List of works - Geert van Amerongen

A recombinant influenza A virus expressing domain III of West Nile virus induces protective immune responses against influenza and West Nile virus

scientific article (publication date: 26 April 2011)

A recombinant rabies vaccine expressing the trimeric form of the glycoprotein confers enhanced immunogenicity and protection in outbred mice

scientific article published on 21 June 2014

A single immunization with modified vaccinia virus Ankara-based influenza virus H7 vaccine affords protection in the influenza A(H7N9) pneumonia ferret model

scientific article

Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets

scientific article

Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus

scientific article published on 20 November 2013

Aerosol measles vaccination in macaques: Preclinical studies of immune responses and safety

article

Aetiology: Koch's postulates fulfilled for SARS virus

scientific article

An adenoviral type 5 vector carrying a type 35 fiber as a vaccine vehicle: DC targeting, cross neutralization, and immunogenicity

article by Olga J.A.E Ophorst et al published August 2004 in Vaccine

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

scientific article

Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits

scientific article published on 25 March 2015

Avian H5N1 influenza in cats

scientific article published on 2 September 2004

Characterization of humoral and cellular immune responses in cynomolgus macaques upon primary and subsequent heterologous infections with dengue viruses.

scientific article

Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets

scientific article

Comparison of the efficacy of early versus late viral proteins in vaccination against SIV

scientific article published on 01 July 2002

Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model

scientific article

Cross-clade immunity in cats vaccinated with a canarypox-vectored avian influenza vaccine.

scientific article

Cross-protection against lethal H5N1 challenge in ferrets with an adjuvanted pandemic influenza vaccine

scientific article

DNA vaccination of ferrets with chimeric influenza A virus hemagglutinin (H3) genes

scientific article published in May 2002

Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species

scientific article published on 16 February 2011

Early target cells of measles virus after aerosol infection of non-human primates

scientific article

Efficacy of a live attenuated tetravalent candidate dengue vaccine in naïve and previously infected cynomolgus macaques.

scientific article

Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets

scientific article

Enteric administration of a live attenuated measles vaccine does not induce protective immunity in a macaque model

scientific article published on 01 July 2002

Evaluation of BBG2Na in infant macaques: specific immune responses after vaccination and RSV challenge

scientific article published in February 2004

Evaluation of ISCOM-adjuvanted subunit vaccines containing recombinant feline immunodeficiency virus Rev, OrfA and envelope protein in cats

scientific article published in April 2008

Evaluation of a modified vaccinia virus Ankara (MVA)-based candidate pandemic influenza A/H1N1 vaccine in the ferret model

scientific article

Evaluation of synthetic infection-enhancing lipopeptides as adjuvants for a live-attenuated canine distemper virus vaccine administered intra-nasally to ferrets

scientific article published on 21 June 2012

Evaluation of vaccination strategies against infection with feline immunodeficiency virus (FIV) based on recombinant viral vectors expressing FIV Rev and OrfA.

scientific article published on 19 September 2008

Exacerbated innate host response to SARS-CoV in aged non-human primates

scientific article (publication date: February 2010)

Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract.

scientific article

Experimental infection of macaques with human metapneumovirus induces transient protective immunity

scientific article published on 01 April 2007

Experimental pandemic (H1N1) 2009 virus infection of cats

scientific article

Ferrets as a Novel Animal Model for Studying Human Respiratory Syncytial Virus Infections in Immunocompetent and Immunocompromised Hosts

scientific article published on 14 June 2016

Fusion protein is the main determinant of metapneumovirus host tropism

scientific article

Heterosubtypic immunity to H7N9 influenza virus in isogenic guinea pigs after infection with pandemic H1N1 virus.

scientific article

Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses

scientific article published on December 2008

Highly pathogenic avian influenza virus H5N1 infection in a long-distance migrant shorebird under migratory and non-migratory states

scientific article

Highly pathogenic avian influenza virus H7N7 isolated from a fatal human case causes respiratory disease in cats but does not spread systemically

scientific article published on 16 September 2010

Host proteome correlates of vaccine-mediated enhanced disease in a mouse model of respiratory syncytial virus infection

scientific article

Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.

scientific article

Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection

scientific article published on 26 October 2007

Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection

scientific article

Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus

scientific article

Immunogenicity and efficacy of recombinant subunit vaccines against phocid herpesvirus type 1.

scientific article published in June 2003

Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques

scientific article published on 6 June 2008

In vitro and in vivo isolation and characterization of Duvenhage virus

scientific article (publication date: 2012)

In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species.

scientific article published on 11 December 2006

In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques.

scientific article published on 24 February 2010

Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) with different wild-type measles viruses

scientific article published on July 2007

Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus

scientific article published on 19 June 2013

Infection of the upper respiratory tract with seasonal influenza A(H3N2) virus induces protective immunity in ferrets against infection with A(H1N1)pdm09 virus after intranasal, but not intratracheal, inoculation

scientific article published on 30 January 2013

Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine

scientific article

Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts.

scientific article

Intranasally administered Endocine formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets.

scientific article

Longevity of neutralizing antibody levels in macaques vaccinated with Quil A-adjuvanted measles vaccine candidates

scientific article published on 01 December 2002

Longevity of the protective immune response induced after vaccination with one or two doses of AS03A-adjuvanted split H5N1 vaccine in ferrets

scientific article

MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization.

scientific article

Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats

scientific article published on 16 November 2011

Measles immune suppression: lessons from the macaque model

scientific article (publication date: 2012)

Measles vaccination of macaques by dry powder inhalation

scientific article published on 23 October 2006

Measles vaccination of nonhuman primates provides partial protection against infection with canine distemper virus

scientific article

Measles virus infection of epithelial cells in the macaque upper respiratory tract is mediated by subepithelial immune cells

scientific article published on 30 January 2013

Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus

scientific article published in June 2005

Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets

scientific article published on 29 September 2011

Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection

scientific article published in August 2017

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome.

scientific article published in July 2003

Pandemic H1N1 vaccine requires the use of an adjuvant to protect against challenge in naïve ferrets

scientific article

Paramyxovirus infections in ex vivo lung slice cultures of different host species

scientific article published on 15 June 2013

Pathogenesis of Influenza A/H5N1 virus infection in ferrets differs between intranasal and intratracheal routes of inoculation ⬇️

scientific article

Pathogenesis of infection with 2009 pandemic H1N1 influenza virus in isogenic guinea pigs after intranasal or intratracheal inoculation.

scientific article

Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques

scientific article published on 22 February 2004

Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques

scientific article

Priming of measles virus-specific humoral- and cellular-immune responses in macaques by DNA vaccination

scientific article published in May 2002

Prolonged influenza virus shedding and emergence of antiviral resistance in immunocompromised patients and ferrets

scientific article

Pulmonary pathology of pandemic influenza A/H1N1 virus (2009)-infected ferrets upon longitudinal evaluation by computed tomography

scientific article

Recombinant modified vaccinia virus Ankara-based vaccine induces protective immunity in mice against infection with influenza virus H5N1.

scientific article

Recombinant soluble, multimeric HA and NA exhibit distinctive types of protection against pandemic swine-origin 2009 A(H1N1) influenza virus infection in ferrets

scientific article

Seasonal influenza vaccine provides priming for A/H1N1 immunization

scientific article published in December 2009

Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus.

scientific article

Simian varicella virus infection of Chinese rhesus macaques produces ganglionic infection in the absence of rash

scientific article published on 8 March 2012

Streptococcus pneumoniae Enhances Human Respiratory Syncytial Virus Infection In Vitro and In Vivo

scientific article published on 13 May 2015

Susceptibility of Carrion Crows to Experimental Infection with Lineage 1 and 2 West Nile Viruses

scientific article published in August 2015

Susceptibility of European jackdaws (Corvus monedula) to experimental infection with lineage 1 and 2 West Nile viruses

scientific article

T-Cell tropism of simian varicella virus during primary infection

scientific article

Transmission of Human Respiratory Syncytial Virus in the Immunocompromised Ferret Model

scientific article published on 2 January 2018

Vaccination Is More Effective Than Prophylactic Oseltamivir in Preventing CNS Invasion by H5N1 Virus via the Olfactory Nerve

scientific article published on April 2016

Vaccination against human influenza A/H3N2 virus prevents the induction of heterosubtypic immunity against lethal infection with avian influenza A/H5N1 virus.

scientific article

Vaccination of infant macaques with a recombinant modified vaccinia virus Ankara expressing the respiratory syncytial virus F and G genes does not predispose for immunopathology

scientific article published in February 2004

Virus replication kinetics and pathogenesis of infection with H7N9 influenza virus in isogenic guinea pigs upon intratracheal inoculation.

scientific article

Wild ducks as long-distance vectors of highly pathogenic avian influenza virus (H5N1)

scientific article published on April 2008

List of works by Geert van Amerongen

A recombinant influenza A virus expressing domain III of West Nile virus induces protective immune responses against influenza and West Nile virus

A recombinant rabies vaccine expressing the trimeric form of the glycoprotein confers enhanced immunogenicity and protection in outbred mice

A single immunization with modified vaccinia virus Ankara-based influenza virus H7 vaccine affords protection in the influenza A(H7N9) pneumonia ferret model

Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets

Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus

Aerosol measles vaccination in macaques: Preclinical studies of immune responses and safety

Aetiology: Koch's postulates fulfilled for SARS virus

An adenoviral type 5 vector carrying a type 35 fiber as a vaccine vehicle: DC targeting, cross neutralization, and immunogenicity

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits

Avian H5N1 influenza in cats

Characterization of humoral and cellular immune responses in cynomolgus macaques upon primary and subsequent heterologous infections with dengue viruses.

Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets

Comparison of the efficacy of early versus late viral proteins in vaccination against SIV

Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model

Cross-clade immunity in cats vaccinated with a canarypox-vectored avian influenza vaccine.

Cross-protection against lethal H5N1 challenge in ferrets with an adjuvanted pandemic influenza vaccine

DNA vaccination of ferrets with chimeric influenza A virus hemagglutinin (H3) genes

Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species

Early target cells of measles virus after aerosol infection of non-human primates

Efficacy of a live attenuated tetravalent candidate dengue vaccine in naïve and previously infected cynomolgus macaques.

Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets

Enteric administration of a live attenuated measles vaccine does not induce protective immunity in a macaque model

Evaluation of BBG2Na in infant macaques: specific immune responses after vaccination and RSV challenge

Evaluation of ISCOM-adjuvanted subunit vaccines containing recombinant feline immunodeficiency virus Rev, OrfA and envelope protein in cats

Evaluation of a modified vaccinia virus Ankara (MVA)-based candidate pandemic influenza A/H1N1 vaccine in the ferret model

Evaluation of synthetic infection-enhancing lipopeptides as adjuvants for a live-attenuated canine distemper virus vaccine administered intra-nasally to ferrets

Evaluation of vaccination strategies against infection with feline immunodeficiency virus (FIV) based on recombinant viral vectors expressing FIV Rev and OrfA.

Exacerbated innate host response to SARS-CoV in aged non-human primates

Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract.

Experimental infection of macaques with human metapneumovirus induces transient protective immunity

Experimental pandemic (H1N1) 2009 virus infection of cats

Ferrets as a Novel Animal Model for Studying Human Respiratory Syncytial Virus Infections in Immunocompetent and Immunocompromised Hosts

Fusion protein is the main determinant of metapneumovirus host tropism

Heterosubtypic immunity to H7N9 influenza virus in isogenic guinea pigs after infection with pandemic H1N1 virus.

Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses

Highly pathogenic avian influenza virus H5N1 infection in a long-distance migrant shorebird under migratory and non-migratory states

Highly pathogenic avian influenza virus H7N7 isolated from a fatal human case causes respiratory disease in cats but does not spread systemically

Host proteome correlates of vaccine-mediated enhanced disease in a mouse model of respiratory syncytial virus infection

Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.

Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection

Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection

Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus

Immunogenicity and efficacy of recombinant subunit vaccines against phocid herpesvirus type 1.

Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques

In vitro and in vivo isolation and characterization of Duvenhage virus

In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species.

In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques.

Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) with different wild-type measles viruses

Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus

Infection of the upper respiratory tract with seasonal influenza A(H3N2) virus induces protective immunity in ferrets against infection with A(H1N1)pdm09 virus after intranasal, but not intratracheal, inoculation

Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine

Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts.

Intranasally administered Endocine formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets.

Longevity of neutralizing antibody levels in macaques vaccinated with Quil A-adjuvanted measles vaccine candidates

Longevity of the protective immune response induced after vaccination with one or two doses of AS03A-adjuvanted split H5N1 vaccine in ferrets

MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization.

Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats

Measles immune suppression: lessons from the macaque model

Measles vaccination of macaques by dry powder inhalation

Measles vaccination of nonhuman primates provides partial protection against infection with canine distemper virus

Measles virus infection of epithelial cells in the macaque upper respiratory tract is mediated by subepithelial immune cells

Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus

Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets

Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome.

Pandemic H1N1 vaccine requires the use of an adjuvant to protect against challenge in naïve ferrets

Paramyxovirus infections in ex vivo lung slice cultures of different host species

Pathogenesis of Influenza A/H5N1 virus infection in ferrets differs between intranasal and intratracheal routes of inoculation ⬇️

Pathogenesis of infection with 2009 pandemic H1N1 influenza virus in isogenic guinea pigs after intranasal or intratracheal inoculation.

Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques

Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques

Priming of measles virus-specific humoral- and cellular-immune responses in macaques by DNA vaccination

Prolonged influenza virus shedding and emergence of antiviral resistance in immunocompromised patients and ferrets

Pulmonary pathology of pandemic influenza A/H1N1 virus (2009)-infected ferrets upon longitudinal evaluation by computed tomography

Recombinant modified vaccinia virus Ankara-based vaccine induces protective immunity in mice against infection with influenza virus H5N1.

Recombinant soluble, multimeric HA and NA exhibit distinctive types of protection against pandemic swine-origin 2009 A(H1N1) influenza virus infection in ferrets

Seasonal influenza vaccine provides priming for A/H1N1 immunization

Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus.