List of works - Raok Jeon

A lignan induces lysosomal dependent degradation of FoxM1 protein to suppress β-catenin nuclear translocation

scientific article published on 05 April 2017

Activation of microglial TLR3 promotes neuronal survival against cerebral ischemia

scientific article published on 25 November 2015

Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease

scientific article published on 10 November 2015

Ajoene restored behavioral patterns and liver glutathione level in morphine treated C57BL6 mice

scientific article published on 28 October 2016

Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes.

scientific article published on 12 May 2010

Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

scientific article

Anti-Inflammatory Activity of Sulfur-Containing Compounds from Garlic ⬇️

scientific article published on October 11, 2012

Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): <i>in vitro</i> and <i>in vivo</i> studies

scientific article published on 01 December 2021

Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro ⬇️

scientific article published on July 28, 2013

Decursin from Angelica gigas suppresses RANKL-induced osteoclast formation and bone loss

scientific article published on 26 January 2016

Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists ⬇️

scientific article published on November 22, 2012

Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics

scientific article published on 15 July 2014

Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists ⬇️

scientific article published on March 24, 2011

Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages ⬇️

scientific article published on March 16, 2012

Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors

scientific article

Design and synthesis of urea and thiourea derivatives and their inhibitory activities on lipopolysaccharide-induced NO production

scientific article published on 06 April 2007

Design, synthesis and activity of benzothiazole-based inhibitors of NO production in LPS-activated macrophages ⬇️

scientific article published on September 16, 2010

Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor γ/δ agonists

scientific article published on 23 April 2015

Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway

scientific article published on 3 March 2017

Discovery of 5-Phenoxy-2-aminopyridine Derivatives as Potent and Selective Irreversible Inhibitors of Bruton's Tyrosine Kinase

scientific article published on 28 October 2020

Discovery of Tricyclic Pyranochromenone as Novel Bruton's Tyrosine Kinase Inhibitors with in Vivo Antirheumatic Activity

scientific article published on 25 October 2020

Effects of bisphenol A on breast cancer and its risk factors

scientific article published on 9 October 2008

Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice.

scientific article published on 25 March 2016

Enhanced antioxidant effect of prenylated polyphenols as Fyn inhibitor ⬇️

scientific article published on July 6, 2012

Garlic (Allium sativum) extract inhibits lipopolysaccharide-induced Toll-like receptor 4 dimerization

scientific article published on 7 February 2008

Histone deacetylase 8 inhibition alleviates cholestatic liver injury and fibrosis

scientific article published on 29 October 2020

Identification of a Novel PPAR-γ Agonist through a Scaffold Tuning Approach

scientific article published on 04 October 2018

Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach

scientific article published on 31 December 2020

In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii

scientific article published on 26 December 2008

Inhibition of TNF-α-mediated inflammatory responses by a benzodioxolylacetylamino-linked benzothiazole analog in human fibroblast-like synoviocytes ⬇️

scientific article published on April 21, 2011

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium

scientific article

Kazinol-E is a specific inhibitor of ERK that suppresses the enrichment of a breast cancer stem-like cell population

scientific article published on 13 January 2016

Negative regulation of NOD1 mediated angiogenesis by PPARγ-regulated miR-125a.

scientific article published on 8 November 2016

Optimization and biological evaluation of 2-aminobenzothiazole derivatives as Aurora B kinase inhibitors

scientific article published on 6 April 2017

Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates

scientific article published in May 2003

SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice

scientific article

SPA0355 prevents ovariectomy-induced bone loss in mice

SPA0355 suppresses T-cell responses and reduces airway inflammation in mice

scientific article

Selective Targeting of Cancer Stem Cells by 2-Aminodihydroquinoline Analogs

scientific article published on 27 January 2017

Skin-Specific Deletion of Mis18α Impedes Proliferation and Stratification of Epidermal Keratinocytes

scientific article

Stilbenoids from Rheum undulatum Protect Hepatocytes Against Oxidative Stress Through AMPK Activation

scientific article published on 27 August 2015

Structure-Activity Relationship of Phytoestrogen Analogs as ERα/β Agonists with Neuroprotective Activities

scientific article published on 01 January 2021

Synthesis and anticancer activity of aminodihydroquinoline analogs: Identification of novel proapoptotic agents ⬇️

scientific article published on April 25, 2013

Synthesis and biological activity of 5-{4-[2-(methyl-p-substituted phenylamino)ethoxy]benzyl}thiazolidine-2,4-diones

scientific article published in September 2007

Synthesis and biological activity of [[(heterocycloamino)alkoxy] benzyl]-2,4-thiazolidinediones as PPARgamma agonists

scientific article published on May 2006

Synthesis and biological activity of benzoxazole containing thiazolidinedione derivatives.

scientific article

Synthesis of 6-[2-(benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acid and inhibitory activity on beta-amyloid aggregation

scientific article

Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia

scientific article

Synthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages.

scientific article published on 7 April 2009

Synthesis of polymeric thiazolidinedione and fibrate conjugates

scientific article published in February 2008

Synthesis of polymeric thiazolidinediones and L-ascorbic acid towards the development of insulin-sensitizer

scientific article

Systemic approaches identify a garlic-derived chemical, Z-ajoene, as a glioblastoma multiforme cancer stem cell-specific targeting agent

scientific article

The efficacy of SPA0355 in protecting β cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes

scientific article

The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells

scientific article published on 20 July 2016

βTrCP-mediated ubiquitylation regulates protein stability of Mis18β in a cell cycle-dependent manner

scientific article published on 21 November 2013

List of works by Raok Jeon

A lignan induces lysosomal dependent degradation of FoxM1 protein to suppress β-catenin nuclear translocation

Activation of microglial TLR3 promotes neuronal survival against cerebral ischemia

Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease

Ajoene restored behavioral patterns and liver glutathione level in morphine treated C57BL6 mice

Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes.

Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

Anti-Inflammatory Activity of Sulfur-Containing Compounds from Garlic ⬇️

Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): <i>in vitro</i> and <i>in vivo</i> studies

Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro ⬇️

Decursin from Angelica gigas suppresses RANKL-induced osteoclast formation and bone loss

Design and synthesis of alkoxyindolyl-3-acetic acid analogs as peroxisome proliferator-activated receptor-γ/δ agonists ⬇️

Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics

Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists ⬇️

Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages ⬇️

Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors

Design and synthesis of urea and thiourea derivatives and their inhibitory activities on lipopolysaccharide-induced NO production

Design, synthesis and activity of benzothiazole-based inhibitors of NO production in LPS-activated macrophages ⬇️

Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor γ/δ agonists

Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway

Discovery of 5-Phenoxy-2-aminopyridine Derivatives as Potent and Selective Irreversible Inhibitors of Bruton's Tyrosine Kinase

Discovery of Tricyclic Pyranochromenone as Novel Bruton's Tyrosine Kinase Inhibitors with in Vivo Antirheumatic Activity

Effects of bisphenol A on breast cancer and its risk factors

Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice.

Enhanced antioxidant effect of prenylated polyphenols as Fyn inhibitor ⬇️

Garlic (Allium sativum) extract inhibits lipopolysaccharide-induced Toll-like receptor 4 dimerization

Histone deacetylase 8 inhibition alleviates cholestatic liver injury and fibrosis

Identification of a Novel PPAR-γ Agonist through a Scaffold Tuning Approach

Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach

In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii

Inhibition of TNF-α-mediated inflammatory responses by a benzodioxolylacetylamino-linked benzothiazole analog in human fibroblast-like synoviocytes ⬇️

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium

Kazinol-E is a specific inhibitor of ERK that suppresses the enrichment of a breast cancer stem-like cell population

Negative regulation of NOD1 mediated angiogenesis by PPARγ-regulated miR-125a.

Optimization and biological evaluation of 2-aminobenzothiazole derivatives as Aurora B kinase inhibitors

Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates

SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice

SPA0355 prevents ovariectomy-induced bone loss in mice

SPA0355 suppresses T-cell responses and reduces airway inflammation in mice

Selective Targeting of Cancer Stem Cells by 2-Aminodihydroquinoline Analogs

Skin-Specific Deletion of Mis18α Impedes Proliferation and Stratification of Epidermal Keratinocytes

Stilbenoids from Rheum undulatum Protect Hepatocytes Against Oxidative Stress Through AMPK Activation

Structure-Activity Relationship of Phytoestrogen Analogs as ERα/β Agonists with Neuroprotective Activities

Synthesis and anticancer activity of aminodihydroquinoline analogs: Identification of novel proapoptotic agents ⬇️

Synthesis and biological activity of 5-{4-[2-(methyl-p-substituted phenylamino)ethoxy]benzyl}thiazolidine-2,4-diones

Synthesis and biological activity of [[(heterocycloamino)alkoxy] benzyl]-2,4-thiazolidinediones as PPARgamma agonists

Synthesis and biological activity of benzoxazole containing thiazolidinedione derivatives.

Synthesis of 6-[2-(benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acid and inhibitory activity on beta-amyloid aggregation

Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia

Synthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages.

Synthesis of polymeric thiazolidinedione and fibrate conjugates

Synthesis of polymeric thiazolidinediones and L-ascorbic acid towards the development of insulin-sensitizer

Systemic approaches identify a garlic-derived chemical, Z-ajoene, as a glioblastoma multiforme cancer stem cell-specific targeting agent

The efficacy of SPA0355 in protecting β cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes

The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells

βTrCP-mediated ubiquitylation regulates protein stability of Mis18β in a cell cycle-dependent manner