List of works - Keiju Aokage

A non-randomized confirmatory trial of segmentectomy for clinical T1N0 lung cancer with dominant ground glass opacity based on thin-section computed tomography (JCOG1211).

scientific article

A proposal for a comprehensive risk scoring system for predicting postoperative complications in octogenarian patients with medically operable lung cancer: JACS1303.

scientific article

A randomized Phase III trial of lobe-specific vs. systematic nodal dissection for clinical Stage I-II non-small cell lung cancer (JCOG1413)

Abundant tumor promoting stromal cells in lung adenocarcinoma with hypoxic regions

scientific article published on 20 November 2017

Annual abdominal ultrasonographic examination after curative NSCLC resection.

scientific article published on 11 May 2007

Association between the mutational smoking signature and the immune microenvironment in lung adenocarcinoma

scientific article published on 01 July 2020

Cancer‐initiating cell marker‐positive cells generate metastatic tumors that recapitulate the histology of the primary tumors ⬇️

scientific article published on February 22, 2013

Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia

scientific article published on 06 November 2018

Clinical and Pathological Staging Validation in the Eighth Edition of the TNM Classification for Lung Cancer: Correlation between Solid Size on Thin-Section Computed Tomography and Invasive Size in Pathological Findings in the New T Classification

scientific article published on 13 June 2017

Clinical prediction of solitary pulmonary nodule after a curative resection for gastric cancer

scientific article published on 01 December 2018

Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer

scientific article published on 14 February 2019

Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma

scientific article published on 22 October 2016

Comparison of pulmonary segmentectomy and lobectomy: Safety results of a randomized trial

scientific article published on 09 April 2019

Correlation between maximum standardized uptake values on FDG-PET and microenvironmental factors in patients with clinical stage IA radiologic pure-solid lung adenocarcinoma

scientific article published on 09 August 2019

Delayed cut-end recurrence after wedge resection for pulmonary ground-glass opacity adenocarcinoma despite negative surgical margin

scientific article published on 18 July 2019

Differences between squamous cell carcinoma and adenocarcinoma of the lung: are adenocarcinoma and squamous cell carcinoma prognostically equal?

scientific article published on 30 December 2011

Differences of tumor microenvironment between stage I lepidic-positive and lepidic-negative lung adenocarcinomas

scientific article published on 04 June 2018

Distinctive histopathological features of lepidic growth predominant node-negative adenocarcinomas 3-5 cm in size.

scientific article published on 21 November 2012

Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma

scientific article published on 18 June 2015

Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation

scientific article published on 07 June 2010

Effectiveness of Bone Suppression Imaging in the Detection of Lung Nodules on Chest Radiographs: Relevance to Anatomic Location and Observer's Experience

scientific article published on 13 September 2017

Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma

scientific article

Extended bronchoplasty for locally advanced left lower lobe lung cancer: surgical technique and outcomes

scientific article published on 2 April 2018

Ezrin-expressing lung adenocarcinoma cells and podoplanin-positive fibroblasts form a malignant microenvironment

scientific article published on 11 October 2014

Feasibility and efficacy of salvage lung resection after definitive chemoradiation therapy for Stage III non-small-cell lung cancer.

scientific article published on 19 August 2016

Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma

scientific article published on 19 February 2013

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung

scientific article published on 9 August 2016

Ground-Glass Opacity Is a Strong Prognosticator for Pathologic Stage IA Lung Adenocarcinoma

scientific article published on 12 March 2019

Growth patterns of small peripheral squamous cell carcinoma of the lung and their impacts on pathological and biological characteristics of tumor cells

scientific article published on 21 May 2019

High-Risk Factors for Recurrence of Stage I Lung Adenocarcinoma: Follow-up Data From JCOG0201

scientific article published on 20 July 2019

Histological progression of small intrapulmonary metastatic tumor from primary lung adenocarcinoma

scientific article published on 14 September 2010

Histology is a Prognostic Indicator After Pulmonary Metastasectomy from Renal Cell Carcinoma

scientific article published on 28 November 2016

Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness

scientific article published in September 2010

Identification of early t1b lung adenocarcinoma based on thin-section computed tomography findings

scientific article published in October 2013

Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma

scientific article published on 28 July 2013

Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia

scientific article published on 5 October 2017

Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma.

scientific article

Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung

scientific article published on 12 February 2018

Impact of extratumoral lymphatic permeation on postoperative survival of non-small-cell lung cancer patients

scientific article

Impact of positive pleural lavage cytology on survival in patients having lung resection for non-small-cell lung cancer: An international individual patient data meta-analysis

scientific article

Influence of Ground-Glass Opacity and the Corresponding Pathological Findings on Survival in Patients with Clinical Stage I Non-Small Cell Lung Cancer

scientific article published on 12 December 2017

Interstitial growth as an aggressive growth pattern in primary lung cancer

scientific article

Intrapulmonary metastasis in resected pathologic stage IIIB non-small cell lung cancer: possible contribution of aerogenous metastasis to the favorable outcome.

scientific article published in August 2007

Is cancer history really an exclusion criterion for clinical trial of lung cancer? Influence of gastrointestinal tract cancer history on the outcomes of lung cancer surgery

scientific article

Is cancer history really an exclusion criterion for clinical trial of lung cancer? Influence of gastrointestinal tract cancer history on the outcomes of lung cancer surgery

scientific article published on 01 February 2017

Large pulmonary sclerosing pneumocytoma with massive necrosis and vascular invasion: a case report

scientific article published on 01 July 2019

Late recurrence of non-small cell lung cancer more than 5 years after complete resection: incidence and clinical implications in patient follow-up

scientific article published on 09 April 2010

Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery: a review

scientific article

Limited resection trial for pulmonary ground-glass opacity nodules: case selection based on high-resolution computed tomography-interim results

scientific article published on 21 April 2015

Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma

scientific article published on 28 October 2018

Long-term outcome and late recurrence in patients with completely resected stage IA non-small cell lung cancer

scientific article published on 01 August 2010

Long-term outcome of surgical resection for residual or regrown advanced non-small cell lung carcinomas following EGFR-TKI treatment: report of four cases.

scientific article published on 16 December 2014

Long-term outcomes of 50 cases of limited-resection trial for pulmonary ground-glass opacity nodules

scientific article published in October 2012

Long-term survival after complete resection of non-small-cell lung cancer in patients with interstitial lung disease

scientific article published on 18 December 2017

Long-term survival and risk factors for recurrence in stage I non-small cell lung cancer patients with tumors up to 3 cm in maximum dimension

scientific article published on 30 April 2010

Long-term survival in two cases of resected gastric metastasis of pulmonary pleomorphic carcinoma

scientific article published on 01 July 2008

Long-term survival outcome after lobectomy in patients with clinical T1 N0 lung cancer

scientific article published on 11 January 2020

Long-term survival outcome after postoperative recurrence of non-small-cell lung cancer: who is 'cured' from postoperative recurrence?

scientific article

Low-fat diet management strategy for chylothorax after pulmonary resection and lymph node dissection for primary lung cancer

scientific article published on 12 June 2013

Machine learning-based histological classification that predicts recurrence of peripheral lung squamous cell carcinoma

scientific article published on 18 July 2020

Mediastinal nodal involvement in patients with clinical stage I non-small-cell lung cancer: possibility of rational lymph node dissection

scientific article published on 01 June 2015

Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung

scientific article published on 27 July 2016

Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis

scientific article published on 23 April 2012

Multiple Perivascular Epithelioid Cell Tumors: Clear Cell Tumor of the Lung Accompanied by Angiomyolipoma of the Liver ⬇️

scientific article published on April 20, 2013

Optimal method for measuring invasive size that predicts survival in invasive mucinous adenocarcinoma of the lung

scientific article published on 22 February 2020

P31: Salvage surgery for PMGCT: beneficial for persistent positive-marker patients?

scientific article published in December 2015

Perioperative pirfenidone treatment as prophylaxis against acute exacerbation of idiopathic pulmonary fibrosis: a single-center analysis

scientific article published on 06 March 2020

Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma

scientific article published on 6 March 2018

Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibrobla

scientific article published in April 2013

Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi type B, in three patients

scientific article published in April 2010

Postoperative oligo-recurrence of non-small-cell lung cancer: clinical features and survival†.

scientific article published on 22 July 2015

Prediction of prolonged air leak after lung resection using continuous log data of flow by digital drainage system

scientific article published on 15 April 2019

Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.

scientific article

Prognosis of lung cancer patients with a past history of colorectal cancer

scientific article published on 24 August 2014

Prognostic Impact of the Number of Metastatic Lymph Nodes on the Eighth Edition of the TNM Classification of NSCLC

scientific article published on 02 May 2019

Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma: possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment.

scientific article

Prognostic impact of a ground-glass opacity component in clinical stage IA non-small cell lung cancer

scientific article published on 06 April 2020

Prognostic impact of intratumoural microvascular invasion and microlymphatic permeation on node-negative non-small-cell lung cancer: which indicator is the stronger prognostic factor?

scientific article published on 3 August 2012

Prognostic impact of microscopic vessel invasion and visceral pleural invasion in non-small cell lung cancer: a retrospective analysis of 2657 patients

scientific article published in August 2014

Prognostic impact of node involvement pattern in pN1 non-small cell lung cancer patients

scientific article published in October 2010

Prognostic significance of a solid component in pulmonary adenocarcinoma.

scientific article

Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung

scientific article published on 01 September 2019

Pulmonary metastasis from encapsulated cervical ectopic type a thymoma

scientific article published in December 2012

Radiologic Criteria in Predicting Pathologic Less Invasive Lung Cancer According to TNM 8th Edition

scientific article published on 15 November 2018

Randomized Phase III Study of Irinotecan Plus Cisplatin Versus Etoposide Plus Cisplatin for Completely Resected High-Grade Neuroendocrine Carcinoma of the Lung: JCOG1205/1206

scientific article published on 02 November 2020

Reasonable extent of lymph node dissection in intentional segmentectomy for small-sized peripheral non-small-cell lung cancer: from the clinicopathological findings of patients who underwent lobectomy with systematic lymph node dissection

scientific article published on 01 November 2012

Recent advances and future perspectives in adjuvant and neoadjuvant immunotherapies for lung cancer

scientific article published on 05 November 2020

Severity of lung fibrosis affects early surgical outcomes of lung cancer among patients with combined pulmonary fibrosis and emphysema ⬇️

scientific article published on July 2016

Stapling cartridge lavage cytology in limited resection for pulmonary malignant tumors: assessment of cytological status of the surgical margin

Subcarinal lymph node in upper lobe non-small cell lung cancer patients: is selective lymph node dissection valid?

scientific article published on 16 March 2010

Sublobar resection versus lobectomy for patients with resectable stage I non-small cell lung cancer with idiopathic pulmonary fibrosis: a phase III study evaluating survival (JCOG1708, SURPRISE)

scientific article published on 17 June 2020

Surgical outcomes after initial surgery for clinical single-station N2 non-small-cell lung cancer

scientific article published on 7 November 2013

Surgical outcomes of non-small-cell lung carcinoma in patients previously treated for gastric cancer

scientific article published on 30 June 2014

Survival and prognostic factors after pulmonary metastasectomy of head and neck cancer: what are the clinically informative prognostic indicators?

scientific article published on 01 May 2019

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

scientific article published on 31 August 2020

The association of intravascular stromal cells with prognosis in high-grade neuroendocrine carcinoma of the lung

scientific article published on 22 December 2015

The availability of pre- and intraoperative evaluation of a solitary pulmonary nodule in breast cancer patients

scientific article published on 16 May 2014

The clinical outcome of non-small cell lung cancer patients with adjacent lobe invasion: the optimal classification according to the status of the interlobar pleura at the invasion point.

scientific article published on 16 May 2012

The difference in Ezrin-pAkt signaling axis between lepidic and papillary predominant invasive adenocarcinomas of the lung

scientific article published on 08 April 2016

The differences of biological behavior based on the clinicopathological data between resectable large-cell neuroendocrine carcinoma and small-cell lung carcinoma

scientific article

The impact on survival of positive intraoperative pleural lavage cytology in patients with non-small-cell lung cancer

scientific article published on 17 September 2009

The ratio of cancer cells to stroma after induction therapy in the treatment of non-small cell lung cancer

scientific article published on 17 September 2016

The ratio of cancer cells to stroma within the invasive area is a histologic prognostic parameter of lung adenocarcinoma

scientific article published on 31 January 2018

The recurrence of malignant pleural mesothelioma 14 years after extrapleural pneumonectomy: possible histological transformation

scientific article published in November 2012

The role of pulmonary resection in tumors metastatic from esophageal carcinoma

scientific article published on 21 September 2016

Thin-section computed tomography findings of lung adenocarcinoma with inherent metastatic potential

scientific article published on 22 September 2016

Tumor-size-based morphological features of metastatic lymph node tumors from primary lung adenocarcinoma

scientific article published on 30 October 2014

Utility of Site-Specific Biopsy for Diagnosis of Desmoplastic Malignant Mesothelioma.

scientific article published on 27 March 2018

Wedge Resection Versus Anatomic Resection: Extent of Surgical Resection for Stage I and II Lung Cancer

scientific article published in January 2017

List of works by Keiju Aokage

A non-randomized confirmatory trial of segmentectomy for clinical T1N0 lung cancer with dominant ground glass opacity based on thin-section computed tomography (JCOG1211).

A proposal for a comprehensive risk scoring system for predicting postoperative complications in octogenarian patients with medically operable lung cancer: JACS1303.

A randomized Phase III trial of lobe-specific vs. systematic nodal dissection for clinical Stage I-II non-small cell lung cancer (JCOG1413)

Abundant tumor promoting stromal cells in lung adenocarcinoma with hypoxic regions

Annual abdominal ultrasonographic examination after curative NSCLC resection.

Association between the mutational smoking signature and the immune microenvironment in lung adenocarcinoma

Cancer‐initiating cell marker‐positive cells generate metastatic tumors that recapitulate the histology of the primary tumors ⬇️

Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia

Clinical and Pathological Staging Validation in the Eighth Edition of the TNM Classification for Lung Cancer: Correlation between Solid Size on Thin-Section Computed Tomography and Invasive Size in Pathological Findings in the New T Classification

Clinical prediction of solitary pulmonary nodule after a curative resection for gastric cancer

Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer

Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma

Comparison of pulmonary segmentectomy and lobectomy: Safety results of a randomized trial

Correlation between maximum standardized uptake values on FDG-PET and microenvironmental factors in patients with clinical stage IA radiologic pure-solid lung adenocarcinoma

Delayed cut-end recurrence after wedge resection for pulmonary ground-glass opacity adenocarcinoma despite negative surgical margin

Differences between squamous cell carcinoma and adenocarcinoma of the lung: are adenocarcinoma and squamous cell carcinoma prognostically equal?

Differences of tumor microenvironment between stage I lepidic-positive and lepidic-negative lung adenocarcinomas

Distinctive histopathological features of lepidic growth predominant node-negative adenocarcinomas 3-5 cm in size.

Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma

Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation

Effectiveness of Bone Suppression Imaging in the Detection of Lung Nodules on Chest Radiographs: Relevance to Anatomic Location and Observer's Experience

Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma

Extended bronchoplasty for locally advanced left lower lobe lung cancer: surgical technique and outcomes

Ezrin-expressing lung adenocarcinoma cells and podoplanin-positive fibroblasts form a malignant microenvironment

Feasibility and efficacy of salvage lung resection after definitive chemoradiation therapy for Stage III non-small-cell lung cancer.

Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung

Ground-Glass Opacity Is a Strong Prognosticator for Pathologic Stage IA Lung Adenocarcinoma

Growth patterns of small peripheral squamous cell carcinoma of the lung and their impacts on pathological and biological characteristics of tumor cells

High-Risk Factors for Recurrence of Stage I Lung Adenocarcinoma: Follow-up Data From JCOG0201

Histological progression of small intrapulmonary metastatic tumor from primary lung adenocarcinoma

Histology is a Prognostic Indicator After Pulmonary Metastasectomy from Renal Cell Carcinoma

Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness

Identification of early t1b lung adenocarcinoma based on thin-section computed tomography findings

Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma

Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia

Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma.

Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung

Impact of extratumoral lymphatic permeation on postoperative survival of non-small-cell lung cancer patients

Impact of positive pleural lavage cytology on survival in patients having lung resection for non-small-cell lung cancer: An international individual patient data meta-analysis

Influence of Ground-Glass Opacity and the Corresponding Pathological Findings on Survival in Patients with Clinical Stage I Non-Small Cell Lung Cancer

Interstitial growth as an aggressive growth pattern in primary lung cancer

Intrapulmonary metastasis in resected pathologic stage IIIB non-small cell lung cancer: possible contribution of aerogenous metastasis to the favorable outcome.

Is cancer history really an exclusion criterion for clinical trial of lung cancer? Influence of gastrointestinal tract cancer history on the outcomes of lung cancer surgery

Is cancer history really an exclusion criterion for clinical trial of lung cancer? Influence of gastrointestinal tract cancer history on the outcomes of lung cancer surgery

Large pulmonary sclerosing pneumocytoma with massive necrosis and vascular invasion: a case report

Late recurrence of non-small cell lung cancer more than 5 years after complete resection: incidence and clinical implications in patient follow-up

Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery: a review

Limited resection trial for pulmonary ground-glass opacity nodules: case selection based on high-resolution computed tomography-interim results

Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma

Long-term outcome and late recurrence in patients with completely resected stage IA non-small cell lung cancer

Long-term outcome of surgical resection for residual or regrown advanced non-small cell lung carcinomas following EGFR-TKI treatment: report of four cases.

Long-term outcomes of 50 cases of limited-resection trial for pulmonary ground-glass opacity nodules

Long-term survival after complete resection of non-small-cell lung cancer in patients with interstitial lung disease

Long-term survival and risk factors for recurrence in stage I non-small cell lung cancer patients with tumors up to 3 cm in maximum dimension

Long-term survival in two cases of resected gastric metastasis of pulmonary pleomorphic carcinoma

Long-term survival outcome after lobectomy in patients with clinical T1 N0 lung cancer

Long-term survival outcome after postoperative recurrence of non-small-cell lung cancer: who is 'cured' from postoperative recurrence?

Low-fat diet management strategy for chylothorax after pulmonary resection and lymph node dissection for primary lung cancer

Machine learning-based histological classification that predicts recurrence of peripheral lung squamous cell carcinoma

Mediastinal nodal involvement in patients with clinical stage I non-small-cell lung cancer: possibility of rational lymph node dissection

Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung

Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis

Multiple Perivascular Epithelioid Cell Tumors: Clear Cell Tumor of the Lung Accompanied by Angiomyolipoma of the Liver ⬇️

Optimal method for measuring invasive size that predicts survival in invasive mucinous adenocarcinoma of the lung

P31: Salvage surgery for PMGCT: beneficial for persistent positive-marker patients?

Perioperative pirfenidone treatment as prophylaxis against acute exacerbation of idiopathic pulmonary fibrosis: a single-center analysis

Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma

Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibrobla

Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi type B, in three patients

Postoperative oligo-recurrence of non-small-cell lung cancer: clinical features and survival†.

Prediction of prolonged air leak after lung resection using continuous log data of flow by digital drainage system

Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.

Prognosis of lung cancer patients with a past history of colorectal cancer

Prognostic Impact of the Number of Metastatic Lymph Nodes on the Eighth Edition of the TNM Classification of NSCLC

Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma: possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment.

Prognostic impact of a ground-glass opacity component in clinical stage IA non-small cell lung cancer

Prognostic impact of intratumoural microvascular invasion and microlymphatic permeation on node-negative non-small-cell lung cancer: which indicator is the stronger prognostic factor?

Prognostic impact of microscopic vessel invasion and visceral pleural invasion in non-small cell lung cancer: a retrospective analysis of 2657 patients