List of works by Graça Raposo

A dual mechanism controlling the localization and function of exocytic v-SNAREs

scientific article

A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting

scientific article

A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis

scientific article published on March 2006

A novel dendritic cell subset involved in tumor immunosurveillance

scientific article published on 29 January 2006

ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation

scientific article published on 22 June 2018

ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages

scientific article

AP-1 and ARF1 control endosomal dynamics at sites of FcR mediated phagocytosis

scientific article

AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis

scientific article

AP-1/KIF13A Blocking Peptides Impair Melanosome Maturation and Melanin Synthesis

scientific article published on 14 February 2018

ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis.

scientific article published in February 2009

ARF6 controls post-endocytic recycling through its downstream exocyst complex effector

scientific article

ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles

scientific article

Accelerated recycling of transferrin receptor in Theileria-transformed B cells

scientific article

Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation

scientific article published on December 1997

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

scientific article

Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes.

scientific article

Analysis of de novo Golgi complex formation after enzyme-based inactivation

scientific article

Analyzing Lysosome-Related Organelles by Electron Microscopy.

scientific article

Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex

scientific article

Antigen-dependent and -independent Ca2+ responses triggered in T cells by dendritic cells compared with B cells

scientific article

Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells

scientific article (publication date: October 2015)

Are beta-ARs internalized via caveolae or coated pits?

scientific article published on 01 December 1994

As we wait: coping with an imperfect nomenclature for extracellular vesicles

scientific article published on 15 February 2013

Assembly of an abundant endogenous major histocompatibility complex class II/peptide complex in class II compartments

scientific article published on March 1997

Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties

scientific article (publication date: May 1997)

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

scientific article published on 10 June 2013

BCR-bound antigen is targeted to exosomes in human follicular lymphoma B-cells

scientific article published on August 2006

BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes

scientific article

BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers

scientific article

BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes

scientific journal article

BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles

scientific article

BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery

scientific article

Binding kinetics of soluble ligands to transmembrane proteins: comparing an optical biosensor and dynamic flow cytometry

scientific article published on 01 May 2000

Biogenesis of Melanosomes

Biogenesis of melanosomes - the chessboard of pigmentation ⬇️

scientific article

Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles

scientific article (publication date: 2014)

Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates

scientific article

Caveolae and sorting in the trans-Golgi network of epithelial cells

scientific article

Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax

scientific article

Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

scientific article

Cells release prions in association with exosomes

scholarly article

Cells respond to mechanical stress by rapid disassembly of caveolae

scientific article

Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption

scientific article published on 15 February 2021

Characterization of MHC Class II Compartments by Immunoelectron Microscopy

scientific article published on 01 October 1996

Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity

scientific article

Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC.

scientific article published on October 2005

Control of MT1-MMP transport by atypical PKC during breast-cancer progression

scientific article

Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function

scientific article published on 31 July 2018

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article

Correction: The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation (doi:10.1242/jcs.229500)

scientific article published on 28 March 2019

Corrigendum to "Lysosome related organelles as functional adaptations of the endolysosomal system", Current Opinion in Cell Biology, volume 59, 2019, 147-158

scientific article published on 01 December 2019

Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation

scientific article published on 12 June 2020

Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndrome

scientific article

Dendritic cells or their exosomes are effective biotherapies of cancer.

scientific article

Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination

scientific article published on December 2006

Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells

scientific article published on 10 March 2009

Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes

scientific article

Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells

scientific article

Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation

scientific article published on 16 April 2012

Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes

scientific article

Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17

scientific article

Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation

scientific journal article

ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane

scientific article published on 09 June 2009

Early endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments

scientific article published on September 1999

Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway

scientific article published on 6 June 2015

Emerging roles of extracellular vesicles in the nervous system

scientific article

Endosomes, exosomes and Trojan viruses

scientific article published in July 2004

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes

scientific article (publication date: May 1998)

Erratum: Corrigendum: eC-CLEM: flexible multidimensional registration software for correlative microscopies

scholarly article published in Nature Methods

Erratum: Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin–AP-1-coated carrier biogenesis at the TGN

scholarly article published in Nature Cell Biology

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

scientific article

Excision of a large cervical meningioma of anterior localization adhering to the spinal cord. Review of the literature and discussion of the case

scientific article published in May 1974

Exosomal-like vesicles are present in human blood plasma

scientific article

Exosome secretion: molecular mechanisms and roles in immune responses

scientific article published on 30 June 2011

Exosomes and extracellular vesicles: the path forward

scientific article published on 15 May 2018

Exosomes are released by cultured cortical neurones.

scientific article published on 30 January 2006

Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells

scientific article published on February 2004

Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells

scientific article published on July 2002

Exosomes in cancer immunotherapy: preclinical data

scientific article

Exosomes released by keratinocytes modulate melanocyte pigmentation

scientific article published on 24 June 2015

Exosomes--vesicular carriers for intercellular communication

scientific article (publication date: August 2009)

Exosomes: a bubble ride for prions?

scientific article

Exosomes: a common pathway for a specialized function

scientific article

Exosomes: endosomal-derived vesicles shipping extracellular messages

scientific article

Expression of the Longin domain of TI-VAMP impairs lysosomal secretion and epithelial cell migration

scientific article published on May 2007

Extracellular Vesicles: Exosomes and Microvesicles, Integrators of Homeostasis

scientific article published on 01 May 2019

Extracellular vesicles shuffling intercellular messages: for good or for bad.

scientific article published on 19 May 2015

Extracellular vesicles: a new communication paradigm?

scientific article published on 01 September 2019

Extracellular vesicles: exosomes, microvesicles, and friends

scientific article (publication date: 18 February 2013)

First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications.

scientific article published on 4 May 2013

Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties

scientific article

Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes

scientific article

General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.

scientific article

Graça Raposo: melanosomes, more than skin deep. Interviewed by Caitlin Sedwick

scientific article published in May 2012

HIV-1 Nef impairs MHC class II antigen presentation and surface expression

scientific article

HLA-DR4 molecules in neuroendocrine epithelial cells associate to a heterogeneous repertoire of cytoplasmic and surface self peptides

scientific article published on November 2002

Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase

scientific article

Human macrophages accumulate HIV-1 particles in MHC II compartments

scientific article (publication date: October 2002)

ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

scientific article published on 24 March 2005

Identification and characterization of multiple novel Rab-myosin Va interactions

scientific article

Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability

scientific article

Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure

scholarly article

Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes.

scientific article

Illuminating the dark side of recycling endosomes

scientific article

Immature dendritic cells (DCs) use chemokines and intercellular adhesion molecule (ICAM)-1, but not DC-specific ICAM-3-grabbing nonintegrin, to stimulate CD4+ T cells in the absence of exogenous antigen

scientific article published in July 2004

In vitro differentiation of retinal pigment epithelium from adult retinal stem cells

scientific article published on 10 November 2010

Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation

scientific journal article

Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB

scientific article

Inhibition of retrograde transport protects mice from lethal ricin challenge

scientific article

Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles.

scientific article

Intestinal epithelial cells secrete exosome-like vesicles

scientific article

Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells

scientific article published on 18 September 2005

Isolation of Exosomes and Microvesicles from Cell Culture Systems to Study Prion Transmission

scientific article published on January 2017

KIF13A mediates trafficking of influenza A virus ribonucleoproteins

scientific article published on 23 October 2017

LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route.

scientific article

LYST Controls the Biogenesis of the Endosomal Compartment Required for Secretory Lysosome Function

scientific article published on 06 January 2015

Lipid raft-associated protein sorting in exosomes

scientific article published on 24 July 2003

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

scientific article published on 07 February 2019

Live tracking of inter-organ communication by endogenous exosomes in vivo

scientific article published on 30 July 2018

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses

scholarly article

Lysosome-related organelles as functional adaptations of the endolysosomal system

scientific article published on 22 June 2019

Lysosome-related organelles: a view from immunity and pigmentation

scientific article

Lysosome-related organelles: driving post-Golgi compartments into specialisation

scientific article published on 12 July 2007

Lysosome-related organelles: unusual compartments become mainstream

scientific article published on 29 May 2013

MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways.

scientific article published on 14 July 2009

Malignant effusions and immunogenic tumour-derived exosomes

scientific article published in July 2002

Melanosome distribution in keratinocytes in different skin types: melanosome clusters are not degradative organelles

scientific article

Melanosomes and MHC class II antigen-processing compartments: a tinted view of intracellular trafficking and immunity

scientific article

Melanosomes--dark organelles enlighten endosomal membrane transport

scientific article

Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling

scientific article

Membranes and organelles

scientific article published on 07 July 2008

Meningeal Melanocytes in the Mouse: Distribution and Dependence on Mitf

scientific article

Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor

scientific article published on 29 July 2013

Microphthalmia transcription factor induces both retinal pigmented epithelium and neural crest melanocytes from neuroretina cells

scientific article

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment

scientific article

Mitochondria and Melanosomes Establish Physical Contacts Modulated by Mfn2 and Involved in Organelle Biogenesis

scientific article published on 30 January 2014

Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.

scientific article

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

scientific article

Multifocal structure of the T cell - dendritic cell synapse

scholarly article by Cédric Brossard et al published June 2005 in European Journal of Immunology

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

scientific article published in November 2003

Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic

scientific article

Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes

scientific article

Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers

scientific article published on 06 June 2018

Myosin VI regulates actin dynamics and melanosome biogenesis

scientific article published on 6 March 2012

Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network

scientific article

N-terminal domains elicit formation of functional Pmel17 amyloid fibrils

scientific article published on December 2009

NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment

scientific article

PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes

scientific article published on 31 August 2017

PMEL: a pigment cell-specific model for functional amyloid formation

scientific article published on 19 February 2013

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

scientific article published on 20 September 2018

Peptide loading in the endoplasmic reticulum accelerates trafficking of peptide:MHC class II complexes in B cells

scientific article published on 01 January 1999

Phenotypic characterisation of RAB6A knockout mouse embryonic fibroblasts

scientific article published on 24 August 2015

Phosphoinositide 3-Kinase Activation by Igβ Controls de Novo Formation of an Antigen-processing Compartment

scientific article published in Journal of Biological Chemistry

Pmel17 initiates premelanosome morphogenesis within multivesicular bodies

scientific article

Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes

scientific article published on 8 November 2007

Prion strains are differentially released through the exosomal pathway

scientific article published on 18 September 2014

Prions and exosomes: from PrPc trafficking to PrPsc propagation

scientific article

Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis ⬇️

scientific article published on May 5, 2003

Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.

scientific article

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

scientific article published on 16 January 2018

Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites

scientific article

Rab27a and Rab27b control different steps of the exosome secretion pathway

scientific article

Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes

scientific article published on 11 March 2007

Rab27b regulates mast cell granule dynamics and secretion

scientific article

Rab30 is required for the morphological integrity of the Golgi apparatus

scientific article

Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes

scientific article

Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles

scientific article published on 20 September 2018

Rab6-interacting protein 1 links Rab6 and Rab11 function

scientific article published on 23 August 2007

Recycling endosome tubule morphogenesis from sorting endosomes requires the kinesin motor KIF13A.

scientific article published on 23 January 2014

Redistribution of muscarinic acetylcholine receptors on human fibroblasts induced by regulatory ligands

scientific article published on 01 January 1987

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles ⬇️

scientific article

Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain

scientific article published on 01 December 2008

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.

scientific article

Reply to Valencia et al

Retrovirus infection strongly enhances scrapie infectivity release in cell culture

scientific article published on 25 May 2006

Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes ⬇️

scientific article

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.

scientific article

Sas-4 proteins are required during basal body duplication in Paramecium

scientific article

Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

scientific article

Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis

scientific article

Shedding light on the cell biology of extracellular vesicles

scientific article published on 17 January 2018

Shiga toxin induces tubular membrane invaginations for its uptake into cells

scientific article

Step by step manipulation of the CryoCapsule with HPM high pressure freezers.

scientific article published on January 2014

Synchronization of secretory protein traffic in populations of cells

scientific article published on 11 March 2012

T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells

scientific article published on 22 February 2007

TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex

scientific article published in April 2002

TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages

scientific article

The CryoCapsule: simplifying correlative light to electron microscopy

scientific article

The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes

scientific article

The Hermansky-Pudlak syndrome (HPS) protein is part of a high molecular weight complex involved in biogenesis of early melanosomes

scientific article

The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation

scientific article published on 28 February 2019

The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function

scientific article

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.

scientific article

The biogenesis and functions of exosomes

scientific article

The complex ultrastructure of the endolysosomal system.

scientific article

The dark side of lysosome-related organelles: specialization of the endocytic pathway for melanosome biogenesis

scientific article

The gene responsible for Dyggve-Melchior-Clausen syndrome encodes a novel peripheral membrane protein dynamically associated with the Golgi apparatus

scientific article

The invariant chain induces compact forms of class II molecules localized in late endosomal compartments

scientific article published on 01 December 1993

The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions

scientific article published on 10 July 2015

The launch of Journal of Extracellular Vesicles (JEV), the official journal of the International Society for Extracellular Vesicles - about microvesicles, exosomes, ectosomes and other extracellular vesicles

scientific article published on 16 April 2012

The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition

scientific article

The ocular albinism type 1 (OA1) GPCR is ubiquitinated and its traffic requires endosomal sorting complex responsible for transport (ESCRT) function

scientific article

The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation

scientific article published on 18 July 2019

The retromer complex and clathrin define an early endosomal retrograde exit site.

scientific article

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

scientific article

Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism

scientific article

Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex.

scientific article published in November 2000

Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome

scientific article published on 24 June 2020

Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties

scientific article

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

scientific article

[Exosomes: carriers of prions?]

scientific article published on 01 February 2005

[Treatment and care of mental patients]

scientific article published on 01 November 1994

eC-CLEM: A multidimension, multimodel software to correlate intermodal images with a focus on light and electron microscopy

scientific article published on 19 April 2017

eC-CLEM: Flexible Multidimensional Registration Software for Correlative Microscopies with Refined Accuracy Mapping

eC-CLEM: flexible multidimensional registration software for correlative microscopies.

scientific article

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