List of works - Andrew Wakeham

14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.

scientific article

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

scientific journal article

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

scientific article published on 07 February 2019

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

scientific article

Author Correction: Fcmr regulates mononuclear phagocyte control of anti-tumor immunity

scientific article published on 03 September 2019

Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis

scientific article

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

scientific article published on 15 July 2013

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.

scientific article

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

scholarly article

CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.

scientific article

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

scientific article

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

scientific article

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

scientific article

Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses

scientific article published on 29 June 2003

DIPG-13. A NOVEL MOUSE MODEL REVEALS UNEXPECTED MECHANISMS OF ACTION OF ACVR1 MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA

scientific article published on 23 April 2019

Differential Requirement for Malt1 in T and B Cell Antigen Receptor Signaling ⬇️

scientific article published on November 1, 2003

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

scientific article published on 24 February 2014

Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis

scientific article

Fcmr regulates mononuclear phagocyte control of anti-tumor immunity

scientific article published on 18 June 2019

Generation and Characterization of the Anp32e-Deficient Mouse ⬇️

scientific article published on October 26, 2010

Generation and characterization of B7-H4/B7S1/B7x-deficient mice

scientific journal article

Generation and characterization of Smac/DIABLO-deficient mice.

scientific article

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

scientific article published on 22 January 2015

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53

scientific article

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.

scientific article

Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development

scientific article

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

scientific article

IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization

scientific article published on 23 December 2016

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

scientific article published on August 2012

Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice

scientific article published on 19 January 2016

Involvement of Toso in activation of monocytes, macrophages, and granulocytes

scientific article published on 28 January 2013

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

scientific article published in March 2010

K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.

scientific article published on 13 January 2017

Largen: a molecular regulator of mammalian cell size control

scientific article

Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury

scientific journal article

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis

scientific article published on 01 November 2002

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

scientific article published on 11 May 2016

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

scientific article published on May 2013

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

scientific article published on 05 March 2020

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

scientific article published on 9 July 2016

Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540-543

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

scientific article published on 15 February 2019

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

scientific article

Role of SODD in Regulation of Tumor Necrosis Factor Responses ⬇️

scientific article published on June 1, 2003

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

scientific article (publication date: 18 April 2002)

Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle

scientific article

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

scientific journal article

Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

scientific article

TAp73 is required for spermatogenesis and the maintenance of male fertility

scientific article published on 21 January 2014

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

scientific article published on 19 September 2008

Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.

scientific article published on 26 July 2010

The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

scientific journal article

The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo

scholarly article

The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.

scientific article published on 2 January 2012

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

scientific article published on 12 December 2016

The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.

scientific article published in May 2004

XB130 deficiency affects tracheal epithelial differentiation during airway repair

scientific article

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

scientific article

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

scientific journal article

List of works by Andrew Wakeham

14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

Author Correction: Fcmr regulates mononuclear phagocyte control of anti-tumor immunity

Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses

DIPG-13. A NOVEL MOUSE MODEL REVEALS UNEXPECTED MECHANISMS OF ACTION OF ACVR1 MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA

Differential Requirement for Malt1 in T and B Cell Antigen Receptor Signaling ⬇️

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis

Fcmr regulates mononuclear phagocyte control of anti-tumor immunity

Generation and Characterization of the Anp32e-Deficient Mouse ⬇️

Generation and characterization of B7-H4/B7S1/B7x-deficient mice

Generation and characterization of Smac/DIABLO-deficient mice.

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.

Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice

Involvement of Toso in activation of monocytes, macrophages, and granulocytes

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.

Largen: a molecular regulator of mammalian cell size control

Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540-543

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

Role of SODD in Regulation of Tumor Necrosis Factor Responses ⬇️

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

TAp73 is required for spermatogenesis and the maintenance of male fertility

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.

The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo

The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.

XB130 deficiency affects tracheal epithelial differentiation during airway repair

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1