List of works - Carol A Lange

"Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers"

article

A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells

scientific article published on 05 August 2013

Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming

scientific article published on 17 November 2015

Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer

scientific article published on 29 January 2016

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

scientific article

Breast tumor kinase (Brk/PTK6) mediates advanced cancer phenotypes via SH2-domain dependent activation of RhoA and aryl hydrocarbon receptor (AhR) signaling

scientific article published on 10 November 2020

Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

scientific article

Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells

scientific article

Brk/PTK6 signaling in normal and cancer cell models

scientific article

Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models are Promoted by PELP1/AIB1 Complexes

scientific article published on 18 January 2018

Cross-talk between growth factor and progesterone receptor signaling pathways: implications for breast cancer cell growth

scientific article

Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation

scientific article published on January 2013

Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events

scientific article

Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer

scientific article published on 01 May 2020

Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer

scientific article published on 04 November 2020

Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation

scientific article published on 11 December 2008

Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators

scientific article

Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth

scientific article

Lost in translation: can we afford to miss the trees for the forest?

scientific article published on 01 August 2014

MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association

scientific article

Making Sense of Cross-Talk between Steroid Hormone Receptors and Intracellular Signaling Pathways: Who Will Have the Last Word? ⬇️

scientific article published on October 16, 2003

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

scientific article published on 17 September 2011

Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression

scientific article

Meeting review: Extra-nuclear steroid receptors-Integration with multiple signaling pathways

scientific article

Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications

scientific article

Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family members

scientific article

Minireview: Deciphering the Cellular Functions of PELP1

scientific article

Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.

scientific article

Modifications to glucocorticoid and progesterone receptors alter cell fate in breast cancer

scientific article

Molecular determinants of context-dependent progesterone receptor action in breast cancer

scientific article

OR26-1 Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem-Like and Proliferative Breast Cancer Cell Fates.

scientific article

OR34-1 Regulation of Breast Cancer Stem Cells by Nuclear Receptor Co-Regulatory Proteins

PELP1: a review of PELP1 interactions, signaling, and biology

scientific article

Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates

scientific article published on 01 February 2019

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

scientific article

Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells

scientific article

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs

scientific article

Progesterone Receptor Action:

Progesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models

scientific article published on 01 June 2021

Progesterone action in breast, uterine, and ovarian cancers

scientific article

Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes

scientific article published on 16 September 2016

Progesterone receptor action: defining a role in breast cancer

scientific article

Progesterone receptor action: translating studies in breast cancer models to clinical insights

scientific article published on January 2008

Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors

scientific article

Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells

scientific article

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models

scientific article

Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models

scientific article

Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells.

scientific article published on 10 April 2013

Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases

scientific article

Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells

scientific article published on 30 October 2006

Regulated association of protein kinase B/Akt with breast tumor kinase

scientific article

Role of phosphorylation in progesterone receptor signaling and specificity

scientific article

SUN-004 Unique Cell Fates and Metastatic Phenotypes Are Activated by Progesterone Receptor (PR) Isoform-specific Gene Expression in Fallopian Tube Models of HGSC.

scientific article published on 30 April 2019

SUN-007 Discovery of Novel Signaling Pathways Downstream of PTK6 in TNBC Models

scientific article published on 30 April 2019

SUN-008 The Glucocorticoid Receptor Is Essential For TGFβ and p38 MAPK Mediated Cancer Phenotypes in Triple Negative Breast Cancer

scientific article published on 30 April 2019

Scaffolding actions of membrane-associated progesterone receptors

scientific article published on 24 December 2008

Signaling inputs to progesterone receptor gene regulation and promoter selectivity

scientific article

Statement of principle

scientific article published on 01 December 2014

Statement of principle

scientific article published on 03 November 2014

Statement of principle

scientific article published on 01 February 2015

Steroid Receptors as MAPK Signaling Sensors in Breast Cancer: Let the Fates Decide

scientific article published on 01 March 2020

Targeting steroid receptor co-activators to inhibit breast cancer stem cells

scientific article published on 28 August 2018

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis

scientific article published on 10 July 2018

The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention

scientific article

Tracking progesterone receptor-mediated actions in breast cancer

scientific article

ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells

scientific article

List of works by Carol A Lange

"Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers"

A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells

Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming

Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

Breast tumor kinase (Brk/PTK6) mediates advanced cancer phenotypes via SH2-domain dependent activation of RhoA and aryl hydrocarbon receptor (AhR) signaling

Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells

Brk/PTK6 signaling in normal and cancer cell models

Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models are Promoted by PELP1/AIB1 Complexes

Cross-talk between growth factor and progesterone receptor signaling pathways: implications for breast cancer cell growth

Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation

Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events

Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer

Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer

Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation

Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators

Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth

Lost in translation: can we afford to miss the trees for the forest?

MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association

Making Sense of Cross-Talk between Steroid Hormone Receptors and Intracellular Signaling Pathways: Who Will Have the Last Word? ⬇️

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression

Meeting review: Extra-nuclear steroid receptors-Integration with multiple signaling pathways

Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications

Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family members

Minireview: Deciphering the Cellular Functions of PELP1

Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.

Modifications to glucocorticoid and progesterone receptors alter cell fate in breast cancer

Molecular determinants of context-dependent progesterone receptor action in breast cancer

OR26-1 Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem-Like and Proliferative Breast Cancer Cell Fates.

OR34-1 Regulation of Breast Cancer Stem Cells by Nuclear Receptor Co-Regulatory Proteins

PELP1: a review of PELP1 interactions, signaling, and biology

Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs

Progesterone Receptor Action:

Progesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models

Progesterone action in breast, uterine, and ovarian cancers

Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes

Progesterone receptor action: defining a role in breast cancer

Progesterone receptor action: translating studies in breast cancer models to clinical insights

Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors

Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models

Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models

Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells.

Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases

Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells

Regulated association of protein kinase B/Akt with breast tumor kinase

Role of phosphorylation in progesterone receptor signaling and specificity

SUN-004 Unique Cell Fates and Metastatic Phenotypes Are Activated by Progesterone Receptor (PR) Isoform-specific Gene Expression in Fallopian Tube Models of HGSC.

SUN-007 Discovery of Novel Signaling Pathways Downstream of PTK6 in TNBC Models

SUN-008 The Glucocorticoid Receptor Is Essential For TGFβ and p38 MAPK Mediated Cancer Phenotypes in Triple Negative Breast Cancer

Scaffolding actions of membrane-associated progesterone receptors

Signaling inputs to progesterone receptor gene regulation and promoter selectivity

Statement of principle

Statement of principle

Statement of principle

Steroid Receptors as MAPK Signaling Sensors in Breast Cancer: Let the Fates Decide

Targeting steroid receptor co-activators to inhibit breast cancer stem cells

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis

The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention

Tracking progesterone receptor-mediated actions in breast cancer

ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells