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List of works by Christine A Pratilas

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

scholarly article

3'-deoxy-3'-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition

scientific article

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors

scientific article published on 10 September 2019

A Secondary Mutation in Confers Resistance to RAF Inhibition in a -Mutant Brain Tumor

scientific article published in September 2018

A clinically and genomically annotated nerve sheath tumor biospecimen repository

scientific article published on 19 June 2020

A novel RBMX-TFE3 gene fusion in a highly aggressive pediatric renal perivascular epithelioid cell tumor

scientific article published on 13 August 2019

Activation of receptor tyrosine kinases mediates acquired resistance to MEK inhibition in malignant peripheral nerve sheath tumors

scientific article published on 17 November 2020

Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase-Driven Leukemias and Other Malignancies

scientific article published on 18 September 2017

Author Correction: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling

scientific article published on 01 April 2019

BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors

scientific article published on 28 August 2019

BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition

scientific article published on 01 April 2020

BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines

scientific article published on April 2008

Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma

scientific article published on 01 January 2020

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

scientific article published on 2 June 2015

Combined inhibition of SHP2 and MEK is effective in models of NF1-deficient malignant peripheral nerve sheath tumors

scientific article published on 08 October 2020

DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female

scientific article published on 07 October 2020

Dermatologic adverse events in pediatric patients receiving targeted anticancer therapies: a pooled analysis.

scientific article

Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum

scientific article published on 01 September 2018

FLT3-IRAK dual targeting: an exciting new therapeutic option guided by adaptive activation of immune response pathways

scientific article published on 01 April 2020

From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor

scientific article published on 24 June 2020

Genetic predictors of MEK dependence in non-small cell lung cancer

scientific article

Genomic and biological characterization of exon 4 KRAS mutations in human cancer

scientific article

Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance ⬇️

scientific article published on July 1, 2012

Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma

scientific article published on 28 January 2015

Improving Detection of Cancer Predisposition Syndromes in Pediatric Oncology

scientific article published on 23 December 2020

Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1

scientific article published on 21 February 2020

Interferon α/β Enhances the Cytotoxic Response of MEK Inhibition in Melanoma

scientific article

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

scientific article

Metanephric Adenoma-Epithelial Wilms Tumor Overlap Lesions: An Analysis of BRAF Status

scientific article published on 01 September 2019

Models from experiments: combinatorial drug perturbations of cancer cells

scientific article published on 02 September 2008

New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target

scientific article

Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor

scientific article published on January 2014

Personalized Medicine in the Oncology Clinic: Implementation and Outcomes of the Johns Hopkins Molecular Tumor Board

scientific article published on 31 May 2017

Perturbation biology nominates upstream-downstream drug combinations in RAF inhibitor resistant melanoma cells

scientific article

Perturbation biology: inferring signaling networks in cellular systems

scientific article (publication date: 2013)

Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition

scientific article published on 03 June 2019

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

scientific article

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas ⬇️

scientific article published on November 13, 2012

Size-based detection of sarcoma circulating tumor cells and cell clusters

scientific article published on 24 August 2017

Socioeconomic and health care coverage disparities in children, adolescents, and young adults with sarcoma

scientific article published on 17 September 2020

Special Issue: "Genomics and Models of Nerve Sheath Tumors"

scientific article published on 01 September 2020

Sporadic Malignant Glomus Tumor of the Brachial Plexus With Response to Targeted Therapy Directed Against Oncogenic BRAF

scientific article published on 04 May 2018

Targeted therapy for soft tissue sarcomas in adolescents and young adults

scientific article published on 30 March 2017

Targeting Oncogenic BRAF in Human Cancer ⬇️

scientific article published on January 1, 2012

Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response

scientific article published on 14 May 2010

Telomere alterations in neurofibromatosis type 1-associated solid tumors

scientific article published on 28 August 2019

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner ⬇️

scientific article published on July 28, 2010

The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.

scientific article

The promise of signal transduction in genetically driven sarcomas of the nerve

scientific article published on 28 August 2017

Therapeutic potential of NTRK3 inhibition in desmoplastic small round cell tumor

scientific article published on 23 November 2020

Therapeutic strategies for targeting BRAF in human cancer

scientific article published on May 2007

Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)

scientific article published on 09 March 2010

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