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List of works by Colin Kovacs

A Case of a Potential Drug Interaction between Clobazam and Etravirine-Based Antiretroviral Therapy ⬇️

scientific article published on 04 November 2011

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.

scientific article

A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection.

scientific article

A randomized controlled trial of HIV therapeutic vaccination using ALVAC with or without Remune ⬇️

scientific article published on March 27, 2011

Anal dysplasia and HIV shedding in ART-treated men

scientific article published on 06 January 2020

Antibody-Dependent Cellular Cytotoxicity Activity of Effector Cells from HIV-Infected Elite and Viral Controllers

scientific article published on 7 August 2016

Antigen-Independent Induction of Tim-3 Expression on Human T Cells by the Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Is Associated with Proliferation and Is Dependent on the Phosphoinositide 3-Kinase Pathway ⬇️

scientific article published on March 14, 2012

Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions

scientific article

Assessment of antiretroviral third agent virologic durability after initiation of first antiretroviral regimen

scientific article published on 01 May 2019

Asymptomatic neurocognitive impairment is a risk for symptomatic decline in a large HIV Canadian cohort study

scientific article published on 08 October 2020

Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir

scientific article

CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitro

scientific article published on 01 March 2007

Can Probiotics Reduce Inflammation and Enhance Gut Immune Health in People Living with HIV: Study Designs for the Probiotic Visbiome for Inflammation and Translocation (PROOV IT) Pilot Trials.

scientific article published on 7 June 2016

Cardiovascular events in an inner-city HIV clinic and relation to abacavir- vs. TDF- containing antiretroviral regimens

scientific article published on 06 October 2020

Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals

scientific article

Characterization of cross-reactive CD8+ T-cell recognition of HLA-A2-restricted HIV-Gag (SLYNTVATL) and HCV-NS5b (ALYDVVSKL) epitopes in individuals infected with human immunodeficiency and hepatitis C viruses.

scientific article

Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection

scientific article

Clinical and Mucosal Immune Correlates of HIV-1 Semen Levels in Antiretroviral-Naive Men.

scientific article

Clinical impact of double protease inhibitor boosting with lopinavir/ritonavir and amprenavir as part of salvage antiretroviral therapy

scientific article published in September 2003

Coinfection with herpes simplex virus type 2 is associated with reduced HIV-specific T cell responses and systemic immune activation

scientific article published in May 2008

Concomitant use of an active boosted protease inhibitor with enfuvirtide in treatment-experienced, HIV-infected individuals: recent data and consensus recommendations

scientific article

Cooperation of TNF family members CD40 ligand, receptor activator of NF-kappa B ligand, and TNF-alpha in the activation of dendritic cells and the expansion of viral specific CD8+ T cell memory responses in HIV-1-infected and HIV-1-uninfected indivi

scientific article published on 01 February 2003

Correction

Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily

scientific article

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.

scientific article

Differential predictors of ART adherence among HIV-monoinfected versus HIV/HCV-coinfected individuals

scientific article published on 14 March 2016

Disproportionately high semen shedding of HIV is associated with compartmentalized cytomegalovirus reactivation.

scientific article

Distinct transcriptional profiles in ex vivo CD4+ and CD8+ T cells are established early in human immunodeficiency virus type 1 infection and are characterized by a chronic interferon response as well as extensive transcriptional changes in CD8+ T c

scientific article published on 24 January 2007

Effect of antiretroviral therapy on HIV reservoirs in elite controllers

scientific article published on 11 July 2013

Effect of raltegravir intensification on HIV proviral DNA in the blood and gut mucosa of men on long-term therapy: a randomized controlled trial

scientific article published on 01 January 2012

Endometrial epithelial cell response to semen from HIV-infected men during different stages of infection is distinct and can drive HIV-1-long terminal repeat

article

Enhancing effects of adjuvanted 2009 pandemic H1N1 influenza A vaccine on memory B-cell responses in HIV-infected individuals ⬇️

scientific article published on January 28, 2011

Epigenetic analysis of HIV-1 proviral genomes from infected individuals: predominance of unmethylated CpG's.

scientific article

Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent Reservoirs

scientific article published on 05 March 2019

Expression of membrane drug efflux transporters in the sigmoid colon of HIV-infected and uninfected men.

scientific article published on 15 July 2013

Four-Year Follow-Up of Polyalkylimide Gel Use for the Treatment of HIV-Associated Lipoatrophy ⬇️

scientific article published on November 1, 2011

HCV Specific IL-21 Producing T Cells but Not IL-17A Producing T Cells Are Associated with HCV Viral Control in HIV/HCV Coinfection

scientific article

HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression

scientific article published in September 2010

HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.

scientific article

HIV RNA Rebound in Seminal Plasma after Antiretroviral Treatment Interruption

scientific article published on 20 May 2020

HIV delays IFN-α production from human plasmacytoid dendritic cells and is associated with SYK phosphorylation

scientific article

HIV viral shedding in semen: lack of correlation with systemic virus-specific CD8 responses

scientific article published in November 2004

HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium

scientific article published on 16 September 2013

HIV-Specific Granzyme B-Secreting but Not Gamma Interferon-Secreting T Cells Are Associated with Reduced Viral Reservoirs in Early HIV Infection.

scientific article published on 8 February 2017

HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir

scientific article

HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV shedding.

scientific article

HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection

scientific article

Herpes simplex virus type 2 coinfection does not accelerate CD4 count decline in untreated HIV infection.

scientific article published on 9 April 2013

Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes

scientific article

Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening.

scientific article published on 28 December 2011

Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations

scientific article published on 24 June 2009

IL-10-producing B cells are induced early in HIV-1 infection and suppress HIV-1-specific T cell responses.

scientific article

Immediate versus delayed polyalkylimide gel injections to correct facial lipoatrophy in HIV-positive patients

scientific article published in May 2007

Immunologic Effectiveness of Maraviroc- and Raltegravir-Containing Regimens (R+M+) versus Raltegravir-Based Regimens That Do Not Include Maraviroc (R+M−) ⬇️

scientific article published on January 13, 2012

Impact of CMV therapy with valganciclovir on immune activation and the HIV viral load in semen and blood: an observational clinical study

scientific article published on March 2014

Impact of Treatment Interruption on HIV Reservoirs and Lymphocyte Subsets in Individuals Who Initiated Antiretroviral Therapy During the Early Phase of Infection

scientific article published on 01 June 2019

Impact of antiretroviral therapy duration and intensification on isolated shedding of HIV-1 RNA in semen

scientific article

Impact of collection method on assessment of semen HIV RNA viral load

scientific article

Impact of intensified antiretroviral therapy during early HIV infection on gut immunology and inflammatory blood biomarkers

scientific article published on May 2017

Intensifying Antiretroviral Therapy With Raltegravir and Maraviroc During Early Human Immunodeficiency Virus (HIV) Infection Does Not Accelerate HIV Reservoir Reduction

scientific article

La trithérapie antirétrovirale active à based’enfuvirtide administré à l’aide du Biojector est sûre et efficace

scientific article published in 2007

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.

scientific article published on 22 January 2018

Latent TGF-β1 is compartmentalized between blood and seminal plasma of HIV-positive men and its activation in semen is negatively correlated with viral load and immune activation

scientific article

Long-term efficacy and safety of polyalkylimide gel for the treatment of HIV-associated lipoatrophy

scientific article published in October 2009

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

scientific article published on 18 May 2003

Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals

scientific article

Maintenance of HIV-Specific Memory B-Cell Responses in Elite Controllers Despite Low Viral Burdens

scientific article published on 27 April 2016

Mucosal Th17 cell function is altered during HIV infection and is an independent predictor of systemic immune activation

scientific article published on 26 July 2013

Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-α response from plasmacytoid dendritic cells

article

Persistent HIV RNA shedding in semen despite effective antiretroviral therapy

scientific article published on 01 September 2009

Pharmacokinetics of Maraviroc, Raltegravir, Darunavir, and Etravirine in the Semen of HIV-Infected Men ⬇️

scientific article published on February 1, 2013

Pharmacologic HIV-1 Nef blockade promotes CD8 T cell-mediated elimination of latently HIV-1-infected cells in vitro

scientific article published on 7 September 2017

Prescribing and using self-injectable antiretrovirals: how concordant are physician and patient perspectives?

scientific article published on 05 February 2009

Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study

scientific article (publication date: October 2007)

Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication

scientific article

Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57

scientific article

Recognizing cognitive and psychiatric changes in the post-highly active antiretroviral therapy era.

scientific article published on January 2012

Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy ⬇️

scientific article published on July 1, 2011

Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals

scholarly article

Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy

scientific article published on 8 May 2002

Short Communication: Human Immunodeficiency Virus Rebound in Blood and Seminal Plasma Following Discontinuation of Antiretroviral Therapy ⬇️

scientific article published on September 25, 2012

Short communication: HIV type 1 accumulates in influenza-specific T cells in subjects receiving seasonal vaccination in the context of effective antiretroviral therapy

scientific article

Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy

scientific article published in March 2011

Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection

scientific article published in November 2009

T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers ⬇️

scientific article published on June 16, 2011

T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy

scientific article published on 20 September 2017

The Canadian HIV and aging cohort study - determinants of increased risk of cardio-vascular diseases in HIV-infected individuals: rationale and study protocol.

scientific article published on 11 September 2017

The impact of CCL3L1 copy number in an HIV-1-infected white population

scientific article published on 01 June 2010

The recombinant hepatitis B surface antigen vaccine in persons with HIV: is seroconversion sufficient for long-term protection?

scientific article published on 23 March 2012

The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase signal transduction pathways in CD40 ligand-induced dendritic cell activation and expansion of virus-specific CD8+ T cell m

scientific article published in May 2004

The semen microbiome and its relationship with local immunology and viral load in HIV infection

scientific article

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

scientific article published on 10 November 2008

Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9.

scientific article published on 6 March 2017

Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection

scientific article

Time to Viremia for Patients Taking their First Antiretroviral Regimen and the Subsequent Resistance Profiles

scientific article

Time to virologic failure for patients taking their first antiretroviral regimen and the subsequent resistance profiles

scientific article

Triple active antiretroviral regimen including enfuvirtide via the Biojector is effective and safe

scientific article published in January 2007

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