List of works - Matteo Porotto

A broad-spectrum antiviral targeting entry of enveloped viruses

scientific article

A general strategy to endow natural fusion-protein-derived peptides with potent antiviral activity

scientific article (publication date: 2012)

A recombinant sialidase fusion protein effectively inhibits human parainfluenza viral infection in vitro and in vivo

scientific article

A second receptor binding site on human parainfluenza virus type 3 hemagglutinin-neuraminidase contributes to activation of the fusion mechanism

scientific article published on 17 January 2007

A three-dimensional model of human lung development and disease from pluripotent stem cells.

scientific article published on 24 April 2017

Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model

scientific article published on 21 December 2021

Adaptation of human parainfluenza virus to airway epithelium reveals fusion properties required for growth in host tissue

scientific article

Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain

scientific article published on 05 February 2019

Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

scientific article published on 14 July 2020

Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length.

scientific article published on 15 July 2017

Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro

scientific article

Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol.

scientific article published on 31 October 2017

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides.

scientific article published on 08 March 2017

Capturing a fusion intermediate of influenza hemagglutinin with a cholesterol-conjugated peptide, a new antiviral strategy for influenza virus

scientific article published on 12 October 2011

Circulating clinical strains of human parainfluenza virus reveal viral entry requirements for in vivo infection

scientific article

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

scientific article published on 14 May 2008

Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus.

scientific article published on 04 March 2008

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

scientific article published on 05 November 2020

Dual Inhibition of Human Parainfluenza Type 3 and Respiratory Syncytial Virus Infectivity with a Single Agent

scientific article published on 05 August 2019

Effects of single α-to-β residue replacements on recognition of an extended segment in a viral fusion protein

scientific article published on 21 July 2020

Electron tomography imaging of surface glycoproteins on human parainfluenza virus 3: association of receptor binding and fusion proteins before receptor engagement

scientific article

Erratum for Gui et al., Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement

scientific article published on 19 January 2016

Fatal measles virus infection prevented by brain-penetrant fusion inhibitors

scientific article

Features of Circulating Parainfluenza Virus Required for Growth in Human Airway.

scientific article published on 15 March 2016

Fusion Inhibitory Lipopeptides Engineered for Prophylaxis of Nipah Virus in Primates.

scientific article published on 16 March 2018

Fusion promotion by a paramyxovirus hemagglutinin-neuraminidase protein: pH modulation of receptor avidity of binding sites I and II

scientific article

Human parainfluenza virus fusion complex glycoproteins imaged in action on authentic viral surfaces

scientific article published on 21 September 2020

Human parainfluenza virus infection of the airway epithelium: viral hemagglutinin-neuraminidase regulates fusion protein activation and modulates infectivity.

scientific article published on 22 April 2009

Identification of a region in the stalk domain of the nipah virus receptor binding protein that is critical for fusion activation

scientific article published on 31 July 2013

Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure.

scientific article published on 23 January 2014

In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age

scientific article published on 22 June 2020

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

scientific article published on 08 September 2020

Infection of primary neurons mediated by nipah virus envelope proteins: role of host target cells in antiviral action

scientific article published on 8 June 2011

Influence of the human parainfluenza virus 3 attachment protein's neuraminidase activity on its capacity to activate the fusion protein

scientific article

Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry

scientific article

Inhibition of parainfluenza virus type 3 and Newcastle disease virus hemagglutinin-neuraminidase receptor binding: effect of receptor avidity and steric hindrance at the inhibitor binding sites.

scientific article published on December 2004

Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo

scientific article

Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

preprint posted on 05 November 2020

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

scientific article published on 17 February 2021

Kinetic dependence of paramyxovirus entry inhibition.

scientific article published on 15 April 2009

Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route

scientific article published on 03 April 2019

Measles fusion machinery is dysregulated in neuropathogenic variants

scientific article published on 10 February 2015

Measles virus fusion machinery activated by sialic acid binding globular domain

scientific article published on 9 October 2013

Mechanism of fusion triggering by human parainfluenza virus type III: communication between viral glycoproteins during entry

scientific article published on 22 November 2011

Modeling Infection and Tropism of Human Parainfluenza Virus Type 3 in Ferrets

scientific article published on 15 February 2022

Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain

scientific article published on 01 June 2021

Mutations in human parainfluenza virus type 3 hemagglutinin-neuraminidase causing increased receptor binding activity and resistance to the transition state sialic acid analog 4-GU-DANA (Zanamivir).

scientific article

Paramyxovirus receptor-binding molecules: engagement of one site on the hemagglutinin-neuraminidase protein modulates activity at the second site

scientific article

Premature activation of the paramyxovirus fusion protein before target cell attachment with corruption of the viral fusion machinery

scientific article published on 28 July 2011

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

scientific article published on 30 March 2017

Rapid screening for entry inhibitors of highly pathogenic viruses under low-level biocontainment

scientific article (publication date: 2012)

Regulation of paramyxovirus fusion activation: the hemagglutinin-neuraminidase protein stabilizes the fusion protein in a pretriggered state.

scientific article

Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy.

scientific article published on 4 March 2009

Spring-loaded model revisited: paramyxovirus fusion requires engagement of a receptor binding protein beyond initial triggering of the fusion protein

scientific article published on 5 October 2011

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor

scientific article published on 23 January 2020

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor

Structure-Stability-Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles

scientific article published on 24 September 2018

Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

scientific article published in 2023

Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus

scientific article

The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion

scientific article

Triggering of human parainfluenza virus 3 fusion protein (F) by the hemagglutinin-neuraminidase (HN) protein: an HN mutation diminishes the rate of F activation and fusion

scientific article

Unity in diversity: shared mechanism of entry among paramyxoviruses

scientific article

Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation.

scientific article

Viral entry inhibitors targeted to the membrane site of action.

scientific article

List of works by Matteo Porotto

A broad-spectrum antiviral targeting entry of enveloped viruses

A general strategy to endow natural fusion-protein-derived peptides with potent antiviral activity

A recombinant sialidase fusion protein effectively inhibits human parainfluenza viral infection in vitro and in vivo

A second receptor binding site on human parainfluenza virus type 3 hemagglutinin-neuraminidase contributes to activation of the fusion mechanism

A three-dimensional model of human lung development and disease from pluripotent stem cells.

Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model

Adaptation of human parainfluenza virus to airway epithelium reveals fusion properties required for growth in host tissue

Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain

Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length.

Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro

Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol.

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides.

Capturing a fusion intermediate of influenza hemagglutinin with a cholesterol-conjugated peptide, a new antiviral strategy for influenza virus

Circulating clinical strains of human parainfluenza virus reveal viral entry requirements for in vivo infection

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus.

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Dual Inhibition of Human Parainfluenza Type 3 and Respiratory Syncytial Virus Infectivity with a Single Agent

Effects of single α-to-β residue replacements on recognition of an extended segment in a viral fusion protein

Electron tomography imaging of surface glycoproteins on human parainfluenza virus 3: association of receptor binding and fusion proteins before receptor engagement

Erratum for Gui et al., Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement

Fatal measles virus infection prevented by brain-penetrant fusion inhibitors

Features of Circulating Parainfluenza Virus Required for Growth in Human Airway.

Fusion Inhibitory Lipopeptides Engineered for Prophylaxis of Nipah Virus in Primates.

Fusion promotion by a paramyxovirus hemagglutinin-neuraminidase protein: pH modulation of receptor avidity of binding sites I and II

Human parainfluenza virus fusion complex glycoproteins imaged in action on authentic viral surfaces

Human parainfluenza virus infection of the airway epithelium: viral hemagglutinin-neuraminidase regulates fusion protein activation and modulates infectivity.

Identification of a region in the stalk domain of the nipah virus receptor binding protein that is critical for fusion activation

Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure.

In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

Infection of primary neurons mediated by nipah virus envelope proteins: role of host target cells in antiviral action

Influence of the human parainfluenza virus 3 attachment protein's neuraminidase activity on its capacity to activate the fusion protein

Inhibition of Nipah virus infection in vivo: targeting an early stage of paramyxovirus fusion activation during viral entry

Inhibition of parainfluenza virus type 3 and Newcastle disease virus hemagglutinin-neuraminidase receptor binding: effect of receptor avidity and steric hindrance at the inhibitor binding sites.

Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo

Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

Kinetic dependence of paramyxovirus entry inhibition.

Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route

Measles fusion machinery is dysregulated in neuropathogenic variants

Measles virus fusion machinery activated by sialic acid binding globular domain

Mechanism of fusion triggering by human parainfluenza virus type III: communication between viral glycoproteins during entry

Modeling Infection and Tropism of Human Parainfluenza Virus Type 3 in Ferrets

Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain

Mutations in human parainfluenza virus type 3 hemagglutinin-neuraminidase causing increased receptor binding activity and resistance to the transition state sialic acid analog 4-GU-DANA (Zanamivir).

Paramyxovirus receptor-binding molecules: engagement of one site on the hemagglutinin-neuraminidase protein modulates activity at the second site

Premature activation of the paramyxovirus fusion protein before target cell attachment with corruption of the viral fusion machinery

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

Rapid screening for entry inhibitors of highly pathogenic viruses under low-level biocontainment

Regulation of paramyxovirus fusion activation: the hemagglutinin-neuraminidase protein stabilizes the fusion protein in a pretriggered state.

Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy.

Spring-loaded model revisited: paramyxovirus fusion requires engagement of a receptor binding protein beyond initial triggering of the fusion protein

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor

Structure-Stability-Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles

Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus

The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion

Triggering of human parainfluenza virus 3 fusion protein (F) by the hemagglutinin-neuraminidase (HN) protein: an HN mutation diminishes the rate of F activation and fusion

Unity in diversity: shared mechanism of entry among paramyxoviruses

Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation.

Viral entry inhibitors targeted to the membrane site of action.