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List of works by David Ayares

AN INVESTIGATION OF EXTRACELLULAR HISTONES IN PIG-TO-BABOON ORGAN XENOTRANSPLANTATION.

scientific article

Activation of the lectin pathway of complement in pig-to-human xenotransplantation models

scientific article

Adipose-derived mesenchymal stromal cells from genetically modified pigs: immunogenicity and immune modulatory properties

scientific article published on 23 January 2012

Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans

scientific article published on July 2006

Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here?

scientific article published on July 2007

An in vitro model of pig liver xenotransplantation--pig complement is associated with reduced lysis of wild-type and genetically modified pig cells

scientific article published on 01 September 2010

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans

scientific article published on 17 July 2017

Anti-Pig Antibody in Infants: Can a Genetically Engineered Pig Heart Bridge to Allotransplantation?

scientific article published on 30 September 2019

Anti-Pig IGE and IGA Antibodies in Naive Primates and Nonhuman Primates With Pig Xenografts

scientific article published on 04 August 2020

Antibodies directed to pig non-Gal antigens in naïve and sensitized baboons

scientific article published on 01 September 2006

Antibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons

scientific article published on 09 September 2020

Anti‐gal antibodies in α1,3‐galactosyltransferase gene‐knockout pigs ⬇️

scientific article published on September 13, 2012

Atorvastatin down-regulates the primate cellular response to porcine aortic endothelial cells in vitro

scientific article published on September 2008

Author Correction: Consistent success in life-supporting porcine cardiac xenotransplantation

scientific article published on 01 April 2019

B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy

scientific article published on 06 August 2018

B-Cell-Deficient and CD8 T-Cell-Depleted Gnotobiotic Pigs for the Study of Human Rotavirus Vaccine-Induced Protective Immune Responses

scientific article published on 29 January 2016

Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation

scientific article published on 16 February 2019

Carbohydrates in xenotransplantation.

scientific article

Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs

scientific article published on 05 October 2018

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

scientific article published on 5 April 2016

Clinical islet xenotransplantation: how close are we?

scientific article

Clinical lung xenotransplantation--what donor genetic modifications may be necessary?

scientific article

Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation

scientific article published on 25 August 2020

Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species

scientific article

Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood

scientific article published on 17 March 2014

Consistent success in life-supporting porcine cardiac xenotransplantation

scientific article published on 05 December 2018

Costimulation blockade in pig artery patch xenotransplantation – a simple model to monitor the adaptive immune response in nonhuman primates ⬇️

scientific article published on July 1, 2012

Current status of xenotransplantation and prospects for clinical application

scientific article

Data on B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy

Development of retrocorneal membrane following pig-to-monkey penetrating keratoplasty.

scientific article published on 5 November 2016

Discordant cardiac xenotransplantation: broadening the horizons

scientific article published on 3 October 2013

Does expression of a human complement-regulatory protein on xenograft cells protect them from systemic complement activation? Experimental research

scientific article published on 25 September 2020

Early Experience With Preclinical Perioperative Cardiac Xenograft Dysfunction in a Single Program

scientific article published on 04 October 2019

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.

scientific article published on 14 July 2015

Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated?

scientific article published on 05 July 2012

Effect of intravenous immunoglobulin (IVIg) on primate complement-dependent cytotoxicity of genetically engineered pig cells: relevance to clinical xenotransplantation

scientific article published on 16 July 2020

Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.

scientific article published in December 2009

Evaluating the functionality of xeno-relevant transgenes

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

scientific article published on 24 July 2020

Expression levels of growth-regulating imprinted genes in cloned piglets.

scientific article published in January 2007

Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation.

scientific article published on 28 September 2015

Expression of human thrombomodulin on porcine endothelial cells can reduce platelet aggregation but did not reduce activation of complement or endothelium - an experimental study

scientific article published on 09 February 2020

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 2b: genetically modified source pigs

scientific article published on March 2016

Further evidence for sustained systemic inflammation in xenograft recipients (SIXR).

scientific article

GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels

scientific article published on 12 March 2018

Genetically engineered pig red blood cells for clinical transfusion: initial in vitro studies

scientific article published on 14 July 2009

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

scientific article

Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs

scientific article (publication date: 2012)

Genetically-modified pig mesenchymal stromal cells: xenoantigenicity and effect on human T-cell xenoresponses

scientific article published on 01 May 2011

Glucose metabolism in pigs expressing human genes under an insulin promoter.

scientific article

Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies

scientific article published on 25 November 2020

Hepatic function after genetically engineered pig liver transplantation in baboons.

scientific article

Heterotopic Porcine Cardiac Xenotransplantation in the Intra-Abdominal Position in a Non-Human Primate Model

scientific article published on 01 July 2020

Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantation

scientific article published on 28 August 2019

Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells

scientific article published on 29 August 2013

Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses

article

Human T‐cell proliferation in response to thrombin‐activated GTKO pig endothelial cells ⬇️

scientific article published on September 13, 2012

Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration?

scientific article

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status

scientific article published in September 2013

IMMUNE RESPONSES OF HLA-HIGHLY-SENSITIZED AND NONSENSITIZED PATIENTS TO GENETICALLY-ENGINEERED PIG CELLS.

scientific article published on 21 December 2017

Immunobiology of liver xenotransplantation

scientific article

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts.

scientific article

In vitro exposure of pig neonatal isletlike cell clusters to human blood.

scientific article published on 14 July 2015

In vitro investigation of pig cells for resistance to human antibody-mediated rejection

scientific article published on 01 September 2008

In vitro testing of an anti-CD40 monoclonal antibody, clone 2C10, in primates and pigs

scientific article

Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models.

scientific article published on February 2006

Increased soluble CD154 (CD40 ligand) levels in xenograft recipients correlate with the development of de novo anti-pig IgG antibodies

article

Indicators of impending pig kidney and heart xenograft failure: Relevance to clinical organ xenotransplantation - Review article

scientific article published on 21 August 2019

Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation

scientific article published on 16 January 2016

Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs

scientific article published on 14 March 2016

Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wild-type pigs.

scientific article published in March 2010

Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls

scientific article published on 25 July 2019

Intra-bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival

scientific article published on 23 September 2019

Investigation of potential carbohydrate antigen targets for human and baboon antibodies.

scientific article

Is interleukin-6 receptor blockade (tocilizumab) beneficial or detrimental to pig-to-baboon organ xenotransplantation?

scientific article published on 03 January 2020

Is there a correlation between anti-pig antibody levels in humans and geographic location during childhood?

scientific article published on August 2013

Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

scientific article published on 15 April 2019

Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants

scientific article published on 10 September 2007

Life-supporting Kidney Xenotransplantation From Genetically Engineered Pigs in Baboons: A Comparison of Two Immunosuppressive Regimens

scientific article published on 01 October 2019

Life-supporting function of genetically modified swine lungs in baboons

scientific article published on 02 April 2007

Minimal effect of bortezomib in reducing anti-pig antibodies in human leukocyte antigen-sensitized patients: a pilot study.

scientific article published on 03 September 2013

Monitoring of porcine and baboon cytomegalovirus infection in xenotransplantation

scientific article published in November 2009

Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood

scientific article published on 14 March 2018

N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.

scientific article

New concepts of immune modulation in xenotransplantation.

scientific article published on December 2013

Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

scientific article published on 17 June 2020

P- and E-selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage.

scientific article

Pig Kidney Xenotransplantation: Progress Towards Clinical Trials

scientific article published on 01 November 2020

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

scientific article

Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

scientific article

Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade

scientific article

Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation?

scientific article published on 15 May 2020

Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation

scientific article

Pre-clinical heterotopic intrathoracic heart xenotransplantation: a possibly useful clinical technique.

scientific article published on 25 November 2015

Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs

scientific article

Progress in xenotransplantation following the introduction of gene-knockout technology

scientific article published on February 2007

Recent advances in pig-to-human organ and cell transplantation

scientific article

Reduction of early graft loss after intraportal porcine islet transplantation in monkeys

scientific article published on 01 January 2007

Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition

scientific article

Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs

scientific article published on January 2014

Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules ⬇️

scientific article published on December 1, 2011

Role of P-selectin and P-selectin glycoprotein ligand-1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells

scientific article published on 01 January 2014

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model

scientific article published on 29 October 2013

Safe use of anti-CD154 monoclonal antibody in pig islet xenotransplantation in monkeys

scientific article published on 6 January 2017

Structural characterization of alpha1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies

scientific article published in January 2010

Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses

scientific article

Synthetic liver function is detectable in transgenic porcine livers perfused with human blood

scientific article published on 25 October 2017

Systemic inflammation in xenograft recipients precedes activation of coagulation

scientific article

The effect of Gal expression on pig cells on the human T‐cell xenoresponse ⬇️

scientific article published on January 1, 2012

The final obstacle to successful pre-clinical xenotransplantation?

scientific article published on 25 June 2020

The human T-cell proliferative response to triple-knockout pig cells in mixed lymphocyte reaction

scientific article published on 12 June 2020

The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients

scientific article

The pig-to-primate immune response: relevance for xenotransplantation

scientific article published on 01 May 2007

The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation

scientific article

The potential of genetically-modified pig mesenchymal stromal cells in xenotransplantation

scientific article published on January 2010

The potential role of 3D-bioprinting in xenotransplantation

scientific article published on 01 October 2019

The potential role of genetically-modified pig mesenchymal stromal cells in xenotransplantation

scientific article published on February 2014

The problem of the "4th xenoantigen" after pig organ transplantation in non-human primates may be overcome by expression of human "protective" proteins

scientific article published on 01 November 2020

The role of genetically engineered pigs in xenotransplantation research

scientific article

Therapeutic regulation of systemic inflammation in xenograft recipients

scientific article published on 12 March 2017

Thrombocytopenia after pig-to-baboon liver xenotransplantation: where do platelets go?

scientific article

Thyroid hormone: relevance to xenotransplantation.

scientific article published on 04 July 2016

Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions

scientific article published on 8 May 2015

Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation.

scientific article published on 13 April 2016

Transgenic expression of human CD46: does it reduce the primate T-cell response to pig endothelial cells?

scientific article published on 20 November 2015

Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages

scientific article published on 08 September 2019

Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury

scientific article

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