irradiation