List of works - Ann M Richard

A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing

article

A mechanistic framework for integrating chemical structure and high-throughput screening results to improve toxicity predictions

article

A novel approach: chemical relational databases, and the role of the ISSCAN database on assessing chemical carcinogenicity.

scientific article published on January 2008

A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents

scientific article published on 03 April 2009

ACToR — Aggregated Computational Toxicology Resource

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

scientific article published on 18 January 2011

Advancing exposure characterization for chemical evaluation and risk assessment.

scientific article published in February 2010

Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

scientific article

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

scientific article

Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling

scientific article published on 30 December 2019

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

scientific article published in July 2016

Chemical effects in biological systems--data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and 'omics data

scientific article

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

scientific article published on 07 February 2020

Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".

scientific article published on January 2017

Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra

scientific article published in October 2004

Computational Tools for ADMET Profiling

Computational toxicology--a state of the science mini review

scientific article published on 07 December 2007

Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function

scientific article published on 10 December 2019

Conversion of Developmental Neurotoxicity (DNT) information into a structure-searchable relational database

EADB: an estrogenic activity database for assessing potential endocrine activity.

scientific article published on 28 July 2013

EPA's non-targeted analysis collaborative trial (ENTACT): genesis, design, and initial findings

scientific article published on 06 December 2018

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

scientific article

Endocrine profiling and prioritization of environmental chemicals using ToxCast data

scientific article

Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals

scientific article

Exposure science and the U.S. EPA National Center for Computational Toxicology

scientific article

Genetic toxicology in the 21st century: reflections and future directions

scientific article

Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations

scientific article

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

scientific article published on 28 February 2019

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

scientific article

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

scientific article

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

article

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.

scientific article published on 13 August 2015

Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA.

scientific article published on 29 December 2017

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

scientific article

Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring

scientific article

Mutagenicity in Salmonella of halonitromethanes: a recently recognized class of disinfection by-products in drinking water

scientific article

New publicly available chemical query language, CSRML, to support chemotype representations for application to data mining and modeling

scientific article published on 19 February 2015

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

scientific article (publication date: 2013)

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

scientific article

Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays

scientific article published on 16 May 2013

Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential

scientific article

QSAR modeling: where have you been? Where are you going to?

scientific article (publication date: 26 June 2014)

Rapid experimental measurements of physicochemical properties to inform models and testing

scientific article published on 02 May 2018

Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells

scientific article published on 10 June 2013

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.

scientific article

Suspect Screening Analysis of Chemicals in Consumer Products

scientific article published on 6 February 2018

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

scientific article

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency

scientific article published on 01 June 2019

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

scientific article published on 03 November 2020

The ToxCast program for prioritizing toxicity testing of environmental chemicals

scientific article

The expanding role of predictive toxicology: an update on the (Q)SAR models for mutagens and carcinogens

scientific article published on January 2007

The toxicity data landscape for environmental chemicals

scientific article

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

scientific article (publication date: 15 August 2016)

ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

article

Toxicity data informatics: supporting a new paradigm for toxicity prediction

scientific article

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

scientific article published on 15 May 2012

Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity

scientific article

Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity ⬇️

scientific article published on October 27, 2010

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

scientific article

Using prepared mixtures of ToxCast chemicals to evaluate non-targeted analysis (NTA) method performance

scientific article published on 05 January 2019

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

scientific article published on 01 January 2020

Wikipedia on the CompTox Chemicals Dashboard: Connecting Resources to Enrich Public Chemical Data

scientific article published on 10 October 2022

List of works by Ann M Richard

A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing

A mechanistic framework for integrating chemical structure and high-throughput screening results to improve toxicity predictions

A novel approach: chemical relational databases, and the role of the ISSCAN database on assessing chemical carcinogenicity.

A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents

ACToR — Aggregated Computational Toxicology Resource

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

Advancing exposure characterization for chemical evaluation and risk assessment.

Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

Chemical effects in biological systems--data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and 'omics data

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".

Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra

Computational Tools for ADMET Profiling

Computational toxicology--a state of the science mini review

Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function

Conversion of Developmental Neurotoxicity (DNT) information into a structure-searchable relational database

EADB: an estrogenic activity database for assessing potential endocrine activity.

EPA's non-targeted analysis collaborative trial (ENTACT): genesis, design, and initial findings

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Endocrine profiling and prioritization of environmental chemicals using ToxCast data

Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals

Exposure science and the U.S. EPA National Center for Computational Toxicology

Genetic toxicology in the 21st century: reflections and future directions

Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.

Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA.

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring

Mutagenicity in Salmonella of halonitromethanes: a recently recognized class of disinfection by-products in drinking water

New publicly available chemical query language, CSRML, to support chemotype representations for application to data mining and modeling

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays

Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential

QSAR modeling: where have you been? Where are you going to?

Rapid experimental measurements of physicochemical properties to inform models and testing

Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.

Suspect Screening Analysis of Chemicals in Consumer Products

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

The ToxCast program for prioritizing toxicity testing of environmental chemicals

The expanding role of predictive toxicology: an update on the (Q)SAR models for mutagens and carcinogens

The toxicity data landscape for environmental chemicals

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

Toxicity data informatics: supporting a new paradigm for toxicity prediction

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity

Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity ⬇️

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

Using prepared mixtures of ToxCast chemicals to evaluate non-targeted analysis (NTA) method performance

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

Wikipedia on the CompTox Chemicals Dashboard: Connecting Resources to Enrich Public Chemical Data